دانلود مقالات ISI درباره عوامل ضد سرطان + ترجمه فارسی

Design and synthesis of new bioisosteres of spirooxindoles (MI-63/219) as anti-breast cancer agents

Keywords: عوامل ضد سرطان; Spirooxindoles; MDM2-p53; Bioisosteres; Breast cancer; Anticancer agents;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2015 سفارش ترجمه

Design and synthesis of novel 2,4-diaryl-5H-indeno[1,2-b]pyridine derivatives, and their evaluation of topoisomerase inhibitory activity and cytotoxicity

Keywords: عوامل ضد سرطان; 2,4-Diaryl-5H-indeno[1,2-b]pyridine; Topoisomerase I and II inhibition; Cytotoxicity; Anticancer agents;

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines

Keywords: عوامل ضد سرطان; Hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines; Anticancer agents; Topoisomerase I and II inhibitor; Cytotoxicity;

دانلود رایگان متن کامل مقاله ISI 58 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis and biological evaluation of novel N-phenyl ureidobenzenesulfonate derivatives as potential anticancer agents. Part 2. Modulation of the ring B

Keywords: عوامل ضد سرطان; Anticancer agents; N-phenyl ureidobenzenesulfonates; PUB-SOs; S-phase arrest; DNA double strand-breaks; γH2AX; DSB; double strand-breaks; PUB-SOs; N-phenyl ureidobenzenesulfonates; γH2AX; H2AX phosphorylated;

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis of amino acid esters of the ruthenium naphthalene complex [(C5Me4CH2OH)Ru(C10H8)]+

Keywords: عوامل ضد سرطان; Ruthenium; Cyclopentadienyl; Naphthalene; Amino acids; Bioorganometallic chemistry; Anticancer agents

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Virtual screening and biochemical evaluation to identify new inhibitors of mammalian target of rapamycin (mTOR)

Keywords: عوامل ضد سرطان; Virtual screening; mTOR; Docking; Kinase inhibitor; Anticancer agents;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1)

Keywords: عوامل ضد سرطان; Triazoles; Huisgen cycloaddition; Vinyl ethers; Aromatase; Anticancer agents

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis and identification of α-cyano bis(indolyl)chalcones as novel anticancer agents

Keywords: عوامل ضد سرطان; Bis(indole); Microwave-assisted synthesis; Chalcones; Anticancer agents; Tubulin inhibitors

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Monocyclic 4-amino-6-(phenylamino)-1,3,5-triazines as inhibitors of human DNA topoisomerase IIα

Keywords: عوامل ضد سرطان; MGDYIPCYODQSPN-UHFFFAOYSA-N; ZVXUBOYNSIFJCE-UHFFFAOYSA-N; YBPFGQOUIFXUKD-UHFFFAOYSA-N; AMBYAGOLFITNCD-UHFFFAOYSA-N; DVTLQDKKTSMLFA-UHFFFAOYSA-N; MCXVVYZJZJYNDY-UHFFFAOYSA-N; FWWDDVMPZGWHLH-UHFFFAOYSA-N; SLAJSNKCZPRUOA-UHFFFAOYSA-N; DWZKLOGJPBZBJI-UHFFFAOY

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Cyclic tertiary sulfamates: Selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives

Keywords: عوامل ضد سرطان; Acesulfame derivatives; Anticancer agents; N-alkylation; O-alkylation; Selective hCA IX/hCAXII inhibitors; Sulfamate

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

The effect of celastrol, a triterpene with antitumorigenic activity, on conformational and functional aspects of the human 90 kDa heat shock protein Hsp90α, a chaperone implicated in the stabilization of the tumor phenotype

Keywords: عوامل ضد سرطان; CD; circular dichroism; DLS; dynamic light scattering; DSC; differential scanning calorimetry; DSF; differential scanning fluorimetry; PAGE; polyacrylamide gel electrophoresis; SDS; sodium dodecyl sulfate; SEC-MALS; size-exclusion chromatography coupled

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Platinated benzonaphthyridone is a stronger inhibitor of poly(ADP-ribose) polymerase-1 and a more potent anticancer agent than is the parent inhibitor

Keywords: عوامل ضد سرطان; Poly(ADP-ribose) polymerase-1 inhibitors; Cisplatin; Anticancer agents; DNA damage repair

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

CYP-dependent Metabolism of Antitumor Pyrazolo[3,4-d]pyrimidine Derivatives Is Characterized by an Oxidative Dechlorination Reaction

Keywords: عوامل ضد سرطان; anticancer agents; cytochrome P450; CYP3A4; liver microsomes; metabolite kinetics; metabolite identification

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Discovery of novel antitumor dibenzocyclooctatetraene derivatives and related biphenyls as potent inhibitors of NF-κB signaling pathway

Keywords: عوامل ضد سرطان; Dibenzocyclooctatetraene derivatives; Unsymmetrical biphenyls; Anticancer agents; NF-κB inhibitor;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3)

Keywords: عوامل ضد سرطان; STAT3 inhibitors; Oral bioavailability; Breast cancer; Pancreatic cancer; Anticancer agents

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis and pharmacological evaluation of novel substituted quinoline-2-carboxamide derivatives as human dihydroorotate dehydrogenase (hDHODH) inhibitors and anticancer agents

Keywords: عوامل ضد سرطان; Dihydroorotate dehydrogenase (DHODH); Pyrimidine biosynthesis; hDHODH inhibitors; Quinolines; Anticancer agents

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis and in vitro cytotoxic effect of 6-amino-substituted 11H- and 11Me-indolo[3,2-c]quinolines

Keywords: عوامل ضد سرطان; 11-H-indolo[3,2-c]quinoline; 11-Methyl-indolo[3,2-c]quinoline; Isocryptolepine congener; Anticancer agents; Cytotoxicity

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

In vitro moxifloxacin drug interaction with chemotherapeutics: Implications for retinoblastoma management

Keywords: عوامل ضد سرطان; moxifloxacin; multidrug resistant (MDR); retinoblastoma; anticancer agents

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Novel ruthenium complexes ligated with 4-anilinoquinazoline derivatives: Synthesis, characterisation and preliminary evaluation of biological activity

Keywords: عوامل ضد سرطان; Ruthenium complexes; EGFR inhibitors; Multi-targeting; Anticancer agents; MCF-7

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis, antitumor activity, and structure–activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors

Keywords: عوامل ضد سرطان; Trihydroxylated 2,4,6-triphenyl pyridines; Topoisomerase I; Topoisomerase II; Topo II inhibitory activity; Cytotoxicity; Anticancer agents; Docking study

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Discovery of dihydroxylated 2,4-diphenyl-6-thiophen-2-yl-pyridine as a non-intercalative DNA-binding topoisomerase II-specific catalytic inhibitor

Keywords: عوامل ضد سرطان; Topoisomerase I; Topoisomerase II; Cytotoxicity; Anticancer agents; Dihydroxylated 2,4-diphenyl-6-thiophen-2-yl-pyridines; 3D-QSAR

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

DNA condensation induced by metal complexes

Keywords: عوامل ضد سرطان; Metal complexes; DNA condensation; Gene delivery; Anticancer agents

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes

Keywords: عوامل ضد سرطان; Trifluoromehylquinoxaline; Anticancer agents; Enzyme inhibition; Dihydrofolate reductase; Thymidylate synthase

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

Discovery and characterization of novel imidazopyridine derivative CHEQ-2 as a potent CDC25 inhibitor and promising anticancer drug candidate

Keywords: عوامل ضد سرطان; CDC25 inhibitor; Anticancer agents; Cell cycle arrest; Apoptosis; Reactive oxygen species

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

Recent advances in small organic molecules as DNA intercalating agents: Synthesis, activity, and modeling

Keywords: عوامل ضد سرطان; DNA intercalators; Drug discovery; Docking; Molecular modeling; Anticancer agents; Cancer chemotherapy;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2014 سفارش ترجمه

Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents

Keywords: عوامل ضد سرطان; Benzimidazole; HDAC inhibitors; Structure-activity relationship; Anticancer agents;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Syntheses of prodelphinidin B1, B2, and B4 and their antitumor activities against human PC-3 prostate cancer cell lines

Keywords: عوامل ضد سرطان; Polyphenols; Synthesis; Natural product; Anticancer agents;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Preparation of novel antiproliferative emodin derivatives and studies on their cell cycle arrest, caspase dependent apoptosis and DNA binding interaction

Keywords: عوامل ضد سرطان; Emodin derivatives; Rheum emodi; Anticancer agents; Anthraquinones; Apoptosis; Caspase-3; Cell cycle;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Identification and synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors

Keywords: عوامل ضد سرطان; BRAF; Kinase inhibitors; Virtual screening; Anticancer agents;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Syntheses of prodelphinidin B3 and C2, and their antitumor activities through cell cycle arrest and caspase-3 activation

Keywords: عوامل ضد سرطان; Polyphenols; Synthesis; Natural product; Anticancer agents;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

New platinum(II) complexes conjugated at position 7α of 17β-acetyl-testosterone as new combi-molecules against prostate cancer: Design, synthesis, structure-activity relationships and biological evaluation

Keywords: عوامل ضد سرطان; Platinum(II) complexes; 17β-Acetyl-testosterone; Combi-molecules; Prostate cancer; Anticancer agents; AR; androgen receptor; CRPC; castration-resistant prostate cancer; CDDP; cisplatin; PSA; prostate-specific antigen; CAM; chick chorioallantoic membrane;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Exploring the anticancer potential of pyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-one derivatives: The effect on apoptosis induction, cell cycle and proliferation

Keywords: عوامل ضد سرطان; Pyrazolo[1,2-a]benzo[1,2,3,4]tetrazinone; VLAK protocol; Anticancer agents; Apoptosis inducers; Cell cycle; IVIXLCNJJYDFDM-UHFFFAOYSA-N; ZWEYSKQUDJAYOM-UHFFFAOYSA-N; YZXLJNWLBZWUHP-UHFFFAOYSA-N; VCRFOXARHRQMBG-UHFFFAOYSA-N; WVLLHNZZQMBOEU-UHFFFAOYSA-N; JK

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity

Keywords: عوامل ضد سرطان; Synthesis; Imine-pyrazolopyrimidinones; Anticancer agents; Effects on G2/M phase of the cell cycle; Catalytic topoisomerase inhibitors;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Curcumin-I Knoevenagel's condensates and their Schiff's bases as anticancer agents: Synthesis, pharmacological and simulation studies

Keywords: عوامل ضد سرطان; Anticancer agents; Curcumin-I derivatives; Docking studies; DNA binding and hemolysis and cell line profiles;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Influence of anticancer agents on cell survival, proliferation, and CD4+CD25+Foxp3+ regulatory T cell-frequency in human peripheral-blood mononuclear cells activated by T cell-mitogen

Keywords: عوامل ضد سرطان; Anticancer agents; Cytokine; T cell mitogen; CD4+CD25+Foxp3+ regulatory T cells; Peripheral blood mononuclear cells

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Therapeutic potential of snake venom in cancer therapy: current perspectives

Keywords: عوامل ضد سرطان; Snake venom; Cytotoxin; Anticancer agents; Apoptosis inducer;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Solution equilibrium studies on anticancer ruthenium(II)–η6-p-cymene complexes of 3-hydroxy-2(1H)-pyridones

Keywords: عوامل ضد سرطان; Solution equilibria; Stability constants; Chelators; Anticancer agents; HydroxypyridonesCT, charge transfer; D, distribution coefficient; EHP, N-[(ethoxycarbonyl)methyl]-3-hydroxy-2-(1H)-pyridone; EHMP, N-[(ethoxycarbonyl)methyl]-3-hydroxy-4-methyl-2-(1H)

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase IIα catalytic inhibitor with low DNA damage

Keywords: عوامل ضد سرطان; Xanthones; Anticancer agents; Topoisomerase IIα catalytic inhibitor; ATP-competitive inhibitor; DNA intercalator

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

An unexpected Dimroth rearrangement leading to annelated thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidines with potent antitumor activity

Keywords: عوامل ضد سرطان; Annelated thienotriazolopyrimidines; Domino reactions; Dimroth rearrangement; Developmental Therapeutics Program (DTP); Anticancer agents

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

An ortho-carbonyl substituted hydroquinone derivative is an anticancer agent that acts by inhibiting mitochondrial bioenergetics and by inducing G2/M-phase arrest in mammary adenocarcinoma TA3

Keywords: عوامل ضد سرطان; Mitochondrial bioenergetics; Cancer; Oxidative phosphorylation; Anticancer agents; Cell cycle arrest; Mitochondria; Hydroquinone

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy

Keywords: عوامل ضد سرطان; Fragment-based drug design; Anticancer agents; Drug discovery; STAT3; Breast cancerFBDD, fragment-based drug design; STATs, signal transducers and activators of transcription; ER, estrogen receptor; HBTU, 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluroniu

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Design, synthesis, and in vitro cancer cell growth inhibition evaluation and antimalarial testing of trioxanes installed in cyclic 2-enoate substructures

Keywords: عوامل ضد سرطان; Endoperoxides; 1,2,4-Trioxanes; Anticancer agents; COMPARE study; Antimalarial

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Phenylpropiophenone derivatives as potential anticancer agents: Synthesis, biological evaluation and quantitative structure–activity relationship study

Keywords: عوامل ضد سرطان; Propafenone derivatives; Chalcones; QSAR; Anticancer agents

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2013 سفارش ترجمه

Binding of serum albumins with bioactive substances – Nanoparticles to drugs

Keywords: عوامل ضد سرطان; Serum albumins; Fluorescence quenching; Nanoparticles; Quantum dots; Anticancer agents; Antibiotics; Flavonoids; Receptors

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2013 سفارش ترجمه

N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3

Keywords: عوامل ضد سرطان; Anthranilic acid; AKR1C3 inhibitors; Anticancer agents;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Novel bis(indolyl)hydrazide-hydrazones as potent cytotoxic agents

Keywords: عوامل ضد سرطان; Bisindoles; Hydrazide-hydrazone; Anticancer agents; Bis(indole) alkaloids;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Structure-based de novo design and biochemical evaluation of novel BRAF kinase inhibitors

Keywords: عوامل ضد سرطان; BRAF kinase; Inhibitor; Docking; Anticancer agents; De novo design;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

The central valine concept provides an entry in a new class of non peptide inhibitors of the p53–MDM2 interaction

Keywords: عوامل ضد سرطان; p53–MDM2 inhibitors; Protein–protein interaction inhibitors; Anticancer agents; Structure-based design

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction

Keywords: عوامل ضد سرطان; Mcl-1; Bcl-2; Protein-protein interactions; Small molecule inhibitors; Anticancer agents;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Capillary zone electrophoresis and capillary zone electrophoresis–electrospray ionization mass spectrometry studies on the behavior of anticancer cis- and trans-[dihalidobis(2-propanone oxime)platinum(II)] complexes in aqueous solutions

Keywords: عوامل ضد سرطان; Anticancer agents; CZE–ESI-MS; Degradation products; Geometric isomers; Platinum complexes

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه