کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5854780 | 1562041 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genistein alleviates lead-induced neurotoxicity in vitro and in vivo: Involvement of multiple signaling pathways
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کلمات کلیدی
NACnuclear factor erythroid 2 p45-related factor 2N-acetyl-l-cysteineBLLERKBcl-2Nrf2CATGCINF-κBMAPK - MAPKMAPKs - MAPK هاROS - ROSAkt - آکتGlobal cerebral ischemia - ایسکمی مغز جهانیBax - باکسOxidative stress - تنش اکسیداتیوApoptosis - خزان یاختهایSOD - سدLead - سربBlood lead level - سطح سرب خونSuperoxide dismutase - سوکسوکس دیسموتازNuclear factor-kappa B - فاکتور هسته ای-کاپا BGenistein - ماده جنستئینBcl-2-associated X protein - پروتئین X مرتبط با Bcl-2protein kinase B - پروتئین کیناز Bprotein kinase C alpha - پروتئین کیناز C آلفاmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenGEN - ژنرالCatalase - کاتالازextracellular signal-regulated kinases - کیناز های تنظیم شده سیگنال خارج سلولیReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
Lead (Pb) is a ubiquitous environmental and industrial pollutant. It induces neurotoxicity and cell death by disrupting the pro- and anti-oxidative balance; however, the mechanisms of its toxicity have yet to be fully understood. The soy-derived isoflavonoid, genistein (GEN), was reported to possess neuroprotective and antioxidative properties. The present study investigated the molecular mechanisms of Pb-induced neurotoxicity in vivo and in vitro, addressing the efficacy of GEN in protecting against Pb-induced toxicity. Pb exposure was associated with reduction of cell viability and cell apoptosis, concomitant with reactive oxygen species (ROS) generation in vitro, and pre-treatment with GEN markedly ameliorated the Pb-induced oxidative injury by increasing the expression of key antioxidant enzymes and the antioxidant transcription factor, nuclear factor erythroid 2 p45-related factor 2 (Nrf2). Next, PKC-α activation was found after Pb exposure in vitro and pretreatment with GEN attenuated Pb-induced ROS generation by PKC-α inhibition. MAPK-NF-κB activation triggered by Pb was also inhibited by GEN. In summary, our study establishes that GEN alleviates Pb-induced impairment in spatial memory, and reduces cell apoptosis caused by Pb exposure and GEN protects neurons from Pb-induced neurotoxicity by downstream activation of antioxidant and anti-apoptotic pathways via regulation of Nrf2 and MAPK-NF-κB signaling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 53, March 2016, Pages 153-164
Journal: NeuroToxicology - Volume 53, March 2016, Pages 153-164
نویسندگان
Peng Su, Jianbin Zhang, Siwang Wang, Michael Aschner, Zipeng Cao, Fang Zhao, Diya Wang, Jiangyuan Chen, Wenjing Luo,