MicroRNA-375 inhibits colorectal cancer growth by targeting PIK3CA
Keywords: آکت; miR-375; Colorectal cancer; PIK3CA; PI3K; Akt
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Gβγ interacts with mTOR and promotes its activation
Keywords: آکت; Gβγ; G-protein; mTOR; AKT; G-protein coupled receptor; Raptor; Rictor; Cell signaling
Therapeutic potential of metformin in papillary thyroid cancer in vitro and in vivo
Keywords: آکت; Metformin; AMPK; Akt; Papillary thyroid cancer (PTC); Ectopic tumor; Mouse;
Activation of Akt involves resistance to NF-κB inhibition and abrogation of both triggers synergistic apoptosis in lung adenocarcinoma cells
Keywords: آکت; Lung adenocarcinoma; NF-κB; Akt; S6K; DHMEQ; Rapamycin;
RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells
Keywords: آکت; 4E-BP1; eukaryotic initiation factor 4E binding protein 1; caRags; constitutively active Rags B and C; caRheb; constitutively active Rheb; caRhoA; constitutively active RhoA; mTOR; mechanistic target of rapamycin; mTORC; mechanistic target of rapamycin co
Blockage of Stat3 enhances the sensitivity of NSCLC cells to PI3K/mTOR inhibition
Keywords: آکت; Akt; Bim; CHOP; mTOR; PI3K; Stat3;
Protein kinase C-beta: An emerging connection between nutrient excess and obesity
Keywords: آکت; Akt; protein kinase B; BAT; brown adipose tissue; DAG; diacylglycerol; HFD; high-fat diet; p66shc; 66 kDa isoform of mammalian ShcA gene; PKC; protein kinase C; PKCβ; protein kinase C beta; PGC-1α; peroxisome proliferator-activated receptor-γ coactiva
Dihydromyricetin induces autophagy in HepG2 cells involved in inhibition of mTOR and regulating its upstream pathways
Keywords: آکت; DHM; dihydromyricetin; mTOR; mammalian targets of rapamycin; ERK1/2; extracellular signal-regulated kinase 1/2; AMPK; AMP-activated kinase; PI3K; class III phosphatidylinositol 3-kinase; PDK 1; phosphoinositide-dependent protein kinase 1; Akt; protein kin
A monoterpene, unique component of thyme honeys, induces apoptosis in prostate cancer cells via inhibition of NF-κB activity and IL-6 secretion
Keywords: آکت; NF-κB; nuclear factor-kappaB; mapk; mitogen-activated protein kinase; PI3K; phosphatidylinositide 3-kinase; Akt; protein kinase B; FAK; focal adhesion kinase; PSG; prostate-specific G-protein-coupled receptor; IL-6; interleukin-6; JNK; c-Jun NH(2)-termin
Resveratrol prevents neuronal apoptosis in an early brain injury model
Keywords: آکت; Resveratrol; Subarachnoid hemorrhage; Early brain injury; Apoptosis; PI3K; Akt
Sildenafil Promotes eNOS Activation and Inhibits NADPH Oxidase in the Transgenic Sickle Cell Mouse Penis
Keywords: آکت; eNOS Phosphorylation; AKT; HSP90; 4‐HNE; Oxidative Stress
Rapamycin Treatment of Healthy Pigs Subjected to Acute Myocardial Ischemia-Reperfusion Injury Attenuates Cardiac Functions and Increases Myocardial Necrosis
Keywords: آکت; AAR; Area at risk; ADP; adenosine diphosphate; AKT; Protein kinase B; ANOVA; Analysis of variance; cTnI; Cardiac troponin I; dP/dT Max; left ventricular maximum contractility; dV/dT max; Left ventricular maximum filling; ECL; Enhanced chemiluminescense; E
Phosphorylation of Carma1, but not Bcl10, by Akt regulates TCR/CD28-mediated NF-κB induction and cytokine production
Keywords: آکت; TCR, T cell receptor; CARD, caspase recruitment domain; CBM, Carma1/Bcl10/MALT1Signal transduction; NF-κB; T cells; Phosphorylation; Akt
Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders
Keywords: آکت; AKT; mTOR; Autism spectrum disorders; Rett syndrome
Caffeine suppresses exercise-enhanced long-term and location memory in middle-aged rats: Involvement of hippocampal Akt and CREB signaling
Keywords: آکت; Caffeine; Memory; Exercise; CREB; Akt; Middle-aged
Correlation Between Akt and p53 Protein Expression and Chemoradiotherapy Response in Cervical Cancer Patients
Keywords: آکت; Akt; p53; cervical cancer; chemoradiotherapy
Hepatoprotective effects of berberine on liver fibrosis via activation of AMP-activated protein kinase
Keywords: آکت; BBR, berberine; AMPK, AMP-activated protein kinase; HSC, hepatic stellate cells; TGF, transforming growth factor; ROS, reactive oxygen species; CCl4, carbon tetrachloride (CCl4)Liver fibrosis; Berberine; AMPK; ROS; Akt
Suppressive effects of 17β-estradiol on tributyltin-induced neuronal injury via Akt activation and subsequent attenuation of oxidative stress
Keywords: آکت; Tributyltin; 17β-Estradiol; Neuroprotection; Oxidative stress; Akt
Selective inhibition of class I but not class IIb histone deacetylases exerts cardiac protection from ischemia reperfusion
Keywords: آکت; Akt; protein kinase B; dP/dt; rate of pressure change; ERK; extracellular regulated kinase; FOXO; forkhead box protein family, subclass O; HDAC; histone deacetylase; IR; ischemia reperfusion; HEK293; human endothelial kidney cells, line 293; LV; left vent
Herbimycin A inhibits cell growth with reversal of epithelial-mesenchymal transition in anaplastic thyroid carcinoma cells
Keywords: آکت; Anaplastic thyroid carcinoma; Herbimycin A; Epithelial-mesenchymal transition; E-cadherin; p53; Akt;
CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition
Keywords: آکت; CCT128930; Akt; Cell cycle; DNA damage; Autophagy
Tissue transglutaminase promotes serotonin-induced AKT signaling and mitogenesis in pulmonary vascular smooth muscle cells
Keywords: آکت; MDC; monodansylcadaverine; PASMC; pulmonary arterial smooth muscle cells; 5-HT; 5-hydroxytryptamine (serotonin); SERT; serotonin transporter; TG2; transglutaminase 2 aka tissue transglutaminase; Transglutaminase 2; AKT; S6K; S6; Serotonin; SERT;
Periexercise coingestion of branched-chain amino acids and carbohydrate in men does not preferentially augment resistance exercise-induced increases in phosphatidylinositol 3 kinase/protein kinase B-mammalian target of rapamycin pathway markers indica
Keywords: آکت; Branched-chain amino acids; Carbohydrate; Muscle protein synthesis; Insulin; Men; 1-RM; 1 repetition maximum; 4E-BP1; 4E binding protein 1; Akt; protein kinase B; BCAA; branched-chain amino acid; CHO; carbohydrate; IRS-1; insulin receptor substrate 1; MPS
Vav1 increases Bcl-2 expression by selective activation of Rac2-Akt in leukemia T cells
Keywords: آکت; GEF; guanine nucleotide exchange factor; T-CVID; T cell type common variable immunodeficiency; B-CLL; B-cell chronic lymphocytic leukemia; shRNA; short-hairpin RNA; SDS-PAGE; SDS-polyacrylamide gel electrophoresis; GST; Glutathione S-transferase; PAK1; p2
Status of PI3K/Akt/mTOR Pathway Inhibitors in Lymphoma
Keywords: آکت; Akt; Lymphoma; mTor; PI3K; Review; Signalling; Targeted; Therapy;
18β-Glycyrrhetinic acid suppresses TNF-α induced matrix metalloproteinase-9 and vascular endothelial growth factor by suppressing the Akt-dependent NF-κB pathway
Keywords: آکت; 18β-Glycyrrhetinic acid; Matrix metalloproteinase; Vascular endothelial growth factor; Nuclear factor-kappa B; Phosphatidyl-inositol 3 kinase; Akt;
Role of NADPH oxidase-4 in saturated fatty acid-induced insulin resistance in SK-Hep-1 cells
Keywords: آکت; Insulin resistance; Akt; Reactive oxygen species; Stearic acid; NOX4;
Antitumour effect and modulation of expression of the ABCB1 gene by perifosine in canine lymphoid tumour cell lines
Keywords: آکت; Canine; Lymphoma cell lines; ABCB1; P-glycoprotein; Multidrug resistance; Akt; ERK; JNK
N-Hydroxycinnamide derivatives of osthole inhibit cell migration and invasion by suppressing Smad2 and Akt pathways in human colorectal adenocarcinoma cells
Keywords: آکت; Osthole; Migration; Invasion; TGF-β; Smad; Akt;
The cardioprotectant 3â²,4â²-dihydroxyflavonol inhibits opening of the mitochondrial permeability transition pore after myocardial ischemia and reperfusion in rats
Keywords: آکت; ADP; adenosine diphosphate; AKT; protein kinase B; CaMKII; Ca2+/calmodulin-dependent kinase II; CsA; cyclosporin A; DiOHF; 3â²,4â²-dihydroxyflavonol; DMSO; dimethyl sulfoxide; ERK; extracellular signal regulated kinase; IR; ischemia/reperfusion; mPTP; m
Magnesium lithospermate B improves myocardial function and prevents simulated ischemia/reperfusion injury-induced H9c2 cardiomyocytes apoptosis through Akt-dependent pathway
Keywords: آکت; SI/R; simulated ischemia/reperfusion; MLB; magnesium lithospermate B; LDH; lactate dehydrogenase; CK-MB; creatine phosphokinase-MB; ELISA; enzyme-linked immunosorbent assay; OGD; oxygen and glucose deprived; MI/R; myocardial ischemia/reperfusion; Magnesiu
The volatile oil of Nardostachyos Radix et Rhizoma inhibits the oxidative stress-induced cell injury via reactive oxygen species scavenging and Akt activation in H9c2 cardiomyocyte
Keywords: آکت; Volatile oil; H9c2 cells; Oxidative stress; Cardioprotection; Akt;
Agmatine protects against intracerebroventricular streptozotocin-induced water maze memory deficit, hippocampal apoptosis and Akt/GSK3β signaling disruption
Keywords: آکت; STZ; Agmatine; Learning and memory; Apoptosis; Akt; GSK-3β
Resveratrol suppresses the proliferation of breast cancer cells by inhibiting fatty acid synthase signaling pathway
Keywords: آکت; Akt; FASN; Her2; PI3K; Resveratrol; SKBR-3;
Somatostatin receptor sst2 reduces Akt activity and aggravates hypoxic/ischemic death in cerebral cortical neurons
Keywords: آکت; Stroke; Neuroprotection; Akt; Ischemia; Somatostatin; Preconditioning; PKB; Apoptosis; BSS; balanced salt solution; DIV; days in vitro; NG; normoxia/glucose; OGD; oxygen/glucose deprivation;
Chinese herbal formula Qi-Lian-Gui-Shou Tang protects against acute ischemic cerebral injury in rats
Keywords: آکت; Acute ischemic stroke; Qi-Lian-Gui-Shou Tang; Akt; GSK3β;
BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB–ERK/Akt signaling cascade
Keywords: آکت; BDNF mimetic LM22A-4; TrkB; ERK; Akt; OPN
Statins upregulate cystathionine γ-lyase transcription and H2S generation via activating Akt signaling in macrophage
Keywords: آکت; Hydrogen sulfide; Statins; Cystathionine γ-lyase; 3-Mercaptopyruvate sulfurtransferase; Macrophage; Akt
Acrolein activates cell survival and apoptotic death responses involving the endoplasmic reticulum in A549 lung cells
Keywords: آکت; AFC; amino trifluorocoumarin; AKT; protein kinase B; AMC; amino methylcoumarin; ARE; antioxidant response element; ATF6; activating transcription factor-6; BAPTA-AM; 1,2-Bis(2-aminophenoxy)ethane-N,N,N,N-tetraacetic acid tetrakis (acetoxymethyl ester); Ba
AKT3 regulates ErbB2, ErbB3 and estrogen receptor α expression and contributes to endocrine therapy resistance of ErbB2+ breast tumor cells from Balb-neuT mice
Keywords: آکت; AKT; ErbB2; Estrogen receptor α; Therapy resistance; Breast cancer; Balb-neuT mice;
Akt1 isoform modulates phenotypic conversion of vascular smooth muscle cells
Keywords: آکت; Akt; Laminin; Integrin-linked kinase; Neointima; Phenotypic change
Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence
Keywords: آکت; oncogene-induced senescence; p38; phosphoinositide 3-kinase; AKT
The effects of age and muscle contraction on AMPK activity and heterotrimer composition
Keywords: آکت; ACC; acetyl CoA carboxylase; ADP; adenosine diphosphate; AKT; protein kinase B; AMP; adenosine monophosphate; ATP; adenosine triphosphate; AMPK; AMP-activated protein kinase; ERK; extracellular signal-regulated kinase; GAST; gastrocnemius; HPLC; high perf
Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from KrasG12D mice
Keywords: آکت; Rottlerin; Pancreatic cancer; Cancer prevention; Akt; Sonic Hedgehog; Notch
IGF-I and amino acids effects through TOR signaling on proliferation and differentiation of gilthead sea bream cultured myocytes
Keywords: آکت; Sparus aurata; Growth and myogenic factors; 4EBP1; 70S6K; AKT; Myocytes;
Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets
Keywords: آکت; Thymoquinone; HaCaT cells; Heme oxygenase-1; Nrf2; Akt; AMPKα;
Notoginsenoside Ft1 activates both glucocorticoid and estrogen receptors to induce endothelium-dependent, nitric oxide-mediated relaxations in rat mesenteric arteries
Keywords: آکت; Akt; protein kinase B; cGMP; cyclic guanosine monophosphate; DMSO; dimethyl sulfoxide; EDH; endothelium-dependent hyperpolarizations; EDRF; endothelium-derived relaxing factor; eNOS; endothelial nitric oxide synthase; ERÃ; estrogen receptor beta; ERK1/2;
Cytotoxicity of the bisphenolic honokiol from Magnolia officinalis against multiple drug-resistant tumor cells as determined by pharmacogenomics and molecular docking
Keywords: آکت; ABC; ATP-binding cassette; Akt; v-Akt murine thymoma viral oncogene homolog 1; BCRP; breast cancer resistance protein; EGFR; epidermal growth factor; MAPK; mitogen-activated protein kinase; MDR; multidrug resistance; mTOR; mammalian target of rapamycin; P
Magnolol protects neurons against ischemia injury via the downregulation of p38/MAPK, CHOP and nitrotyrosine
Keywords: آکت; Magnolol; Stroke animal model; Inducible NO synthase; p38 mitogen-activated protein kinases; Akt; NF-κB