کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2548361 | 1560411 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of chronic administrations of aconitine on body weight and rectal temperature in mice
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کلمات کلیدی
TMCsLD50BSTFAS.E.M.i.p.i.v.ICRp.o.GC/MS - GC / MSPer os - per osAconitine - آکسونیتینnot done - انجام نشدهanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceTrimethylchlorosilane - تری متیل کلروسیلانintraperitoneal - داخل صفاقیIntravenous - داخل وریدیRectal temperature - دما رکتومlethal dose 50% - دوز مرگبار 50٪Chronic administration - مدیریت مزمنinstitute of cancer research - موسسه تحقیقات سرطانbody weight - وزن بدنgas chromatography/mass spectrometry - کروماتوگرافی گاز / طیف سنج جرمی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Aconitine, a major Aconitum alkaloid, is well known for its high toxicity that induces severe arrhythmias leading to death. However, aconitine has been used as one of the most popular compounds in Shino-Japanese traditional herbal medicine. Little has been reported concerned with the long-term effects of aconitine. Therefore, the authors investigated the physiological effects of chronic administrations of aconitine by determining the changes in body weight and rectal temperature of mice, compared with the concentrations of aconitine and its metabolites (benzoylaconine and aconine) in the liver and kidneys. The concentration ratio of aconitine to the total Aconitum alkaloids (from day 0 to 22; 90Â min after the last administration) gradually decreased, whereas its metabolites increased until day 22. The body weight gain in aconitine-administered group was less than that of the control group until day 22. Transient rectal hypothermia occurred within 30Â min after the last administration of aconitine. Then the rectal temperature gradually increased to normal level in respect to time. This study might reveal the possibilities that the drug metabolism of aconitine increased and the toxicity of aconitine decreased due to long-term administrations of aconitine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 105, Issues 1â2, 21 April 2006, Pages 89-94
Journal: Journal of Ethnopharmacology - Volume 105, Issues 1â2, 21 April 2006, Pages 89-94
نویسندگان
Kentaro Wada, Makoto Nihira, Youkichi Ohno,