Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2â²,3â²:3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 synthase-1 (mPGE
Keywords: بنزیمیدازول; Rheumatoid arthritis; Benzimidazole; mPGES-1 inhibitor; PGE2; CSF concentration; Scaffold hopping;