کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9989590 1580761 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cerebrospinal fluid of Alzheimer patients promotes β-amyloid fibril formation in vitro
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Cerebrospinal fluid of Alzheimer patients promotes β-amyloid fibril formation in vitro
چکیده انگلیسی
Cerebral deposition of amyloid β-peptide (Aβ) is an invariant feature of Alzheimer's disease (AD). To answer why soluble Aβ does not aggregate to β-amyloid fibrils (fAβ) in the brain of normal humans, we examined the influence of cerebrospinal fluid (CSF) obtained from AD and non-AD patients on the formation of fAβ(1-40) and fAβ(1-42) in vitro, by using fluorescence spectroscopy with thioflavin T and electron microscopy. Although the CSF obtained from both groups inhibited the formation of both fAβ(1-40) and fAβ(1-42), the CSF from non-AD patients inhibited the formation of fAβs more strongly than that from AD patients. In AD patients, the final levels of fAβs formation showed a significant negative correlation with the Aβ(1-42) level in CSF. These results indicate that fAβ deposition in the brain of AD may be enhanced by the decrease of specific inhibitory factors and/or by the increase of specific accelerating factors in CSF.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 20, Issue 2, November 2005, Pages 233-240
نویسندگان
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