دانلود مقالات ISI درباره α-سینوکلین + ترجمه فارسی

LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells

Keywords: α-سینوکلین; lncRNA SNHG1; α-synuclein; miR-15b-5p; SIAH1;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

Yeast red pigment modifies cloned human α-synuclein pathogenesis in Parkinson disease models in Saccharomyces cerevisiae and Drosophila melanogaster

Keywords: α-سینوکلین; Amyloid; Parkinson's disease; α-synuclein; Red pigment; Yeast; Drosophila; AIR; 1-(5′-Phosphoribosyl)-5-aminoimidazole; ER; endoplasmic reticulum; FM; the mobile fraction; FRAP; fluorescence recovery after photobleaching; HR, MR, LR; α-synuclein inclu

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

The small heat shock proteins, especially HspB4 and HspB5 are promising protectants in neurodegenerative diseases

Keywords: α-سینوکلین; α-Crystallins; Neurodegenerative diseases; Neuroprotection; Gene regulation; Aβ; β-amyloid peptides; AD; Alzheimer's disease; ALS; Amyotrophic lateral sclerosis; AxD; Alexander's disease; CNS; Central nervous system; EAE; experimental autoimmune enceph

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

Locomotor differences in mice expressing wild-type human α-synuclein

Keywords: α-سینوکلین; α-Synuclein; Mouse model; Motor behavior; Burrowing; Nest building; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2018 سفارش ترجمه

Phospholipase D1 downregulation by α-synuclein: Implications for neurodegeneration in Parkinson's disease

Keywords: α-سینوکلین; α-syn; alpha synuclein; AU; arbitrary units; CF; cytosolic fraction; DAG; diacylglycerol; ERK; extracellular signal-regulated kinase; ev; IMR-32 cell line stably transfected with pcDNA empty vector; IMR32; human neuroblastoma cell line; LW; Lewy bodies;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice

Keywords: α-سینوکلین; α-synuclein; G2019S knock-in mice; iba-1; LRRK2; Microglia; Parkinson's disease; AAV2/9; adeno-associated viral vector pseudotype 2/9; DA; dopamine; G2019S knock-in; G2019S KI; hα-syn; p.A53T human α-synuclein; ionized calcium binding adaptor molecule

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

In vitro neurotoxicity of salsolinol is attenuated by the presynaptic protein α-synuclein

Keywords: α-سینوکلین; Salsolinol; α-Synuclein; Dopamine; Oligomers; Parkinson's disease; NMR;

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal

Keywords: α-سینوکلین; 4-hydroxynonenal; α-synuclein; Exosomes; Extracellular vesicles; Lipid peroxidation; Parkinson's disease; Striatum;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease

Keywords: α-سینوکلین; α-Syn; alpha-Synuclein; h-α-Syn; transgenic human alpha-Synuclein; D1 receptor; dopamine receptor type 1; D2 receptor; dopamine receptor type 2; DA; dopamine; DAT; dopamine transporter; VMAT2; vesicular monoamine transporter 2; DOPAC; 3,4-dihydroxypheny

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Lipid metabolism alterations in the neuronal response to A53T α-synuclein and Fe-induced injury

Keywords: α-سینوکلین; Dopaminergic neurons; A53T α-synuclein; Iron; Oxidative stress; Triacylglycerol; Lipid metabolism; ACS; Acyl-CoA synthetase; α-syn; α-synuclein; A53T α-syn cell; N27 neurons expressing the vector pcDNA3-A53T α-synuclein; BSA; bovine serum albumin; Ch

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Chronic nicotine improves cognitive and social impairment in mice overexpressing wild type α-synuclein

Keywords: α-سینوکلین; Parkinson's disease; Mouse model; α-synuclein; Nicotine; Motor deficits; Cognitive deficits; Social impairment;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Epothilone D inhibits microglia-mediated spread of alpha-synuclein aggregates

Keywords: α-سینوکلین; α-syn; α-Synuclein; EpoD; Epothilone D; MSA; Multiple System Atrophy; PD; Parkinson's Disease; CNS; Central nervous system; DLB; Dementia with Lewy Bodies; LB; Lewy Bodies; GCI; Glial Cytoplasmic Inclusion; PMA; Phorbol-12-Myristate-13-Acetate; HAPI; Hi

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2018 سفارش ترجمه

Ambroxol modulates 6-Hydroxydopamine-induced temporal reduction in Glucocerebrosidase (GCase) enzymatic activity and Parkinson's disease symptoms

Keywords: α-سینوکلین; Glucocerebrosidase; 6-Hydroxydopamine; Parkinson's disease; Ambroxol; α-synuclein; Mitochondrial dysfunction;

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2018 سفارش ترجمه

Membrane-induced initial structure of α-synuclein control its amyloidogenesis on model membranes

Keywords: α-سینوکلین; AFM; atomic force microscopy; αSNWT; wild-type α-synuclein; αSN103; C-terminally truncated α-synuclein; CD; circular dichroism; DLS; dynamic light scattering; DOPC; 1,2-dioleoyl-sn-glycero-3-phosphocholine; DOPS; 1,2-dioleoyl-sn-glycero-3-phospho-l-se

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2018 سفارش ترجمه

Osmotic stress induced toxicity exacerbates Parkinson's associated effects via dysregulation of autophagy in transgenic C. elegans model

Keywords: α-سینوکلین; PD; Parkinson's disease; α-synuclein; alpha-synuclein; C.elegans; Caenorhabditis elegans; ROS; reactive oxygen species; NGM; nutrient growth medium; H2-DCF-DA; 2, 7-dichlorodihydrofluorescein-diacetate; SP; spermidine; WT; wortmannin; HN; high osmotic; L

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2018 سفارش ترجمه

Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner

Keywords: α-سینوکلین; 5-HT; 5-hydroxytryptamine; Aβ; β-amyloid; ABCA8; ATP binding cassette subfamily A member 8; AD; Alzheimer's disease; ADP; adenosine diphosphate; AGD; argyrophilic grain disease; ALS; amyotrophic lateral sclerosis; AMBRA-1; autophagy and beclin 1 regul

دانلود رایگان متن کامل مقاله ISI 131 صفحه سال انتشار : 2018 سفارش ترجمه

Mitochondrial ROS-mediated post-transcriptional regulation of α-synuclein through miR-7 and miR-153

Keywords: α-سینوکلین; α-SYN; alpha-synuclein; ROS; reactive oxygen species; 3′-UTR; 3′-untranslated region; DAT; dopamine transporter; MPP+; 1-methyl-4-phenylpyridinium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; α-synuclein; microRNA; 3′-UTR; Mitochondria; Pa

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Bilateral upregulation of α-synuclein expression in the mouse substantia nigra by intracranial rotenone treatment

Keywords: α-سینوکلین; α-synuclein; Tyrosine hydroxylase; Striatum; Substantia nigra; Rotenone; Mouse;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein

Keywords: α-سینوکلین; O-GlcNAc; α-Synuclein; Calpain; Proteolysis; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and biological evaluation of novel radioiodinated benzimidazole derivatives for imaging α-synuclein aggregates

Keywords: α-سینوکلین; α-Synuclein; Imaging probe; Parkinson's disease; Lewy body;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Research articleBaicalein blocks α-synuclein secretion from SN4741 cells and facilitates α-synuclein polymerization to big complex

Keywords: α-سینوکلین; α-Synuclein; Baicalein; Synucleinopathies; Secretion; Polymerization;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Research articlePrion-like transmission of α-synuclein pathology in the context of an NFL null background

Keywords: α-سینوکلین; Aβ; amyloid β; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; αS; α-synuclein; BCA; bicinchoninic acid; BSA; bovine serum albumin; CMT; Charcot Marie Tooth; DAB; 3,3′ diaminobenzidine; E. coli; Escherichia coli; FBS; fetal bovine ser

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons

Keywords: α-سینوکلین; LRRK2-G2019S; CRISPR/Cas9; piggyBac; Parkinson's disease; hiPS; α-Synuclein; Serine129 phosphorylated α-Synuclein; PD; Parkinson's disease; LRRK2; leucine-rich repeat kinase 2; G2019S; Glycine 2019 mutated to Serine; SNpc; substantia nigra pars compacta

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Interaction of α-synuclein with Rhus typhina tannin - Implication for Parkinson's disease

Keywords: α-سینوکلین; α-Synuclein; Rhus typhina tannin; Parkinson's disease; Human serum albumin;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Research articleNeuroprotective effects of lentivirus-mediated cystathionine-beta-synthase overexpression against 6-OHDA-induced parkinson's disease rats

Keywords: α-سینوکلین; PD; parkinson's disease; DA; dopaminergic; SN; substantia nigra; H2S; hydrogen sulfide; CBS; cystathionine-beta-synthas; 6-OHDA; 6-Hydroxydopamine; SOD; superoxide dismutase; GSH-Px; glutathione peroxidase; MDA; mlonic dialdehyde; α-SYN; α-synuclein; AO

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Neuroprotective effects of endurance exercise against neuroinflammation in MPTP-induced Parkinson's disease mice

Keywords: α-سینوکلین; Parkinson's disease; α-synuclein; Tyrosine hydroxylase; Endurance exercise; Toll-like receptor-2;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Antibodies against the C-terminus of α-synuclein modulate its fibrillation

Keywords: α-سینوکلین; Aβ; amyloid-β; aSN; α-synuclein; DOPG; dioleoyl-phosphatidylglycerol; EGCG; Epigallocatechin gallate; ELISA; enzyme-linked immunosorbent assay; LUV; large unilamellar vesicles; mAbs; monoclonal antibodies; NAC; non-Amyloid beta component; NC; negative

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Polyunsaturated chains in asymmetric lipids disorder raft mixtures and preferentially associate with α-Synuclein

Keywords: α-سینوکلین; α-Synuclein; Lipid rafts; Polyunsaturated fatty acids; Molecular dynamics simulations; Phase separation; Amphipathic helices;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Experimental animal models of Parkinson's disease: A transition from assessing symptomatology to α-synuclein targeted disease modification

Keywords: α-سینوکلین; α-Synuclein; Parkinson's disease; Animal models; Lewy Body;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Nanoparticle standards for immuno-based quantitation of α-synuclein oligomers in diagnostics of Parkinson's disease and other synucleinopathies

Keywords: α-سینوکلین; Parkinson's disease; α-Synuclein; Diagnostic biomarker; Surface-based fluorescence intensity distribution analysis (sFIDA); Silica nanoparticles (SiNaPs); Automation; Protein aggregates; Neurodegenerative diseases;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?

Keywords: α-سینوکلین; α-Synuclein; Astrocytes; Chronic stress; Microglia; Neurodegeneration; Oxidative stress; Substantia nigra;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

FTY720 (Fingolimod) reverses α-synuclein-induced downregulation of brain-derived neurotrophic factor mRNA in OLN-93 oligodendroglial cells

Keywords: α-سینوکلین; Anti-inflammatory; Glioprotective; Multiple system atrophy; Neuroprotective; Restorative effects; AcH3; acetylated histone 3; aSyn; α-synuclein; BDNF; brain-derived neurotrophic factor; bp; base pair; DLB; Dementia with Lewy Bodies; FDA; Food and Drug Ad

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Featured ArticleEvaluation of α-synuclein as a novel cerebrospinal fluid biomarker in different forms of prion diseases

Keywords: α-سینوکلین; Cerebrospinal fluid; α-Synuclein; Biomarker; ELISA; Neurodegenerative diseases; Sporadic Creutzfeldt-Jakob disease; Genetic Creutzfeldt-Jakob disease; Prion diseases;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease

Keywords: α-سینوکلین; PINK1; α-Synuclein; Kinetin; Neurodegeneration; Parkinson's disease; Adeno-associated virus; AAV;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Towards understanding cellular structure biology: In-cell NMR

Keywords: α-سینوکلین; In-cell NMR; Structure biology; Protein-protein interactions; Protein stability; Protein maturation; α-Synuclein;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course

Keywords: α-سینوکلین; CAT; cathepsin; CBE; conduritol-β-epoxide; ER; endoplasmic reticulum; gba+/−;  heterozygous null mouse gba allele; GCase; glucocerebrosidase; GD; Gaucher disease; HMW; high molecular weight; LAMP2; lysosomal membrane protein 1; LIMP2; lysosomal integr

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

HIV-1 Vpr disrupts mitochondria axonal transport and accelerates neuronal aging

Keywords: α-سینوکلین; HIV-Associated neurocognitive disorder; Viral protein R; Mitochondria axonal transport; α-synuclein; Aging; Vpr; viral protein R; HAND; HIV-associated neurocognitive disorder; cART; combined anti-retroviral therapy; MPTP; mitochondria permeability transi

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy

Keywords: α-سینوکلین; AEBSF; 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride; α-syn; α-synuclein; BiFC; bimolecular fluorescence complementation; CT; C-terminal; DLB; dementia with Lewy bodies; ER; endoplasmic reticulum; mAbs; monoclonal antibodies; MSA; multiple syst

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

In vitro α-synuclein neurotoxicity and spreading among neurons and astrocytes using Lewy body extracts from Parkinson disease brains

Keywords: α-سینوکلین; α-Synuclein; High-throughput; 96-well plate; Microfluidic; High content imaging;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Research PaperFunctional alterations of the dopaminergic and glutamatergic systems in spontaneous α-synuclein overexpressing rats

Keywords: α-سینوکلین; α-syn; α-synuclein; m/m; homozygous mutant rats;  +/+;  control animals; PD; Parkinson's disease; LBs; Lewy bodies; SNpc; substantia nigra pars compacta; VTA; ventral tegmental area; DA; dopamine; DAergic neurons; dopaminergic neurons; MSNs; medium sp

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Analysis of sheep α-synuclein provides a molecular strategy for the reduction of fibrillation

Keywords: α-سینوکلین; α-Synuclein; Parkinson's disease; Amyloid; Aggregation; Fibril;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Polo-like kinase 2 modulates α-synuclein protein levels by regulating its mRNA production

Keywords: α-سینوکلین; Parkinson's disease; α-synuclein; Polo-like kinase 2; transcription; phosphorylation;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Review articleDeregulation of α-synuclein in Parkinson's disease: Insight from epigenetic structure and transcriptional regulation of SNCA

Keywords: α-سینوکلین; α-synuclein; Parkinson's disease; Epigenetics; Gene regulation; DNA methylation; Histone post translational modification; α-SYN; α-synuclein; CGI; CpG island; CTD; c-terminal domain; DA; dopaminergic neurons; DLB; Diffuse Lewy Body; ENCODE; Encyclopedi

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease

Keywords: α-سینوکلین; ATP; Parkinson's disease; ER stress; Dopaminergic neurons; Mitochondria; α-Synuclein;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

α-synuclein aggregation and its modulation

Keywords: α-سینوکلین; α-synuclein; Aggregation; Amyloid fibrils;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

Tctex1 plays a key role in the α-synuclein autophagy lysosomal degradation pathway

Keywords: α-سینوکلین; Tctex1; α-Synuclein; Autophagy; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

α-Synuclein binds to cytoplasmic vesicles in U251 glioblastoma cells

Keywords: α-سینوکلین; α-synuclein; Oxidative stress; Cytoplasmic vesicles;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

CpG demethylation in the neurotoxicity of 1-methyl-4-phenylpyridinium might mediate transcriptional up-regulation of α-synuclein in SH-SY5Y cells

Keywords: α-سینوکلین; Parkinson's disease; α-synuclein; 6-hydroxydopamine; 1-methyl-4-phenylpyridinium; CpG demethylation;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

Mulberry fruit ameliorates Parkinson's-disease-related pathology by reducing α-synuclein and ubiquitin levels in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model

Keywords: α-سینوکلین; Mulberry fruit; α-Synuclein; Parkinson's disease; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Probenecid;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

Pressure effects on α-synuclein amyloid fibrils: An experimental investigation on their dissociation and reversible nature

Keywords: α-سینوکلین; Amyloid; High-pressure; SAXS; FTIR; α-synuclein;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه