دانلود مقالات ISI درباره App + ترجمه فارسی

Early-onset subicular microvascular amyloid and neuroinflammation correlate with behavioral deficits in vasculotropic mutant amyloid β-protein precursor transgenic mice

Keywords: cerebral microvascular amyloid; cognitive impairment; neuroinflammation; subiculum; transgenic mice; ANOVA; analysis of variance; APP; amyloid β-protein precursor; Aβ; amyloid β protein; CAA; cerebral amyloid angiopathy; ELISA; enzyme-linked immunosorb

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Tau overexpression in transgenic mice induces glycogen synthase kinase 3β and β-catenin phosphorylation

Keywords: Alzheimer; transgenic; tau; GSK3; Wnt; aa; amino acid; Aβ; amyloid β-protein; AD; Alzheimer's disease; APP; amyloid precursor protein; EM; electron microscopy; GSK3β; glycogen synthase kinase 3β; NFT; neurofibrillary tangle; Non-tg; non-transgenic l

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Notch1 intracellular domain suppresses APP intracellular domain-Tip60-Fe65 complex mediated signaling through physical interaction

Keywords: Notch1-IC; Notch1 intracellular domain; ΔE1; Notch1 lacking the extracellular domain; APP; Amyloid beta-Precursor Protein; AICD; APP intracellular domain; ROS; Reactive oxygen species;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma *

Keywords: ADAM10; APP; Carcinogenesis; Mouth

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Iron dysregulation in Alzheimer's disease: Multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents

Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; BDNF; brain-derived neurotrophic factor; Aβ; beta-amyloid peptide; β-CTF; beta-C-terminal fragment; EGCG; epigallocatechin gallate; DFO; desferrioxamine; ERK1/2

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه

Adenosine A2A receptors and brain injury: Broad spectrum of neuroprotection, multifaceted actions and “fine tuning” modulation

Keywords: AD; Alzheimer's disease; 4-AP; 4-aminopyridine; APP; amyloid precursor protein; A2AR; adenosine A2A receptor; BMDCs; bone marrow-derived cells; CGS 15943; 9-chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine; CGS 21680; 2-[p-(2-carbonylethyl)ph

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2007 سفارش ترجمه

De la physiopathologie au traitement de la maladie d'Alzheimer

Keywords: APP; Tau; Dégénérescence neuronale; Démence; Approche thérapeutique; APP; Tau; Neurodegeneration; Dementia; Therapy;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2006 سفارش ترجمه

Gene silencing analyses against amyloid precursor protein (APP) gene family by RNA interference

Keywords: RNAi; App; Aplp1; Aplp2; Neuro2a cell; Neurite outgrowth; Viability;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Chloroquine-induced endocytic pathway abnormalities: Cellular model of GM1 ganglioside-induced Aβ fibrillogenesis in Alzheimer's disease

Keywords: AD; Alzheimer's disease; Aβ; amyloid β-protein; GM1; GM1 ganglioside; GAβ; GM1-bound Aβ; APP; amyloid precursor protein; apoE; apolipoprotein E; CTB; cholera toxin B subunit; HRP; horseradish peroxidase; NGF; nerve growth factor; Alzheimer's disea

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Aβ 11–40/42 production without γ-secretase ε-site cleavage

Keywords: Alzheimer’s disease; APP; Presenilin; γ-Secretase; Aβ; AICD

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis

Keywords: AICD; Apoptosis; APP; Fe65; γ-Secretase; p53

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Fluorescence lifetime imaging microscopy (FLIM) detects stimulus-dependent phosphorylation of the low density lipoprotein receptor-related protein (LRP) in primary neurons

Keywords: LRP; Phosphorylation; FLIM; FRET; PDGF; APP

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Polychlorinated biphenyls alter expression of α-synuclein, synaptophysin and parkin in the rat brain

Keywords: PCBs; α-Synuclein; Parkin; Synaptophysin; APP

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Allele-specific silencing of Alzheimer's disease genes

Keywords: AD; Alzheimer's disease; Aβ; β-amyloid protein; APP; amyloid precursor protein; APPLON; APP with the London mutation; APPSW; APP with the Swedish mutations; CHO; Chinese hamster ovary; NT2; NTERA-2 cl.D1; oligo; oligonucleotide; PCR; polymerase chain re

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

COPI-mediated retrograde transport is required for efficient γ-secretase cleavage of the amyloid precursor protein

Keywords: β-Amyloid; Alzheimer’s disease; APP; Retrograde transport; COPI; Neurodegeneration

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Over-expression of two different forms of the α-secretase ADAM10 affects learning and memory in mice

Keywords: Transgenic mice; Alzheimer's disease; α-Secretase; ADAM10; APP; Morris water maze

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Evaluation of white matter integrity in ex vivo brains of amyloid plaque-bearing APPsw transgenic mice using magnetic resonance diffusion tensor imaging

Keywords: Transgenic mice; APP; Amyloid; White matter; Corpus callosum; Diffusivity; Magnetic resonance imaging; Diffusion tensor imaging

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

A quantitative method for comparison of expression of alternatively spliced genes using different primer pairs

Keywords: GPI; glycosyl-phosphatidylinositol; DAF; decay accelerating factor; QPCR; quantitative polymerase chain reaction; kPCR; kinetic polymerase chain reaction; APP; β-amyloid precursor protein; EDC; 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide; GAPDH; glyce

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Age-related evolution of amyloid burden, iron load, and MR relaxation times in a transgenic mouse model of Alzheimer's disease

Keywords: Alzheimer's disease; Amyloid; APP; Biomarker; Iron; MRI; PS1; T1; T2; Transgenic mouse

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

BACE inhibitor reduces APP-β-C-terminal fragment accumulation in axonal swellings of okadaic acid-induced neurodegeneration

Keywords: Alzheimer's disease; Okadaic acid; APP; APP-CTF; Axonopathy; Axonal swelling; Transport deficit

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Different dendrite and dendritic spine alterations in basal and apical arbors in mutant human amyloid precursor protein transgenic mice

Keywords: APP; Morphology; Neocortex; Plasticity; Pyramidal neuron;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Pathogenic accumulation of APP in fast twitch muscle of IBM patients and a transgenic model

Keywords: Inclusion body myositis; Single fiber; Amyloid; APP

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

The coding sequence of amyloid-β precursor protein APP contains a neural-specific promoter element

Keywords: APP, amyloid-β precursor protein; Cac, cardiac actin; EF1α, elongation factor 1 alpha; GFP, green fluorescent protein; ICAM, intracellular adhesion molecule; Ntub, neural β-tubulin; POMC, proopiomelanocortinAlzheimer's disease; APP; Cell-specific transgen

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

The Secondary AbdominalCompartment Syndrome: Iatrogenic or Unavoidable?

Keywords: ACS; abdominal compartment syndrome; APP; abdominal perfusion pressure; ARDS; acute respiratory distress syndrome; IAH; intraabdominal hypertension; IAP; intraabdominal pressure; MAP; mean arterial pressure; pHi; gastric tonometry;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Small heat shock proteins inhibit amyloid-β protein aggregation and cerebrovascular amyloid-β protein toxicity

Keywords: Aβ; amyloid-β protein; sHsp; small heat shock proteins; NFTs; neurofibrillary tangles; CAA; cerebral amyloid angiopathy; APP; amyloid β precursor protein; D-Aβ1-40; Aβ1-40 containing the 'Dutch' mutation; SPR; surface plasmon resonance; CD; c

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Metallothionein-I and -III expression in animal models of Alzheimer disease

Keywords: metallothionein-I; metallothionein-III; Alzheimer's disease; Tg2576; TgCRND8; TgSwDI; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; β-amyloid; Aβ42; amyloid beta 42; ALS; amyotrophic lateral sclerosis; GFAP; glial fibrillary acid pro

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11α protein up-regulation in Alzheimer's disease

Keywords: β-amyloid; neuron loss; neurotransmission; occipital cortex; parietal cortex; Tg2576 transgenic mice; Aβ; β-amyloid peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; BA; Brodmann's area; Cdk5; cyclin-dependent kinase 5; Mint; Munc18

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Different patterns of axonal damage after intracerebral injection of malonate or AMPA

Keywords: APP; Axonal damage; Excitotoxicity; Glucose use; Neurofilament; Oxidative stress

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

In vivo MRI and histological evaluation of brain atrophy in APP/PS1 transgenic mice

Keywords: Alzheimer's disease; APP; Amyloid precursor protein; Aβ peptide; Atrophy; Brain; MRI; PS1; Presenilin; Mouse; Animal model; Transgenesis; Midbrain; Fiber tracts; Morphometry; Hippocampus; Development

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه

Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice

Keywords: AD; Alzheimer disease; Aβ; amyloid β; APP; amyloid precursor protein; DAF-2-DA; diaminofluorescein-2-diacetate; DHE; dihydroethidium; DHR; dihydrorhodamine 123; FAD; familial Alzheimer disease; GPx; glutathione peroxidase; GR; glutathione disulfide redu

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه

Novel isoforms of NADPH-oxidase in cerebral vascular control

Keywords: Aβ; amyloid-β peptide; ACE; angiotensin-converting enzyme; ACh; acetylcholine; AD; Alzheimer's disease; AEBSF; aminoethylbenzenesulfono fluoride; APP; amyloid precursor protein; CBF; cerebral blood flow; cGMP; guanosine monophosphate; DETCA; diethyldith

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2006 سفارش ترجمه

Estradiol regulates APP mRNA alternative splicing in the mice brain cortex

Keywords: APP; Alternative splicing; RT-PCR; Sex steroids; Aging; Mouse brain;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2005 سفارش ترجمه

Imipramine and citalopram facilitate amyloid precursor protein secretion in vitro

Keywords: Alzheimer's disease; Antidepressant; Neuronal culture; APP; PKC;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Blockade of γ-secretase activity within the hippocampus enhances long-term memory

Keywords: APP; DCC; E-cadherin; LTP; Nicastrin; Notch; N-cadherin; Pen-2; Presenilins;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

A Western Australian kindred with Dutch cerebral amyloid angiopathy

Keywords: APP; Aβ; Familial Cerebral Haemorrhage; Mutations;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Human-like rodent amyloid-β-peptide determines Alzheimer pathology in aged wild-type Octodon degu

Keywords: Alzheimer's disease; Alzheimer model; Neuropathology; Amyloid-β-peptide; APP; Octodon degu;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac

Keywords: ACh; acetylcholine; AD; Alzheimer's disease; ADAM; a disintegrin and metalloprotease; Aβ; amyloid β-peptide; APP; amyloid precursor protein; sAPPα; soluble form of the amyloid precursor protein; FSK; forskolin; GEF; guanine nucleotide exchange factor

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

A new method for determination of uric acid by the lactic acid-acetone-BrO3−-Mn2+-H2SO4 oscillating reaction using the analyte pulse perturbation technique

Keywords: Oscillating chemical reaction; APP; Uric acid; CSTR;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

Restraint stress induces β-amyloid precursor protein mRNA expression in the rat basolateral amygdala

Keywords: β-Amyloid; APP; Restraint stress; Amygdala; Hippocampus; In situ hybridization;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

Secreted β-amyloid precursor protein activates microglia via JNK and p38-MAPK

Keywords: Alzheimer's disease; APP; Inflammation; MAP kinase; Microglia; Nitric oxide synthase; Stress-activated kinase;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Effects of Bambusae concretio Salicea (Chunchukhwang) on amyloid β-induced cell toxicity and antioxidative enzymes in cultured rat neuronal astrocytes

Keywords: Astrocyte; Alzheimer's disease; Amyloid-β; Bombusae concretio Salicea (Chunchukhwang); Antioxidative enzyme; BCS; Bambusae concretio Salicea water extract; Aβ; amyloid-β; LDH; lactate dehydrohenase; SOD; superoxide dismutase; GPx; glutathione peroxidas

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Age-dependent differential expression of BACE splice variants in brain regions of tg2576 mice

Keywords: β-Secretase; Alternative splice variants; Brain regions; Age dependent; APP; β-Amyloid; tg2576 transgenic mice; Alzheimer disease;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

The expression of p75 neurotrophin receptor protects against the neurotoxicity of soluble oligomers of β-amyloid

Keywords: Aβ; β-amyloid; AD; Alzheimer's disease; APP; β-amyloid precursor protein; DD; death domain; JICD; juxtamembrane domain; p75NTR; p75 neurotrophin receptor; PI3K; phosphatidylinositide 3-kinase; AO; acridine orange; EB; ethidium bromide; WT; wortmannin;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Presenilin endoproteolysis is an intramolecular cleavage

Keywords: Aβ; amyloid-β peptide; APP; β-amyloid precursor protein; CTF; C-terminal fragment; ELISA; enzyme-linked immunosorbent assay; FL; full-length; HEK; human embryonic kdney 293; IP; immunoprecipitation; MEF; mouse embryonic fibroblasts; NΔE; Notch ΔE; NC

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice

Keywords: APP; β-amyloid; Tau; Lysosomes; Stereology; Neuronal loss; Transgenic mice; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

Keywords: Endosomes; Lysosomes; Amyloid; Huntington disease; ALS; APP;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Sex steroids, APOE genotype and the innate immune system

Keywords: Aβ; amyloid beta peptide; AD; Alzheimer's disease; APOE; apolipoprotein E; APOE TR; apolipoprotein E targeted replacement; APP; amyloid precursor protein; AR; androgen receptor; c-fms; colony stimulating factor receptor gene; CSF; colony stimulating fact

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Human monoclonal antibodies against amyloid-beta from healthy adults

Keywords: Aβ; amyloid-beta; AD; Alzheimer's disease; AL; amyloid L; AP; alkaline phosphatase; APP; amyloid precursor protein; IAPP; islet amyloid polypeptide; IVIG; intravenous immunoglobulin; LCL; lymphoblastoid cell line; Alzheimer's disease; Anti-amyloid-beta a

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Chronic treatment with amyloid β1-42 inhibits non-cholinergic high-affinity choline transport in NG108-15 cells through protein kinase C signaling

Keywords: Disorders of the nervous system; Degenerative disease: Alzheimer's beta amyloid; Amyloid β-peptide1-42; Aβ1-42; Amyloid Precursor Protein; APP; Hemicholinum-3; HC-3; Choline Transporter-like Protein 1; CTL1; High-affinity choline transporter 1; ChT1

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Reductions in β-amyloid concentrations in vivo by the γ-secretase inhibitors BMS-289948 and BMS-299897

Keywords: Aβ; β-amyloid; APP; Amyloid precursor protein; DAPT; [N-(3,5-difluor-phenacetyl)-l-alanyl]-S-phenylglycine; BMS-289948; 4-chloro-N-(2,5-difluorophenyl)-N-((1R)-{4-fluoro-2-[3-(1H-imidazol-1-yl)propyl]phenyl}ethyl)benzenesulfonamide hydrochloride; BMS-29

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه