Differential roles of AMPKα1 and AMPKα2 in regulating 4-HNE-induced RPE cell death and permeability
Keywords: AMPK; oxidative stress; 4-HNE; permeability; RPE
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Increase in placental apolipoprotein D as an adaptation to human gestational diabetes
Keywords: ApoD; 4-HNE; Placenta; Gestational diabetes; Oxidative stress;
NGF induced differentiated PC12 cells as in vitro tool to study 4-hydroxynonenal induced cellular damage
Keywords: PC12 cells; 4-HNE; DA-D2 receptor; Glutathione; GSTP1-1; Intracellular Ca++
Basic-Liver, Pancreas, and Biliary TractComplement and Alcoholic Liver Disease: Role of C1q in the Pathogenesis of Ethanol-Induced Liver Injury in Mice
Keywords: Complement; Alcoholic Liver Disease; Macrophages; C1q; Apoptosis; ALD; alcoholic liver disease; ALT; alanine aminotransferase; AST; aspartate aminotransferase; C3b; C3b/iC3b/C3c; CYP2E1; cytochrome P450 2E1; 4-HNE; 4-hydroxynonenal; IL; interleukin; ROS;
Eicosapentaenoic acid improves hepatic steatosis independent of PPARα activation through inhibition of SREBP-1 maturation in mice
Keywords: ACC; acetyl-CoA carboxylase; ALT; alanine aminotransferase; apo; apolipoprotein; AOX; acyl-CoA oxidase; AST; aspartate aminotransferase; CoA; coenzyme A; CPT-I; carnitine palmitoyl-CoA transferase-I; EPA; eicosapentaenoic acid; FA; fatty acid; FAS; fatty
Expansion of Hepatic Tumor Progenitor Cells in Pten-Null Mice Requires Liver Injury and Is Reversed by Loss of AKT2
Keywords: Liver Cancer Stem Cells; DDC; Lipotoxic Cell Death; Mixed-Lineage Tumors; AFP; α-fetoprotein; Akt; protein kinase B; Alb; albumin; DDC; 3,5-dietoxycarbonyl-1,4 dihydrocollidine; Dm; Pten/Akt2 double mutant; HepPar; hepatocyte paraffin; 4-HNE; trans-4-hyd
Age-related NMDA signaling alterations in SOD2 deficient mice
Keywords: NMDA; N-methyl-d-aspartate; ROS; reactive oxidative species; RNS; reactive nitrogen species; SOD; superoxide dismutase; STEP; striatal-enriched protein tyrosine phosphatase; CREB; cAMP response element-binding; AD; Alzheimer's disease; PD; Parkinson's dis
4-HNE inhibits tube formation and up-regulates chondromodulin-I in human endothelial cells
Keywords: 4-HNE; Chondromodulin-I; Tube formation assay; Angiogenesis; Endothelial cells; ALDH3A1
Tissue concentrations of 4-HNE in the black walnut extract model of laminitis: Indication of oxidant stress in affected laminae
Keywords: Laminitis; Oxidant stress; Lipid peroxidation; 4-HNE;
Role of human aldo-keto-reductase AKR1B10 in the protection against toxic aldehydes
Keywords: DEPT; distortionless enhancement by polarization transfer; 4-HNE; (2E)-4-hydroxynon-2-enal; HPLC; high-pressure liquid chromatography; 4-MP; 4-methylpentanal; 4-ONE; (2E)-4-oxonon-2-enal; TLC; thin layer chromatography; TMS; tetramethylsilane; Aldo-keto
Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice
Keywords: ROS; reactive oxygen species; SOD; superoxide dismutase; FALS; familial amyotrophic lateral sclerosis; GST; glutathione S-transferase; 4-HNE; 4-hydroxynonenal; CDNB; 1-chloro-2,4-dinitrobenzene; MDA; malondialdehyde; Fe-NTA; ferric nitrilotriacetate; HE
Activation of transcription factors and gene expression by oxidized low-density lipoprotein
Keywords: OxLDL; oxidized LDL; AP1; activator protein 1; NF-κB; nuclear factor κ of B cells; STAT; signal transducer and activator of transcription; NFAT; nuclear factor of activated T cells; HIF; hypoxia-inducible factor; Sp1; specific protein 1; PPAR; peroxisom
Polyenephosphatidylcholine prevents alcoholic liver disease in PPARα-null mice through attenuation of increases in oxidative stress
Keywords: ADH; alcohol dehydrogenase; ALDH; aldehyde dehydrogenase; AOX; acyl-coenzyme A oxidase; AP-1; activator protein-1; ASK1; apoptosis signal-regulating kinase 1; COL1A1; collagen type 1 α1; COX-2; cyclo-oxygenase 2; CYP2E1; cytochrome P450 2E1; GAPDH; glyce
Convergence of nitric oxide and lipid signaling: Anti-inflammatory nitro-fatty acids
Keywords: âNO; nitric oxide; sGC; soluble guanylate cyclase; cGMP; cyclic guanosine monophosphate; COX; cyclooxygenase; LOX; lipoxygenase; NO2-FA; nitrated fatty acids; NOS; nitric oxide synthase; ONOO-; peroxynitrite; RSNO; nitrosothiols; PUFAs; polyunsaturated
Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats
Keywords: NAFLD; non-alcoholic fatty liver disease; RAS; renin-angiotensin system; Ang II; Angiotensin II; Ren2; transgenic TG(mRen2)27(Ren2) rat; SD; Sprague-Dawley rat; NASH; non-alcoholic steatohepatitis; ROS; reactive oxygen species; ACE; angiotensin-conver
Membrane phospholipids, lipoxidative damage and molecular integrity: A causal role in aging and longevity
Keywords: AA; arachidonic acid; AKR; aldo-keto reductase; ALDH; aldehyde dehydrogenase; ALEs; advanced lipoxidation end-product; ARE; antioxidant response element; CBP; CREB-binding protein; CR; caloric restriction; CREB; cAMP-responsive element-binding factor; DBI
Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis
Keywords: Atherosclerosis; Reactive oxygen species; Free radical scavenger; Edaravone; 4-HNE; Apolipoprotein E knockout mouse
Prevention of in vitro and in vivo acute ischemic neuronal damage by (2S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-fluorobenzyl) phenyl]-1-piperazinyl}-2-propanol dimethanesulfonate (SUN N8075), a novel neuroprotective agent with antioxidant properti
Keywords: cerebral ischemia; lipid peroxidation; neuroprotection; Ac-DEVD-CHO; Ac-Asp-Glu-Val-Asp-H; AMC; 7-amino-4-methylcoumarin; HR; heart rate; LDH; lactate dehydrogenase; MABP; mean arterial blood pressure; MCA; middle cerebral artery; PBS; phosphate-buffered
Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal
Keywords: Longevity; Aging; 4-Hydroxynonenal; 4-HNE; Caenorhabditis elegans; Glutathione transferase (GST)
Oxidation, glycoxidation, lipoxidation, nitration, and responses to oxidative stress in the cerebral cortex in Creutzfeldt–Jakob disease
Keywords: Prion; Creutzfeldt–Jakob disease; Oxidative stress; CEL; CML; AGE; RAGE; 4-HNE; MDAL; NOS; Nitrotyrosine; Superoxide dismutase
Oxidative stress in head trauma in aging
Keywords: CON; contralateral; Cu/ZnSOD; copper/zinc superoxide dismutase; GPx; glutathione peroxidase; GRed; glutathione reductase; GST; glutathione transferase; 4-HNE; 4-hydroxynonenal; IP; ipsilateral; MnSOD; manganese superoxide dismutase; NBD-Cl; 7-chloro-4-nit
Decreased susceptibility to oxidative stress underlies the resistance of specific dopaminergic cell populations to paraquat-induced degeneration
Keywords: paraquat; substantia nigra; ventral tegmental area; calbindin; Parkinson's disease; lipid peroxidation; ANOVA; analysis of variance; CB; calbindin-D28k; DAB; 3,3â²-diaminobenzidine; IACUC; Institutional Animal Care and Use Committee; MOM; Mouse-on-Mous
Methamphetamine and human immunodeficiency virus protein Tat synergize to destroy dopaminergic terminals in the rat striatum
Keywords: HIV-1 associated dementia; silver stain; basal ganglia; tyrosine hydroxylase; terminal degeneration; oxidative stress; DAT; dopamine transporter; DNP; 2,4-dinitrophenylhydrazine; DOPAC; 3,4-dihydroxyphenylacetic acid; HAD; human immunodeficiency virus-1-a
Post-exposure administration of edaravone attenuates noise-induced hearing loss
Keywords: Edaravone; Cochlear protection; Antioxidant; Reactive oxygen species; Acoustic trauma; 4-HNE; (4-hydroxy-2-nonenal);
Interleukin-6 induces glutathione in hippocampal cells
Keywords: BSA; bovine serum albumin; BSO; buthionine sulfoximine; CNS; central nervous system; DTNB; 5,5â²-dithio-bis(2-nitrobenzoic acid); DMEM; Dulbecco's modified Eagle's medium; FCS; fetal calf serum; GSH; glutathione; GSSG; glutathione disulfide; GR; glutathi
The effect of ethanol-induced CYP2E1 on proteasome activity: the role of 4-hydroxynonenal
Keywords: Dex; dextrose; Et; ethanol; 4-HNE; 4-hydroxynonenal; CYP2E1; cytochrome P450 2E1; MW; molecular weight standard; Ethanol feeding; CYP2E1 induction; 4-Hydroxynonenal; Proteasome;
Heat shock protein 27 expression in patients with chronic liver damage
Keywords: Liver disease; Heat shock protein; AC; Alcohol-related cirrhosis; C; Controls; CC; HCV-related cirrhosis; CH; Chronic hepatitis; GSH; Glutathione; GSNO; Nitrosoglutathione; αGST; α-glutathione-S-transferase activity; 4-HNE; 4-hydroxinonenal; HSP; Heat s
Effects of oxidative stress on adiponectin secretion and lactate production in 3T3-L1 adipocytes
Keywords: Free radicals; Adiponectin; Aldehyde; Hydrogen peroxide; Lactate; Lipoic acid; Oxidative stress; 3T3-L1; 4-HNE;
Post-exposure treatment attenuates noise-induced hearing loss
Keywords: inner ear; hair cells; free radicals; antioxidants; 4-hydroxynonenal; nitrotyrosine; ABR; auditory brainstem response; dB SPL; decibels sound-pressure-level; IHC; inner hair cell(s); JNK; c-Jun-N-terminal kinase; L-NAC; N-L-acetylcysteine; NIHL; noise-ind
Lipid peroxidation during ischemia depends on ischemia time in warm ischemia and reperfusion of rat liver
Keywords: ALT; alanine aminotransferase; c-GPx; cytosolic glutathione peroxidase; CL; chemiluminescence; Cu/Zn-SOD; copper zinc superoxide dismutase; 4-HNE; 4-hydroxy-2-nonenal; GSH; glutathione; GSSG; glutathione disulfide; PC; phosphatidylcholine; PC-OOH; phospha
Cystathionine β Synthase Deficiency Promotes Oxidative Stress, Fibrosis, and Steatosis in Mice Liver
Keywords: α-SMA; α-smooth muscle actin; BHMT; betaine-homocysteine methyltransferase; CBS; cystathionine β synthase; CBS +/+ mice; wild-type mice; CBS +/â mice; heterozygous CBS-deficient mice; CBS â/â mice; homozygous CBS-deficient mice; DNPH; 2,4-dinitro
Potential markers of oxidative stress in stroke
Keywords: 4-HNE; 4-hydroxynonenal; 8-OH-dG; 8-hydroxydeoxyguanosine; CEOOH; cholesteryl ester hydroperoxides; COX; cyclooxygenase; CSF; cerebrospinal fluid; CT; computerized tomography; ELISA; enzyme-linked immunosorbent assay; eNOS; endothelial NOS; ESR; electron
Induction of apoptosis by adenovirus-mediated manganese superoxide dismutase overexpression in SV-40-transformed human fibroblasts
Keywords: AdEmpty; an adenoviral vector without cDNA of interest; Adhsod2; an adenoviral vector containing human MnSOD (Ile58) cDNA; Adhsod2H26L; an adenoviral vector containing an active-site mutant form of human MnSOD (His26Leu) cDNA; DHE; dihydroethidium; EM; el
Insulin neuroprotection against oxidative stress in cortical neurons-Involvement of uric acid and glutathione antioxidant defenses
Keywords: BSA; bovine serum albumin; t-BHP; tert-butylhydroperoxide; CNS; central nervous system; ERK; extracellular signal-related kinase; DNPH; 2,4-dinitrophenylhydrazine; DTT; 1,4-dithiotreitol; GLUT; glucose transporter; GPx; glutathione peroxidase; GRed; gluta
Mitochondrial proteomics in free radical research
Keywords: ALDH; aldehyde dehydrogenase; BIAM; biotinylated iodoacetamide; BN-PAGE; blue native polyacrylamide gel electrophoresis; 1(2)-D; one (two)-dimensional; DNPH; 2,4-dinitrophenylhydrazine; 4-HNE; 4-hydroxynonenal; IBTP; (4, iodobutyl) triphenylphosphonium; I
Cinnamophilin reduces oxidative damage and protects against transient focal cerebral ischemia in mice
Keywords: ROS; reactive oxygen species; RNS; reactive nitrogen species; CINN; (8R, 8'S)-4,4â²-dihydroxy-3,3â²-dimethoxy-7-oxo-8,8â²-neolignan; LCBF; local cortical blood flow; MCA; middle cerebral artery; LDF; laser-Doppler flowmetry; HPCD; hydroxypropyl-β-cycl
Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease
Keywords: Aβ; β-amyloid; AD; Alzheimer's disease; AIF; apoptosis-inducing factor; ALS; amyotrophic lateral sclerosis; Apaf-1; apoptotic protease-activating factor; APC; adenomatous polyposis coli; APP; amyloid precursor protein; BrdU; bromodeoxyuridine; CARD; cas