کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5859719 1562615 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of the NADPH oxidase derived brain oxidative stress in the cocaine-related death associated with excited delirium: A literature review
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
The role of the NADPH oxidase derived brain oxidative stress in the cocaine-related death associated with excited delirium: A literature review
چکیده انگلیسی
Excited delirium syndrome (ExDS) is a term used to describe a clinical condition characterized by bizarre and aggressive behaviour, commonly associated with the use of psychoactive compounds, especially cocaine. The pathophysiology of ExDS is complex and not yet fully understood. In addition to a central dopamine hypothesis, other mechanisms are thought to be involved in cocaine-related ExDS, such as increased reactive oxygen species production by the family of the NADPH oxidase NOX enzymes. In this review, we will summarize current knowledge on the crucial contribution of brain NADPH oxidase derived oxidative stress in the development of cocaine-induced ExDS. Data from animal models as well as human evidence will be discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 258, 6 September 2016, Pages 29-35
نویسندگان
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