Differential roles of phospholipases A2 in neuronal death and neurogenesis: Implications for Alzheimer disease

► Inhibition of isoforms of the cPLA2 and iPLA2 groups in AD might impair neurogenesis. ► Stimulation of sPLA2-IIA and cPLA2-IVA might contribute to neurodegeneration in AD. ► Further studies could assess the role of cPLA2-IVB, cPLA2-IVC, iPLA2-VIA and iPLA2-VIB in AD. ► Further research could investigate the status of sPLA2-III, sPLA2-V and sPLA2-X in the AD brain.