کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2564303 | 1127639 | 2006 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel isoforms of NADPH-oxidase in cerebral vascular control
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کلمات کلیدی
EDHFcGMPNOSeNOSDPICBFAEBSFSOD1SOD2APPEDRFTPCKSOD3PEG-SODNoxA1Nox Activator 1NoxO1ACEAβVSMNADPH-oxidase - NADPH-اکسیدازO2− - O2-ONOO− - ONOO-ROS - ROSHydrogen peroxide - آب اکسیژنهAngiotensin-converting enzyme - آنژیوتانسین تبدیل آنزیمACh - آهAcetylcholine - استیل کولینFAD - بدAlzheimer's disease - بیماری آلزایمرTetraethylammonium - تترا اتیل آمونیومcerebral blood flow - جریان خون مغزیdiethyldithiocarbamate - دیاتیدیدیتیو کرباماتDiphenyleneiodonium - دیفنیلن اندونیمSOD - سدendothelial nitric oxide synthase - سنتاز اکسید نیتریک اندوتلیالNitric oxide synthases - سنتز اکسید نیتروژنSuperoxide - سوپر اکسیدsuperoxide dismutases - سوکسوکس دیسموتازهاVascular smooth muscle - عضله صاف عضلانیendothelium-derived relaxing factor - فاکتور آرامش بخش اندوتلیومEndothelium-derived hyperpolarizing factor - فاکتور هیپرپولاریزاسیون حاصل از اندوتلیومHypertension - فشار خون بالاflavin adenine nucleotide - فلوین آدنین نوکلئوتیدNitric oxide - نیتریک اکسیدH2O2 - هیدروژن پراکسیدhydroxyl - هیدروکسیلamyloid precursor protein - پروتئین پیش ماده آمیلوئیPeroxynitrite - پروکسی نیتریتamyloid-β peptide - پپتید آمیلیید بTEA - چایGuanosine monophosphate - گوئنوسین مونوفسفرهReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Reactive oxygen species (ROS) are thought to play an important role in the initiation and progression of a variety of vascular diseases. Furthermore, accumulating evidence indicates that ROS may also serve as important cell signalling molecules for the regulation of normal vascular function. Recently, a novel family of proteins (Nox1, 2 and 4) that act as the catalytic subunit of the superoxide (O2â) producing enzyme NADPH-oxidase has been discovered in vascular cells. There is now preliminary evidence suggesting that NADPH-oxidase-derived ROS may serve as a physiological vasodilator mechanism in the cerebral circulation. Moreover, the activity of NADPH-oxidase is profoundly greater in cerebral versus systemic arteries. Studies have shown that Nox1, Nox2 (also known as gp91phox) and Nox4 are all expressed in cerebral arteries, suggesting that multiple isoforms of NADPH-oxidase may be important for ROS production by cerebral arteries. Enhanced NADPH-oxidase activity is associated with several vascular-related diseases, including hypertension, stroke, subarachnoid haemorrhage and Alzheimer's dementia; however, the consequences of this for cerebral vascular function are controversial. For example, there is some evidence suggesting that NADPH-oxidase-derived O2â may play a role in endothelial dysfunction of cerebral arteries and a subsequent rise in cerebral vascular tone, associated with hypertension. However, activation of NADPH-oxidase elicits cerebral vasodilatation in vivo, and this mechanism is enhanced in chronic hypertension. While further supportive evidence is needed, it is an intriguing possibility that NADPH-oxidase-derived ROS may play a protective role in regulating cerebral vascular tone during disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 111, Issue 3, September 2006, Pages 928-948
Journal: Pharmacology & Therapeutics - Volume 111, Issue 3, September 2006, Pages 928-948
نویسندگان
Alyson A. Miller, Grant R. Drummond, Christopher G. Sobey,