Troubleshooting methods for APP processing in vitro
Keywords: Aβ; Alzheimer's disease; APP; Secretases; Methods
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Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease
Keywords: estradiol; Aβ; APP; TTR; BACE; Alzheimer's diseaseAβ, amyloid-beta; AD, Alzheimer's disease; APP, amyloid precursor protein; APPCTFs, APP C-terminal fragments; APPim, immature APP; APPm, mature APP; BACE, β-site APP cleaving enzyme; E2, 17 β-estradiol; ID
Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts
Keywords: Alzheimer’s disease; Amyloid-β; APP; Cholesterol; Lipid rafts; Niemann Pick type C disease; NPC1
p24 family type 1 transmembrane proteins are required for insulin biosynthesis and secretion in pancreatic β-cells
Keywords: APP; amyloid precursor protein; COP; coat proteins; ER; endoplasmic reticulum; siRNA; short interfering RNA; PMSF; phenylmethylsulphonyl fluoride; p24 protein; Insulin biosynthesis; Insulin secretion; Pancreatic β-cell;
TAG-1 is an inhibitor of TGFβ2-induced neuronal death via amyloid β precursor protein
Keywords: APP; TAG-1; Alzheimer's disease; TGFβ2;
Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP
Keywords: Early-onset Alzheimer's disease; Presenilins; APP; Mutations;
Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease
Keywords: JNK; APP; Neurodegeneration; Neuroprotection; Biolistics; Brain slice; Drug discovery;
Searching for new animal models of Alzheimerâ²s disease
Keywords: Alzheimerâ²s disease; Transgenic mouse; APP; ADAM10;
Intracellular cholesterol homeostasis and amyloid precursor protein processing
Keywords: Alzheimer's disease; Amyloid; Apolipoprotein E (apoE); APP; Cholesterol; Cholesterol ester; Lipid raft; Sterol regulatory element binding protein (SREBP); SREBP cleavage activating protein (Scap); Niemann–Pick type C disease (NPC)
Enhanced dentate gyrus synaptic plasticity but reduced neurogenesis in a mouse model of amyloidosis
Keywords: Alzheimer; Neurogenesis; LTP; Potentiation; Dentate gyrus; Presenilin; PS2; APP; IGF; BDNF
Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid–Alzheimer's disease relationships?
Keywords: Alzheimer's disease; Amyloid precursor protein; APP; Cholesterol; NMR; Lipid raft; Membrane; Structure; Trafficking
Neuroprotective effects of salidroside against beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells
Keywords: Aβ; beta-amyloid; AD; Alzheimer's disease; Apaf-1; apoptosis activating factor-1; APP; beta-amyloid precursor protein; ARE; antioxidant responsive element; DCF; 2â²,7â²-dichlorofluorescin; DCFH-DA; 2â²,7â²-dichlorofluorescin diacetate; EB; ethidium b
Differential roles of phospholipases A2 in neuronal death and neurogenesis: Implications for Alzheimer disease
Keywords: AD; Alzheimer disease; Aβ; β-amyloid; APP; amyloid precursor protein; AACOCF3; arachidonyl trifluoromethylketone; BEL; bromoenol lactone; COX-2; cyclooxygenase-2; GCL; granule cell layer; IFN-γ; interferon-γ; IL-1β; interleukin-1β; 5-LOX; 5-lipoxyge
Megalin interacts with APP and the intracellular adapter protein FE65 in neurons
Keywords: Megalin; LRP2; Neurons; APP; FE65; Alzheimer's disease; Central nervous system
β-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain
Keywords: APP; AICD; Fe65; Proteasome; Insulin degrading enzyme
Mitochondria: The calcium connection
Keywords: Aβ; amyloid beta; ÎΨm; inner mitochondrial membrane potential; APP; amyloid precursor protein; BRET; bioluminescence resonance energy transfer; [Ca2+]c; cytosolic Ca2+ concentration; [Ca2+]ER; endoplasmic reticulum Ca2+ concentration; [Ca2+]m; mitochon
Protective effects of galantamine against Aβ-induced PC12 cell apoptosis by preventing mitochondrial dysfunction and endoplasmic reticulum stress
Keywords: AD; Alzheimer's disease; Gal; galantamine; APP; amyloid precursor protein; DMEM; Dulbecco's modified Eagle's medium; Aβ25-35; fragment 25-35 of amyloid beta; PC12; pheochromocytoma; FBS; fetal bovine serum; ROS; reactive oxygen species; MTT; 3-[4,5-d
Diffuse traumatic brain injury initially attenuates and later expands activation of the rat somatosensory whisker circuit concomitant with neuroplastic responses
Keywords: APP; amyloid precursor protein; CA; cornu ammonis of the hippocampus; cDNA; complementary DNA; DAI; diffuse axonal injury; FPI; fluid percussion injury; GAP-43; growth-associated protein 43Â kDa; IACUC; institutional animal care and use committee; NGS; no
Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes
Keywords: Alzheimer's disease; Amylin; Beta amyloid; Apolipoprotein-E; Apolipoprotein-a; APP; LPS; Type 2 diabetes; IB1/JIP-1; JNK-1; Tau; Ubiquitin
Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease
Keywords: Tau; APP; axonal degeneration; spheroids; head injury; immunizationAβ, beta amyloid peptide; AD, Alzheimer's disease; APP, amyloid precursor protein; APP670, 671, APP with the Swedish (sw) mutation (670/671KM→NL); Asw, transgenic mice expressing mutated A
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
Keywords: APP; amyloid precursor protein; Aβ; amyloid peptide; AV10; autophagic vacuoles; AV20; autolysosomes; CHIP; C-terminal HSP70 interacting protein; CBD; corticobasal degeneration; DA; dopamine; DAT; dopamine transport; FTD; frontotemporal dementia; HSP; hea
Intracellular Ca2+ storage in health and disease: A dynamic equilibrium
Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; ADPKD; autosomal dominant polycystic kidney disease; APP; amyloid precursor protein; Bax; Bcl-2-associated Xprotein; BI-1; Bax Inhibitor-1; [Ca2+]cyt; cytosolic Ca2+ concentration; [Ca2+]ER; endoplasmic-reticulum
Application of the essential work of fracture (EWF) concept for polymers, related blends and composites: A review
Keywords: AE; Acoustic emission; Al2O3; Aluminium oxide; aPP; Atactic polypropylene; ABS; Acrylonitrile butadiene styrene copolymer; BaSO4; Barium sulphate; BOPET; Biaxially oriented polyethylene terephthalate; CaCO3; Calcium carbonate (chalk); CB; Carbon black; CO
Polymer/layered silicate (clay) nanocomposites: An overview of flame retardancy
Keywords: ABS; acrylonitrile-butadiene-styrene copolymer; ABS-g-MA; acrylonitrile-butadiene-styrene-graft-maleic anhydride; ACPB; acrylic acid pentabromobenzyl ester; AO; antimony trioxide; APP; ammonium polyphosphate; AS; ammonium sulfamate; ATH; aluminum trihydra
Suppression of interleukin-6-induced C-reactive protein expression by FXR agonists
Keywords: FXR; farnesoid X receptor; SHP; small heterodimer partner; CRP; C-reactive protein; SAP; serum amyloid P component; SAA; serum amyloid A; APP; acute-phase protein; IL-6; interleukin-6; IL-1; interleukin-1; PPAR-α; peroxisome proliferator-activated recept
Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice
Keywords: Caloric restriction; Unbiased stereology; Stereologer; APP; PS1
The clathrin assembly protein AP180 regulates the generation of amyloid-β peptide
Keywords: Amyloid-β peptide; APP; AP180; CALM; Clathrin assembly protein; Neuron; Alzheimer’s disease
Alzheimer’s disease and Notch signaling
Keywords: Alzheimer’s disease; Notch; Presenilin; γ-Secretase; APP; Aβ
Bridging the gap: From protein misfolding to protein misfolding diseases
Keywords: SDS-PAGE; sodium dodecyl sulfate-polyacrylamide gel electrophoresis; AD; Alzheimer's Disease; Aβ; Amyloid Beta; APP; Amyloid Precursor Protein; AFM; Atomic Force Microscopy; TCCD; Two Colour Coincidence Detection; QCM; Quartz Crystal Microbalance;
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
Keywords: Alzheimer's disease; Diabetes; Insulin signalling; Tau; APP; Abeta; GSK-3; PP2a; Transthyretin; Irs2;
FAD-mutation of APP is associated with a loss of its synaptotrophic activity
Keywords: Mouse model; Alzheimer's disease; Neocortex; APP; FAD-linked mutations; Quantitative ultrastructural analysis; Synaptic density; Sub-synaptic structure; Synaptophysin;
Shock membrane electropotential drops and limited diffusive distance of β-amyloids in cerebral neurons are detrimental enhancement to Alzheimer's diseases
Keywords: Aβ; beta-amyloids; AD; Alzheimer's disease; ALS; amylotrophic lateral sclerosis; APP; amyloid precursor protein; BACE; β site APP cleaving enzyme; HD; Huntington's disease; NFT; intraneuronal tau-rich neurofibrillar tangles; PD; Parkinson's disease; ROS
Neurotoxic effects induced by the Drosophila amyloid-β peptide suggest a conserved toxic function
Keywords: APP; APPL; Drosophila; Amyloid; Neurodegeneration; β-secretase; Behavioral deficits
Senescence accelerated mouse strain is sensitive to neurodegeneration induced by mild impairment of oxidative metabolism
Keywords: Aβ; β-Amyloid peptide; AD; Alzheimer's disease; APP; Amyloid precursor protein; mt; mammillothalamic tract; NeuN; Neuronal specific nuclear protein; SAMP8; Senescence accelerated prone 8; SAMR1; Senescence accelerated resistant 1; SmTN; Submedial thalam
Function, regulation and therapeutic properties of β-secretase (BACE1)
Keywords: AD, Alzheimer's disease; ADAM, a disintegrin and metalloprotease; APP, amyloid precursor protein; Aβ, amyloid-β-peptide; BACE1, β-site APP cleaving enzyme 1; NRG1, Neuregulin-1; PS, presenilinAlzheimer's disease; Aβ; APP; BACE1; Neuregulin; Secretase
Residues at P2-P1 positions of ɛ- and ζ-cleavage sites are important in formation of β-amyloid peptide
Keywords: Alzheimer's disease; β-amyloid; γ-secretase; APP; Intramembrane processing
The interaction of beta-amyloid protein with cellular membranes stimulates its own production
Keywords: Beta amyloid; Membrane fluidity; GM-1 ganglioside; APP; Alzheimer
Epigenetics, oxidative stress, and Alzheimer disease
Keywords: Epigenetics; DNA methylation; DNA oxidation; APP; Amyloid; Alzheimer disease; Pb exposure; Free radicals
Impaired axonal transport and neurofilament compaction occur in separate populations of injured axons following diffuse brain injury in the immature rat
Keywords: AMPA; Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; APP; Amyloid precursor protein; CC; Corpus Callosum; Cg; Cingulum; CNQX; 6-cyano-7-nitroquinoxaline-2,3-dione; IAT; Impaired Axonal Transport; LWM; Lateral White Matter Tracts; NBQX; 1,2,3,4
Reduced amyloidogenic processing of the amyloid β-protein precursor by the small-molecule Differentiation Inducing Factor-1
Keywords: Aβ; amyloid beta peptide; AD; Alzheimer's disease; ALLN; Acetyl-l-Leucyl-l-Leucyl-l-Norleucinal; APP; amyloid-β protein precursor; APLP1; amyloid precursor-like protein 1; APLP2; amyloid precursor-like protein 2; αCTF (C83); C-terminal fragment of APP
Attenuation of Notch signaling promotes the differentiation of neural progenitors into neurons in the hippocampal CA1 region after ischemic injury
Keywords: cerebral ischemia; γ-secretase; hippocampus; neurogenesis; regeneration; aCSF; artificial cerebrospinal fluid; APP; amyloid precursor protein; aSVZ; anterior subventricular zone; BrdU; bromodeoxyuridine; DCX; doublecortin; DLL4; delta-like protein 4; DMS
Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Aβ levels
Keywords: Alzheimer's disease; APP; Amyloid; Tau; Synapse; Hippocampus; Memory
The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression
Keywords: APR; acute-phase reaction; APP; acute-phase protein; IL; interleukin; EGFR; epidermal growth factor receptor; AR; amphiregulin; OSM; oncostatin M; STAT; signal transducer and activator of transcription; TNF; tumour necrosis factor; JAK; Janus-activated ki
Effects of memantine on soluble Îβ25-35-induced changes in peptidergic and glial cells in Alzheimer's disease model rat brain regions
Keywords: Alzheimer's disease; memantine; peptidergic system; dendritic spine; glial cells; AD; Alzheimer's disease; ANOVA; analysis of variance; APP; amyloid-β precursor protein; Aβ; amyloid-β; DTT; dithiothreitol; EDTA; ethylenediaminetetraacetic acid; EP 24.1
Trace amounts of copper exacerbate beta amyloid-induced neurotoxicity in the cholesterol-fed mice through TNF-mediated inflammatory pathway
Keywords: Aβ; APP; Cholesterol; Copper; Inflammatory;
Measurement of cellular β-site of APP cleaving enzyme 1 activity and its modulation in neuronal assay systems
Keywords: BACE1; Amyloid-β peptide (Aβ); APP; SEAP; CGC; HEK293
Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice
Keywords: Alzheimer's disease; Animal models; Amyloid; APP; Calcium; Iron; Mineralization; MRI; PS1; Transgenic mouse
Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors
Keywords: AD; Alzheimer 's disease; ADDL; amyloid-β derived diffusible ligand; APP; amyloid-β precursor protein; BBB; blood-brain barrier; CNS; central nervous system; CSF; cerebrospinal fluid; DAMP; danger-associated molecular pattern; FPR; N-formyl peptide re
Caspase substrates and neurodegenerative diseases
Keywords: Neurodegenerative diseases; Caspases; Substrates; Apoptosis; Survival; Huntingtin; APP; Tau; Preselinins; RasGAP; Rb; PARP
Synaptic contact number and size in stratum radiatum CA1 of APP/PS1ΔE9 transgenic mice
Keywords: Synapses; Alzheimer's; Amyloid; APP; Disector; Hippocampus; Stereology; Transgenic