Keywords: آکسونیتین; Taurine-Magnesium coordination compound; Arrhythmia; Veratridine; Bay K8644; Whole-cell patch-clamp technique; Aconitine;
مقالات ISI آکسونیتین (ترجمه نشده)
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Keywords: آکسونیتین; Aconitine; Systemic lupus erythematosus (SLE); Pristane-induced lupus (PIL); Autoantibodies; Traditional Chinese medicine (TCM);
Keywords: آکسونیتین; Aconite; Aconitine; Conduction disturbance; Ventricular tachycardia; Long QT; Shock; Hmong;
Keywords: آکسونیتین; Fatal poisoning; Aconitum; Aconitine; Retrospective study; Autopsy
Recurrent Ventricular Arrhythmia Caused by Ingestion of Aconitum (Monkshood) Flowers
Keywords: آکسونیتین; aconitine; aconite; cardiotoxins; neurotoxins; ventricular arrhythmias; wolfsbane;
A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine
Keywords: آکسونیتین; Aconitum carmichaeli Debx.; Aconitum alkaloids; Pharmacokinetics; Herb-drug interactions; Toxicology; Personalized medicine; DMEs; drug-metabolizing enzymes; ETs; efflux transporters; BB; bioavailability barrier; DDAs; diester-diterpene alkaloids; MDAs; m
Rapid construction of the unique BCD ring system of tricyclo[6.2.1.0]undecane in the C19-diterpenoid alkaloid aconitine
Keywords: آکسونیتین; Aconitine; Diterpenoid alkaloid; Diels-Alder reaction; Cascade reaction; Wagner-Meerwein rearrangement;
Gram-scale purification of aconitine and identification of lappaconitine in Aconitum karacolicum
Keywords: آکسونیتین; Aconitine; Lappaconitine; Aconitum karacolicum; Plant extract; Purification methods; Aconitine degradation;
Mdr1a plays a crucial role in regulating the analgesic effect and toxicity of aconitine by altering its pharmacokinetic characteristics
Keywords: آکسونیتین; AC; aconitine; AUC; area under concentration-time curve; cTnI; cardia troppnin I; CL; clearance; CK; creatine kinase; LD50; 5% half-lethal dose; LD50; half-lethal dose; NSE; neurone specific enolase; P-gp; P-glycoprotein; S100-β; neuron-enriched S100 bet
A review of traditional and current methods used to potentially reduce toxicity of Aconitum roots in Traditional Chinese Medicine
Keywords: آکسونیتین; TCM; Traditional Chinese Medicine; DDA; diester diterpene alkaloid; MDA; monoester diterpene alkaloid; NDA; non-esterified diterpene alkaloid; AC; aconitine; MA; mesaconitine; HA; hypaconitine; BAC; benzoylaconine; BMA; benzoylmesaconine; BHA; benzoylhypa
Assessment of in vitro cardiotoxicity of extract fractions and diterpene alkaloids from Aconitum leucostomum Worosch: A short communication
Keywords: آکسونیتین; Aconitum leucostomum Worosch; Aconitine; Chemical composition; Cardiomyocytes; Toxicity;
Human intestine and liver microsomal metabolic differences between C19-diester and monoester diterpenoid alkaloids from the roots of Aconitum carmichaelii Debx.
Keywords: آکسونیتین; AC; Aconitine; BAC; 14-Benzoylaconine or 8-O-deacetyl aconitine; BHA; 14-Benzoylhypaconine or 8-O-deacetyl hypaconitine; BMA; 14-Benzoylmesaconine or 8-O-deacetyl mesaconitine; CHAPS; 3-[(3-cholamidopropyl) dimethyl-ammonio]-1-propane sulfonate; CYP450s;
Calix[8]arene functionalized single-walled carbon nanohorns for dual-signalling electrochemical sensing of aconitine based on competitive host-guest recognition
Keywords: آکسونیتین; Single-walled carbon nanohorns; Calix[8]Arene; Dual-signalling; Competitive host–guest Recognition; Aconitine; Electrochemical determination
p-sulfonated calix[8]arene functionalized graphene as a “turn on” fluorescent sensing platform for aconitine determination
Keywords: آکسونیتین; Competitive host–guest interaction; Fluorescent indicator displacement assay; Calix[8]arene; Graphene; Aconitine
Antitoxic effect of Veratrilla baillonii on the acute toxicity in mice induced by Aconitum brachypodum, one of the genus Aconitum
Keywords: آکسونیتین; Aconitum brachypodum; Veratrilla baillonii; Aconitine; Detoxication;
Metabolomics Study of Aconitine and Benzoylaconine Induced Reproductive Toxicity in BeWo Cell
Keywords: آکسونیتین; Aconitine; Benzoylaconine; Gas chromatography-mass spectrometry; Metabolomics; BeWo cell; Fetal toxicity;
The total alkaloids of Aconitum tanguticum protect against lipopolysaccharide-induced acute lung injury in rats
Keywords: آکسونیتین; TAA; total alkaloids of Aconitum tanguticum; AC; aconitine; HDTAA; high dose of TAA; LDTAA; low dose of TAA; ALI; acute lung injury; LPS; lipopolysaccharide; H-E; hematoxylin-eosin; BALF; bronchoalveolar lavage fluid; TNF-α; tumor necrosis factor-alp
Aconitine-induced Ca2 + overload causes arrhythmia and triggers apoptosis through p38 MAPK signaling pathway in rats
Keywords: آکسونیتین; Aconitine; Apoptosis; Arrhythmia; Heart; Calcium overload; Cardiotoxicity
Transcellular transport of aconitine across human intestinal Caco-2 cells
Keywords: آکسونیتین; Aconitine; Caco-2 cells; P-glycoprotein (P-gp); pH-dependent carrier-mediated transport;
The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography-tandem mass spectrometric method of a specific probe buspirone
Keywords: آکسونیتین; Aconitine; CYP3A; Buspirone; Drug-drug interaction; UPLC-MS/MS;
A novel concept for detoxification: Complexation between aconitine and liquiritin in a Chinese herbal formula ('Sini Tang')
Keywords: آکسونیتین; Sini Tang; Decoction; Aconitine; Liquiritin; Herbal interaction; Complex formation;
P-glycoprotein is responsible for the poor intestinal absorption and low toxicity of oral aconitine: In vitro, in situ, in vivo and in silico studies
Keywords: آکسونیتین; Aconitine; P-glycoprotein; Oral absorption; Caco-2 cells; MDCKII-MDR1 cells; In situ intestinal perfusion;
Evaluation of toxicity of 'Vatsanabha' (Aconitum ferox, Ranunculaceae) Before and After Shodhana
Keywords: آکسونیتین; Aconitine; Shodhana; Toxicity;
Distribution of Aconitum alkaloids in autopsy cases of aconite poisoning
Keywords: آکسونیتین; Aconitine; Aconitum alkaloids; Fatal poisoning; Liquid chromatography–tandem mass spectrometry
Development and assessment of a complete-detoxication strategy for Fuzi (lateral root of Aconitum carmichaeli) and its application in rheumatoid arthritis therapy
Keywords: آکسونیتین; Detoxication; Decoction; Fuzi; Acute toxicity; Aconitine; Adjuvant arthritis
Interaction of aconitine with bovine serum albumin and effect of atropine sulphate and glycyrrhizic acid on the binding
Keywords: آکسونیتین; Aconitine; Atropine sulphate; Bovine serum albumin; Fluorescence quenching; Glycyrrhizic acid; Thermodynamic parameter;
Paeoniflorin reduced acute toxicity of aconitine in rats is associated with the pharmacokinetic alteration of aconitine
Keywords: آکسونیتین; Aconitine; Paeoniflorin; Pharmacokinetics; Acute toxicity
Establishment of a bioassay for the toxicity evaluation and quality control of Aconitum herbs
Keywords: آکسونیتین; Aconitum; Aconitine; Bioassay; Aconite poisoning; Quality control;
Simultaneous determination of 11 aconitum alkaloids in human serum and urine using liquid chromatography–tandem mass spectrometry
Keywords: آکسونیتین; Aconitine; Aconitum alkaloids; Liquid chromatography–tandem mass spectrometry
Distinct models of induced hyperactivity in zebrafish larvae
Keywords: آکسونیتین; Zebrafish; Disease model; Hyperactivity; Pentylenetrazole; Aconitine; 4-aminopyridine
Seven cases of fatal aconite poisoning: Forensic experience in China
Keywords: آکسونیتین; Aconitine; Aconitum; Fatal poisoning; Chuanwu; Caowu
Evidence for aconitine-induced inhibition of delayed rectifier K+ current in Jurkat T-lymphocytes
Keywords: آکسونیتین; ACO; aconitine; 1-EBIO; 1-ethyl-2-benzimidazolinone; FBS; fetal bovine serum; IC50; the concentration required for a 50% inhibition; IKCa channel; intermediate-conductance Ca2+-activated K+ channel; IK(DR); delayed-rectifier K+ current; I-V; current-v
Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes
Keywords: آکسونیتین; Aconitine; Cytochrome P450; Metabolism; Microsomes; LC-MS/MS;
Antiarrhythmic effect of acute oxygen-ozone administration to rats
Keywords: آکسونیتین; Ozone; Arrhythmias; Ischemia; Reperfusion; Aconitine; Potassium chloride; (Rats)
Aconitine blocks HERG and Kv1.5 potassium channels
Keywords: آکسونیتین; Electrophysiology; Aconitine; HERG potassium channel; Kv1.5 potassium channel; Arrhythmias; Voltage clamp techniques;
Application of experimental design and radial basis function neural network to the separation and determination of active components in traditional Chinese medicines by capillary electrophoresis
Keywords: آکسونیتین; Capillary electrophoresis; Experimental design; Radial basis function neural network; Aconitine; Hypaconitine
Aconitine induces prolonged seizure-like events in rat neocortical brain slices
Keywords: آکسونیتین; Cerebral cortex; Aconitine; Seizure; Cortical slice; (Rat)
Determination of aconitine-type alkaloids as markers in fuzi (Aconitum carmichaeli) by LC/(+)ESI/MS3
Keywords: آکسونیتین; Aconitine; Mesaconitine; Hypaconitine; Aconitum carmichaeli; Fuzi
Sarcoplasmic reticulum Ca2+ release channel ryanodine receptor (RyR2) plays a crucial role in aconitine-induced arrhythmias
Keywords: آکسونیتین; RyR2, type 2-ryanodine receptor; KD, knockdown; e–c coupling, excitation–contraction coupling; ACO, aconitine; SR, sarcoplasmic reticulum; siRNA, small interfering RNARyR2; Knockdown; Aconitine; Arrhythmia; Excitation–contraction coupling
Contribution of slowly inactivating potassium current to delayed firing of action potentials in NG108-15 neuronal cells: Experimental and theoretical studies
Keywords: آکسونیتین; Delayed-rectifier K+ current; Slow inactivation; Action potential; Aconitine; Computer simulations
Characterization of aconitine-induced block of delayed rectifier K+ current in differentiated NG108-15 neuronal cells
Keywords: آکسونیتین; Aconitine; NG108-15 cells; Delayed rectifier K+ current; Na+ current; Action potential
Disruption of the intracellular Ca2+ homeostasis in the cardiac excitation-contraction coupling is a crucial mechanism of arrhythmic toxicity in aconitine-induced cardiomyocytes
Keywords: آکسونیتین; Aconitine; Ca2+ homeostasis; Arrhythmic cytotoxicity; The cardiac EC coupling; Ca2+ handling proteins; Inhibitors; Ca2+-dependent arrhythmia;
Aconitine alters connexin43 phosphorylation status and [Ca2+] oscillation patterns in cultured ventricular myocytes of neonatal rats
Keywords: آکسونیتین; Aconitine; Myocardium; Connexins; Protein phosphorylation; Calcium (cellular)
Quantitative determination of diterpenoid alkaloids in four species of Aconitum by HPLC
Keywords: آکسونیتین; Benzoylmesaconine; Mesaconitine; Aconitine; Hypaconitine; Deoxyaconitine; High performance liquid chromatography
Effects of chronic administrations of aconitine on body weight and rectal temperature in mice
Keywords: آکسونیتین; LD50; lethal dose 50%; BSTFA; Bis (trimethylsilyl) trifluoroacetimide; TMCS; trimethylchlorosilane; ICR; Institute of Cancer Research; GC/MS; gas chromatography/mass spectrometry; S.E.M.; standard erroe of mean; ANOVA; analysis of variance; p.o.; per os;
Effects of processed Aconiti tuber and its ingredient alkaloids on the development of antinociceptive tolerance to morphine
Keywords: آکسونیتین; Processed Aconiti tuber; Mesaconitine; Aconitine; Hypaconitine; Morphine tolerance; Kappa-opioid receptor;
Characterization of metabolites and cytochrome P450 isoforms involved in the microsomal metabolism of aconitine
Keywords: آکسونیتین; Aconitine; Cytochrome P450; Metabolites; Metabolism; Microsome
Separation and identification of Aconitum alkaloids and their metabolites in human urine
Keywords: آکسونیتین; Liquid chromatography-mass spectrometry; Aconitum alkaloids; metabolites; 16-O-demethylaconitine; 16-O-demethylhypaconitine; Aconitine poisoning; ESI; electrospray ionization; HPLC; high performance liquid chromatography; LC; liquid chromatography; M1; ac
Effects of long-term administrations of aconitine on electrocardiogram and tissue concentrations of aconitine and its metabolites in mice
Keywords: آکسونیتین; Aconitine; Metabolites; Chronic administration; Arrhythmia; GC/MS;