Akt1 isoform modulates phenotypic conversion of vascular smooth muscle cells
Keywords: آکت; Akt; Laminin; Integrin-linked kinase; Neointima; Phenotypic change
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Effects of protein tyrosine phosphatase-PEST are reversed by Akt in T cells
Keywords: آکت; Ab; antibody; PTP; Protein Tyrosine Phosphatase; Protein Tyrosine Phosphatase (PTP); PTP-PEST; Cell death; Growth factor signaling; Akt;
Neuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor function
Keywords: آکت; 5-HT; serotonin; Akt; protein kinase B; DOI; (±)-2,5-dimethoxy-4-iodoamphetamine hydrochloride; ERK1/2; extracellular signal-regulated protein kinases 1 and 2; GSK-3β; glycogen synthase kinase-3beta; KO; knock out; 8-OH-DPAT; [8-hydroxy-2-(di-n-propylam
Insulin-like modulation of Akt/FoxO signaling by copper ions is independent of insulin receptor
Keywords: آکت; Insulin signaling; PTPase (protein tyrosine phosphatase); ROS; Copper ions; Hepatoma cells; Linsitinib; Akt; FoxO;
The effects of age and muscle contraction on AMPK activity and heterotrimer composition
Keywords: آکت; ACC; acetyl CoA carboxylase; ADP; adenosine diphosphate; AKT; protein kinase B; AMP; adenosine monophosphate; ATP; adenosine triphosphate; AMPK; AMP-activated protein kinase; ERK; extracellular signal-regulated kinase; GAST; gastrocnemius; HPLC; high perf
Research ReportSquamosamide derivative FLZ protected dopaminergic neuron by activating Akt signaling pathway in 6-OHDA-induced in vivo and in vitro Parkinson's disease models
Keywords: آکت; PD; Parkinson's disease; PI3K; phosphoinositide-3-kinase; α-Syn; α-synuclein; 6-OHDA; 6-hydroxydopamine; TH; tyrosine hydroxylase; Co-IP; Co-Immunoprecipitation; FLZ; Parkinson's disease; Akt; α-synuclein; Tyrosine hydroxylase;
ReviewPro- and anti-inflammatory cytokines in tuberculosis: A two-edged sword in TB pathogenesis
Keywords: آکت; AEC; airway epithelial cells; Ag; antigen; AIM; apoptosis inhibitor of macrophages; AKT; RAC-alpha serine/threonine-protein kinase; APC; antigen presenting cells; ASC; apoptosis-associated speck-like protein containing a CARD; BCG; Bacillus Calmette-Guér
Notoginsenoside Ft1 activates both glucocorticoid and estrogen receptors to induce endothelium-dependent, nitric oxide-mediated relaxations in rat mesenteric arteries
Keywords: آکت; Akt; protein kinase B; cGMP; cyclic guanosine monophosphate; DMSO; dimethyl sulfoxide; EDH; endothelium-dependent hyperpolarizations; EDRF; endothelium-derived relaxing factor; eNOS; endothelial nitric oxide synthase; ERÃ; estrogen receptor beta; ERK1/2;
Cytotoxicity of the bisphenolic honokiol from Magnolia officinalis against multiple drug-resistant tumor cells as determined by pharmacogenomics and molecular docking
Keywords: آکت; ABC; ATP-binding cassette; Akt; v-Akt murine thymoma viral oncogene homolog 1; BCRP; breast cancer resistance protein; EGFR; epidermal growth factor; MAPK; mitogen-activated protein kinase; MDR; multidrug resistance; mTOR; mammalian target of rapamycin; P
Neuroprotective and anti-apoptotic effects of valproic acid on adult rat cerebral cortex through ERK and Akt signaling pathway at acute phase of traumatic brain injury
Keywords: آکت; Valproic acid; Neuroprotective effect; Traumatic brain injury; Extracellular signal-regulated kinase; Akt; Rat
Catalpol promotes oligodendrocyte survival and oligodendrocyte progenitor differentiation via the Akt signaling pathway in rats with chronic cerebral hypoperfusion
Keywords: آکت; Catalpol; Oligodendrocyte; Oligodendrocyte progenitor; Akt; White matter lesions; Chronic cerebral hypoperfusion
miR-21 alleviated apoptosis of cortical neurons through promoting PTEN-Akt signaling pathway in vitro after experimental traumatic brain injury
Keywords: آکت; TBI; Neuron; miR-21; Apoptosis; PTEN; Akt
Arachidonic acid promotes migration and invasion through a PI3K/Akt-dependent pathway in MDA-MB-231 breast cancer cells
Keywords: آکت; Breast cancer; Migration; Invasion; Akt; PI3K
Magnolol protects neurons against ischemia injury via the downregulation of p38/MAPK, CHOP and nitrotyrosine
Keywords: آکت; Magnolol; Stroke animal model; Inducible NO synthase; p38 mitogen-activated protein kinases; Akt; NF-κB
Study of the protective mechanisms of Compound Danshen Tablet (Fufang Danshen Pian) against myocardial ischemia/reperfusion injury via the Akt-eNOS signaling pathway in rats
Keywords: آکت; Compound Danshen Tablet; Myocardial ischemia/reperfusion injury; Akt; eNOS; Protective Mechanisms; Signaling pathway
The estrogen receptor β-PI3K/Akt pathway mediates the cytoprotective effects of tocotrienol in a cellular Parkinson's disease model
Keywords: آکت; Vitamin E; Parkinson's disease; Estrogen receptor; PI3K; Akt; Caveolin;
Significance of Akt activation and AKT gene increases in soft tissue tumors
Keywords: آکت; Bone and soft tissue; AKT; Polysomy; Activation; Isoforms; Metastasis; Molecular targeting therapy
Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain
Keywords: آکت; mTOR; Akt; PI3K; Autophagy; Insulin signaling; Trisomy 21;
(â)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress
Keywords: آکت; Akt; protein kinase B, ATF6, activating transcription factor 6; EC; (â)-epicatechin; eIF2α; eukaryotic initiation factor 2α; ER; endoplasmic reticulum; ERK; extracellular signal-regulated kinase; GTT; glucose tolerance test; HFr; high fructose; IκB;
Map2k4δ - Identification and functional characterization of a novel Map2k4 splice variant
Keywords: آکت; AKT; protein kinase B; ATF-2; activating transcription factor 2; BrdU; 5-bromo-2-deoxyuridine; DVD; domain of versatile docking; E; embryonic day; ERK; extracellular signal-regulated kinase; Fas-L; Fas ligand; ID; immunodepletion; IP; immunoprecipitation;
In vivo hyperoxia induces hypoxia-inducible factor-1α overexpression in LNCaP tumors without affecting the tumor growth rate
Keywords: آکت; In vivo hypoxia; In vivo hyperoxia; LNCaP tumor; Angiogenesis; Hypoxia-inducible factor; Akt; phosphatidylinositol-3-phosphate/protein kinase B; Hb; hemoglobin; HIF-1α; hypoxia-inducible factor-1α; Ki67; Antigen anti-KI-67; LNCaP; androgen-sensitive hum
Physiological cardiac hypertrophy: Critical role of AKT in the prevention of NHE-1 hyperactivity
Keywords: آکت; Sed; sedentary, not-trained rats; Swim; swim-trained rats; CH; cardiac hypertrophy; NHE-1; Na +/H + exchanger isoform 1; ERK1/2; extracellular signal-regulated kinase 1 and 2; PI3K; phosphatidylinositol 3-kinase; p90RSK; 90 kDa ribosomal S6 protein ki
Insulin drives glucose-dependent insulinotropic peptide expression via glucose-dependent regulation of FoxO1 and LEF1/β-catenin
Keywords: آکت; Akt; Serine/threonine-specific protein kinase also known as Protein Kinase B (PKB); ChIP; Chromatin immunoprecipitation; FoxO1; Forkhead box protein O1; GLP-1; Glucagon-Like Peptide 1; HDAC1; Histone Deacetylase 1; IRE; Insulin-Response Element; PI3K; Pho
Regulation of the biogenesis of OXPHOS complexes in cell transition from replicating to quiescent state
Keywords: آکت; AKAP; A-kinase anchor proteins; Akt; protein kinase B; CREB; cAMP response element-binding protein; HT; hydroxytyrosol; NHDF-neo; neonatal normal human dermal fibroblasts; NRF1; nuclear respiratory factor 1; OXPHOS; oxidative phosphorylation system; PGC-1
The inhibition effects of insulin on BMP2-induced muscle heterotopic ossification
Keywords: آکت; BMP2; Heterotopic ossification; Insulin; AKT; Osterix
PTEN inhibits the invasion and metastasis of gastric cancer via downregulation of FAK expression
Keywords: آکت; PTEN; phosphatase and tensin homolog; FAK; focal adhesion kinase; AKT; protein kinase B; NF-κB; nuclear factor B or NF-kappaB; ChIP; chromatin immunoprecipitation; EMSA; electrophoretic mobility shift assay; DAPI; 4â²,6-diamidino-2-phenylindole; Focal a
Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease
Keywords: آکت; 4E-BP1; eukaryotic initiation factor 4E binding protein 1; 6-OHDA; 6-hydroxydopamine; ACC; acetyl-CoA carboxylase; AD; Alzheimer's disease; AMPK; AMP-dependent/activated protein kinase; DAB; 3,3â²-diaminobenzidine tetrachloride; DAPI; 4â²,6-diamidino-2-
Microtubule dynamics regulates Akt signaling via dynactin p150
Keywords: آکت; Akt; Microtubules; Signal transduction; Protein phosphorylation; Cell death;
Metadherin regulates metastasis of squamous cell carcinoma of the head and neck via AKT signalling pathway-mediated epithelial-mesenchymal transition
Keywords: آکت; Squamous cell carcinoma of the head and neck; Metastasis; Epithelial-mesenchymal transition; Metadherin; AKT;
Molecular cross talk between Notch1, Shh and Akt pathways during erythroid differentiation of K562 and HEL cell lines
Keywords: آکت; NICD; Notch1 intracellular domain; Shh; Sonic Hedgehog; GSI; Gamma secretase inhibitor; DNCSL; Dominant negative CSL; Ptch1; Patched1; Smo; Smoothened; myr-Akt; myristoylated-Akt; Gli; Glioma-associated oncogene homologue; Notch1; Erythropoiesis; Shh; Akt
Targeting the PI3K/AKT/mTOR pathway in estrogen receptor-positive breast cancer
Keywords: آکت; Luminal type; Breast cancer; Phosphatidylinositol 3-kinase; PI3K; AKT; Mammalian target of rapamycin; mTOR; Estrogen receptor; Endocrine therapy; Endocrine resistance
Shock/sepsis/trauma/critical carePuerarin ameliorates oxidative stress in a rodent model of traumatic brain injury
Keywords: آکت; Traumatic brain injury; Puerarin; Oxidative stress; Akt;
Activation of the Akt/mammalian target of rapamycin pathway in myxofibrosarcomas
Keywords: آکت; Myxofibrosarcoma; Akt; mTOR; MAPK;
Neuropharmacology and analgesiaBeta-asarone attenuates amyloid beta-induced autophagy via Akt/mTOR pathway in PC12 cells
Keywords: آکت; Beta-asarone (PubChem CID: 5281758); 3-methyladenine (PubChem CID: 1673); Rapamycin (PubChem CID: 5284616); NVP-BEZ235 (PubChem CID: 11977753); Alzheimerâ²s disease; Akt; Autophagy; Beclin-1; Beta-asarone; Mammalian target of rapamycin;
Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1
Keywords: آکت; Ms-EE; ethanolic extract of Myrsine seguinii; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumour necrosis factor; ERK; extracellular signal-related kinase; TLR; toll-like receptors (TLR); MAPK; mit
PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways
Keywords: آکت; Focal cerebral ischemia; Akt; Stroke; mTOR; PRAS40; PTEN;
Saikosaponin D acts against corticosterone-induced apoptosis via regulation of mitochondrial GR translocation and a GR-dependent pathway
Keywords: آکت; MD; major depression; HPA axis; hypothalamic-pituitary-adrenal axis; CNS; central nervous system; GC; glucocorticoid; GR; glucocorticoid receptors; mPTP; mitochondrial permeability transition pore; MMP; mitochondrial membrane potential; GILZ; glucocor
Raloxifene activates G protein-coupled estrogen receptor 1/Akt signaling to protect dopamine neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice
Keywords: آکت; Raloxifene; GPER; MPTP; Neuroprotection; Akt; Dopamine; Striatum;
TGF-β1-elevated TRPM7 channel regulates collagen expression in hepatic stellate cells via TGF-β1/Smad pathway
Keywords: آکت; 2-APB; 2-aminoethoxydiphenyl borate; α-SMA; α-smooth muscle actin; AKT; protein kinase B; Col1a1; collagen type 1 alpha 1; ECM; extracellular matrix; eEF2-k; eukaryotic elongation factor-2 kinase EGF, epidermal growth factor; HSC; hepatic stellate cell;
Hepatic transcriptional analysis in rats treated with Cassia occidentalis seed: Involvement of oxidative stress and impairment in xenobiotic metabolism as a putative mechanism of toxicity
Keywords: آکت; AIF; apoptosis inducing factor; AKT; v-akt murine thymoma viral oncogene homolog; BAX; Bcl-2 associated X gene; CAT; catalase; CO; Cassia occidentalis; CREB; cAMP responsive element binding protein; CYP; cytochrome p450; EROD; ethoxyresorufin-O-deethylase
Human cord blood stem cell paracrine factors activate the survival protein kinase Akt and inhibit death protein kinases JNK and p38 in injured cardiomyocytes
Keywords: آکت; Akt; apoptosis; JNK; myocytes; p38; umbilical cord stem cells;
Activation of PI3K/Akt signaling in rostral ventrolateral medulla impairs brain stem cardiovascular regulation that underpins circulatory depression during mevinphos intoxication
Keywords: آکت; aCSF; artificial cerebrospinal fluid; Akt; serine/threonine protein kinase; EMSA; electrophoretic mobility shift assay; HR; heart rate; LF; low-frequency; 3-MA; 3-methyladenine; NF-κB; nuclear factor-κB; NO; nitric oxide; NOS; nitric oxide synthase; NRS
GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression
Keywords: آکت; Aβ; amyloid-β; AD; Alzheimer's disease; Akt; protein kinase B; APP; amyloid precursor protein; BACE1; β-site APP-cleaving enzyme 1; BDNF; brain-derived neurotrophic factor; CGI-S; Clinical Global Impression-Severity scale; CREB; cAMP-response element
SET-mediated NDRG1 inhibition is involved in acquisition of epithelial-to-mesenchymal transition phenotype and cisplatin resistance in human lung cancer cell
Keywords: آکت; NSCLC; non-small-cell lung cancer; CDDP; cisplatin; EMT; epithelial-to-mesenchymal transition; SET; SET oncoprotein; PP2A; serine/threonine protein phosphatase 2A; NDRG1; N-myc downstream regulated gene1; MMP; matrix metalloproteinase; AKT; protein kinase
Signaling specificity in the Akt pathway in biology and disease
Keywords: آکت; Akt; PI 3-Kinase; Signaling; Cancer; Nucleus; Protein kinase
The links between AKT and two intracellular proteolytic cascades: Ubiquitination and autophagy
Keywords: آکت; BRCA1; breast cancer susceptibility gene 1; BRCT; Brca1 C-terminal; CHIP; chaperone-associated ubiquitin ligase; CYLD; cylindromatosis; DAPK; death-associated protein kinase; DUB; deubiquitinating enzyme); EGF; epidermal growth factor; FADD; fas-associate
Phytoestrogens as alternative hormone replacement therapy in menopause: What is real, what is unknown
Keywords: آکت; Akt; protein kinase B; AMPK; 5â² AMP-activated protein kinase; BBB; blood-brain barrier; COX2; cyclooxygenase 2; E2; estradiol; EGTA; ethylene glycol tetraacetic acid; ER; estrogen receptor; ERE; Estrogen-responsive elements; ERK; Extracellular signal-re
The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro
Keywords: آکت; Alpha-synuclein; Neurotoxicity; Neuroprotection; AMPK; Akt; Autophagy; AICAR; Metformin;
Compound library screening identified Akt/PKB kinase pathway inhibitors as potential key molecules for the development of new chemotherapeutics against schistosomiasis
Keywords: آکت; Protein kinase; Inhibitor; Protein kinase B (PKB); Akt; Schistosoma mansoni; Chemotherapy
Acquisition of epithelial–mesenchymal transition phenotype and cancer stem cell-like properties in cisplatin-resistant lung cancer cells through AKT/β-catenin/Snail signaling pathway
Keywords: آکت; Cisplatin; EMT; Cancer stem cell; Snail; AKT; β-catenin