Design, synthesis and biological evaluation of 3-aryl-rhodanine benzoic acids as anti-apoptotic protein Bcl-2 inhibitors
Keywords: Apoptosis; Bcl-2; Inhibitor; Rhodanine;
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Upregulation of galectin-3 in immortalized Schwann cells IFRS1 under diabetic conditions
Keywords: AGE; advanced glycation endproducts; 3-DG; 3-deoxyglucosone; DRG; dorsal root ganglia; GAL-3; galectin-3; 4HNE; 4-hydroxynonenal; IFRS1; immortalized adult Fischer rat Schwann cell 1; RAGE; receptor for AGE; Bcl-2; B-cell lymphoma 2; Diabetic neuropathy;
Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo
Keywords: Dibenzocyclooctadiene lignans; Schisantherin A; Bcl-2; Neuroprotection
Buforin IIb induces endoplasmic reticulum stress-mediated apoptosis in HeLa cells
Keywords: Buforin IIb; Anticancer peptide; Apotosis; ER stress; Mitochondrial membrane permeabilization; AMP; antimicrobial peptide; ER; endoplasmic reticulum; SAPK/JNK; stress-activated protein kinase/Jun-amino-terminal kinase; p38 MAPK; p38 mitogen-activated prot
Research paperIschemic postconditioning provides cardioprotective and antiapoptotic effects against ischemia-reperfusion injury through iNOS inhibition in hyperthyroid rats
Keywords: IPost; ischemic postconditioning; IR; ischemia-reperfusion; NO; nitric oxide; iNOS; inducible NO synthase; eNOS; endothelial NO synthase; Bax; Bcl-2 Associated X protein; Bcl-2; B-cell lymphoma 2; HP; hyperthyroidism; CK; creatine kinase; LDH; lactate d
Lack of GCN5 remarkably enhances the resistance against prolonged endoplasmic reticulum stress-induced apoptosis through up-regulation of Bcl-2 gene expression
Keywords: Apoptosis; Bcl-2; ER stress; GCN5; Gene targeting; AFT4; activating transcription factor 4; AFT6; activating transcription factor 6; Bax; B-cell lymphoma-associated X; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma extra-large; CHOP; C/EBP-homologous p
Bcl-2 may play a role in the progression of endometrial hyperplasia and early carcinogenesis, but not linked to further tumorigenesis
Keywords: Bcl-2; Endometrial cancer; Simple endometrial hyperplasia; Atypical endometrial hyperplasia; Complex endometrial hyperplasia
Endothelial-monocyte-activating polypeptide II induces rat C6 glioma cell apoptosis via the mitochondrial pathway
Keywords: EMAP II; Apoptosis; Glioma; Reactive oxygen species; Bax; Bcl-2;
Pure versus combined Merkel cell carcinomas: immunohistochemical evaluation of cellular proteins (p53, Bcl-2, and c-kit) reveals significant overexpression of p53 in combined tumors
Keywords: Merkel cell carcinoma; Cutaneous neuroendocrine carcinoma; p53; Bcl-2; CD117 (c-kit); Combined Merkel cell carcinoma; Pure Merkel cell carcinoma
TGF-β/Smad2/3 signal pathway involves in U251 cell proliferation and apoptosis
Keywords: TGF-β, transforming growth factor-β; RNAi, RNA interferenceTGF-β/Smad2/3; Caspase-3; Bcl-2; Apoptosis
Copper-64-labeled anti-bcl-2 PNA-peptide conjugates selectively localize to bcl-2-positive tumors in mouse models of B-cell lymphoma
Keywords: bcl-2; Antisense imaging; Peptide nucleic acid; Micro-PET/CT
Insulinlike growth factor I improves yak (Bos grunniens) spermatozoa motility and the oocyte cleavage rate by modulating the expression of Bax and Bcl-2
Keywords: Insulinlike growth factor 1; Yak; Motility; Spermatozoon; Bax; Bcl-2;
Short communicationMolecular delineation of a caspase 10 homolog from black rockfish (Sebastes schlegelii) and its transcriptional regulation in response to pathogenic stress
Keywords: DED; death effector domain; PCR; polymerase chain reaction; qPCR; quantitative real-time PCR; BCL-2; B-cell lymphoma 2; TNF; tumor necrosis factor; IAP; inhibitor of apoptosis; N-termini; amino termini; FADD; FAS-associating death domain-containing protei
Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors
Keywords: Bcl-2; Imidazolidine-2,4-dione; Inhibitors; Antitumor
Targeted antisense radiotherapy and dose fractionation using a 177Lu-labeled anti-bcl-2 peptide nucleic acid-peptide conjugate
Keywords: Non-Hodgkin's lymphoma; bcl-2; Lutetium-177; Peptide nucleic acid; Targeted antisense radiotherapy;
Effects of mood stabilizers on oxidative stress-induced cell death signaling pathways in the brains of rats subjected to the ouabain-induced animal model of mania
Keywords: Bipolar disorder; Ouabain; Oxidative stress; P53; Bax; Bcl-2;
Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways: Involvement of P38 and ERK
Keywords: Apoptosis; Bcl-2; Death receptor; P38; ERK; Ampelopsin;
Characterization of the enhanced apoptotic response to azidothymidine by pharmacological inhibition of NF-kB
Keywords: Apoptosis; AZT; Bcl-2; Chemotherapy; NF-kB;
Deletion of prolyl hydroxylase domain proteins (PHD1, PHD3) stabilizes hypoxia inducible factor-1 alpha, promotes neovascularization, and improves perfusion in a murine model of hind-limb ischemia
Keywords: Hindlimb ischemia; Prolyl hydroxylase; HIF; VEGF; Bcl-2;
Dipeptidyl peptidase-4 inhibition in diabetic rats leads to activation of the transcription factor CREB in β-cells
Keywords: BCL-2; B-cell lymphoma 2; BIRC3; Baculoviral IAP repeat-containing protein 3; CREB; Cyclic AMP response element binding protein; DPP-4; Dipeptidyl peptidase 4; GLP-1; Glucagon-like peptide-1; IRS2; Insulin receptor substrate 2; T2DM; Type 2 diabetes melli
The Keap1-Nrf2-antioxidant response element pathway: A review of its regulation by melatonin and the proteasome
Keywords: Melatonin; Proteasome; Keap1; NF-κB; Bcl-2; Bax;
Lithium chloride administration prevents spatial learning and memory impairment in repeated cerebral ischemia-reperfusion mice by depressing apoptosis and increasing BDNF expression in hippocampus
Keywords: Repeated cerebral ischemia-reperfusion; Lithium chloride; Learning; Memory; Bcl-2; Bax; BDNF; p-CREB
Bcl-2 predicts response to neoadjuvant chemotherapy and is overexpressed in lymph node metastases of urothelial cancer of the bladder
Keywords: Bladder cancer; Neoadjuvant chemotherapy; Response prediction; Bcl-2;
Alpha2beta1 integrin promotes T cell survival and migration through the concomitant activation of ERK/Mcl-1 and p38 MAPK pathways
Keywords: T-ALL; T-cell acute lymphoblastic leukemia; ECM; Extracellular matrix; BMSCs; Bone marrow stromal cells; BSA; Bovine serum albumin; Collagen type I; Collagen; PLL; Poly-l-Lysine; Mcl-1; Myeloid cell leukemia 1; Bcl-2; B-cell lymphoma-2; Bcl-xL; B-cell lym
AML sensitivity to YM155 is modulated through AKT and Mcl-1
Keywords: YM155; Akt; XIAP; Bcl-2; Mcl-1; AML;
Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors
Keywords: Apoptosis; Bcl-2; Mcl-1; Pyrrolidine; Anti-tumor;
Lewis y enhances CAM-DR in ovarian cancer cells by activating the FAK signaling pathway and upregulating Bcl-2/Bcl-XL expression
Keywords: Lewis y; CAM-DR; Integrin α5β1; FAK signaling pathway; Bcl-2; ECM; extracellular matrix; CAM-DR; cell adhesion-mediated drug resistance; FN; fibronectin; FAK; focal adhesion kinase; PI3K; phosphatidyl inositol 3-kinase; Akt; protein kinase B; ERK; extra
Cyclin C interacts with steroid receptor coactivator 2 and upregulates cell cycle genes in MCF-7 cells
Keywords: 6His; hexahistidine tag; aa; amino acids; Bcl-2; apoptosis regulator B-cell CLL/lymphoma 2; cAMP; cyclic adenosine monophosphate; CCNC; cyclin C; CCPG1; cell cycle progression protein 1; CDK6; cyclin-dependent kinase 6; cDNA; coding DNA; CXCR4; chemokine
The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function
Keywords: BRCA1; breast cancer regulatory protein-1; BARD1; BRCA1-associated RING domain 1; CMX-Ros; chloromethyl-X-rosamine; FCS; fetal calf serum; mtHSP70; mitochondrial heat shock protein 70; NES; nuclear export sequence(s); NLS; nuclear localization sequence; O
The anti-tumour activity of rLj-RGD4, an RGD toxin protein from Lampetra japonica, on human laryngeal squamous carcinoma Hep-2 cells in nude mice
Keywords: rLj-RGD4; Laryngeal squamous carcinoma; Anti-tumour; Hep-2; Nude mice; RGD; Arg-Gly-Asp; rLj-RGD4; recombinant Lampetra japonica (Arg-Gly-Asp) 4; TUNEL; terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labelling; MVD; intratumoural micr
Small molecule Mcl-1 inhibitors for the treatment of cancer
Keywords: Mcl-1; Myeloid cell leukemia-1; Inhibitors; Small molecule; BH3-mimetic; Bad; Bcl-2-associated death promoter; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2 associated X; Bcl-2; B-cell lymphoma-2; BH; Bcl-2 homology; BH3; Bcl-2 homology domain 3; Bc
Changes in microRNAs associated with Twist-1 and Bcl-2 overexpression identify signaling pathways
Keywords: miRNAs; Twist-1; Bcl-2; EMT; VM
Some new indole–coumarin hybrids; Synthesis, anticancer and Bcl-2 docking studies
Keywords: Apoptosis; Cytotoxicity; Indole–coumarin; Bcl-2
Expression of c-erb-B2 gene in bladder cancer of Egyptian patients and its correlation with p53 and bcl-2
Keywords: Bladder cancer; c-erb-B2 gene; p53; bcl-2
Hypoxia induced epithelial–mesenchymal transition and vasculogenic mimicry formation by promoting Bcl-2/Twist1 cooperation
Keywords: Hypoxia; Bcl-2; Twist1; Epithelial–mesenchymal transition; Vasculogenic mimicry
BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma
Keywords: Salivary gland cancer; Resistance to therapy; Targeted therapy; Bcl-2; Bcl-xL; Apoptosis; Tumor recurrence
Mori Fructus improves cognitive and neuronal dysfunction induced by beta-amyloid toxicity through the GSK-3β pathway in vitro and in vivo
Keywords: AD; Alzheimer׳s disease; Aβ; amyloid-beta; ABC; avidin-biotin peroxidase complex; Bcl-2; B-cell lymphoma 2; Bax; Bcl-2-associated X; DAB; 3,3-diaminobenzidine; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; GSK-3β; glycogen syntha
Diagnostic significance of cell kinetic parameters in World Health Organization type A and B3 thymomas and thymic carcinomas
Keywords: Bcl-2; Ki-67 labeling index; Mitoses; Thymoma; Thymic carcinoma;
Cyclophilin D and myocardial ischemia-reperfusion injury: A fresh perspective
Keywords: ANT; adenine nucleotide translocator; ATP; adenosine triphosphate; ATP5G; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9); BAK; BCL2-antagonist/killer; BAX; BCL2-associated X protein; BCL-2; B cell lymphoma protein 2; C1QBP
Ginsenoside Rg3 antagonizes adriamycin-induced cardiotoxicity by improving endothelial dysfunction from oxidative stress via upregulating the Nrf2-ARE pathway through the activation of akt
Keywords: Ginsenoside Rg3; Adriamycin; Cardiotoxicity; Oxidative stress; Nrf2; Aortic ring; ADM; adriamycin; AKT; protein kinase B; Bax; Bcl-2 associated X protein; Bcl-2; B cell lymphoma-2; CMEC; cardiac microvascular endothelial cells; eNOS; endothelial nitric ox
Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway
Keywords: ATG4d; autophagy-related gene 4d; ATG6; autophagy-related gene 6; ATG12; autophagy-related gene 12; BAX; BCL-2 Associated X Protein; BCL-2; B-cell lymphoma-2; BW; body weight; Bet; piglets born to sows supplemented with betaine diets; CCND2; cyclin D2; Co
BHRF1 exerts an antiapoptotic effect and cell cycle arrest via Bcl-2 in murine hybridomas
Keywords: Hybridoma; BHRF1; Bcl-2; Apoptosis; HA14-1; YC-137;
Baicalin inhibiting cerebral ischemia/hypoxia-induced neuronal apoptosis via MRTF-A-mediated transactivity
Keywords: Baicalin; MRTF-A; Neuronal apoptosis; MCL-1; BCL-2; PI3K; ERK1/2
PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer
Keywords: A1AR; adenosine A1 receptor; ABC transporters; ATP-binding cassette; ABCB1/P-gp/MDR1; P-glycoprotein; ABCG2/BCRP; breast cancer resistant protein; Ang-1; angiopoietin 1; ASCs; Adipose stem cells; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma extra-lar
Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells
Keywords: Bcl-2; IAP; DNA damage; Genotoxic; Late effects; Second malignant neoplasms
BH3-only protein Bim is associated with the degree of Helicobacter pylori-induced gastritis and is localized to the mitochondria of inflammatory cells in the gastric mucosa
Keywords: BH3-only protein; Bim; Bcl-2; Bax; Apoptosis; Gastritis; Mitochondria; Helicobacter pyloriH. pylori, Helicobacter pylori; Bax, Bcl-2-associated X protein; Bak, Bcl-2 antagonistic killer; Bcl-2, B-cell lymphoma 2; Bcl-xL, B-cell lymphoma-extra large; Mcl-1
Marine steroids as potential anticancer drug candidates: In silico investigation in search of inhibitors of Bcl-2 and CDK-4/Cyclin D1
Keywords: Echinoderms; Marine steroids; Anticancer drug candidate; Bcl-2; CDK-4/Cyclin D1; Docking;
Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy
Keywords: LRRK2 G2019S; Bcl-2; Phosphorylation; Mitochondrial depolarization; Mitophagy
BCL-2 family protein, BAD is down-regulated in breast cancer and inhibits cell invasion
Keywords: AIF; apoptosis inducible factor; AP-1; activator protein-1; AKT; protein kinase B; Apaf-1; apoptosis protease activating factor-1; BAD; Bcl-2-associated death promoter; BCL-2; B-cell lymphoma 2; BCLxL; B-cell lymphoma-extra large; BH3; Bcl-2 homology doma
Collateral sensitivity to cold stress and differential BCL-2 family expression in new daunomycin-resistant lymphoblastoid cell lines
Keywords: Human lymphoblastic IM-9 cells; MDR; P-glycoprotein; Collateral sensitivity; Caspases; Bcl-2;