Pyroglutamate-Aβ 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aβ 11 forming the central core

► Antibodies raised against AβpE3 and AβpE11 recognize their specific antigen in senile plaques. ► Both AβpE3 and AβpE11 colocalize with Thioflavin S, a marker of mature amyloid plaques. ► AβpE3 and AβpE11 colocalize with each other in amyloid plaques. ► AβpE11 species form cores in plaques surrounded by full length and AβpE3.