Lithium protects against methamphetamine-induced neurotoxicity in PC12 cells via Akt/GSK3β/mTOR pathway
Keywords: آکت; Methamphetamine; Lithium; Neurotoxicity; Akt; GSK3β; mTOR;
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Regulation of the endothelial apelin/APJ system by hemodynamic fluid flow
Keywords: آکت; EC; endothelial cells; eNOS; endothelial nitric oxide synthase; GPCR; G protein-coupled receptor; HUVEC; human umbilical venous endothelial cells; HCASMC; human coronary arterial smooth muscle cells; NO; nitrite oxide; PECAM-1; platelet endothelial cell a
Redox modulation of mitochondriogenesis in exercise. Does antioxidant supplementation blunt the benefits of exercise training?
Keywords: آکت; Akt; protein kinase B; AMPK; 5â²-AMP-activated protein kinase; AP-1; activator protein 1; COX IV; cytochrome c oxidase; CuZnSOD; copper/zinc superoxide dismutase; DMSO; dimethyl sulfoxide; eNOS; endothelial nitric oxide synthase; ERK; extracellular signa
SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway
Keywords: آکت; AMPK; AMP-activated protein kinase; AKT; v-akt murine thymoma viral oncogene homolog; Atg; autophagy-related gene; CAY; CAY-10566; CC; compound C; CQ; chloroquine; DAB; 3,3â²-diaminobenzidine tetrahydrochloride; ECL; electrochemiluminescence; FBS; fetal
Hsp90/Cdc37 assembly modulates TGFβ receptor-II to act as a profibrotic regulator of TGFβ signaling during cardiac hypertrophy
Keywords: آکت; Hsp90; Heat shock protein 90; Cdc37; Cell division cycle 37; AngII; Angiotensin II; TGFβ; Transforming growth factor β; ECM; Extracellular matrix; TβR-I; Transforming growth factor β receptor-I; TβR-II; Transforming growth factor β receptor-II; 17AA
Neuroprotection by JM-20 against oxygen-glucose deprivation in rat hippocampal slices: Involvement of the Akt/GSK-3β pathway
Keywords: آکت; JM-20; Neuroprotection; Oxygen-glucose deprivation; Akt; GSK-3β; Neuroinflammation;
Silibinin-induced glioma cell apoptosis by PI3K-mediated but Akt-independent downregulation of FoxM1 expression
Keywords: آکت; FoxM1; Silibinin; PI3K; Akt; apoptosis;
Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice
Keywords: آکت; NSAIDs; Cyclooxygenase; Colon Cancer; Tumorigenesis; CRC; colorectal cancer; CSC; cancer stem cells; Akt; protein kinase B; EP; prostaglandin E2 receptors; EpCAM; epithelial cellular adhesion molecule; ERK1; extracellular signal-regulated kinase 1; IHC;
δ-Tocotrienol treatment is more effective against hypoxic tumor cells than normoxic cells: potential implications for cancer therapy
Keywords: آکت; Akt; protein kinase B; CDK4; cyclin-dependent kinase 4; DLD-1; human colorectal adenocarcinoma cell line; H&E; hematoxylin and eosin; HIF-1α; hypoxia inducible factor-1α; NIH; National Institutes of Health; PBS; phosphate-buffered saline; PECAM-1; plate
Phosphorylation of phosphatidylinositol 4-phosphate 5-kinase γ by Akt regulates its interaction with talin and focal adhesion dynamics
Keywords: آکت; EGF; epidermal growth factor; FAs; focal adhesions; PIP2; phosphatidylinositol 4,5-bisphosphate; PIP5Kγ90; phosphatidylinositol 4-phosphate 5-kinase γ 90 kDa; S555; serine 555; WT; wild-type; Phosphatidylinositol 4-phosphate 5-kinase γ; Phosphatidylin
Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways
Keywords: آکت; GTT; glucose tolerance test; ITT; insulin tolerance test; shRNA; short-hairpin RNA; STZ; streptozotocin; PRAS40; proline-rich AKT substrate of 40Â kDa; HbA1C; hemoglobin A1; PRAS40; AKT; mTORC1; GLUT4; Diabetes; Insulin;
PIM kinase (and Akt) biology and signaling in tumors
Keywords: آکت; PIM kinases; Akt; Oncogenes; Cancer; Therapeutic resistance; AML; acute myeloid leukemia; AMPK; AMP activated protein kinase; CXCR-4; C-X-C chemokine receptor type 4; EGFR; epidermal growth factor receptor; EBV; Epstein-Barr virus; FLT3; FMS-like ty
The liver-selective NO donor, V-PYRRO/NO, protects against liver steatosis and improves postprandial glucose tolerance in mice fed high fat diet
Keywords: آکت; Nitric oxide; Hepatoprotection; Liver steatosis; Glucose tolerance; Fatty acid metabolism; ABCA1; ATP-binding cassette transporter family member 1; ACC; native isoform acetyl-CoA carboxylase; Akt; serine/threonine-protein kinase; ALT; alanine aminotransfe
Central acylated ghrelin improves memory function and hippocampal AMPK activation and partly reverses the impairment of energy and glucose metabolism in rats infused with β-amyloid
Keywords: آکت; GOAT; ghrelin O-acyltransferase; GHSR; growth hormone secretagogue receptor; LV; lateral ventricle; ICV; intracerebroventricular; AD-G; Acyl-ghrelin ICV infusion; AD-DES-G; Des-acyl-ghrelin ICV infusion; AD-C; phosphate buffered saline ICV infusion; Non-A
AKT mediated glycolytic shift regulates autophagy in classically activated macrophages
Keywords: آکت; IFN-gamma; ROS; Autophagy; Glycolysis; AKT;
Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells
Keywords: آکت; Prognostic Marker; Tissue Microarray; Signal Transduction; Tumor Suppressor; AKT; v-akt murine thymoma viral oncogene homolog 1; CI; confidence interval; DNAJB6; DnaJ (Hsp40) homolog, subfamily B, member 6; EAC; esophageal adenocarcinoma; ESCC; esophageal
Signaling and stress: The redox landscape in NOS2 biology
Keywords: آکت; 5-caC; 5-carboxylcytosine; 5-fC; 5-formylcytosine; 5-hmc; 5-hydroxymethylcytosine; 5-mC; 5- methylcytosine; α-KG; α-ketoglutarate; Akt; v-akt murine thymoma viral oncogene homolog; AMPK, 5' AMP-activated protein kinase; ApoE apolipoprotein E; ARE; antio
Phosphatidylinositol-3 kinase-Akt-mammalian target of rapamycin signaling pathway mediates contractility of human endometriotic stromal cells: A promising new target for the treatment of endometriosis-associated fibrosis
Keywords: آکت; Akt; contractility; endometriosis; mammalian target of rapamycin; phosphatidylinositol-3 kinase
miRNA and piRNA mediated Akt pathway in heart: Antisense expands to survive
Keywords: آکت; Heart; Akt; Cell survival; miRNA; piRNA;
Adipose stem cells-conditioned medium blocks 6-hydroxydopamine-induced neurotoxicity via the IGF-1/PI3K/AKT pathway
Keywords: آکت; Neuronal cell death; ASC-CM; 6-hydroxydopamine; IGF-1; AKT;
SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models
Keywords: آکت; Akt; Extracellular signal-regulated kinase (ERK) 1/2; Sigma-1 receptor;
Novel α-galactosidase A mutation in patients with severe cardiac manifestations of Fabry disease
Keywords: آکت; Akt; protein kinase B; Bp; base pair; cDNA; DNA complementary to RNA; CT; threshold cycle number; ERK; extracellular signal-regulated kinase; FSGD; fish specific genome duplication; GH; growth hormone; GHR; growth hormone receptor; JAK; Janus kinase; mRNA
Resistin regulates the expression of plasminogen activator inhibitor-1 in 3T3-L1 adipocytes
Keywords: آکت; PAI-1; plasminogen activator inhibitor-1; PI3K; phosphoinositide 3-kinase; PP2A; protein phosphatase 2A; GLUT4; glucose transporter type 4; ChREBP; carbohydrate responsive element-binding protein; PPARγ; peroxisome proliferator activated receptor γ; C/E
Anti-pneumococcal deficits of monocyte-derived macrophages from the advanced-age, frail elderly and related impairments in PI3K-AKT signaling
Keywords: آکت; Macrophage; Streptococcus pneumoniae; Cytokine; AKT; Aging;
Protective effect of rutin on LPS-induced acute lung injury via down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation
Keywords: آکت; Rutin; LPS; Acute lung injury; MMP-9; MIP-2; Akt;
Maternal exposure to bisphenol A may increase the risks of Parkinson's disease through down-regulation of fetal IGF-1 expression
Keywords: آکت; AMY; amygdala; AFP; alpha fetoglobulin; AKT; protein kinase B; BPA; bisphenol A; DA; dopamine; 6-OHDA; 6-OH-dopamine; DOPAC; dihydroxyphenylacetic acid; EB; embryoid body; EDC; environmental endocrine disruptors; ESCs; embryonic stem cells; FACS; fluoresc
Knockdown expression of eukaryotic initiation factor 5 C-terminal domain containing protein extends lifespan in Drosophila melanogaster
Keywords: آکت; ECP/KRA; AMPK; AKT; S6K; Longevity; Drosophila melanogaster;
Heat shock induces expression of OSTC/DC2, a novel subunit of oligosaccharyltransferase, in vitro and in vivo
Keywords: آکت; AKT; OSTC/DC2; Heat shock; Oligosaccharyltransferase
MicroRNA-145 suppresses hepatocellular carcinoma by targeting IRS1 and its downstream Akt signaling
Keywords: آکت; Hepatocellular carcinoma (HCC); MicroRNA-145; Insulin receptor substrate 1 (IRS1); Akt; Forkhead box protein O1 (FOXO1);
AKT-mediated enhanced aerobic glycolysis causes acquired radioresistance by human tumor cells
Keywords: آکت; Glycolysis; AKT; Radioresistance; Glut1; 2-Deoxy-d-glucose;
Therapeutic potential of metformin in papillary thyroid cancer in vitro and in vivo
Keywords: آکت; Metformin; AMPK; Akt; Papillary thyroid cancer (PTC); Ectopic tumor; Mouse;
AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats
Keywords: آکت; PhIP; amino-1-methyl-6-phenylimidazo [4,5-b] pyridine; HCA; heterocyclic amine; ACF; aberrant crypt foci; GSEA; gene set enrichment analysis; Colon cancer; Rat; Susceptibility; Obesity; PhIP; AKT;
Saponin monomer 13 of dwarf lilyturf tuber (DT-13) protects serum withdrawal-induced apoptosis through PI3K/Akt in HUVEC
Keywords: آکت; DT-13; EC; Apoptosis; Akt;
Inhibition of autophagy promoted sphingosylphosphorylcholine induced cell death in non-small cell lung cancer cells
Keywords: آکت; Sphingosylphosphorylcholine; Non-small cell lung cancer cells; Autophagy; Apoptosis; AKT; P53
microRNA-7: A tumor suppressor miRNA with therapeutic potential
Keywords: آکت; ACK1; activated CDC42 kinase 1; Akt; V-Akt murine thymoma viral oncogene homolog; BCL-2; B-cell CLL/lymphoma 2; CCNE1; cyclin E1; ciRS-7; circular RNA sponge 7; c-Myc; V-Myc avian myelocytomatosis viral oncogene homolog; EGFR; epidermal growth factor rece
Akt and p53R2, partners that dictate the progression and invasiveness of cancer
Keywords: آکت; Akt; P53R2; Ribonucleotide reductase; Cancer progression; Cell cycle;
Stem cell factor (SCF) protects osteoblasts from oxidative stress through activating c-Kit-Akt signaling
Keywords: آکت; Osteoblasts; Oxidative stress; Stem cell factor; c-Kit; Akt;
Fasting mediated increase in p-BADser155 and p-AKTser473 in the prefrontal cortex of mice
Keywords: آکت; Fasting; Hypoglycemia; AKT; BAD; Prefrontal cortex; Betahydroxybutyrate; BHB; beta-hydroxybutyrate; NIRKO; neuronal specific insulin receptor knockout; PFC; prefrontal cortex; BGL; blood glucose level; CNS; central nervous system; PVN; paraventricular nuc
Kidney cancer cells secrete IL-8 to activate Akt and promote migration of mesenchymal stem cells
Keywords: آکت; Kidney cancer; Mesenchymal stem cell; Interleukin-8; Extracellular signal-regulated protein kinase; Akt;
Dual mTORC1/2 inhibition in a preclinical xenograft tumor model of endometrial cancer
Keywords: آکت; mTOR pathway; Endometrial cancer; Rapamycin; Preclinical study; Translational regulation; eIF4E; Akt; therapeutics;
Metformin modulates PI3K and GLUT4 expression and Akt/PKB phosphorylation in human endometrial stromal cells after stimulation with androgen and insulin
Keywords: آکت; Endometrial stromal cells; Metformin; Insulin; Akt; PI3K; GLUT4;
Regular dipyridamole therapy produces sustained protection against cardiac ischemia-reperfusion injury: Is it time to revisit PARIS?
Keywords: آکت; Dipyridamole; Adenosine; Endothelial nitric oxide synthase; Akt; Ischemia-reperfusion injury; Preconditioning;
Transferred inter-cell ischemic preconditioning-induced neuroprotection may be mediated by adenosine A1 receptors
Keywords: آکت; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; LDH; lactate dehydrogenase; OGD; oxygen-glucose deprivation; Adenosine A1 receptor; Akt; Inter-cell preconditioning; Neuroprotection;
Reactive oxygen species contribute to arsenic-induced EZH2 phosphorylation in human bronchial epithelial cells and lung cancer cells
Keywords: آکت; Arsenic; Oxidative stress; EZH2; Akt; Phosphorylation; Cytoplasmic translocation
SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines
Keywords: آکت; SOX2; Non-small cell lung cancer; EGFR; Akt; Erlotinib; H1975; HCC827
Inhibition of fatty acid synthase induces pro-survival Akt and ERK signaling in K-Ras-driven cancer cells
Keywords: آکت; FAS, fatty acid synthase; IGF-1R, insulin-like growth factor-1 receptor; mTORC2, mammalian/mechanistic target of rapamycin complex 2; PI3K, phosphatidylinositol 3-kinaseFatty acid synthase; K-Ras; Akt; ERK
MicroRNA-224 upregulation and AKT activation synergistically predict poor prognosis in patients with hepatocellular carcinoma
Keywords: آکت; Hepatocellular carcinoma; Microrna-224; AKT; Tumor progression; Prognosis
Gβγ interacts with mTOR and promotes its activation
Keywords: آکت; Gβγ; G-protein; mTOR; AKT; G-protein coupled receptor; Raptor; Rictor; Cell signaling
MicroRNA-375 inhibits colorectal cancer growth by targeting PIK3CA
Keywords: آکت; miR-375; Colorectal cancer; PIK3CA; PI3K; Akt
Sangivamycin induces apoptosis by suppressing Erk signaling in primary effusion lymphoma cells
Keywords: آکت; KSHV, Kaposi’s sarcoma-associated herpesvirus; HHV-8, human herpes virus-8; PEL, primary effusion lymphomaPrimary effusion lymphoma; KSHV; Sangivamycin; Erk; Akt; Apoptosis