کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5623671 1406217 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleEvaluation of α-synuclein as a novel cerebrospinal fluid biomarker in different forms of prion diseases
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Featured ArticleEvaluation of α-synuclein as a novel cerebrospinal fluid biomarker in different forms of prion diseases
چکیده انگلیسی

IntroductionAccurate diagnosis of prion diseases and discrimination from alternative dementias gain importance in the clinical routine, but partial overlap in cerebrospinal fluid (CSF) biomarkers impedes absolute discrimination in the differential diagnostic context.MethodsWe established the clinical parameters for prion disease diagnosis for the quantification of CSF α-synuclein in patients with sporadic (n = 234) and genetic (n = 56) prion diseases, in cases with cognitive impairment/dementia or neurodegenerative disease (n = 278), and in the neurologic control group (n = 111).ResultsAn optimal cutoff value of 680 pg/mL α-synuclein results in 94% sensitivity and 96% specificity when diagnosing sporadic Creutzfeldt-Jakob disease (CJD). Genetic CJD cases showed increased CSF α-synuclein values. No increased α-synuclein levels were detected in non-CJD cases with rapid progression course.DiscussionDetection of α-synuclein in the CSF of patients with suspected CJD is a valuable diagnostic test reaching almost full discrimination from non-prion disease cases. These data highlight the utility of CSF α-synuclein quantification in front of classical CSF biomarkers in clinical routine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 13, Issue 6, June 2017, Pages 710-719
نویسندگان
, , , , , , , , , , , , , , , ,