دانلود مقالات ISI درباره α-سینوکلین + ترجمه فارسی

Surface behavior of α-Synuclein and its interaction with phospholipids using the Langmuir monolayer technique: A comparison between monomeric and fibrillar α-Synuclein

Keywords: α-سینوکلین; α-Syn; alpha Synuclein; ThT; Thioflavine T; DLS; Dynamic Light Scattering; AFM; Atomic Force Microscopy; RH; Hydrodynamic Radius; α-Synuclein; Monomer and fibrillar forms; Monolayer technique;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Research ReportRNA interference targeting α-synuclein attenuates methamphetamine-induced neurotoxicity in SH-SY5Y cells

Keywords: α-سینوکلین; METH; methamphetamine; α-syn; α-synuclein; LBs; Lewy bodies; DA; dopamine; TH; tyrosine hydroxylase; DAT; dopamine transporter; VMAT-2; vesicular monoamine transporter 2; ROS; reactive oxygen species; NOS; nitric oxide synthase; NO; nitrogen monoxide; Î

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Vitamins K interact with N-terminus α-synuclein and modulate the protein fibrillization in vitro. Exploring the interaction between quinones and α-synuclein

Keywords: α-سینوکلین; Parkinson's disease; α-Synuclein; Vitamin K; Naphthoquinones; Fibrils;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Effect of ginsenoside Rg3 on tyrosine hydroxylase and related mechanisms in the forced swimming-induced fatigue rats

Keywords: α-سینوکلین; Rg3; Fatigue; Tyrosine hydroxylase; PKAα; α-Synuclein;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Exploring the accessible conformations of N-terminal acetylated α-synuclein

Keywords: α-سینوکلین; αsyn; α-synuclein; Ac-αsyn; acetylated α-synuclein; BOG; beta-octyl glucopyranoside; GST; glutathione S-transferase; CD; circular dichroism; CN-PAGE; clear native PAGE; ESI-MS; electrospray ionization-mass spectrometry; ESI-IMS-MS; electrospray ioni

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

A non-cholinergic neuronal loss in the pedunculopontine nucleus of toxin-evoked Parkinsonian rats

Keywords: α-سینوکلین; SNCA [protein]; α-synuclein; ABC; Avidin-biotin-complex; CCD; Charge-coupled device; CFV; Cresyl Fast Violet; DAPI; 4′,6-diamidino-2-phenylindole; DBS; Deep-brain stimulation; DAB; Diaminobenzidine dihydrochloride; DA; Dopamine; EtOH; Ethanol; HuC/D;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Comparison of motor performance, brain biochemistry and histology of two A30P α-synuclein transgenic mouse strains

Keywords: α-سینوکلین; aSyn; α-synuclein; ANOVA; analysis of variance; DOPAC; 3,4-dihydroxyphenylacetic acid; DA; dopamine; HVA; homovanillic acid; 5-HT; 5-hydroxytryptamine; 6-OHDA; 6-hydroxydopamine; LB; Lewy bodies; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PFA; p

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Telmisartan attenuates MPTP induced dopaminergic degeneration and motor dysfunction through regulation of α-synuclein and neurotrophic factors (BDNF and GDNF) expression in C57BL/6J mice

Keywords: α-سینوکلین; MPTP; Telmisartan; Motor function; α-synuclein; BDNF; GDNF; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; BDNF; brain derived neurotrophic factor; GDNF; glial derived neurotrophic factor; TEL; Telmisartan; AT1R; angiotensin type 1 receptor; PD; Par

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

The sources of salidroside and its targeting for multiple chronic diseases

Keywords: α-سینوکلین; 6-OHDA; 6-hydroxydopamine; Aβ; β-amyloid protein; MPTP; 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine; MPP+; N-methyl-4-phenylpyridine; AD; Alzheimer's disease; PD; Parkinson's disease; STZ; streptozotocin; PI3K; phosphatidylinositol 3-kinase; ROS; react

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2020 سفارش ترجمه

Alpha-synuclein overexpression induced mitochondrial damage by the generation of endogenous neurotoxins in PC12 cells

Keywords: α-سینوکلین; PD; Parkinson's disease; salsolinol; 1-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline; NM-salsolinol; 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolin; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahy-dropyridine; α-Synuclein; Salsolinol; NM-salsolinol;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Oxidized quercetin inhibits α-synuclein fibrillization

Keywords: α-سینوکلین; Quercetin; α-Synuclein; Parkinson's disease; Hydrophilicity; Inhibition; Aggregation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Prion-like acceleration of a synucleinopathy in a transgenic mouse model

Keywords: α-سینوکلین; α-synuclein; Prion; Neurodegeneration; Parkinson's; Transgenic;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

α-Synuclein potentiates interleukin-1β-induced CXCL10 expression in human A172 astrocytoma cells

Keywords: α-سینوکلین; Parkinson's disease; α-Synuclein; Astrocyte; Neuroinflammation; Chemokine; NF-κB;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Superiority of PLK-2 as α-synuclein phosphorylating agent relies on unique specificity determinants

Keywords: α-سینوکلین; α-Synuclein; PLK2; PLK3; CK2; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Regulatory effects of costunolide on dopamine metabolism-associated genes inhibit dopamine-induced apoptosis in human dopaminergic SH-SY5Y cells

Keywords: α-سینوکلین; Costunolide; Dopamine; α-Synuclein; Nurr1; DAT; VMAT2;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Advanced glycation end products and neurodegenerative diseases: Mechanisms and perspective

Keywords: α-سینوکلین; Advanced glycation end products; Amyloid β; Tau; α-Synuclein; Neurodegenerative diseases; Neurotoxicity;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

MicroRNAs in Parkinson's disease

Keywords: α-سینوکلین; Parkinson; MicroRNA; α-synuclein; Neurodegeneration; Genetic; Gene regulation; mRNA translation; Dopamine; Neuron; LRRK2; Polymorphism;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

α-synuclein increases the cellular level of phospholipase Cβ1

Keywords: α-سینوکلین; Cβ (PLCβ); phospholipase; (FRET); Forster resonance energy transfer; α-synuclein; Phospholipase Cβ; Calpain; G protein signaling;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Expression pattern and localization of alpha-synuclein in the human enteric nervous system

Keywords: α-سینوکلین; α-syn; α-synuclein; p-α-syn; phosphorylated α-synuclein; ENS; enteric nervous system; CNS; central nervous system; LB; Lewy bodies; LN; Lewy neurites; LMD; laser microdissection; GI; gastrointestinal; PD; Parkinson´s disease; qPCR; quantitative PCR;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Prenatal exposure to methanol as a dopamine system sensitization model in C57BL/6J mice

Keywords: α-سینوکلین; l-aromatic amino acid decarboxylase; Dopamine; Methanol; Nigrostriatal neurons; Neurotoxins; Parkinson's disease; α-Synuclein; Tyrosine hydroxylase;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Research reportDJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats

Keywords: α-سینوکلین; DJ-1 protein; Parkinson's disease; 6-OHDA; MG-132; SOD2; α-Synuclein;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Interaction of α-synuclein with vesicles that mimic mitochondrial membranes

Keywords: α-سینوکلین; Fluorescence anisotropy; Fluorine NMR; Lipid vesicles; Mitochondria; Parkinson's disease; α-Synuclein;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Differential inhibition of α-synuclein oligomeric and fibrillar assembly in parkinson's disease model by cinnamon extract

Keywords: α-سینوکلین; α-synuclein; Cinnamon extract; Aggregation inhibitor; Parkinson's disease; Drosophila model for Parkinson;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

GSM-900 MHz at low dose temperature-dependently downregulates α-synuclein in cultured cerebral cells independently of chaperone-mediated-autophagy

Keywords: α-سینوکلین; GSM; global system for mobile communication; SAR; specific absorption rate; HSP; heat shock protein; LAMP-2A; lysosome-associated membrane protein type 2A; DAPI; 4′, 6-diamidino-2-phenylindole; GFAP; glial fibrillary acidic protein; CMA; chaperone-media

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Polyphenolic compounds are novel protective agents against lipid membrane damage by α-synuclein aggregates in vitro

Keywords: α-سینوکلین; αS; α-synuclein; AFM; atomic force microscopy; Api; apigenin; Baic; baicalein; BTE; black tea extract; EGCG; (−)-epigallocatechin gallate; Gen; genistein; Gink; ginkgolide B; Mor; morin; NBB; N′-benzylidene-benzohydrazide; NDGA; nordihydroguaiaretic

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

SF-6 attenuates 6-hydroxydopamine-induced neurotoxicity: An in vitro and in vivo investigation in experimental models of Parkinson's disease

Keywords: α-سینوکلین; α-Synuclein; 6-Hydroxydopamine; Reactive oxygen species; Parkinson's disease; Indigofera tinctoria;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Neuropathological investigation of the hypometabolic regions on positron emission tomography with [18F] fluorodeoxyglucose in patients with dementia with Lewy bodies

Keywords: α-سینوکلین; Dementia with Lewy bodies; Alzheimer's disease; 18F-FDG PET; Neuropathology; α-Synuclein; Tau; Aβ;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

A30P α-synuclein impairs dopaminergic fiber regeneration and interacts with L-DOPA replacement in MPTP-treated mice

Keywords: α-سینوکلین; α-synuclein; MPTP; Dopamine; Regeneration; Striatum; L-DOPA;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson's disease

Keywords: α-سینوکلین; A53T; mutant alpha-synuclein; ChIP; chromatin immunoprecipitation; dox; doxycycline; -dox; absence of doxycycline; +dox; doxycycline addition; IP; immunoprecipitation; I; 100% input; Nuc; nuclear; syn; synuclein; TSS; transcription start site; WT; wildt

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

α-Synuclein interactions with phospholipid model membranes: Key roles for electrostatic interactions and lipid-bilayer structure

Keywords: α-سینوکلین; α-Synuclein; Parkinson's disease; Structural properties; Lipid bilayer; Membrane ordering;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Effect of melatonin on α-synuclein self-assembly and cytotoxicity

Keywords: α-سینوکلین; Parkinson's disease; Dementia with Lewy bodies; α-synuclein; Melatonin; Oligomers; Cytotoxicity;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Can Parkinson's disease pathology be propagated from one neuron to another?

Keywords: α-سینوکلین; AD; Alzheimer's disease; PD; Parkinson's disease; αsyn; α-synuclein; RBD; REM sleep behavior disorder; NAC; non-amyloid component; GWAS; genome wide association studies; TNTs; tunneling nanotubes; PrP; prion protein; Aβ; amyloid beta; MTBR; microtubule

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse

Keywords: α-سینوکلین; α-syn; α-synuclein; ASK1; Apoptosis signaling-regulating kinase 1; CMA; Chaperone-mediated autophagy; DAT; Dopamine transporter; ETC; Electron transport chain; iPS; Induced pluripotent stem; LAMP-2A; Lysosome-associated membrane protein 2A; LB; Lewy bod

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2012 سفارش ترجمه

Closing the gap between clinic and cage: Sensori-motor and cognitive behavioural testing regimens in neurotoxin-induced animal models of Parkinson's disease

Keywords: α-سینوکلین; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; PACAP; adenylate cyclase activating polypeptide; Aβ; amyloid-β; SNCA [gene]; α-synuclein; α-SYN [protein]; α-synuclein; AD; Alzheimer's disease; CeA; central nucleus of the amygdala; DCS; D

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2012 سفارش ترجمه

Aggregation of α-synuclein in brain samples from subjects with glucocerebrosidase mutations

Keywords: α-سینوکلین; Gaucher disease; Glucocerebrosidase; α-synuclein; Lewy body; Synucleinopathies; Parkinson disease;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Triclabendazole protects yeast and mammalian cells from oxidative stress: Identification of a potential neuroprotective compound

Keywords: α-سینوکلین; α-Synuclein; Chronological aging; Reactive oxygen species; Triclabendazole;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation

Keywords: α-سینوکلین; Parkinson's disease; Dementia with Lewy Bodies; α-Synuclein; SUMOylation; Protein aggregation; Proteasome;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Synuclein modulation of monoamine transporters

Keywords: α-سینوکلین; α-Syn; α-synuclein; β-Syn; β-synuclein; γ-Syn; γ-synuclein; AD; Alzheimer's disease; CNS; central nervous system; DA; dopamine; DAT; dopamine transporter; DMI; desipramine; MAT; presynaptic plasma membrane monoamine transporters; NAC; non-Aβ comp

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Human α-synuclein modulates vesicle trafficking through its interaction with prenylated Rab acceptor protein 1

Keywords: α-سینوکلین; PD; Parkinson's disease; PRA1; prenylated Rab acceptor protein 1; PBST; phosphate buffered saline with 0.3% Tween 20; α-Synuclein; Protein interaction; PRA1; Vesicle trafficking;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Interaction between α-synuclein and tau in Parkinson's disease

Keywords: α-سینوکلین; AD; Alzheimer's disease; Aβ; β-amyloid; DAT; dopamine transporter; GSK-3β; glycogen-synthase-kinase-3β; IFG; inferior frontal gyrus; LB; Lewy body; NFT; neurofibrillary tangle; PD; Parkinson's disease; PDD; Parkinson's disease with dementia; pGSK-3β;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Neuroprotection of α-synuclein under acute and chronic rotenone and maneb treatment is abolished by its familial Parkinson's disease mutations A30P, A53T and E46K

Keywords: α-سینوکلین; α-Synuclein; Parkinson's disease; Rotenone; Maneb; Oxidative stress; Reactive oxygen species;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Immunoprotection against toxic biomarkers is retained during Parkinson's disease progression

Keywords: α-سینوکلین; Parkinson's disease; α-synuclein; amyloid toxicity; autoantibodies; T-cells; B-cells;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Redox activity of α-synuclein-Cu is silenced by Zn7-metallothionein-3

Keywords: α-سینوکلین; Aβ; amyloid-β; AD; Alzheimer disease; α-Syn; α-synuclein; CC; cluster centered; 3-CCA; coumarin 3-carboxylic acid; CD; circular dichroism; CysS; cysteine thiolate; DEAE; diethylaminoethyl; EPR; electron paramagnetic resonance; ESI-Q-TOF MS; electrospr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

The neurotransmitter serotonin interrupts α-synuclein amyloid maturation

Keywords: α-سینوکلین; AS; α-synuclein; 5-HT; serotonin; 5,7-HT; 5,7 dihydroxytryptamine; 5-HIAA; 5-hydroxyindoleacetic acid; ThioT; thioflavin T; TEM; transmission electron spectroscopy; DLS; dynamic light scattering; NAC-region; non-Aβ component region; Protein misfolding;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties

Keywords: α-سینوکلین; PD; Parkinson disease; DLB; dementia with Lewy bodies; MSA; multiple-system atrophy; ONE; 4-oxo-2-nonenal; HNE; 4-hydroxy-2-nonenal; SEC-HPLC; size-exclusion-high-performance liquid chromatography; CD; circular dichroism; AFM; atomic force microscopy;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

α-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator

Keywords: α-سینوکلین; α-Synuclein; Adenylate translocator; Mitochondria; mPTP; Mitochondrial membrane potential;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Familial Parkinson disease mutations influence α-synuclein assembly

Keywords: α-سینوکلین; Parkinson's disease; α-Synuclein; Mutations; Oligomers; Electron microscopy; Atomic force microscopy;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

ReviewRabs, SNAREs and α-synuclein - Membrane trafficking defects in synucleinopathies

Keywords: α-سینوکلین; α-synuclein; Parkinson's disease (PD); Neurodegeneration; Synucleinopathy;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Involvement of endoplasmic reticulum stress defined by activated unfolded protein response in multiple system atrophy

Keywords: α-سینوکلین; Multiple system atrophy; Endoplasmic reticulum stress; Unfolded protein response; α-Synuclein; Granulovacuolar degeneration;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Residue Glu83 plays a major role in negatively regulating α-synuclein amyloid formation

Keywords: α-سینوکلین; α-Synuclein; Amyloid; Parkinson disease;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه