کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1224732 967930 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quantitative determination of diterpenoid alkaloids in four species of Aconitum by HPLC
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Quantitative determination of diterpenoid alkaloids in four species of Aconitum by HPLC
چکیده انگلیسی

A high performance liquid chromatography (HPLC) method has been developed for the determination of five principal alkaloids (benzoylmesaconine, mesaconitine, aconitine, hypaconitine and deoxyaconitine) found in four species of genus Aconitum. The five alkaloids were analyzed simultaneously with an XTerra™RP18 column by gradient elution using 0.03 M ammonium hydrogen carbonate–acetonitrile as mobile phase. The recovery of the method was 94.6–101.9%, and all the alkaloids showed good linearity (γ = 0.9999) in a relatively wide concentration range. The results indicated that contents of alkaloids in Aconitum varied significantly from species to species; hence quality control of Aconitum drugs is very necessary.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 40, Issue 4, 3 March 2006, Pages 1031–1034
نویسندگان
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