The small-molecule IAP antagonist AT406 inhibits pancreatic cancer cells in vitro and in vivo
Keywords: Pancreatic cancer; IAPs; AT406; Bcl-2; Apoptosis;
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The role of the NADPH oxidase derived brain oxidative stress in the cocaine-related death associated with excited delirium: A literature review
Keywords: ExDS; Excited delirium syndrome; NADPH; Nicotinamide adenine dinucleotide phosphate; ROS; Reactive Oxygen Species; GABA; Gamma-AminoButyric Acid; HSP; Heat Shock Protein; 17-DMAG; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin; NF-kB; Nuclear factor
Comparison of apoptosis between adult worms of Schistosoma japonicum from susceptible (BALB/c mice) and less-susceptible (Wistar rats) hosts
Keywords: S. japonicum; Schistosoma japonicum; TEM; transmission electron microscopy; TUNEL; fluorometric terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling; FCM; flow cytometry; RT-PCR; real-time polymerase chain reaction; PZQ; praziquantel; PBS
Research articleInfluences of CCK-8 on expressions of apoptosis-related genes in prefrontal cortex neurons of morphine-relapse rats
Keywords: ANOVA; one way analysis of variance; MOR; morphine; NS; normal saline; CPP; conditioned place preference; Cholecystokinin-8; Morphine; Bax; Bcl-2; Caspase-3; Morphine relapse;
Selection and antitumor activity of anti-Bcl-2 DNAzymes
Keywords: DNAzyme; Bcl-2; Apoptosis; Chemoresistance;
Synthesis and mechanistic aspects of 2-anilinonicotinyl-pyrazolo[1,5-a]pyrimidine conjugates that regulate cell proliferation in MCF-7 cells via estrogen signaling
Keywords: Estrogen receptors; Cell cycle; Cyclin D1; Bcl-2; Pyrazolopyrimidine;
Inhibition of Bcl-2 potentiates AZD-2014-induced anti-head and neck squamous cell carcinoma cell activity
Keywords: Head and neck squamous cell carcinoma (HNSCC); mTOR; AZD-2014; Bcl-2; ABT-737;
MiR-15a/16 regulates the growth of myeloma cells, angiogenesis and antitumor immunity by inhibiting Bcl-2, VEGF-A and IL-17 expression in multiple myeloma
Keywords: miR-15a/16; Bcl-2; VEGF-A; IL-17; Multiple myeloma
Improved contractile force generation of tissue-engineered skeletal muscle constructs by IGF-I and Bcl-2 gene transfer with electrical pulse stimulation
Keywords: Skeletal muscle tissue engineering; IGF-I; Bcl-2; Gene transfer; Electrical pulse stimulation culture; EPS; electrical pulse stimulation; Mag-TE; magnetic force-based tissue engineering; MCL; magnetite cationic liposome;
Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt's lymphoma
Keywords: Q; quercetin; BL; Burkitt's lymphoma; BCR; B cell receptor; GC; Germinal Center; EBV; Epstein-Barr virus; PI3K; phosphatidylinositol-3-kinase; AKT; AKT or protein kinase B; mTOR; mammalian target of rapamycin; BEZ235; NVP-BEZ235; I-c-Myc; c-Myc inhibi
Phenylboronic acid-functionalized polyamidoamine-mediated Bcl-2 siRNA delivery for inhibiting the cell proliferation
Keywords: Phenylboronic acid; Polyamidoamine; Bcl-2; siRNA delivery; Multidrug resistance; Cell proliferation;
Characterization of the membrane-inserted C-terminus of cytoprotective BCL-XL
Keywords: BCL-2; Apoptosis; Membrane; Nanodisc; Structure; NMR16-DSA, 16-doxyl-stearic acid; BH, BCL-2 homology; DMPC, dimyristoyl-phosphatidyl-choline; DMPG, dimyristoyl-phosphatidyl-glycerol; MALDI, Matrix Assisted Laser Desorption/Ionization; MOM, mitochondrial
Radiation-resistant B-1 cells: A possible initiating cells of neoplastic transformation
Keywords: B-1 Cells; Irradiation; Malignant cells; Leukemia; Bcl-2
MicroRNA-143 promotes apoptosis of osteosarcoma cells by caspase-3 activation via targeting Bcl-2
Keywords: Osteosarcoma; MiR-; 143; Bcl-2; Apoptosis
Inhibition of BCL-2 leads to increased apoptosis and delayed neuronal differentiation in human ReNcell VM cells in vitro
Keywords: Apoptosis; BCL-2; HA14-1; Human neural progenitor cells; Neuronal differentiation
MicroRNA-744 inhibited cervical cancer growth and progression through apoptosis induction by regulating Bcl-2
Keywords: Cervical cancer; miR-744; Bcl-2; Caspase-3; Apoptosis
miR-34a and bcl-2 expression in whitefish (Coregonus lavaretus) after microcystin-LR exposure
Keywords: bax; bcl-2; Fish; miR-34a; Reporter analysis;
Gamma-tocotrienol acts as a BH3 mimetic to induce apoptosis in neuroblastoma SH-SY5Y cells ★
Keywords: Gamma-tocotrienol; BH3 mimetic; Neuroblastoma; Bcl-2; Apoptosis; Vitamin E
Resveratrol improves the anticancer effects of doxorubicin in vitro and in vivo models: A mechanistic insight
Keywords: Breast cancer; Resveratrol; Cell signaling; Doxorubicin; Cytotoxicity; Ehrlich ascitic carcinoma; BCL-2; (B-cell lymphoma-2); COX-2; cyclooxygenase-2; DCFDA; 2',7'-dichlorofluorescin diacetate; DOX; doxorubicin; EAC; Ehrlich ascites carcinoma; IC50; h
GAPDH/Siah1 cascade is involved in traumatic spinal cord injury and could be attenuated by sivelestat sodium
Keywords: Bax; Bcl-2-associated X protein; BBB scores; Basso-Beattie-Bresnahan scores; Bcl-2; B-cell lymphoma 2; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HE; hematoxylin and eosin staining; IL-1β; interleukin-1 beta; iNOS; inducible nitric oxide syntha
Spatiotemporal distribution of proliferation, proapoptotic and antiapoptotic factors in the early human limb development
Keywords: Human limb development; Proliferation; Apoptosis; BAX; Bcl-2; AIF
Mosla scabra flavonoids ameliorate the influenza A virus-induced lung injury and water transport abnormality via the inhibition of PRR and AQP signaling pathways in mice
Keywords: MF; total flavonoids extracted from Mosla Scabra; IAV; influenza A virus; LD50; 50% lethal dose; RFQ-PCR; Real-time Fluorescence Quantitative Polymerase Chain Reaction; IC50; 50% influenza virus-inhibitory concentration; HDF-1; 5-hydroxy-6,7-dimethoxyflav
Histone demethylase Jmjd3 regulates osteoblast apoptosis through targeting anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bim
Keywords: Jmjd3; Osteoblast apoptosis; Bcl-2; Bim; Protein kinase D1; Histone demethylation;
Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: A snapshot of IL-6 mediated involvement
Keywords: Cytokine; IL-6; Cancer stem cell; Chemoresistance and EMT; MAPK; mitogen-activated protein kinases; STAT3; signal transducer and activator of transcription 3; gp130; glycoprotein 130; C/EBP; CCAAT/enhancer-binding protein; JAK; Janus kinase; PI3K; phospho
The inhibition of PI3K and NFκB promoted curcumin-induced cell cycle arrest at G2/M via altering polyamine metabolism in Bcl-2 overexpressing MCF-7 breast cancer cells
Keywords: Curcumin; Cell cycle; Bcl-2; NFκB
Chikusetsusaponin IVa methyl ester induces G1 cell cycle arrest, triggers apoptosis and inhibits migration and invasion in ovarian cancer cells
Keywords: Panacis Japonici Rhizoma; Chikusetsusaponin IVa methyl ester; Ovarian cancer; Cell cycle arrest; Apoptosis; Metastasis; Bcl-2; B-cell lymphoma 2; CC; column chromatography; CDK; cyclin-dependent kinase; DMEM; Dulbecco's modified Eagle's medium; DMSO; dime
Genistein alleviates lead-induced neurotoxicity in vitro and in vivo: Involvement of multiple signaling pathways
Keywords: Akt; protein kinase B; BLL; blood lead level; Bax; Bcl-2-associated X protein; Bcl-2; B-cell leukemia/lymphoma-2; CAT; catalase; GEN; genistein; ERK; extracellular signal-regulated kinases; GCI; global cerebral ischemia; Pb; lead; MAPK; mitogen-activated
Astemizole-Histamine induces Beclin-1-independent autophagy by targeting p53-dependent crosstalk between autophagy and apoptosis
Keywords: AST; Astemizole; HIS; Histamine; H1R; Histamine H1 receptor; ROS; Reactive oxygen species; ER; Endoplasmic reticulum; PERK; Protein kinase R-like endoplasmic reticulum kinase; IRE1α; Inositol-requiring enzyme 1; ATF; Activating transcription factor; JNK;
Expression of Bcl-2 genes in channel catfish after bacterial infection and hypoxia stress
Keywords: Bcl-2; Genome; Expression; Disease; Hypoxia; Fish
Characterization of Ambra1 in asexual cycle of a non-vertebrate chordate, the colonial tunicate Botryllus schlosseri, and phylogenetic analysis of the protein group in Bilateria
Keywords: AMBRA1; autophagy/beclin 1 regulator 1; ATG; autophagy-related proteins; Bcl-2; B-cell lymphoma 2; BECN1; Beclin 1, autophagy-related; Bif-1; bax-interacting factor-1; BLAST; Basic Local Alignment Search Tool; BLAT; BLAST Like Alignment Tool; cDNA; comple
Indian gooseberry (Emblica officinalis Gaertn.) suppresses cell proliferation and induces apoptosis in human colon cancer stem cells independent of p53 status via suppression of c-Myc and cyclin D1
Keywords: Colon cancer; Cancer stem cells; Amla (Emblica officinalis Gaertn.) seed and pulp; Proliferation; Apoptosis; Wnt/β-catenin signalling; Trigonelline (PubChem CID: 5570); Naringin (PubChem CID: 442428); Kaempferol (PubChem CID: 5280863); Catechin (PubChem
ReviewAutophagy as a target for hematological malignancy therapy
Keywords: Autophagy; Hematological malignancy; PI3K; AMPK; Bcl-2; MicroRNA;
Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development
Keywords: Nrf2; LXRα/β; Lipid metabolism; Oxidative stress; Bcl-2
MicroRNA: A new therapeutic strategy for cardiovascular diseases
Keywords: MicroRNAs; Endothelial cells; Cardiac fibrosis; Atherosclerosis; Myocardial infarction; Stroke; Hypertension; ATH; atherosclerosis; ALDH2; aldehyde dehydrogenase 2; BMP; bone morphogenetic protein; Bcl-2; B-cell lymphoma; CAD; coronary artery diseases; CD
Synthesis and antiproliferative evaluation of novel 2-(4H-1,2,4-triazole-3-ylthio)acetamide derivatives as inducers of apoptosis in cancer cells
Keywords: 1,2,4-Triazoles; Thioethers; Anticancer activity; Apoptosis; Caspase-3; Caspase-8; Bcl-2;
Discovery of new selective cytotoxic agents against Bcl-2 expressing cancer cells using ligand-based modeling
Keywords: Bcl-2; Pharmacophore; QSAR; MLR; kNN; Virtual screening; Anticancer screening
Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17α-ethinylestradiol and fadrozole exposures
Keywords: Xenoestrogen; Aromatase inhibitor; qRT-PCR; Immunohistochemistry; BCL-2; CASP-6; BIRC5;
Breaking BAG: The Co-Chaperone BAG3 in Health and Disease
Keywords: Bcl-2; Hsc/Hsp70; protein quality control; BAG1–BAG3 switch; proteasome; macroautophagy
BCL-2 family proteins as regulators of mitochondria metabolism
Keywords: Mitochondria metabolism; Stem cells; Apoptosis; BCL-2; BID; MTCH2;
Effect of memantine: A NMDA receptor blocker, on ethambutol-induced retinal injury
Keywords: Neural retina; Memantine; NMDA receptors; Ethambutol; GFAP; Bcl-2;
Effect of the pituitary adenylate cyclase-activating polypeptide on the autophagic activation observed in in vitro and in vivo models of Parkinson's disease
Keywords: Akt; protein kinase B; Bcl-2; B-cell lymphoma 2 anti-apoptotic protein; DA; dopaminergic; DAPI; 2-(4-amidinophenyl)-1Â H-indole-6-carboxamidine hydrochloride; FBS; fetal bovine serum; GFP; green fluorescent protein; JNK; c-Jun. N-terminal kinase; LC3 I an
Potent effects of dioscin against gastric cancer in vitro and in vivo
Keywords: Apoptosis; Cell migration; Dioscin; Gastric cancers; Proteomics; iTRAQ; isobaric tags for relative and absolute quantitation; MTT; 3-(4, 5-dimethylthiazol-2-yl) -2,5-diphenyl tetrazolium bromide; AO; acridine orange; EB; ethidium bromide; DAPI; 4,6-diamid
Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells
Keywords: Head and neck cancer; Dihydroartemisinin; Ferroptosis; Antitumor; Cell cycle; ART; artemisinin; BAX; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; CDC2; cell division cycle protein 2 (also known as cyclin-dependent kinase 1); DFO; deferoxamine; DH
DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress
Keywords: Apaf1; apoptotic protease activating factor-1; Bcl-2; B cell lymphoma 2; DKO; Bax Bak double knockout; Drp1; Dynamin Related Protein 1; ER; endoplasmic reticulum; IMM; inner mitochondrial membrane; MEFs; mouse embryonic fibroblasts; MFN; mitofusin; MOMP;
Oxidative stress plays major role in mediating apoptosis in filarial nematode Setaria cervi in the presence of trans-stilbene derivatives
Keywords: Apaf; apoptotic protease activating factor; BCl-2; B-cell lymphoma 2; CED; cell-death abnormal; CM; culture media; DEC; diethyl-carbamazine citrate; DMSO; dimethyl sulfoxide; EGL; egg laying defective; EtBr; ethidium bromide; FBS; fetal bovine serum; GAPD
An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy
Keywords: AA; Ascorbic acid; AEM1; ARE expression modulator 1; AEG1; Astrocyte elevated gene-1; Akt; Protein kinase B; AMPK; AMP-activated protein kinase; APL; Acute promyelocytic leukemia; ARE; Antioxidant response element; ATO; Arsenic trioxide; Bach; BTB and CNC
The genus Boschniakia in China: An ethnopharmacological and phytochemical review
Keywords: 5-FU; 5-Fluorouracil; β-AP; β-amiloid peptide; AD; Alzheimer disease; ALT; Alanine aminotransferase; ASC; antidepressants sensitive catalepsy; AST; Aspartate Transaminase; BC; human breast cancer; Bcl-2; B-cell lymphoma-2; bFGF; Basic fibroblast growth
ROS/oxidative stress signaling in osteoarthritis
Keywords: ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; ATF/CRE; activating transcription factor/cyclic AMP-response element; ATF-2; activating transcription factor 2; Bach 1; broad complex-tramtrack-bric-a-brac (BTB) and cap'n'collar (CNC
Bcl-2 associated with severity of manic symptoms in bipolar patients in a manic phase
Keywords: Bcl-2; Bipolar; Mania; YMRS;
Erythropoietin activates the phosporylated cAMP [adenosine 3â²5â² cyclic monophosphate] response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury
Keywords: 19; 38; AKT; serine/threonine-specific kinase; BCL-2; B-cell lymphoma 2; BDNF; brain-derived neurotrophic factor; CREB; cAMP [adenosine 3â²5â² cyclic monophosphate] response element-binding protein; EPO; erythropoietin; pAKT; phosphorylated AKT; pCREB;