کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9940727 1572713 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced mRNA and Protein Content of Rho Guanine Nucleotide Exchange Factor (RhoGEF) in Bartter's and Gitelman's Syndromes: Relevance for the Pathophysiology of Hypertension
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Reduced mRNA and Protein Content of Rho Guanine Nucleotide Exchange Factor (RhoGEF) in Bartter's and Gitelman's Syndromes: Relevance for the Pathophysiology of Hypertension
چکیده انگلیسی
Reduced p115RhoGEF may explain the downregulation of RhoA/ROK pathway in BS/GS. This is the first report of upstream regulators of RhoA level in BS/GS, a human clinical condition characterized by reduced vascular tone regulation. Because BS/GS represent the mirror image of derangements involved in hypertension, the reduced RhoGEF expression in BS/GS underlines a major impact of RhoA/ROK pathway on blood pressure regulation and confirms BS/GS as a good human model for exploring mechanisms involved in the pathophysiology of hypertension and remodeling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Hypertension - Volume 18, Issue 9, September 2005, Pages 1200-1205
نویسندگان
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