دانلود مقالات ISI درباره App + ترجمه فارسی

Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease

Keywords: Aβ; amyloid-beta peptide; AMC; 7-amino-4-methyl-coumarin; AMPA; 2-amino-3-(5-methyl-3-oxo-1,2- oxazol-4-yl)propanoic acid; ANOVA; analysis of variance; AV; autophagic vacuole; CatB; cathepsin B; EDTA; ethylenediaminetetraacetic acid; FITC; fluorecein; h;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice

Keywords: Calpain; Calpastatin; APP; Aβ; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice

Keywords: Fyn; APP; Aβ; Tau; Phosphorylation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Effects of ginsenoside Rg1 or 17β-estradiol on a cognitively impaired, ovariectomized rat model of Alzheimer's disease

Keywords: ANOVA; analysis of variances; AD; Alzheimer's disease; ADAM 10; a disintegrin and metallopeptidase domain 10; Aβ; amyloid β-proteins; APP; amyloid precursor protein; BACE 1; β-site APP-cleaving enzyme 1; d-gal; d-galactose; E2; 17β-estradiol; ER; es

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Differential expression of ADAM15 and ADAM17 metalloproteases in the rat brain after severe hypobaric hypoxia and hypoxic preconditioning

Keywords: ADAM, a disintegrin and metalloprotease; APP, amyloid precursor protein; HP, hypoxic preconditioning; SH, severe hypoxiaADAM15; ADAM17; APP; Brain; Hypoxia; Metalloproteases; Neuronal injury and tolerance; Preconditioning

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration

Keywords: APP; APPL; Neuroprotection; Neurodegeneration; Drosophila

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Amyloid precursor protein accumulates in aggresomes in response to proteasome inhibitor

Keywords: Aggresome; APP; Ubiquitin; AD; Vimentin; Proteasome

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models

Keywords: acyl-SG; S-acyl glutathione; AD; Alzheimer disease; APP; amyloid precursor protein; Aβ; amyloid-β peptide; BODIPY; 4,4-difluoro-3a,4a-diaza-s-indacene; ChAT; choline acetyltransferase; CM-H2DCFDA; 2′,7′-dichlorodihydrofluorescein diacetate, acetyl e

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells

Keywords: ROBKOHOXCCIGKA-YDHLFZDLSA-N; CTIXSYGGXMDSBQ-UHFFFAOYSA-N; RXRSCJCBYDKOQS-LTDRVIOCSA-N; MVXLOAFTFDPCPK-LTDRVIOCSA-N; GTGDGIDWSMIASH-UHFFFAOYSA-N; LQLIXLQXXVQGEH-AAAIIBCSSA-N; UFXCYDLBJWLCQS-LTDRVIOCSA-N; JXTAMIXHZPMMRQ-UHFFFAOYSA-N; MFXXCQOJSTXKBJ-UHFFFAOY

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Multiple patterns of spatiotemporal changes in layer-specific gene expression in the developing visual cortex of higher mammals

Keywords: OD column; ocular dominance column; MD; monocular deprivation; BDNF; brain-derived neurotrophic factor; DIG; digoxigenin; GPX1; glutathione peroxidase 1; TCFL5; transcription factor-like 5; TPI1; triosephosphate isomerase 1; MYL6; myosin light chain 6; LA

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Modulating cognitive deficits and tau accumulation in a mouse model of aging Down syndrome through neonatal implantation of neural progenitor cells

Keywords: DS; Down syndrome; AD; Alzheimer's disease; NPC; neural progenitor cells; APP; amyloid precursor protein; DG; dentate gyrus; PND2; postnatal day two; CTA; Conditioned Taste Avoidance; NOR; Novel Object Recognition; gfp; green fluorescent protein; BrdU; br

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Age-dependent disruption in hippocampal theta oscillation in amyloid-β overproducing transgenic mice

Keywords: LTP; Perforant path; Plaque histology; Electrophysiology; Nucleus pontis oralis; APP; PS1; EEG; Alzheimer's disease; Biomarker;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Increased fMRI signal with age in familial Alzheimer's disease mutation carriers

Keywords: PSEN1; APP; fMRI; Familial Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice

Keywords: APP; Amyloid Precursor Protein; Aβ; Amyloid-β; AD; Alzheimer's disease; CDR; Clinical Dementia Rating; ChIP; chromatin immunoprecipitation; EDTA; ethylenediaminetetraacetic acid; FAIRE; formaldehyde-assisted isolation of regulatory elements; PBMCs; pe

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-β peptides involved in Alzheimer disease. Part 1: An overview

Keywords: Amyloid; Copper; Iron; APP; Binding sites; Bioinorganic chemistryAPP, amyloid precursor protein; Aβ, amyloid-β; Aβn-m, Aβ residues spanning from n to m; Aβm, Aβ residues spanning from 1 to m; CHC, central hydrophobic cluster; CSF, cerebrospinal fluid; CuB

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Full Length ArticlesDeficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI

Keywords: AD; Alzheimer's disease; APP; Amyloid precursor protein; APLP1; Amyloid precursor-like protein 1; APLP2; Amyloid precursor-like protein 2; Aβ; amyloid-β; ChAT; choline acetyltransferase; Iba1; Ionized calcium binding adaptor molecule 1; NGF; nerve growt

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Assessment of lesion pathology in a new animal model of MS by multiparametric MRI and DTI

Keywords: AD; axial diffusivity; APP; amyloid precursor protein; BBB; blood brain-barrier; Cup; Cuprizone; DTI; diffusion tensor imaging; EAE; experimental autoimmune encephalomyelitis; FA; fractional anisotropy; Gd-DTPA; gadolinium diethylene triamine pentaacetic

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Characterization of 7- and 19-month-old Tg2576 mice using multimodal in vivo imaging: limitations as a translatable model of Alzheimer's disease

Keywords: Cerebral metabolism; Hypometabolism; Hypermetabolism; FDG-PET; Functional MRI; Proton MRS; APP; Transgenic mice; Alzheimer's disease; Biomarker;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

DISC1-binding proteins in neural development, signalling and schizophrenia

Keywords: DISC1; Schizophrenia; Neurodevelopment; Signalling; Synapse; Association studies; APP; Amyloid precursor protein; ATF4; Activating transcription factor 4; BACE1; β-site APP-cleaving enzyme-1; BBS4; Bardet-Biedl syndrome 4; CEP290; Centrosomal protein 2

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Research ReportStromal cell-derived factor 1α decreases β-amyloid deposition in Alzheimer's disease mouse model

Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid β-peptide; BMDCs; bone marrow-derived cells; BMDM; bone marrow-derived microglia; BBB; blood-brain barrier; CNS; central nervous system; GFP; green fluorescent protein; HPCs; hematop

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Research ReportIntraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis

Keywords: AD; Alzheimer's disease; APP; β-amyloid precursor protein; DAPI; 4′-6 diamidino 2-phenylindole dihydrochloride; ERK; Extracellular stimulus-regulated kinase; Ets; Avian erythroblastosis virus E26 oncogene homolog; GAPDH; Glyceraldehyde-3-phosphate dehy

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines

Keywords: Abeta star 56 kDa; ADAM10; APP; Beta amyloid; Canine; Cingulate; C-terminal fragments of APP; Dog; Insulin degrading enzyme; Neprilysin; Oligomer; Secretase; Temporal;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases

Keywords: P2X7; Familiar Alzheimer's disease; APP transgenic mice; GSK-3; α-secretase; APP; Amyloid plaques;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Central CRF system perturbation in an Alzheimer's disease knockin mouse model

Keywords: Corticotropin releasing factor; CRF; CRH; CRFR1; CRHR1; HPA axis; Alzheimer's disease; Corticosteroids; APP; Presenilin; Anxiety; Depression;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease

Keywords: Preclinical Alzheimer's disease; Aβ-oligomers; Inflammation; iNOS; COX-2; AD; Alzheimer's disease; MCI; mild cognitive impairment; Aβ; amyloid-β peptide; Tg; transgenic; APP; amyloid precursor protein; ADDLs; Alzheimer's disease diffusible ligands; M

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Actualités biologiques sur les angioedèmes à kinines

Keywords: Exploration angioedème; kinines; kininogénase; kininase; perméabilité endothéliale; C1 inhibiteur; facteur XII; Angioedema exploration; kinins; kininogenase; kininase; endothelial permeability; C1 inhibitor; factor XII; BK; bradykinine; C1Inh; C1 inh

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

An age-related axon terminal pathology around the first olfactory relay that involves amyloidogenic protein overexpression without plaque formation

Keywords: AD; Alzheimer's disease; APP; β-amyloid precursor protein; Aβ; β-amyloid peptide; EPL; external plexiform layer; FAD; familial AD; GAP43; growth-associated protein 43; GCL; granule cell layer; GL; glomerular layer; MAP2; microtubule-associated protei

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Interleukin-6 is an efficacious marker of axonal transport disruption during experimental glaucoma and stimulates neuritogenesis in cultured retinal ganglion cells

Keywords: 2VO; bilateral occlusion of the common carotid arteries; APP; β-amyloid precursor protein; CNTF; ciliary neurotrophic factor; CTB; cholera toxin β-subunit; IL-1β; interleukin-1β; IL-6; interleukin-6; IOP; intraocular pressure; LPS; lipopolysaccharide;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells

Keywords: Alzheimer's disease; APP; BACE1; Cholesterol; Endocytosis; NPC1;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Herpes simplex virus type I induces the accumulation of intracellular β-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells

Keywords: HSV-1; Autophagy; β-amyloid; APP; Amyloidogenic pathway; Lysosome; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

The recycling endosome and its role in neurological disorders

Keywords: AD; Alzheimer's disease; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; APP; amyloid precursor protein; CHO; Chinese hamster ovary; EAAC1; excitatory amino acid carrier 1; EAAT3; excitatory amino acid transporter 3; EE; early endosome; EHD;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Structural and functional characterization of H2 haplotype MAPT promoter: Unique neurospecific domains and a hypoxia-inducible element would enhance rationally targeted tauopathy research for Alzheimer's disease

Keywords: AD; Alzheimer's disease; AP; activator protein; APOE; apolipoprotein E gene; APP; amyloid β peptide precursor gene; Aβ; amyloid β peptide; bp; base-pair; C/EBP; CCAAT/enhancer binding protein; C6; rat glioblastoma cells; CAT; chloramphenicol acetyltran

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2012 سفارش ترجمه

Neurodegeneration the RNA way

Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; Aβ42; amyloid β - 42 amino acids; CUGBP1; CUG binding protein 1; DM1; myotonic dystrophy type 1; DM2; myotonic dystrophy type 2; FTD; frontotemporal dementia;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2012 سفارش ترجمه

ReviewAdvances in microRNA experimental approaches to study physiological regulation of gene products implicated in CNS disorders

Keywords: CNS; central nervous system; GOI; gene of interest; mRNA; messenger RNA; siRNA; short interfering RNA; miRNA; microRNA; pri-miRNA; primary microRNA; pre-miRNA; microRNA precursor; AD; Alzheimer disease; Aβ; amyloid-β; APP; amyloid-β precursor protein;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2012 سفارش ترجمه

Associate editor: M.G. BelvisiMatrikines and the lungs

Keywords: aa; amino acid; ADAM; a disintegrin and metalloproteinase; APP; amyloid beta precursor; CXCR; C-X-C motif chemokine receptor; ECM; Extracellular matrix; ED; extra domains; EGF; epidermal growth factor; ERK; extracellular signal-regulated kinase; FAK; foca

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2012 سفارش ترجمه

Pyroglutamate-Aβ 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aβ 11 forming the central core

Keywords: Aβ; Amyloid beta; AD; Alzheimer's disease; N; amino; APP; amyloid precursor protein; BACE 1; beta-site amyloid precursor protein cleaving enzyme 1; QC; glutaminyl cyclase; HPLC; high pressure liquid chromatography; KO; knock out; AβpE3; pyrolyzed Aβ3-x

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Serum acute phase proteins concentrations in dogs during experimentally short-term induced overweight. A preliminary study

Keywords: APP; Dog; CRP; Cp; Hp; SAA; Obesity

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Quinazolinones as γ-secretase modulators

Keywords: Alzheimer; Gamma Secretase; Modulator; APP; Aβ42 lowering

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Purified high molecular weight synthetic Aβ(1-42) and biological Aβ oligomers are equipotent in rapidly inducing MTT formazan exocytosis

Keywords: APP; amyloid precursor protein; ELISA; enzyme-linked immunoassay; FBS; fetal bovine serum; HFIP; 1,1,1,3,3,3-hexafluoroisopropanol; HRP; horseradish peroxidase; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; H4 neuroglioma; C2C12 myobl

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

P2 receptor stimulation induces amyloid precursor protein production and secretion in rat cortical astrocytes

Keywords: 2MeSADP; 2-methylthio-ADP; 8PSPT; 8-(p-sulfophenyl)-theophylline; AD; Alzheimer's disease; APP; amyloid precursor protein; BzATP; 3′-O-(4-benzoyl)benzoyl-ATP; DAPI; 4′-6-diamidino-2-phenylindole; DMEM; Dulbecco's modified Eagle's medium; ERK; extracel

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain

Keywords: Alzheimer's; AICD; APP; Fe65; Electroencephalogram; Seizure

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Expression and significance of DSCAM in the cerebral cortex of APP transgenic mice

Keywords: DSCAM; Down syndrome cell adhesion molecule; DS; Down syndrome; APP; amyloid precursor protein; DSCR; Down Syndrome Critical Region; Ig; immunoglobulin; AD; Alzheimer's disease; PBS; phosphate-buffered saline; RT-PCR; reverse transcription PCR; Tubb3; β-

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Cell death pathology: Perspective for human diseases

Keywords: AIDS; acquired immune deficiency syndrome; TIAF1; TGFβ-induced anti-apoptotic factor 1; TGFβ; transforming growth factor beta; AD; Alzheimer disease; APP; amyloid precursor protein; PD; Parkinson's disease; NSC; neural stem cells; AICD; activation ind

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

p24 proteins from the same subfamily are functionally nonredundant

Keywords: Xenopus laevis; Protein transport and processing; Glycosylation; Sulfation; Prohormone biosynthesis; APP; amyloid-β precursor protein; CLIP; corticotropin-like intermediate lobe peptide; EM; electron microscopy; ER; endoplasmic reticulum; GFP; green fluo

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Adaptor protein containing PH domain, PTB domain and leucine zipper (APPL1) regulates the protein level of EGFR by modulating its trafficking

Keywords: EGFR, epidermal growth factor receptor; MAPK, mitogen-activated protein kinase; PI3K, phosphatidyl inositol 3-kinase; STAT, signal transducer and activator of transcription; PKC, protein kinase C; PLD, phospholipase D; EEA1, early endosomal antigen 1; APP

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Amyloid protein-mediated differential DNA methylation status regulates gene expression in Alzheimer's disease model cell line

Keywords: 5-aza-dC; 5-aza-2′-deoxycytidine; Aβ; beta amyloid; AD; Alzheimer's disease; APP; amyloid precursor protein; APP-sw; Swedish mutation of amyloid precursor protein; DMS; differentially methylated CpG site; MSP; methylation-specific PCR; qRT-PCR; quant

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Research ReportAtorvastatin and pitavastatin protect cerebellar Purkinje cells in AD model mice and preserve the cytokines MCP-1 and TNF-α

Keywords: Aβ; amyloid-β peptide; AD; Alzheimer's disease; AGEs; advanced glycation end products; APP; amyloid precursor protein; BBB; blood-brain barrier; HE; hematoxylin-eosin; HMG-CoA; 3-hydroxy-3-methyl glutaryl coenzyme A; 4-HNE; 4-hydroxy-2-nonenal; Iba-1;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Novel insights for the treatment of Alzheimer's disease

Keywords: 5-HT; 5-hydroxytryptamine (serotonin); Aβ; beta amyloid peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; BDNF; brain-derived neurotrophic factor; cDNA; complementary deoxyribonucleic acid; CoQ10; coenzyme Q10 (ubiquinone); GSK3; glycog

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: Exploring the S2′ region

Keywords: AD; Alzheimer's disease; Aβ; β-amyloid peptide; APP; β-amyloid precursor protein; BACE; β-site APP cleaving enzyme; FRET; fluorescence resonance energy transfer; ELISA; enzyme-linked immune sandwich assay; CHO; Chinese hamster ovary; Alzheimer's d

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging

Keywords: Alzheimer; Tau; Plaque; Multiphoton; In vivo imaging; AD; Alzheimer's disease; Aβ; amyloid beta; NFT; neurofibrillary tangle; APP; amyloid precursor protein;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه