دانلود مقالات ISI درباره α-سینوکلین + ترجمه فارسی

FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease

Keywords: α-سینوکلین; α-Synuclein; Parkinson's disease; FK506; Neuroinflammation; Microglia;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Molecular chaperones and neuronal proteostasis

Keywords: α-سینوکلین; 17-AAG; 17-allylamino-17-demethoxygeldanamycin; 17-DMAG; 17-dimethylamino-ethylamino-17-demethoxygeldanamycin; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ARSACS; autosomal recessive spastic ataxia of Charlevoix-Saguena

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Increased oligomerization and phosphorylation of α-synuclein are associated with decreased activity of glucocerebrosidase and protein phosphatase 2A in aging monkey brains

Keywords: α-سینوکلین; α-Synuclein; Parkinson's disease; Dementia with Lewy bodies; Glucocerebrosidase; Cynomolgus monkey; Aging;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Adverse effects of a SOD1-peptide immunotherapy on SOD1G93A mouse slow model of amyotrophic lateral sclerosis

Keywords: α-سینوکلین; ALS; amyotrophic lateral sclerosis; CS; clinical score; ELISA; enzyme-linked immunosorbent assay; FALS; familial amyotrophic lateral sclerosis; GFAP; glial fibrillary acidic protein; Iba-1; ionized calcium binding adaptor molecule; IgG; immunoglobulin G;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils

Keywords: α-سینوکلین; α-syn; α-synuclein; PD; Parkinson's disease; Aβ; beta amyloid; LBs; Lewy bodies; LNs; Lewy neuritis; Gn; ginsenoside; GST; glutathione S-transferase; IPTG; isopropyl β-d-1-thiogalactopyranoside; DTT; dithiothreitol; SDS; sodium dodecyl sulfate; PBS; p

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Basic NeuroscienceReviewα-Synuclein and nonhuman primate models of Parkinson's disease

Keywords: α-سینوکلین; α-syn; α-synuclein; 6-OHDA; 6-hydroxydopamine; AAV2; adeno-associated viral vector serotype 2/2; ALP; autophagy-lysosomal pathway; BBB; blood-brain-barrier; c-hGH; cadaver-derived human growth hormone; CK; casein kinases; DA; dopamine; DAT; dopamine

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease

Keywords: α-سینوکلین; α-Synuclein; Unfolded protein response; ATF6; XBP1; Endoplasmic reticulum-associated degradation; COPII; Parkinson's disease; Neurodegeneration;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways

Keywords: α-سینوکلین; α-Synuclein; A53T; Autophagy; Proteasome; Ubiquitination; Oxidative stress; AMPK; Copper and Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

P2X7 receptor is critical in α-synuclein-mediated microglial NADPH oxidase activation

Keywords: α-سینوکلین; Parkinson's disease; Microglia; α-Synuclein; P2X7 receptor; PI3K/AKT signaling;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2015 سفارش ترجمه

Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson's disease patients

Keywords: α-سینوکلین; α-Synuclein; DNA methylation; Pyrosequencing; Leukocytes;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Mosaicism of alpha-synuclein gene rearrangements: Report of two unrelated cases of early-onset parkinsonism

Keywords: α-سینوکلین; Parkinson's disease; α-Synuclein; Mosaicism; Gene multiplication;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Pitfalls associated with the use of Thioflavin-T to monitor anti-fibrillogenic activity

Keywords: α-سینوکلین; α-Synuclein; Fibrils; Thioflavin-T; NMR; Dopamine; DOPAL;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Gallic acid interacts with α-synuclein to prevent the structural collapse necessary for its aggregation

Keywords: α-سینوکلین; αS; α-synuclein; DTT; 1,4-dithiothreitol; ESI-IM-MS; electrospray ionisation ion mobility mass spectrometry; GA; gallic acid; HSQC; heteronuclear single quantum coherence; PD; Parkinson disease; TEM; transmission electron microscopy; ThT; Thioflavin T;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Thymoquinone protects cultured hippocampal and human induced pluripotent stem cells-derived neurons against α-synuclein-induced synapse damage

Keywords: α-سینوکلین; Thymoquinone; α-Synuclein; Cultured rat hippocampal neurons; Human induced pluripotent stem cell-derived neurons; Synapse damage;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Effect of endogenous Hsp104 chaperone in yeast models of sporadic and familial Parkinson's disease

Keywords: α-سینوکلین; Amyloid fibrils; Chaperone; Hsp104; Parkinson's disease; Protein aggregation; α-Synuclein;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

CSF α-synuclein and UCH-L1 levels in Parkinson's disease and atypical parkinsonian disorders

Keywords: α-سینوکلین; α-Synuclein; UCH-L1; Cerebrospinal fluid; Parkinson's disease; Atypical parkinsonian disorders;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Ca2 + modulating α-synuclein membrane transient interactions revealed by solution NMR spectroscopy

Keywords: α-سینوکلین; α-Synuclein; Protein membrane transient interaction; Ca2 + function; NMR spectroscopy;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes

Keywords: α-سینوکلین; ANS; 1-anilinonaphthalene-8-sulfonate; A4F; asymmetrical flow field-flow fractionation; αSN; α-synuclein; CD; circular dichroism; DLS; dynamic light scattering; PD; Parkinson's Disease; SDS; sodium dodecyl sulfate; SEC; size exclusion chromatography;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Solution conditions define morphological homogeneity of α-synuclein fibrils

Keywords: α-سینوکلین; αSyn; α-synuclein; AFM; Atomic Force Microscopy; A140C αSyn; substitution mutant of αSyn with residue 140 mutated from alanine to cysteine; EDTA; ethylenediaminetetraacetic acid; TCEP; tris(2-carboxyethyl)phosphine hydrochloride; DTT; dithiothreitol;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Exogenous amyloidogenic proteins function as seeds in amyloid β-protein aggregation

Keywords: α-سینوکلین; Aβ; amyloid β-protein; AD; Alzheimer's disease; Act; actin; αS; α-synuclein; Cas; casein; EM; electron microscopy; Fibro; fibroin; fAβ; Aβ fibrils; fAct; Act fibrils; fCas; casein fibrils; fFibro; fibroin fibrils; fIAPP; IAPP fibrils; fSer; sericin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Featured ArticleIncreased CSF α-synuclein levels in Alzheimer's disease: Correlation with tau levels

Keywords: α-سینوکلین; Biomarker; Dementia; α-Synuclein; Cerebrospinal fluid; Alzheimer's disease; Dementia with Lewy bodies; tau;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Research ReportPrefoldin prevents aggregation of α-synuclein

Keywords: α-سینوکلین; Prefoldin; Chaperone; α-Synuclein; Protein aggregation; Cell death;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Research ReportSquamosamide derivative FLZ protected dopaminergic neuron by activating Akt signaling pathway in 6-OHDA-induced in vivo and in vitro Parkinson's disease models

Keywords: α-سینوکلین; PD; Parkinson's disease; PI3K; phosphoinositide-3-kinase; α-Syn; α-synuclein; 6-OHDA; 6-hydroxydopamine; TH; tyrosine hydroxylase; Co-IP; Co-Immunoprecipitation; FLZ; Parkinson's disease; Akt; α-synuclein; Tyrosine hydroxylase;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Research ReportNeurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease

Keywords: α-سینوکلین; Parkinson's disease; Dementia with Lewy bodies; Neurogranin; α-Synuclein; Calmodulin; LTP;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Lysine residues at the first and second KTKEGV repeats mediate α-Synuclein binding to membrane phospholipids

Keywords: α-سینوکلین; PS; phosphatidylserine; PI; phosphatidylinositol; PA; phosphatidic acid; CL; cardiolipin; PG; phosphatidylglycerol; PC; phosphatidylcholine; PE; phosphatidylethanolamine; CH; cholesterol; SM; sphingomyelin; Parkinson's disease; α-Synuclein; KTKEGV repeat

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Long-term heat shock proteins (HSPs) induction by carbenoxolone improves hallmark features of Parkinson's disease in a rotenone-based model

Keywords: α-سینوکلین; Oxidative stress; Ubiquitin proteasome system; Protein aggregation; α-Synuclein; Protein carbonylation; PD; Parkinson's disease; UPS; Ubiquitin proteasome system; HSPs; Heat shock proteins; Cbx; Carbenoxolone; HSF-1; Heat shock factor-1; TH; Tyrosine hyd

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Conformational heterogeneity of α-synuclein in membrane

Keywords: α-سینوکلین; Membrane binding; α-Synuclein; Peripheral membrane protein; Molecular dynamics; HMMM;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice

Keywords: α-سینوکلین; Parkinson's disease; α-Synuclein; PINK1; Knockout; Knockdown; Mouse; AAV; Neurodegeneration; Aggregation; Phosphorylation;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease

Keywords: α-سینوکلین; Ab; antibody; AD; Alzheimer's disease; αSYN; α-synuclein; CTSD; cathepsin D; CI-MPR; cation-independent mannose 6-phosphate receptor; DMEM; Dulbecco's modified Eagle's medium; elav; embryonic lethal abnormal vision; FBS; fetal bovine serum; GMR; glass m

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Prodegenerative IκBα expression in oligodendroglial α-synuclein models of multiple system atrophy

Keywords: α-سینوکلین; Multiple system atrophy; NF-κB; IκBα; α-Synuclein; Oligodendrocytes;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

The use of nanopore analysis for discovering drugs which bind to α-synuclein for treatment of Parkinson's disease

Keywords: α-سینوکلین; α-Synuclein; Parkinson's disease; Intrinsically disordered protein; Nanopore analysis; Induced folding; Nicotine; Caffeine; Curcumin;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Hsp27 suppresses the Cu2+-induced amyloidogenicity, redox activity, and cytotoxicity of α-synuclein by metal ion stripping

Keywords: α-سینوکلین; AD; Alzheimer disease; ITC; isothermal titration calorimetric; PD; Parkinson disease; ROS; reactive oxygen species; ThT; thioflavin T; 3-CCA; coumarin-3-carboxylic acid.; Hsp27; Cu2+ binding; Amyloid fibril; α-Synuclein; Reactive oxygen species; Free rad

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse

Keywords: α-سینوکلین; Parkinson's disease; α-Synuclein; Dopamine; Norepinephrine; Voltammetry; Behavior;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread

Keywords: α-سینوکلین; α-synuclein; endosome; ependyma; gap junction; internalisation; lysosome; mitochondria; nanotube; prion-like; spreading;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: Targets for disease modification?

Keywords: α-سینوکلین; Aβ; amyloid beta; AD; Alzheimer's disease; Akt; protein kinase B; α-syn; α-synuclein; BAD; Bcl-2 antagonist of death; BBB; blood brain barrier; Bcl-2; B-cell lymphoma 2; Bcl-XL; B-cell lymphoma extra large; Bim; Bcl-2 interacting mediator of death; cAM

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2014 سفارش ترجمه

AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons

Keywords: α-سینوکلین; NH2htau; NH2-human tau fragment of 20-22 kDa; ANT-1; Adenine Nucleotide Translocator-1; AD; Alzheimer's Disease; APP; amyloid precursor protein; Aβ; amyloid beta; PD; Parkinson's disease; α-syn; α-synuclein; FAD; Familiar Alzheimer's Disease; MOI; m

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2014 سفارش ترجمه

α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease

Keywords: α-سینوکلین; PD; Parkinson disease; SNPc; substantia nigra pars compacta; α-syn; α-synuclein; GTPCH; GTP cyclohydrolase I; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP+; 1-methyl-4-phenylpyridinium; NOS; nitric oxide synthase; DAT; dopamine transporter; B

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2014 سفارش ترجمه

Histone deacetylase 6 regulates cytotoxic α-synuclein accumulation through induction of the heat shock response

Keywords: α-سینوکلین; Histone deacetylase 6; α-synuclein; Heat shock; Parkinson's disease; Ubiquitin-proteasome system;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2014 سفارش ترجمه

α-Synuclein mutations cluster around a putative protein loop

Keywords: α-سینوکلین; α-Synuclein; SNCA; Genetics; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Novel A18T and pA29S substitutions in α-synuclein may be associated with sporadic Parkinson's disease

Keywords: α-سینوکلین; α-Synuclein; SNCA gene; Parkinson's disease; Genetic etiology; Missense mutations;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra

Keywords: α-سینوکلین; α-Synuclein; Dopaminergic; Embryonic development; Parkinson's disease; Transgenic mouse;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Research reportDeletion in exon 5 of the SNCA gene and exposure to rotenone leads to oligomerization of α-synuclein and toxicity to PC12 cells

Keywords: α-سینوکلین; α-Synuclein; Oligomerization; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Increased SUMO-1 expression in the unilateral rotenone-lesioned mouse model of Parkinson's disease

Keywords: α-سینوکلین; α-Synuclein; SUMO; Rotenone; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Interaction between viologen-phosphorus dendrimers and α-synuclein

Keywords: α-سینوکلین; Viologen-phosphorus dendrimers; α-Synuclein; Fluorescence quenching; Circular dichroism;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies

Keywords: α-سینوکلین; Dementia with Lewy bodies; MAPT haplotype; Parkinson's disease dementia; Alzheimer's disease; Tau; α-synuclein;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau

Keywords: α-سینوکلین; α-syn:; α-synuclein; ICC:; immunocytochemistry; mAb:; monoclonal antibody; NFT:; neurofibrillary tangle; Tg:; transgenic; Pff:; preformed fibril; ThT:; thioflavin T; Tau; Protein aggregation; Tauopathy; Transmission;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases

Keywords: α-سینوکلین; LRRK2; G2019S; α-Synuclein; Differential solubility; Immunohistochemistry;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synuclein

Keywords: α-سینوکلین; α-synuclein; Acetylcholine; ANS; BDNF; Brainstem; Parasympathetic; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

The secreted oligomeric form of α-synuclein affects multiple steps of membrane trafficking

Keywords: α-سینوکلین; α-Synuclein; Parkinson's disease; Transferrin receptor; Membrane trafficking; Endocytosis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Ankyrin repeat and BTB/POZ domain containing protein-2 inhibits the aggregation of alpha-synuclein: Implications for Parkinson's disease

Keywords: α-سینوکلین; ABTB2; BPOZ-2; Neuron; α-Synuclein;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه