Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson's disease

► Oxidatively induced nuclear α-synuclein binds PGC1alpha promoter regions. ► Alpha-synuclein appears to act as a transcriptional modulator of PGC1alpha. ► Findings link PD, oxidative stress, alpha-synuclein, and mitochondrial dysfunction.