کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7623183 | 1494541 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Indian gooseberry (Emblica officinalis Gaertn.) suppresses cell proliferation and induces apoptosis in human colon cancer stem cells independent of p53 status via suppression of c-Myc and cyclin D1
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کلمات کلیدی
WntWnt/β-catenin signallingColchicine (PubChem CID: 6167)Catechin (PubChem CID: 73160)Naringenin (PubChem CID: 932)Naringin (PubChem CID: 442428)Kaempferol (PubChem CID: 5280863)Quercetin (PubChem CID: 5280343)PARPBcl-2Bax - باکسBrdU - بروموداکسی اوریدینbromodeoxyuridine - برومودسوویریدینProliferation - ترویجApoptosis - خزان یاختهایColon cancer - سرطان کولونCancer stem cells - سلولهای بنیادی سرطانی5-fluorouracil - فلوروراسیل-۵، فلوئورواوراسیلBcl-2 Associated X protein - پروتئین Bcl-2 Associated Xpoly ADP ribose polymerase - پلی ADA ریبوز پلی مراز
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Indian gooseberry, also known as amla, a widely consumed fruit in South Asia, was evaluated for its anti-proliferative and pro-apoptotic mechanisms on human colon cancer stem cells (HCCSC). Amla extracts suppressed proliferation and induced apoptosis independent of p53, a tumour suppressor gene, in HCCSCs. Further, amla extracts suppressed cell proliferation by targeting the Wnt/β-catenin signalling pathway as seen by decreased nuclear translocation of β-catenin. Additionally, this led to suppressed expression of c-Myc and cyclin D1, key proteins involved in cell proliferation. Inhibition of stem-ness of HCCSCs by amla may be due to its effect on the Wnt/β-catenin signalling. These results indicate that amla suppresses HCCSC proliferation and induces apoptosis independent of p53 status via potentially targeting Wnt/β-catenin signalling pathway. Amla is therefore a promising functional food for preventing colon cancer and might be a novel resource for the food industry.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 25, August 2016, Pages 267-278
Journal: Journal of Functional Foods - Volume 25, August 2016, Pages 267-278
نویسندگان
Ramakrishna Vadde, Sridhar Radhakrishnan, Hewage Eranda Karunathilake Kurundu, Lavanya Reddivari, Jairam K.P. Vanamala,