Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: Blockage by curcumin
Keywords: Metal ions; PC12; APP; BACE1;
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Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo
Keywords: Abeta; amyloid beta; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; beta-site amyloid precursor protein-cleaving enzyme-1; Alzheimer's disease; Amyloid beta; Beta-site amyloid precursor protein (APP)-cleaving enzyme-1 (BACE1); Non-transge
SUMO-1 immunoreactivity co-localizes with phospho-Tau in APP transgenic mice but not in mutant Tau transgenic mice
Keywords: SUMO-1; Ubiquitin; Tau; APP; Alzheimer's disease; Transgenic mice
Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40
Keywords: endopeptidase; neprilysin; beta-amyloid; Alzheimer's disease; membrane metallo-endopeptidase-like protein; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; beta-amyloid; MMEL; membrane metallo-endopeptidase-like protein; NEP; neprilysin; T/P;
Increased expression of Aβ degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology
Keywords: Alzheimer's Disease; Beta amyloid (Aβ); Degradation; Insulin degrading enzyme (IDE); Neprilysin (NEP); APP; Transgenic mouse
Competition between the albumin and three histidine fragment of amyloid precursor protein sites to bind Cu(II)
Keywords: Copper(II) complexes; APP; Stability constants; Spectroscopic studies
Inhibition of APP intracellular domain (AICD) transcriptional activity via covalent conjugation with Nedd8
Keywords: APP; AICD; Nedd8; Ubiquitin-like protein; Protein modification; Transcriptional regulation
Promising anti-Alzheimer’s dimer bis(7)-tacrine reduces β-amyloid generation by directly inhibiting BACE-1 activity
Keywords: Bis(7)-tacrine; Aβ; APP; BACE-1; α-Secretase
PI3-K- and PKC-dependent up-regulation of APP processing enzymes by retinoic acid
Keywords: ADAM10; APP; BACE1; BDNF; PI3-kinase; Protein kinase C; Retinoic acid; TACE
Sumoylation of amyloid precursor protein negatively regulates Aβ aggregate levels
Keywords: APP; SUMO-1; SUMO-2; Ubc9; Alzheimer’s
Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age
Keywords: Aβ; amyloid β-peptide; BSA; bovine serum albumin; AD; Alzheimer's disease; APP; amyloid precursor protein; HNE; 4-hydroxy-2-trans-nonenal; 3-NT; 3-nitrotyrosine; PBS; phosphate-buffered saline; PS; presenilin; SDS; sodium dodecyl sulfate; Alzheimer's
Targeting β-Amyloid Pathology in Alzheimer's Disease with Aβ Immunotherapy
Keywords: Humanized monoclonal antibody; neurodegeneration; vaccination; clinical trial; APP; passive immunization;
Effect of phosphorous flame retardants on the thermal decomposition of vinyl polymers and copolymers
Keywords: Pyrolysis; Flame retardant; APP; Polyphosphoric acid; PS; ABS; PAN; Py-GC/MS
Sleep and EEG features in genetic models of Down syndrome
Keywords: Sleep; Wake; EEG; REM; Ts65Dn; Ts1Cje; Theta; App; Down syndrome; Mice
Green tea catechins prevent cognitive deficits caused by Aβ1-40 in rats
Keywords: 0.0% PE group; rats administered with water only; 0.5% PE group; rats administered with 5 g/L of PE; Aβ; amyloid β peptide; Aβ group; amyloid β peptide1-40-infused rats; AD; Alzheimer's disease; ANOVA; analysis of variance; APP; amyloid precursor pr
The granulocyte macrophage colony stimulating factor (GM-CSF) regulates amyloid β (Aβ) production
Keywords: GM-CSF; Alzheimer; CD40; Amyloid; APP
Promoter polymorphisms which modulate APP expression may increase susceptibility to Alzheimer's disease
Keywords: Alzheimer's disease; APP; Promoter; Polymorphism
A genetic interaction between the APP and Dab1 genes influences brain development
Keywords: Dab1; Reelin; APP; Brain development; Cerebellum; Cortical lamination
Phosphorylation of β-amyloid precursor protein (APP) cytoplasmic tail facilitates amyloidogenic processing during apoptosis
Keywords: AD; Alzheimer's disease; Aβ; β-amyloid peptides; APP; β-amyloid precursor protein; P-APP; β-amyloid precursor protein phosphorylated specifically at threonine residue 668 in cytoplasmic tail (APP-695 numbering); ERK/MAPK; extracellular signal-regulate
Emotional responses and memory performance of middle-aged CD1 mice in a 3D maze: Effects of low infrared light
Keywords: Aging; Ageing; Amnesia; Amyloid; APP; Alzheimer; Hippocampus; Rats
Genetic loci modulating amyloid-beta levels in a mouse model of Alzheimer's disease
Keywords: APP; Beta-amyloid; Abeta; Alzheimer; Genetics; QTL; Mouse; Intercross
Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress
Keywords: Alzheimer’s; APP; seizures; neuroprotection; oxidative stressAD, Alzheimer’s disease; ADAM, a disintegrin and metalloprotease; APP, amyloid precursor protein; Aβ, amyloid β; DAPI, 4′-6-diamidino-2-phenylindole dihydrochloride; TACE, tumor necrosis factor-
Activation of protein kinase C modulates BACE1-mediated β-secretase activity
Keywords: BACE1; APP; PKC; Protein degradation; Protein translocation; Amyloid β; β-Secretase; Fibroblast; Neuron
Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease
Keywords: Transgenic mice; Amyloid; Motor deficits; Intraneuronal Aβ; Working memory; Alzheimer; APP; Axonal degeneration; Behavior
Transgenic mice overexpressing human acetylcholinesterase and the Swedish amyloid precursor protein mutation: Effect of nicotine treatment
Keywords: Aβ; hAChE-Tg//APPswe mice; nAChRs; l(â)-nicotine; d(+)-nicotine; AChE; acetylcholinesterase; AChE-S; synaptic acetylcholinesterase; AD; Alzheimer's disease; APP; amyloid precursor protein; APPswe mice; transgenic mice carrying the Swedish mutation of
Research ReportTGFβ2-induced changes in LRP-1/TβR-V and the impact on lysosomal Aβ uptake and neurotoxicity
Keywords: A2M; Alpha 2 macroglobulin; Aβ; Amyloid beta protein; AD; Alzheimer's disease; ApoE; Apolipoprotein E; APP; Amyloid precursor protein; BBB; Blood brain barrier; ir; immunoreactivity; LAMP1; Lysosomal-associated membrane protein 1; LRP; Low-density lipopr
Aged wild-type and APP, PS1, and APP + PS1 mice present similar deficits in associative learning and synaptic plasticity independent of amyloid load
Keywords: CA3–CA1 synapse; Eyeblink; Hippocampus; Old mice; Long-term potentiation; Prepulse inhibition; Synaptic potentiation; Transgenic mice; APP; PS1; Classical conditioning
BACE1 gene deletion: Impact on behavioral function in a model of Alzheimer's disease
Keywords: Aβ; Alzheimer's disease; Amyloid; APP; BACE1; Memory; PDAPP; Seizure; Sensorimotor; Serial water maze
Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription
Keywords: AICD; APP; Neprilysin; KAI1; Endosomes; Lysosomes; Alzheimer's disease; NH4Cl
Differential activation of mitogen-activated protein kinase signalling pathways in the hippocampus of CRND8 transgenic mouse, a model of Alzheimer's disease
Keywords: ERK; p38MAPK; JNK; cholinergic stimulation; immunohistochemistry; ACSF; artificial cerebrospinal fluid; AD; Alzheimer disease; ANOVA; analysis of variance; APP; amyloid precursor protein; BB; blocking buffer; CA1; cornu ammonis area 1; CA3; cornu ammonis
The ubiquitin-proteasome system in spongiform degenerative disorders
Keywords: AD; Alzheimer's disease; AgRP; Agouti related protein; AIDS; acquired immune deficiency syndrome; APP; amyloid precursor protein; ASPA; aspartoacylase gene; Atrn; attractin; BSE; bovine spongiform encephalopathy; CD; Canavan's spongiform leukodystroph
Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders
Keywords: ADAM; a disintegrin and metalloprotease; ACDL; acidic dileucine; ADDL; amyloid-β derived diffusible ligands; APP; amyloid precursor protein; Aph; anterior pharynx defective phenotype; APLP; APP-like protein; AICD; APP intracellular domain; AD; Alzheimer'
β/A4-Amyloid increases nerve growth factor production in rat primary hippocampal astrocyte cultures
Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; (β/A4)β; /A4-Amyloid; BFCN; basal forebrain cholinergic neurons; NGF; nerve growth factor; Alzheimer's disease; Amyloid; Astrocytes; Neurotrophins; NGF;
Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Aβ secretion
Keywords: Aβ; amyloid-β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; APPNL-H4 cells; H4 cells stably expressing Swedish-type of human APP695; ELISA; enzyme-linked immunosorbent assay; FL; full-length; LDH; lactate dehydrogenase; LDL; low-de
Altered cholesterol metabolism in APP695-transfected neuroblastoma cells
Keywords: Amyloid; Cholesterol; Neuroblastoma cell; APP; 24S-hydroxycholesterol
Endosomal abnormalities related to amyloid precursor protein in cholesterol treated cerebral cortex neuronal cells derived from trisomy 16 mice, an animal model of Down syndrome
Keywords: Cell lines; APP; Cholesterol; Early endosomes; Down syndrome
Methotrexate decreases PP2A methylation and increases tau phosphorylation in neuron
Keywords: Alzheimer’s disease; APP; Tau; Okadaic acid; PP2A; BACE; Secretase; Methyltransferase
Munc18a: Munc-y business in mediating exocytosis
Keywords: APP; amyloid precursor protein; Cdk5; cyclin-dependent kinase 5; DOC2; double C2-domain; FRET; fluorescence resonance energy transfer; LDCV; large dense core vesicle; Mint; Munc18-interacting protein; PKC; protein kinase C; SM protein; Sec1/Munc18; SNARE;
Fe65 does not stabilize AICD during activation of transcription in a luciferase assay
Keywords: Aβ; β-amyloid peptide; APP; amyloid precursor protein; AICD; APP intracellular domain; sαAPP; soluble α-amyloid precursor protein; BACE; β-site APP-cleaving enzyme; CHO; Chinese hamster ovary; CTF; C-terminal fragment of APP; DAPT; N-[N-(3,5-difluoro
A macromolecular complex involving the amyloid precursor protein (APP) and the cytosolic adapter FE65 is a negative regulator of axon branching
Keywords: Alzheimer's disease; APP; FE65; Mena; Neurite outgrowth; Branching
ADAM19 is tightly associated with constitutive Alzheimer’s disease APP α-secretase in A172 cells
Keywords: ADAM19; APP; α-Secretase; Alzheimer’s diseaseAD, Alzheimer’s disease; Aβ, amyloid β-peptide; APP, amyloid precursor protein; sAPP α, soluble APPα; ADAM, a disintegrin and metalloprotease; PMA, phorbol 12-myristate 13-acetate; TRANCE, TNF-related activatio
Critical role of methionine-722 in the stimulation of human brain G-proteins and neurotoxicity induced by London familial Alzheimer's disease (FAD) mutated V717G-APP714-723
Keywords: G-proteins; V717G-APP714-723 fragment; methionine-722 oxidation; antioxidants; neurotoxicity; Aβ; amyloid β-peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; DFO; desferrioxamine; FAD; familial Alzheimer's disease; GSH; reduced glu
Expression of APP pathway mRNAs and proteins in Alzheimer’s disease
Keywords: Alzheimer’s disease; APP; Aβ; Kunitz; Microglia
Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans
Keywords: Traumatic brain injury; TBI; Axonal injury; Amyloid β; APP; BACE; PS-1; α-Synuclein; Tau
NeuropharmacologyThe α7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice
Keywords: 4OH-GTS-21; FFX-lesions; cholinergic neurons; GABAergic neurons; APP/PS1 and PS1 mice; AD; Alzheimer's disease; APP; amyloid precursor protein; ChAT; choline acetyltransferase; FFX; fimbria fornix lesions; NGF; nerve growth factor; PBS; phosphate-buffer
C1q binding and complement activation by prions and amyloids
Keywords: Alzheimer; Amyloid; C1q; Prion; Scrapie; Transmissible spongiform encephalopathy; Aβ; amyloid β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; BSE; bovine spongiform encephalopathy; CJD; Creutzfeld-Jacob disease; FBD; familial Briti
Pin1 in Alzheimer's disease: Multiple substrates, one regulatory mechanism?
Keywords: Pin1; Isomerase; APP; Tau; Phosphorylation; Alzheimer's disease; Neurodegeneration
Localization and expression of substance P in transgenic mice overexpressing human APP751 with the London (V717I) and Swedish (K670M/N671L) mutations
Keywords: Substance P; Alzheimer; Amyloid; GFAP; Astrocyte; Transgenic animal; APP
Growth hormone prevents acute liver injury induced by cardiopulmonary bypass in a rat model
Keywords: 18; 25; APP; acute-phase protein; APR; acute-phase response; CPB; cardiopulmonary bypass; GH; growth hormone; GHBP; growth hormone-binding protein; IGF; insulin-like growth factor; JAK; Janus kinase; NF; nuclear factor; SAA; serum amyloid A; STAT; signa
Genetic heterogeneity of Alzheimer's disease: Complexity and advances
Keywords: Monogenic; Sporadic; APP; PS1; PS2; APOE; Polymorphism