کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9954040 | 1535578 | 2018 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cellular senescence in osteoarthritis and anti-aging strategies
ترجمه فارسی عنوان
پیری سلول در استئوآرتریت و استراتژی های ضد پیری
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
پیری سلولی، رفتار، آرتروز، سالخورده، کندروسیت،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
In older adults, the prevalence of osteoarthritis (OA) increases directly with age and is the most common cause of chronic disability. It is necessary to recognize that OA is a degenerative disease that strongly correlates with age, and often promotes elevated levels of cartilage injury. Chondrocytes undergo an age-dependent decline in proliferative and synthetic capacity. It is thought that cellular senescence may play a significant role in the pathology of OA, with chondrocytes exhibiting a variety of senescence-associated phenotypes. In this review, we discuss cellular senescence and its relationship with OA. More importantly, we introduce novel strategies for the modulation of cellular senescence, including the use of sirtuin 6, mammalian target of rapamycin, N-acetyl-l-cysteine, proteoglycan-4 and senolytic, which may help to delay senescence and improve cartilage regeneration in the aging population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 175, October 2018, Pages 83-87
Journal: Mechanisms of Ageing and Development - Volume 175, October 2018, Pages 83-87
نویسندگان
Angyang Hou, Peng Chen, He Tang, Haoye Meng, Xiaoqing Cheng, Yu Wang, Yuming Zhang, Jiang Peng,