دانلود مقالات ISI درباره α-سینوکلین + ترجمه فارسی

The inhibitory effects of biomimetically designed peptides on α-synuclein aggregation

Keywords: α-سینوکلین; Peptide inhibitor; Amyloid fibril formation; α-Synuclein; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

Caloric restriction alleviates alpha-synuclein toxicity in aged yeast cells by controlling the opposite roles of Tor1 and Sir2 on autophagy

Keywords: α-سینوکلین; CLS; chronological lifespan; CR; caloric restriction; CFUs; counting colony-forming units; NCR; non caloric restriction; syn; α-synuclein; Caloric restriction; Autophagy; Sirtuins; Alpha-synuclein; Synucleinopathies;

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

Pathological α-synuclein exacerbates the progression of Parkinson's disease through microglial activation

Keywords: α-سینوکلین; AKT; protein kinase B; AP-1; activator protein-1; BV-2; immortalized murine microglia cell line; CD11b; cluster of differentiation 11b; CD36; cluster of differentiation 36; CD44; cluster of differentiation 44; CD68; cluster of differentiation 68; CNS; cen

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

In vivo and in silico studies to identify mechanisms associated with Nurr1 modulation following early life exposure to permethrin in rats

Keywords: α-سینوکلین; 3-PBA; 3-phenoxybenzoic acid; BBB; blood-brain barrier; DNMTs; DNA methyltransferases; EDTA; ethylenediaminetetraacetic acid; LBD; Ligand Binding Domain; MSP; Methylation-Specific PCR; NOAEL; No Observed Adverse Effect Level; NuIP; Nurr1-interacting pro

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathology

Keywords: α-سینوکلین; Inflammation; ELISA; Neuropathology; Neuroprotection; Plaques; Tangles; α-synuclein;

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2017 سفارش ترجمه

Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans

Keywords: α-سینوکلین; Anti-Parkinsonian effects; β‐amyrin; Caenorhabditis elegans; Antioxidant; α-synuclein; LGG-1; Autophagy;

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2017 سفارش ترجمه

Parkinsonian features in aging GFAP.HMOX1 transgenic mice overexpressing human HO-1 in the astroglial compartment

Keywords: α-سینوکلین; α-Synuclein; Astrocyte; Dopamine; Heme oxygenase-1; Mitochondrial dysfunction; Oxidative stress; Parkinson disease;

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2017 سفارش ترجمه

Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins

Keywords: α-سینوکلین; Tubulin Polymerization Promoting Protein/p25; α-Synuclein; Deletion mutants; Protein chameleon; Drug target; Bimolecular fluorescence complementation;

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2017 سفارش ترجمه

DJ-1, a Parkinson's disease related protein, aggregates under denaturing conditions and co-aggregates with α-synuclein through hydrophobic interaction

Keywords: α-سینوکلین; Parkinson's disease; DJ-1; α-Synuclein; Fibrillization; Aggregation; Denaturing conditions;

دانلود رایگان متن کامل مقاله ISI 61 صفحه سال انتشار : 2017 سفارش ترجمه

Humoral cross reactivity between α-synuclein and herpes simplex-1 epitope in Parkinson's disease, a triggering role in the disease?

Keywords: α-سینوکلین; Parkinson's disease; Autoimmunity; HSV1; α-Synuclein; Cross-reactivity;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Increased copper toxicity in Saccharomyces cerevisiae lacking VPS35, a component of the retromer and monogenic Parkinson disease gene in humans

Keywords: α-سینوکلین; Parkinson disease; Heavy metal homeostasis; Copper; Retromer; VPS35; α-synuclein;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

DNA damage preceding dopamine neuron degeneration in A53T human α-synuclein transgenic mice

Keywords: α-سینوکلین; Parkinson's disease; DNA damage; Neurodegeneration; α-Synuclein; Mouse;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Parkinson's disease: Autoimmunity and neuroinflammation

Keywords: α-سینوکلین; Parkinson; Neurodegenerative disease; Autoimmunity; Inflammation; α-Synuclein; Lewy bodies; Olfactory dysfunction;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Litmus-type thermochromic and solvatochromic sensors prepared with α-synuclein amyloid fibrils and polydiacetylene

Keywords: α-سینوکلین; AF; amyloid fibrils; PCDA; 10,12-pentacosadiynoic acid; PDA; polydiaceylene; Amyloid fibrils; Colorimetric biosensor; Polydiacetylene; α-Synuclein; Litmus-type sensor;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

α-Synuclein aggregation in the olfactory bulb of middle-aged common marmoset

Keywords: α-سینوکلین; α-Synuclein; Common marmoset; Olfactory bulb; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Research articleInsulin on activation of autophagy with integrins and syndecans against MPP+-induced α-synuclein neurotoxicity

Keywords: α-سینوکلین; α-Syn, SNCA; α-synuclein; Cox-2; cyclooxygenase-2; ILK; integrin-linked kinase; ITGAV; integrin αV; ITGB3; integrin β3; LDH; lactate dehydrogenase; MAP1LC3; microtubule-associated protein 1 light chain 3; MPP+; 1-Methyl-4-phenyl pyridinium; SDC1; synd

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Baicalein inhibits α-synuclein oligomer formation and prevents progression of α-synuclein accumulation in a rotenone mouse model of Parkinson's disease

Keywords: α-سینوکلین; PD; Parkinson disease; α-syn; α-synuclein; SN; substantia nigra; LBs; Lewy bodies; PFA; paraformaldehyde; TH; tyrosine hydroxylase; PBS; phosphate buffered saline; ChAT; choline acetyltransferase; HPLC; high performance liquid chromatography; DA; dopami

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Research ReportGeniposide reduces α-synuclein by blocking microRNA-21/lysosome-associated membrane protein 2A interaction in Parkinson disease models

Keywords: α-سینوکلین; Geniposide; Parkinson disease; MiR-21; LAMP2A; α-synuclein;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease

Keywords: α-سینوکلین; AAV2/9; adeno-associated viral vector pseudotype2/9; DA; dopamine; hα-syn; p.A53T human α-synuclein; MPTP; 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine; N/OFQ; nociceptin/orphanin FQ; NOP; N/OFQ peptide receptor; 6-OHDA; 6-hydroxydopamine; p-α-syn; pho

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Research reportβ-asarone increases MEF2D and TH levels and reduces α-synuclein level in 6-OHDA-induced rats via regulating the HSP70/MAPK/MEF2D/Beclin-1 pathway: Chaperone-mediated autophagy activation, macroautophagy inhibition and HSP70 up-expression

Keywords: α-سینوکلین; Myocyte enhancer factor 2D; β-Asarone; Chaperone-mediated autophagy; Macroautophagy; α-Synuclein; HSP70/MAPK/MEF2D/Beclin-1 pathway;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

3,4-seco-28-Nor-oleanane triterpenes from Camellia japonica protect from neurotoxicity in a rotenone model of Parkinson's disease

Keywords: α-سینوکلین; Camellia japonica; Theaceae; 3,4-seco-28-nor-oleanane triterpenoids; α-synuclein; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Early-onset motor impairment and increased accumulation of phosphorylated α-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q

Keywords: α-سینوکلین; PD; Parkinson's disease; CoQ; coenzyme Q; Q; oxidized coenzyme Q; QH2; reduced coenzyme Q; OCR; oxygen consumption rate; α-syn; alpha-synuclein; VGluT1; vesicular glutamate transporter 1; SNc; substantia nigra pars compacta; LBs; Lewy bodies; TH; tyrosin

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Research PaperAberrant adenosine A2A receptor signaling contributes to neurodegeneration and cognitive impairments in a mouse model of synucleinopathy

Keywords: α-سینوکلین; α-Syn; α-synuclein; A2AR; adenosine A2A receptor; AD; Alzheimer's disease; DG; dentate gyrus; DLB; dementia with Lewy bodies; HD; Huntington's disease; KO; knockout; LBs; Lewy bodies; LNs; Lewy neurites; MSA; multiple system atrophy; PD; Parkinson's dis

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Intracellular formation of α-synuclein oligomers and the effect of heat shock protein 70 characterized by confocal single particle spectroscopy

Keywords: α-سینوکلین; α-Synuclein; Venus; Fusion proteins; Fluorescence single particle spectroscopy; Parkinson's disease; Aggregation inhibition; PD; Parkinson's disease; αSyn; α-synuclein; FCS; fluorescence correlation spectroscopy; FIDA; fluorescence intensity distri

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra

Keywords: α-سینوکلین; Parkinson'; s disease; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Neuroinflammation; α-Synuclein; Ginsenoside Rg1;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Effects of different isoforms of apoE on aggregation of the α‐synuclein protein implicated in Parkinson's disease

Keywords: α-سینوکلین; PD; Parkinson's disease; Aβ; β-amyloid; CSF; cerebrospinal fluid; R-α-syn; recombinant α-synuclein; ThT; thioflavin T; TRF; time-resolved fluorescence; LBs; Lewy bodies; SN; substantia nigra; Parkinson's disease; Lewy body; α-Synuclein; Apolipopr

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2016 سفارش ترجمه

Histone H3 acetylation in the postmortem Parkinson's disease primary motor cortex

Keywords: α-سینوکلین; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 6-OHDA; 6-hydroxydopamine; AcH3; acetylated histone H3; AcH3K9; acetylated histone H3 lysine 9; AcH3K14; acetylated histone H3 lysine 14; AcH3K18; acetylated histone H3 lysine 18; AcH3K23; acetylated his

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2016 سفارش ترجمه

The role of NUB1 in α-synuclein degradation in Lewy body disease model mice

Keywords: α-سینوکلین; α-Synuclein; Aggregation; Lewy body disease; NUB1; Parkinson's disease; Proteasome; Transgenic mouse;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2016 سفارش ترجمه

The effect of fluorescent labeling on α-synuclein fibril morphology

Keywords: α-سینوکلین; α-syn; α-synuclein; AFM; atomic force microscopy; WT; wild type; A140C α-syn; α-syn substitution mutant with residue 140 mutated from Alanine to Cysteine; PD; Parkinson's disease; ThT; thioflavin T; EM; electron microscopy; EDTA; ethylenediaminetetraa

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2016 سفارش ترجمه

Membrane remodeling and mechanics: Experiments and simulations of α-Synuclein

Keywords: α-سینوکلین; α-Synuclein; Parkinson's disease; Synaptic vesicles; Membrane curvature; Tubulation; Bilayer rigidity; Coarse-grained molecular dynamics (CGMD);

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2016 سفارش ترجمه

Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice

Keywords: α-سینوکلین; α-Syn; α-Synuclein; AD; Alzheimer's disease; APP; amyloid precursor protein; BBB; blood-brain barrier; DAB; 3,3′-Diaminobenzidine tetrahydrochloride; DFO; deferoxamine; DMEM; Dulbecco's minimum essential medium; DMSO; dimethyl sulfoxide; DMT1; dival

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2016 سفارش ترجمه

ReviewNeuroglobin: From structure to function in health and disease

Keywords: α-سینوکلین; Neuroglobin; Structure; Function; Signaling; Neuroprotection; Neurodegeneration; Cancer; αSyn; α-synuclein; Aβ; amyloid β; AD; Alzheimer's disease; Adgb; androglobin; AIF; apoptotic inducing factor; AMPK; AMP-activated protein kinase; APAF; apoptotic

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2016 سفارش ترجمه

Parkinson disease: α-synuclein mutational screening and new clinical insight into the p.E46K mutation

Keywords: α-سینوکلین; Parkinson's disease; SNCA; α-synuclein; p.E46K mutation; Copy number variation;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Phenazine derivatives cause proteotoxicity and stress in C. elegans

Keywords: α-سینوکلین; PD; Parkinson's disease; HD; Huntington's disease; PCA; phenazine-1-carboxylic acid; PCN; pyocyanin; 1-HP; 1-hydroxyphenazine; NAC; N-acetyl cysteine; UPS; ubiquitin proteasome system; UPR; unfolded protein response; Phenazines; C. elegans; ER stress; α-

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Research articleThe A53E α-synuclein pathological mutation demonstrates reduced aggregation propensity in vitro and in cell culture

Keywords: α-سینوکلین; αS; α-synuclein; E. coli; Escherichia coli; EGFP; enhanced green fluorescent protein; K114; (trans,trans)-1-bromo-2,5-bis-(4-hydroxy)styrylbenzene; MPP+; MPP dihydrochloride hydrate; PBS; phosphate-buffered saline; PD; Parkinson's disease; SEM; standa

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Proteasome subunit and opioid receptor gene expression down-regulation induced by paraquat and maneb in human neuroblastoma SH-SY5Y cells

Keywords: α-سینوکلین; PQ; paraquat; MB; maneb; α-syn; α-synuclein; TH; tyrosine hydroxylase; PD; Parkinson's disease; SN; substantia nigra; UPS; ubiquitin-proteasome 26 S system; CP; core particle; RP; regulatory particle; Rpt; regulatory particle triphosphateses; Rpn; reg

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

The anti-hypertensive drug reserpine induces neuronal cell death through inhibition of autophagic flux

Keywords: α-سینوکلین; Autophagy; Autophagic flux; Reserpine; Parkinson's disease; α-Synuclein;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Inhibition of miR-34b and miR-34c enhances α-synuclein expression in Parkinson's disease

Keywords: α-سینوکلین; microRNA-34b; microRNA-34c; α-Synuclein; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Blood α-synuclein in agricultural pesticide handlers in central Washington State

Keywords: α-سینوکلین; AChE; acetylcholinesterase; α-Syn; α-synuclein; BuChE; butyrylcholinesterase; PON1; paraoxonase; PD; Parkinson disease; α-Synuclein; Aryldialkylphosphatase; Chlorpyrifos; Parkinson disease; Pesticides;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Cholesterol facilitates interactions between α-synuclein oligomers and charge-neutral membranes

Keywords: α-سینوکلین; Parkinson's disease; α-Synuclein; Oligomer; Amyloid; Membranes; Laurdan fluorescence; Multiphoton microscopy; Membrane phase separation;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Carbosilane dendrimers inhibit α-synuclein fibrillation and prevent cells from rotenone-induced damage

Keywords: α-سینوکلین; Carbosilane dendrimers; Parkinson's disease; α-Synuclein; Rotenone;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

The kynurenine pathway and neurodegenerative disease

Keywords: α-سینوکلین; 3-HANA; 3-hydroxyanthranilic acid; 3-HAO; hydroxyanthranilate 3,4-dioxygenase; 3-HK; 3-hydroxykynurenine; α7nACh; α7-nicotinic acetylcholine; Aβ; β-amyloid peptide; ACMS; 2-amino-3-carboxymuconic 6-semialdehyde; AD; Alzheimer's disease; aSyn; α-synuc

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions

Keywords: α-سینوکلین; Aging; α-Synuclein; Heroin; Neuropathology; Opiate; Tau; TDP-43; p62;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Correlation between decreased CSF α-synuclein and Aβ1-42 in Parkinson disease

Keywords: α-سینوکلین; Parkinson's disease; Cerebrospinal fluid; α-Synuclein; Aβ1-42; Tau; Nondemented; PiB; Imaging;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

The molecular mechanism of rotenone-induced α-synuclein aggregation: Emphasizing the role of the calcium/GSK3β pathway

Keywords: α-سینوکلین; PD; Parkinson's disease; LBs; Lewy bodies; mPTP; permeability transition pore; PI3K; phosphatidylinositol 3-kinase; GSK3; glycogen synthase kinase 3; DMSO; dimethyl sulfoxide; BAPTA/AM; 1,2-bis(2-aminophenoxy) ethane-n,n,n,n-tetraacetic acid acetoxymeth

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons

Keywords: α-سینوکلین; GBA; α-Synuclein; Parkinson's disease; Glucocerebrosidase; Autophagy; Gene therapy; Neuroprotection;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Tea polyphenols alleviate motor impairments, dopaminergic neuronal injury, and cerebral α-synuclein aggregation in MPTP-intoxicated parkinsonian monkeys

Keywords: α-سینوکلین; α-syn; α-synuclein; DA; dopamine; DOPAC; 3,4-dihydroxyphenylacetic acid; EC; (-)-epicatechin; ECG; (-)-epicatechin-3-gallate; EGC; (-)-epigal-locatechin; EGCG; (-)-epigallocatechin-3-gallate; ELISA; Enzyme-Linked Immunosorbnent Assay; HVA; homov

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Lysosomal enzyme cathepsin B enhances the aggregate forming activity of exogenous α-synuclein fibrils

Keywords: α-سینوکلین; α-Synuclein; Fibril; Aggregate formation; Cathepsin B; Lysosome;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

FcγRIIB mediates the inhibitory effect of aggregated α-synuclein on microglial phagocytosis

Keywords: α-سینوکلین; Parkinson's disease; α-synuclein; Neuroinflammation; Microglia; Phagocytosis; SHP-1; FcγRIIB;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

TNF compromises lysosome acidification and reduces α-synuclein degradation via autophagy in dopaminergic cells

Keywords: α-سینوکلین; TNF; tumor necrosis factor-α; PD; Parkinson's disease; α-SYN; α-synuclein; DA; dopamine; CQ; chloroquine; CM; conditioned medium; LPS; lipopolysaccharide; CHX; cycloheximide; 3-MA; 3-methyladenine; tf-LC3; RFP-GFP-tandem fluorescent LC3; TFEB; transcri

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه