Guanidine-based α2-adrenoceptor ligands: Towards selective antagonist activity
Keywords: آنتاگونیست ها; Pharmacophore; Alpha 2-adrenoceptor; Antagonists; Human prefrontal cortex tissue; [35S]GTPγSα2-AR, Alpha 2-adrenoceptor; [35S]GTPγS, radio labelled guanosine 5′-O-[gamma-thio]triphosphate; pKi, minus logarithm of the binding constant; [3H]RX821002, 2-meth