Agmatine produces antidepressant-like effects by activating AMPA receptors and mTOR signaling
Keywords: Agmatine; AMPA; Antidepressant; BDNF; mTOR signaling; Tail suspension test;
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Intrahippocampal administration of a domain antibody that binds aggregated amyloid-β reverses cognitive deficits produced by diet-induced obesity
Keywords: Amyloid; AMPA; Obesity; Cognition; Diet; High-Fat; Antibody;
Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice
Keywords: A1; adenosine receptor type 1; A2A; adenosine receptor type 2A; A3; adenosine receptor type 3; ADP; adenosine diphosphate; AMP; adenosine monophosphate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AOPCP; É,β-methyleneadenosine 5â²-diph
The afferent signaling complex: Regulation of type I spiral ganglion neuron responses in the auditory periphery
Keywords: Cochlea; Inner hair cells; Type I spiral ganglion neurons; Lateral olivocochlear efferents; Ion channels and transporters; Neurotransmitter receptors; Postsynaptic density; Auditory neuropathy and synaptopathy; ABR; auditory brainstem response; ACh; acety
TDP-43/FUS in motor neuron disease: Complexity and challenges
Keywords: AD; Alzheimer's disease; Ago2; Argonaute 2; ALS; Amyotrophic lateral sclerosis; ALS/PD; amyotrophic lateral sclerosis and Parkinsonism-dementia complex; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ATF3; activating transcription factor 3
Palmitoylation in Alzheimerâ¿¿s disease and other neurodegenerative diseases
Keywords: ABCA1; ATP-binding cassette transporter A1; AD; Alzheimer⿿s disease; ADAM17; a disintegrin and metalloproteinase 17; AICD; APP intracellular domain; AKAP79; A-kinase anchoring protein 79; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; APP; amy
Voltage-gated calcium channels are abnormal in cultured spinal motoneurons in the G93A-SOD1 transgenic mouse model of ALS
Keywords: ALS; amyotrophic lateral sclerosis; SOD1; superoxide dismutase-1; AMPA; α-amino-3-hydroxy-5-methylisoxazole propionic acid; VGCC; voltage-gated Ca2 + channel; PCCa; persistent Ca2 + current; mSOD1; mutant SOD1; TEA-Cl; tetraethylammonium chloride; 4-AP
RF-amide neuropeptides and their receptors in Mammals: Pharmacological properties, drug development and main physiological functions
Keywords: RF-amide neuropeptides; RF-amide receptors; Feeding; Reproduction; Pain; Drug discovery; AHA; anterior hypothalamic area; Amd; amygdala; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AP; area postrema; ARC; arcuate nucleus; AVPV; anterovent
Dodecafluoropentane emulsion delays and reduces MRI markers of infarction in a rat stroke model: a preliminary report
Keywords: DDFPe; Dodecafluoropentane emulsion; AIS; acute ischemic stroke; tPA; tissue plasminogen activator; FDA; food and drug administration; PFC; perfluorocarbon; STAIR I; Stroke Therapy Academic Industry Roundtable I; GABA; γ-Aminobutyric acid; MCA; middle ce
Research articleOptoactivation of parvalbumin neurons in the spinal dorsal horn evokes GABA release that is regulated by presynaptic GABAB receptors
Keywords: aCSF; artificial cerebrospinal fluid; AAV; adeno-associated virus; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; AP-5; D-2-amino-5-phosphonopentanoic acid; ChR2; channelrhodopsin-2; DNQX; 6,7-dinitroquinoxaline-2,3(1H,4H)-dione; GABA; γ-a
Research paperAbnormally increased surface expression of AMPA receptors in the cerebellum, cortex and striatum of Cln3â/â mice
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; NMDA; N-methyl-d-aspartate; BS3; bis[sulfosuccinimidyl] suberate; ACSF; artificial cerebrospinal fluid; Juvenile neuronal ceroid lipofuscinosis; Batten disease; CLN3; Glutamate receptor; AMPA recept
Neuropharmacology and analgesiaMDMA-induced loss of parvalbumin interneurons within the dentate gyrus is mediated by 5HT2A and NMDA receptors
Keywords: MDMA; 3,4-methylenedioxymethamphetamine; PV; parvalbumin; PV-IR; parvalbumin immunoreactive; 5HT; serotonin; GABA; gamma-Aminobutyric acid; NMDA; N-methyl-d-aspartate; AMPA; α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; RT; room temperature; COX-
GSK3 and KIF5 regulate activity-dependent sorting of gephyrin between axons and dendrites
Keywords: Neuron; Axon; Dendrite; Inhibitory synapse; Gephyrin; Glycine receptor; GABAA receptor; Neuroligin; AMPA; GSK3; Kinesin; KIF5; Sorting;
High-performance liquid chromatography-tandem mass spectrometry method for the determination of perampanel, a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist in human plasma
Keywords: AED; anti-epileptic drugs; AMPA; α-amin-3-hydroxyl-5methyl-4isoxazolepropionic acid; AUC; area under the plasma concentration-time curve; AUC0-inf; AUC extrapolated to infinity; AUC0-last; AUC to the last time points; AUMC; area under the first mom
Nucleus accumbens injections of the mGluR2/3 agonist LY379268 increase cue-induced sucrose seeking following adult, but not adolescent sucrose self-administration
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; MPPG; (RS)-α-Methyl-4-phosphonophenylglycine; MSNs; medium spiny neurons; NMDA; N-Methyl-D-aspartate; MSNs; medium spiny neurons; reward; adolescence; sucrose self-administration; mGluR2/3; nuc
The effects of JM-20 on the glutamatergic system in synaptic vesicles, synaptosomes and neural cells cultured from rat brain
Keywords: JM-20; Glutamatergic system; Synaptic vesicle; Synaptosomes; Astrocytes; Neurons; VGLUTs; vesicular glutamate transporters; V-ATPase; vacuolar-type ATPases; JM-20; 3-ethoxycarbonyl-2-methyl-4-(2-nitrophenyl)-4,11-dihydro-1H-pyrido[2,3-b][1,5]benzodiazepin
Birch (Betula spp.) wood biochar is a potential soil amendment to reduce glyphosate leaching in agricultural soils
Keywords: Biochar; Glyphosate; AMPA; Phosphorus; Leaching; Pyrolysis temperature
Analysis of pooled phase III trials of adjunctive perampanel for epilepsy: Impact of mechanism of action and pharmacokinetics on clinical outcomes
Keywords: AE; adverse event; AED; antiepileptic drug; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid; CYP; cytochrome P450; EIAED; enzyme-inducing antiepileptic drug; SCB; sodium channel blocker; TEAE; treatment-emergent adverse event; Perampanel; Par
Occurrence of glyphosate and AMPA in an agricultural watershed from the southeastern region of Argentina
Keywords: Glyphosate; AMPA; Agricultural watershed; Soil profile;
Sources of aminomethylphosphonic acid (AMPA) in urban and rural catchments in Ontario, Canada: Glyphosate or phosphonates in wastewater?
Keywords: Glyphosate; AMPA; Acesulfame; Surface waters; Ontario;
The DAF-7/TGF-β signaling pathway regulates abundance of the Caenorhabditis elegans glutamate receptor GLR-1
Keywords: TGF-β; transforming growth factor-β; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; GLR-1; glutamate receptor-1, VNC, ventral nerve cord; Transforming growth factor-β; Glutamate; Synapse; GLR-1; AMPA; C. elegans;
Research ReportAMPA receptor activation causes preferential mitochondrial Ca2+ load and oxidative stress in motor neurons
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; EMEM; Eagle׳s minimal essential medium; HEPES; N-2-hydroxyethyl piperazine-n-2 ethanesulphonic acid; [Ca2+]i; Intracellular calcium; Ca2+]m; Mitochondrial calcium; HEt; Dihydroethidium; ROS; R
BaselineGlyphosate and AMPA in the estuaries of the Baltic Sea method optimization and field study
Keywords: Glyphosate; AMPA; Herbicide; LC-MS/MS; Baltic Sea estuaries;
The AMPA receptor antagonist NBQX exerts anti-seizure but not antiepileptogenic effects in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy
Keywords: Glutamate receptors; Epileptogenesis; Perampanel; Ketamine; NMDA receptors; AED; antiepileptic drug; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ED50; effective dose for 50% seizure suppression; EEG; electroencephalogram; HPD; hippocampal
The role of chromatin repressive marks in cognition and disease: A focus on the repressive complex GLP/G9a
Keywords: AAV-Cre; adeno-associated virus with Cre recombinase; AMPA; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF; brain-derived neurotrophic factor; BIX-01924; G9a inhibitor; CA1; cornu ammonis 1; DNA; deoxyribonucleic acid; Drd1; dopamine recep
Interleukin-6 reduces NMDAR-mediated cytosolic Ca2+ overload and neuronal death via JAK/CaN signaling
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF; brain-derived neurotrophic factor; bFGF; basic fibroblast growth factor; CaN; calcineurin; CGNs; cerebellar granule neurons; CNS; central nervous system; Ifen; ifenprodil; IL-6; interleuki
Research ReportThe effect of propofol postconditioning on the expression of K+-Cl--co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats
Keywords: AIS; acute ischemia stroke; AMPA; α-amino-3-hydroxyl-5-methyl- 4-isoxazolepropionic acid; CNS; central nervous system; DIOA; [(dihydroindenyl)oxy] alkanoic acid; GABA; gamma-aminobutyric acid; GAD67; glutamic acid decarboxylase; GluR2; glutamate recept
Adenosine A3 receptor activation is neuroprotective against retinal neurodegeneration
Keywords: A3 adenosine receptor; Retinal ganglion cell; Neuroprotection; Excitotoxicity; Ischemia-reperfusion; Axon injury; A3R; A3 receptor; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; CTZ; cyclothiazide; DARC; Detection of Apoptosing Retinal Cell
Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome
Keywords: 4EBPs; eIF4E-binding proteins; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF; brain-derived neurotrophic factor; CHX; cycloheximide; DG; dentate gyrus; DS; Down's syndrome; eIF4E; eukaryotic translation initiation factor 4E; ERK; extra
Glycine transporters GlyT1 and GlyT2 are differentially modulated by glycogen synthase kinase 3β
Keywords: Glycinergic neurotransmission; GSK3β; GlyT1; GlyT2; Pharmacological inhibitors; Hereditary hyperekplexia; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; CNS; central nervous system; COS-7; CV-1 (simian) in origin and carrying the SV40 genet
Activation of mTOR dependent signaling pathway is a necessary mechanism of antidepressant-like activity of zinc
Keywords: Zinc; FST; mTOR; PKA; PKC; PI3K; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; Akt, PKB; protein kinase B; BDNF; brain derived neurotrophic factor; CaMKII; Ca2+-and calmodulin-dependent protein kinase II; CNS; central nervous system; eEF2;
P2 purinergic receptor activation of neuronal nitric oxide synthase and guanylyl cyclase in the dorsal facial area of the medulla increases blood flow in the common carotid arteries of cats
Keywords: 7-NI; 7-nitroindazole; α,β-MeATP; α,β-methyleneATP; aCSF; artificial cerebrospinal fluid; AMPA; α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate; ANOVA; analysis of variance; CCA; common carotid artery; DFA; dorsal facial area; eNOS; endothelial ni
Research ReportDifferences in AMPA and GABAA/B receptor subunit expression between the chronically reorganized cortex and brainstem of adult squirrel monkeys
Keywords: Reorganization; Peripheral nerve injury; Long-term recovery; GABA; AMPA; Area 3b cortex; Cuneate nucleus brainstem; Non-human primate;
GPR39 Zn2+-sensing receptor: A new target in antidepressant development?
Keywords: 7TM; 7 transmembrane domain; ACPC; 1-aminocylopropanecarboxylic acid; ADs; antidepressants; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid; AP-7; 2 amino-7-phosphonoheptanoic acid; BDNF; brain-derived neurotrophic factor; CAMKII; Ca2+/calmod
LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment
Keywords: 3,5-DHPG; 3,5-dihydroxyphenylglycine; AC; adenylate cyclase; ACPD; 1-amino-1,3-dicarboxycyclopentane; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPH; amphetamine; APDC; dihydroxyphenylglycine; cAMP; cyclic-adenosine monophosphate; DCG-I
Calcium-permeable AMPA receptors trigger vesicular glutamate release from Bergmann gliosomes
Keywords: Cerebellum; Gliosomes; Gliotransmitter release; GluA2-lacking AMPA receptor; Neuroglia; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionate; BLBP; brain specific lipid binding protein; [Ca2+]i; intragliosomal calcium concentration; CNQX; 6-cyano-7-ni
ReviewTheta-burst LTP
Keywords: Long-term potentiation; LTP; Theta burst stimulation; NMDA; AMPA; GABA; Hippocampus; CA1;
Orexin-A potentiates L-type calcium/barium currents in rat retinal ganglion cells
Keywords: AC; amacrine cell; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid; AMPK; AMP-activated protein kinase; Ba2+ Ringer's; barium Ringer's solution; Bis-IV; bisindolylmaleimide IV; cAMP; adenosine 3â²,5â²-cyclic monophosphate; cGMP; guanosi
Research PaperRapid changes in expression of class I and IV histone deacetylases during epileptogenesis in mouse models of temporal lobe epilepsy
Keywords: AMPA; alpha-amino-3-hydroxy-5-methyl-isoxazole-propionic acid; GluA2; AMPA receptor subunit 2; KA; kainic acid; HDAC; histone deacetylase; TLE; temporal lobe epilepsy; BDNF; brain-derived neurotrophic factor; Epilepsy; Epileptogenesis; Status epilepticus;
Contribution of brain serotonin subtype 1B receptors in levodopa-induced motor complications
Keywords: 5-HT1B serotonin receptor; Parkinson's disease; l-DOPA-induced dyskinesia; Human; MPTP-lesioned monkey; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AIMs; abnormal involuntary movements; DA; dopamine; DL; dorsolateral; DM; dorsomedial; GAB
A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures
Keywords: ACSF; artificial cerebrospinal fluid; AMPA; 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid; BDNF; brain-derived neurotrophic factor; CA1; cornu ammonis area 1; CTZ; cyclothiazide; DEPC; diethylpyrocarbonate; DMSO; dimethyl sulfoxide; fEPSP; fie
Episodic sucrose intake during food restriction increases synaptic abundance of AMPA receptors in nucleus accumbens and augments intake of sucrose following restoration of ad libitum feeding
Keywords: AL; ad libitum; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ANOVA; analysis of variance; DA; dopamine; FR; food restriction; MSNs; medium spiny neurons; NAc; nucleus accumbens; NMDA; N-methyl-d-aspartate; PBS; phosphate-buffered saline; P
Repeated forced swim stress prior to complete Freund's adjuvant injection enhances mechanical hyperalgesia and attenuates the expression of pCREB and ÎFosB and the acetylation of histone H3 in the insular cortex of rat
Keywords: ACC; anterior cingulate cortex; ADX; adrenalectomy; AIC; anterior insular cortex; AMPA; aminomethylphosphonic acid; ANOVA; analysis of variance; AP-1; activator protein-1; ATF; activating transcription factor; BSA; bovine serum albumin; CBP; CREB-binding
Orexin-A differentially modulates AMPA-preferring responses of ganglion cells and amacrine cells in rat retina
Keywords: Orexin-A; AMPA-preferring receptor; Neuromodulation; Ganglion cells; Amacrine cells; Retina; AC; amacrine cell; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid; AMPAR; AMPA receptor; AMPA-preferring current; AMPA-preferring receptor-mediated
α6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity
Keywords: αCtxMII; α-conotoxin MII; ACh; acetylcholine; AMPA; α-amino-3-hydroxy-5-methyl-isoxazolepropionic acid; AMPAR; α-amino-3-hydroxy-5-methyl-isoxazolepropionic acid receptor; BAC; bacterial artificial chromosome; DA; dopamine; EGTA; ethylene glycol tetra
Glutamatergic synapse protein composition of wild-type mice is sensitive to in utero MTHFR genotype and the timing of neonatal vigabatrin exposure
Keywords: AED; antiepileptic drugs; AMPA; a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; CaMKII; Calcium/calmodulin-dependent kinase II; Dab1; Disabled-1; EPM; elevated plus maze; FMRP; Fragile X mental retardation 1 protein; GluR1; AMPA receptor subunit 1;
Research report"Hyperglutamatergic cortico-striato-thalamo-cortical circuit" breaker drugs alleviate tics in a transgenic circuit model of Tourette׳s syndrome
Keywords: 5-HT; 5-hydroxytryptamine; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMY; amygdala; ANOVA; analysis of variance; cAMP; 3â²,5â²-cyclic adenosine monophosphate; CGN; cortical/limbic glutamatergic neuron; CSTC; cortico/amygdalo-striato-t
Metaplastic up-regulation of LTP in the rat visual cortex by monocular visual training: Requirement of task mastery, hemispheric specificity, and NMDA-GluN2B involvement
Keywords: aCSF; artificial cerebrospinal fluid; AMPA; 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid; CSD; current source density; EPSC; excitatory postsynaptic current; fPSP; field postsynaptic potential; IO curve; input-output curve; ISI; inter-sti
Small-molecule inhibitors at the PSD-95/nNOS interface protect against glutamate-induced neuronal atrophy in primary cortical neurons
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; ANOVA; analyses of variance; CNS; central nervous system; CUS; chronic unpredictable stress; DAPI; 4â²-6-diamidino-2-phenylindole; EDTA; ethylenediaminetetraacetic acid; FBS; fetal bovine seru
Modulatory effects by CB1 receptors on rat spinal locomotor networks after sustained application of agonists or antagonists
Keywords: 2 AG; 2-arachidonoylglycerol; 5-HT; 5-hydroxytryptamine or serotonin; AEA; N-arachidonoylethanolamine or anandamide; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; cAMP; cyclic adenosine monophosphate; CB1R; cannabinoid receptor-1; DMSO; dim