Copper-assisted interaction between amyloid-β and prion: Ternary metal complexes with Aβ N-terminus and octarepeat
Keywords: ESI-MS; Potentiometry; Copper(II) complexes; Aβ; PrP;
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Down-Regulation of KV4 Channel in Drosophila Mushroom Body Neurons Contributes to Aβ42-Induced Courtship Memory Deficits
Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; AE; after eclosion; APP; Aβ precursor protein; CI; courtship index; DI; discrimination index; DNKv4; Kv4 dominant-negative mutant; IA; A-type K+ current; LI; learning index; MB; mushroom body; PN; projection ne
Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center
Keywords: Aβ; amyloid-beta; AD; Alzheimer's disease; ADC; Alzheimer's Disease Center; AMN; amnestic; CSF; cerebrospinal fluid; DLB; dementia with Lewy bodies; FTLD; frontotemporal lobar degeneration; FX; functional impairments; GEE; generalized estimating equation
Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3ÃTgAD and 2ÃTgAD mice
Keywords: C99; Aβ; 2ÃTgAD; 3ÃTgAD; Alzheimer's disease; Behavior; Actimetry; Morris water maze;
miR-34a deficiency in APP/PS1 mice promotes cognitive function by increasing synaptic plasticity via AMPA and NMDA receptors
Keywords: Aβ; amyloid β; ACSF; artificial cerebrospinal fluid; AD; Alzheimer's disease; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ANOVA; analysis of variance; APP; amyloid precursor protein; BACE1; beta-secretase 1; BSA; bovine serum albumin;
Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-β oligomers
Keywords: AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid precursor protein; AACOCF3; arachidonyl trifluoromethyl ketone; CHO; Chinese hamster ovary; CEH; cholesterol ester hydrolase; CM; conditioned media; CSP; cholesteryl N-(2-dimethylaminoethyl) carbamate
Monomeric amyloid-β reduced amyloid-β oligomer-induced synapse damage in neuronal cultures
Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid-β; PrPC; cellular prion protein; cPLA2; cytoplasmic phospholipase A2; CSP; cysteine-string protein; ELISA; enzyme-linked immunoassay; Fab; fragment antigen-binding; GPI; glycosylphosph
Complement receptor 3 mediates NADPH oxidase activation and dopaminergic neurodegeneration through a Src-Erk-dependent pathway
Keywords: Aβ; β-amyloid; CNS; central nervous system; CR3; complement receptor 3; DAMPs; damage associated molecular patterns; DEPs; diesel exhaust particles; DHE; dihydroethidium; Erk; extracellular regulated protein kinases; HMGB1; high-mobility group box 1; Ib
Apelin, a promising target for Alzheimer disease prevention and treatment
Keywords: Alzheimer disease; Apelin; Amyloid beta; Central nervous system; Oxidative stress; AAA; Abdominal aortic aneurysm; ABCA1; ATP-binding cassette transporter A1; ACE; Angiotensin converting enzyme; ACh; Acetylcholine; AChE; Acetyl choline esterase; AD; Alzhe
SN56 neuronal cell death after 24â¯h and 14â¯days chlorpyrifos exposure through glutamate transmission dysfunction, increase of GSK-3β enzyme, β-amyloid and tau protein levels
Keywords: AChE; acetylcholinesterase; AD; Alzheirmer's disease; α7-nAChRs; alpha7-nicotinic acetylcholine receptors; βAPP; amyloid beta precursor protein; Aβ; amyloid beta protein; BSA; bovine serum albumin; CPF; chlorpyrifos; DMEM; Dulbecco's Modified Eagle's
PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease
Keywords: Alzheimer's disease; Mouse model; Non-receptor tyrosine protein kinase; Pyk2; Src; 5XFAD; mice transgenic for human APP and presenilin1 with 5 mutations found in familial Alzheimer's disease; AAV; adeno-associated virus; Aβ; amyloid β; AD; Alzheimer's d
Cadmium alters heat shock protein pathways in SN56 cholinergic neurons, leading to Aβ and phosphorylated Tau protein generation and cell death
Keywords: Cadmium neurotoxicity; Cognitive disorders; HSF1; Heat shock proteins; SN56 basal forebrain cholinergic neurons; Aβ; amyloid beta protein; AChE; acetylcholine esterase; βAPP; amyloid beta precursor protein; GSK-3β; glycogen synthase kinase 3 beta; DMSO
Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration
Keywords: Cerebrospinal fluid; Aβ; sTREM2; Chronic traumatic encephalopathy; Microglial activation; Alzheimer's disease; Repetitive head impacts; Concussion; Subconcussive;
Mitoferrin-1 is Involved in the Progression of Alzheimer's Disease Through Targeting Mitochondrial Iron Metabolism in a Caenorhabditis elegans Model of Alzheimer's Disease
Keywords: mfn-1; mitoferrin-1; AD; Alzheimer's disease; ROS; reactive oxygen species; Aβ; β-amyloid; TMRE; tetramethylrhodamine ethyl ester; SLC25A28; solute carrier family 25 member 28; SLC25A37; solute carrier family 25 member 37; PCR; polymerase chain reacti
Muscle-dominant wild-type TDP-43 expression induces myopathological changes featuring tubular aggregates and TDP-43-positive inclusions
Keywords: Sporadic inclusion body myositis; TAR DNA-binding protein of 43â¯kDa; Creatine kinase 8 promoter; Endoplasmic reticulum stress; Calcium homeostasis; AST; aspartate aminotransferase; Aβ; amyloid β; ALS; amyotrophic lateral sclerosis; BiP; immunoglobulin
Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease
Keywords: AChE; acetylcholine esterase; AD; Alzheimer's disease; AP1; activator protein 1; APP; amyloid precursor protein; Aβ; amyloid beta; BACE1; β-site of APP cleaving enzyme; Bax; Bcl-2-associated X protein; BBB; blood-brain barrier; Bcl-2; B-cell lymphoma
Modeling endophilin-mediated Aβ disposal in glioma cells
Keywords: AD; Alzheimer disease; Aβ; amyloid-β; GO; gene ontology; LC3; microtubule-associated protein 1A/1B-light chain 3; WT; wide-type; CTSB; cathepsin B; WB; Western blot; ELISA; Intracellular enzyme-linked immunosorbent assay; UTR; untranslated region; GEO;
Functional significance of O-GlcNAc modification in regulating neuronal properties
Keywords: PTM; post-translational modification; OGT; O-GlcNAc transferase; OGA; O-GlcNAcase; O-GlcNAc; O-linked β-N-acetylglucosamine; UDP-GlcNAc; uridine diphosphate N-acetylglucosamine; GalNAc; N-acetylgalactosamine; Gal; galactose; PSD; postsynaptic density; NF
Metal-involved theranostics: An emerging strategy for fighting Alzheimer's disease
Keywords: 3,4Apy; 3,4-diaminopyridine; 4Apy; 4-aminopyridine; AChE; acetylcholinesterase; AD; Alzheimer's disease; AFM; atomic force microscopy; APP; amyloid precursor protein; Aβ; amyloid-β peptide; BBB; blood brain barrier; bpy; 2,2-bipyridine; BSA; bovine se
sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca2+ homeostasis and CREB1-signaling
Keywords: Aβ; amyloid β; AD; Alzheimer's disease; ADAM; A Disintegrin And Metalloproteinase (α-secretase); APP; amyloid precursor protein; AMPA-R; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; BACE; β-site of APP cleavage enzyme (β-secretase)
Elevated phospholipase D isoform 1 in Alzheimer's disease patients' hippocampus: Relevance to synaptic dysfunction and memory deficits
Keywords: Phospholipase D; Alzheimer's disease; Memory; Synaptic; Hippocampus; Electrophysiology; Novel object recognition; Aβ; Tau;
Human amyloid β peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans
Keywords: AD; Alzheimer's disease; Aβ; amyloid-β peptide; PTCH1; patched homolog 1; TBC1D16; the Rab GTPase activating protein; WDFY3; the WD repeat and FYVE domain-containing protein 3; ARFGEF2; ADP-ribosylation factor guanine nucleotide exchange factor 2; EBF1;
The Protective Effects of IGF-I against β-Amyloid-related Downregulation of Hippocampal Somatostatinergic System Involve Activation of Akt and Protein Kinase A
Keywords: AC; adenylyl cyclase; AD; Alzheimer's disease; Akt; protein kinase B; Aβ; beta-amyloid; BDNF; brain-derived neurotrophic factor; CCK; cholecystokinin, CRE, cyclic AMP response element; CREB; CRE-binding protein; GABA; γ-aminobutyric acid; GFAF; glial
The inhibitory effect of chitosan oligosaccharides on β-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells
Keywords: AD; Alzheimer's disease; BACE1; β-secretase or β-site amyloid precursor protein cleaving enzyme 1; Aβ; β-amyloid peptide; APP; amyloid precursor protein; COS; chitosan oligosaccharides; MTT; 3-[4,5-dimethylthiazol-2-yl]- 2,5- diphenyltetrazolium bro
Labelling proteins and peptides with phosphorescent d6 transition metal complexes
Keywords: Aβ; amyloid-β; BRD4; bromodomain-containing protein 4; BSA; bovine serum albumin; COX-2; cyclooxygenase-2; D/P; dye:protein ratio, used to quantify the number of metal complexes attached per protein; DNA; deoxyribonucleic acid; EC50; half maximal effect
Cu and Zn coordination to amyloid peptides: From fascinating chemistry to debated pathological relevance
Keywords: AD; Alzheimer's disease; AFM; atomic force microscopy; APP; amyloid precursor protein; Aβ; amyloid-β peptide; DHA; dihydro ascorbic acid; EPR; electron paramagnetic resonance; FAD; familial Alzheimer's disease; hAβ, hIAPP; human peptides; IAPP; isl
Reduction of amyloid beta by Aβ3-10-KLH vaccine also decreases tau pathology in 3ÃTg-AD mice
Keywords: Alzheimer's disease; Aβ3-10-KLH vaccine; Aβ; Tau phosphorylation;
NLRP3-dependent synaptic plasticity deficit in an Alzheimer's disease amyloidosis model in vivo
Keywords: AD; Alzheimer's disease; Aβ; amyloid beta; APP; amyloid precursor protein; PS1; presenilin 1; IL-1; interleukin-1β; IL-1ra; IL-1 receptor antagonist; LTP; long-term potentiation; EPSPs; excitatory postsynaptic potentials; HFS; high frequency stimulation
Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice
Keywords: AD; Alzheimer's Disease; ADP; Adenosine diphosphate; Aβ; β-amyloid; CAW; Water extract of Centella asiatica; CFR; Conditioned fear response; ETC; Electron transport chain; FCCP; Carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone; GAPDH; Glyceraldehyde
Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study
Keywords: Alzheimer's disease; Positron emission tomography; Microglial activation; Amyloid PET; Tau PET; Aβ; Amyloid-β; MMSE; Mini-Mental State Examination; PiB; Pittsburgh compound B; PK11195; 11C-(R)-PK11195; flortaucipir; 18F-flortaucipir; SPM; Statistical pa
Differential protein expression of hippocampal cells associated with heavy metals (Pb, As, and MeHg) neurotoxicity: Deepening into the molecular mechanism of neurodegenerative diseases
Keywords: Metal exposure; Proteomics; Pathway visualization; Neurodegenerative diseases; AD; Alzheimer's disease; APP; Amyloid precursor protein; Aβ; Amyloid-beta; CAM; Calmodulin; ETC; Electron transport chain; GAD; glutamate decarboxylase; Glu; Glutamate; GO; Ge
PERK as a hub of multiple pathogenic pathways leading to memory deficits and neurodegeneration in Alzheimer's disease
Keywords: Alzheimer's disease; PERK; eIF2α; Translation; BACE1; Aβ; Tau; Learning and memory;
Competitive homo- and hetero- self-assembly of amyloid-β 1-42 and 1-40 in the early stage of fibrillation
Keywords: AD; Alzheimer's disease; Aβ; amyloid-β peptide; Aβ40; amyloid-β peptide (1-40); Aβ42; amyloid β peptide (1-42); APP; amyloid precursor protein; Ala; alanine; ATD; arrival time distribution; CCS; collision cross section; DTIMS; drift tube ion m
Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer's disease
Keywords: Aβ; Amyloid-beta peptide; AD; Alzheimer's disease; BBB; Blood-Brain Barrier; CNS; Central nervous system; GFAP; Glial fibrillary acidic protein; MRI; Magnetic resonance image; MRIgFUS; Magnetic resonance image guided focused ultrasound; SI; scyllo-Inos
Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link
Keywords: 3xTg; triple-transgenic; Aβ; β-amyloid; AD; Alzheimer's disease; ADAS-cog; Alzheimer's Disease Assessment Scale-cognitive subscale; Akt; protein kinase B; APP; amyloid precursor protein; CREB; cAMP-response element binding protein; DM; diabetes mell
CEPO-Fc (An EPO Derivative) Protects Hippocampus Against Aβ-induced Memory Deterioration: A Behavioral and Molecular Study in a Rat Model of Aβ Toxicity
Keywords: AD; Alzheimer's disease; Aβ; amyloid β-protein; BBB; blood-brain barrier; CEPO-Fc; carbamylated erythropoietin-Fc; EPO; erythropoietin; ERK; extracellular signal-regulated kinase; JNK; Jun N-terminal kinase; MAPKs; Mitogen-activated protein kinases;
Reduced retromer function results in the accumulation of amyloid-beta oligomers
Keywords: AF700; AlexaFluor-700; AD; Alzheimer's disease; Aβ; Amyloid beta; oAβ; Amyloid beta oligomers; APP; Amyloid precursor protein; BACE1; Beta-secretase 1; BDNF; Brain-derived neurotrophic factor; cDNA; Complementary DNA; CSF; Cerebrospinal fluid; EEA1; Ear
Piper sarmentosum Roxb. confers neuroprotection on beta-amyloid (Aβ)-induced microglia-mediated neuroinflammation and attenuates tau hyperphosphorylation in SH-SY5Y cells
Keywords: Aβ; Beta amyloid; AD; Alzheimer's disease; ANOVA; Analysis of variance; ATCC; American Tissue Culture Collection; BV-2 cells; Immortalised murine microglial cells; CM; Conditioned media; CNS; Central nervous system; DCM; Dichloromethane; DMEM; Dulbecco's
mTOR in Down syndrome: Role in AÃ and tau neuropathology and transition to Alzheimer disease-like dementia
Keywords: mTOR; mammalian target of rapamycin; AD; Alzheimer Disease; DS; Down Syndrome; NTF; Neurofibrillary tangles; Aβ; β-amyloid; Chr21; Chromosome 21; AMPK; 5' AMP-activated protein kinase; GSK-3β; Glycogen synthase kinase 3β; KIN; Kinase catalytic domain;
The Effects of N-terminal Mutations on β-amyloid Peptide Aggregation and Toxicity
Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; Amyloid β peptides; DLS; Dynamic light scattering; EM; electron microscopy; hAβ1-42; human amyloid β1-42; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; LDH; lactate dehydr
Inhibitive Effect of Resveratrol on the Inflammation in Cultured Astrocytes and Microglia Induced by Aβ1-42
Keywords: AD; Alzheimer's disease; Aβ; beta-amyloid; APC; antigen-presenting cell; BACE1; β-site APP cleaving enzyme 1; BBB; blood-brain barrier; CCK; cell-counting kit; CD40; cluster of differentiation 40; CNS; central nervous system; DAPI; 4â²,6-diamidino-
Can crosstalk between DOR and PARP reduce oxidative stress mediated neurodegeneration?
Keywords: Oxidative stress (OS); Delta opioid receptor (DOR); Poly (ADP-ribose)-polymerase1 (PARP1); Neuroprotection; Attenuation; OS; Oxidative stress; DOR; Delta opioid receptor; PARP; Poly (ADP-ribose)-polymerase; AD; Alzheimer's disease; PD; Parkinson's disease
Methylene blue activates the PMCA activity and cross-interacts with amyloid β-peptide, blocking Aβ-mediated PMCA inhibition
Keywords: Methylene blue; PMCA; Aβ; Molecular interactions; Neuronal Ca2+ dysregulation; Aβ; amyloid β-peptide; AD; Alzheimer's Disease; MB; methylene blue; PMCA; plasma membrane Ca2+-ATPase; CaMBD; calmodulin binding domain;
Biogenesis and function of ESCRT-dependent extracellular vesicles
Keywords: Aβ; amyloid-β protein; Acb1; acyl CoA binding protein1; ALIX; ALG-2 interacting protein X; APP; amyloid precursor protein; ARRDC1; ARRestin domain-containing protein 1; COPI/II; coat protein complex I/II; CUPS; compartment for unconventional protein sec
Plasma β-amyloid1-42 reference values in cognitively normal subjects
Keywords: Aβ; Amyloid β; AD; Alzheimer's disease; Aβ1-42; β-Amyloid1-42; Aβ1-40; β-Amyloid1-40; ELISA; Enzyme-linked Immunosorbent Assay; SPs; senile plaques; APP; Amyloid Protein Precursor; PET; Positron Emission Tomography; CSF; cerebrospinal fluid;
Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation
Keywords: AD; Alzheimer's disease; Aβ; Amyloid-β; AppTg; APPswe/PS1/E9 bigenictransgenic mice; ALS; Amyotrophic lateral sclerosis; Cebpd; CCAAT/enhancer-binding protein delta; GFAP; Glial fibrillary acidic protein; HA/Cd; pcDNA3-HA-Cebpd; NADPH; Nicotinamide aden
The small heat shock proteins, especially HspB4 and HspB5 are promising protectants in neurodegenerative diseases
Keywords: α-Crystallins; Neurodegenerative diseases; Neuroprotection; Gene regulation; Aβ; β-amyloid peptides; AD; Alzheimer's disease; ALS; Amyotrophic lateral sclerosis; AxD; Alexander's disease; CNS; Central nervous system; EAE; experimental autoimmune enceph
Capping effects on polymorphic Aβ16-21 amyloids depend on their size: A molecular dynamics simulation study
Keywords: Aβ; Amyloids; Polymorphism; Capping effect; Molecular dynamics (MD);
In vitro antiglycating effect and in vivo neuroprotective activity of Trigonelline in d-galactose induced cognitive impairment
Keywords: Aβ; amyloid beta; AChE; acetyl cholinesterase; AD; Alzheimer's disease; AG; aminoguanidine; AGEs; advanced glycation end products; ANOVA; analysis of variance; AU; arbitrary units; BSA; bovine serum albumin; d-gal; d-galactose; DNP; Donepezil; GSH; red
Physical exercise reserved amyloid-beta induced brain dysfunctions by regulating hippocampal neurogenesis and inflammatory response via MAPK signaling
Keywords: Aβ; amyloid beta; BrdU; bromodeoxyuridine; SGZ; subgranular zone; GFAP; glial fibrillary acidic protein; MAPK; mitogen-activated protein kinase; NSPCs; neural stem/progenitor cells; Alzheimer's disease; Physical exercise; Neurogenesis; Astrocytes; MAPK