کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8302201 | 1537725 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protein kinase C-beta: An emerging connection between nutrient excess and obesity
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
peroxisome proliferator-activated receptor-γ coactivator-1αPKCβPROX1UCP-1p66ShcPGC-1αHFDBATPKCROS - ROSSp1 - SP1Akt - آکتWhite adipose tissue - بافت چربی سفیدbrown adipose tissue - بافت چربی قهوه ایUncoupling protein-1 - جدا کردن پروتئین-1diacylglycerol - دیسیل گلیسیرینDAG - روزhigh-fat diet - رژیم غذایی با چربی بالاObesity - مرض چاقیMitochondria - میتوکندریاSignal transduction - هدایت سیگنالprotein kinase B - پروتئین کیناز BProtein kinase C - پروتئین کیناز سیWAT - چیReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
There is currently a global epidemic of obesity as a result of recent changes in lifestyle. Excess body fat deposition is caused by an imbalance between energy intake and energy expenditure due to interactions between genetic and environmental factors. The signals and biological mechanisms that trigger fat accumulation by disrupting energy homeostasis are not well understood. There is considerable evidence now supporting a possible role of protein kinase C beta (PKCβ) in energy homeostasis. This review highlights recent findings on the role of PKCβ activation in the genesis and progression of obesity, and of PKCβ repression in mediating the beneficial effects of physical exercise. Available data support a model in which adipose PKCβ activation is among the initiating events that disrupt mitochondrial function through interaction with p66shc and amplify fat accumulation and adipose dysfunction, with systemic consequences. Manipulation of PKCβ levels, activity, or signaling could provide a therapeutic approach to combat obesity and associated metabolic disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1841, Issue 10, October 2014, Pages 1491-1497
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1841, Issue 10, October 2014, Pages 1491-1497
نویسندگان
Neil K. Mehta, Kamal D. Mehta,