کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5813679 | 1556619 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The AMPA receptor antagonist NBQX exerts anti-seizure but not antiepileptogenic effects in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy
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کلمات کلیدی
NMDANBQXED502,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dioneHPDTLEN-methyl-d-aspartatehippocampal paroxysmal dischargeSRSAMPAGCDGYKI 52466AEDα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid - اسید α-آمینو 3-هیدروکسی-5-متیل-4-ایزوکسول پپونیکElectroencephalogram - الکتروانسفالوگرافیepileptogenesis - اپیلوتوژنز، صرع زاییstatus epilepticus - بحران صرعی یا صرع پایدارspontaneous recurrent seizures - تشنج مجدد خودبخودیantiepileptic drug - داروهای ضدصرعseizure-like event - رویداد مشابه تشنجtemporal lobe epilepsy - صرع لوب تمپورالSLE - لوپوس منتشر یا لوپوس اریتماتوس سیستمیکEEG - نوار مغزیPerampanel - پرامانپلgranule cell dispersion - پراکندگی سلول گرانولKetamine - کتامینNMDA receptors - گیرنده NMDAGlutamate receptors - گیرنده های گلوتامات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The AMPA receptor subtype of glutamate receptors, which mediates fast synaptic excitation, is of primary importance in initiating epileptiform discharges, so that AMPA receptor antagonists exert anti-seizure activity in diverse animal models of partial and generalized seizures. Recently, the first AMPA receptor antagonist, perampanel, was approved for use as adjunctive therapy for the treatment of resistant partial seizures in patients. Interestingly, the competitive AMPA receptor antagonist NBQX has recently been reported to prevent development of spontaneous recurrent seizures (SRS) in a neonatal seizure model in rats, indicating the AMPA antagonists may exert also antiepileptogenic effects. This prompted us to evaluate competitive (NBQX) and noncompetitive (perampanel) AMPA receptor antagonists in an adult mouse model of mesial temporal lobe epilepsy. In this model, SRS develop after status epilepticus (SE) induced by intrahippocampal injection of kainate. Focal electrographic seizures in this model are resistant to several major antiepileptic drugs. In line with previous studies, phenytoin was not capable of blocking such seizures in the present experiments, while they were markedly suppressed by NBQX and perampanel. However, perampanel was less tolerable than NBQX in epileptic mice, so that only NBQX was subsequently tested for antiepileptogenic potential. When mice were treated over three days after kainate-induced SE with NBQX (20Â mg/kg t.i.d.), no effect on development or frequency of seizures was found in comparison to vehicle controls. These results suggest that AMPA receptor antagonists, while being effective in suppressing resistant focal seizures, are not exerting antiepileptogenic effects in an adult mouse model of partial epilepsy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 95, August 2015, Pages 234-242
Journal: Neuropharmacology - Volume 95, August 2015, Pages 234-242
نویسندگان
Friederike Twele, Marion Bankstahl, Sabine Klein, Kerstin Römermann, Wolfgang Löscher,