Keywords: Anxiety; Depression; Palatability; Appetite; Cannabinoid; CB1; Tetrahydrocannabivarin; Cannabidiol; Cannabigerol; Rimonabant; Delta-9-tetrahydrocannabinol;
مقالات ISI (ترجمه نشده)
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Keywords: CB1; CB2; Endocannabinoid system; Fatty liver disease; Fibrosis; Steatosis; Liver regeneration; Kupffer cells; Inflammation.;
Keywords: Maternal deprivation; Endocannabinoids; Morphine consumption; Selective CB1 antagonist/inverse agonist; SR141716A; Rat; AEA; N-arachidonoylethanolamine; AFR; animal facility rearing; AM404; inhibitor of endocannabinoid membrane transporter; CB1; cannabino
Keywords: Alzheimer's disease; Endocannbinoid system; CB1; APP processing; APP23; Learning and memory;
Keywords: 5-HT; 5-Hydroxytryptamine or serotonin; AA-5-HT; N-arachidonoyl-serotonin; ACEA; arachidonoyl 2â²-chloroethylamide; AEA; N-arachidonoylethanolamine; 2-AG; 2-arachidonoylglycerol; AM251; N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-
Keywords: ANOVA; analysis of variance; AR; androgen receptor; CB1; cannabinoid receptor type 1; ChIP; chromatin immunoprecipitation; Cnr1; cannabinoid receptor 1; ER; estrogen receptor; EDTA; ethylenediaminetetraacetic acid; IL-1β; interleukin-1 beta; IL-1R; inter
Keywords: Cannabinoid; Anandamide; Vasorelaxation; Human; Mesenteric artery; CB1; Endothelium; Obesity; Paracetamol;
Keywords: CB1; D2 receptor; Globus pallidus; DSI;
Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants
Keywords: CYP450; CYP2C9 variants; Synthetic cannabinoids; Enzyme kinetics; Toxicity; Î9-THC; (â)-Î9-Tetrahydrocannabinol; P450; cytochrome P450; CYP; specific P450; UGTs; uridine diphosphate (UDP)-glucuronosyltransferases; LC-MS/MS; Liquid chromatography-tande
Enantiomer-specific positive allosteric modulation of CB1 signaling in autaptic hippocampal neurons
Keywords: DSE; depolarization-induced suppression of excitation; 2-AG; 2-arachidonoyl glycerol; NAM; negative allosteric modulator; PAM; positive allosteric modulator; EPSC; excitatory postsynaptic current; Allosteric; Orthosteric; G protein-coupled receptor; Canna
Oximes short-acting CB1 receptor agonists
Keywords: CB1; CB2; cannabinoid receptors; GPCR; Î9-THC; (-)-Î9-Tetrahydrocannabinol; Î8-THC; Î8-THC-DMH; Arachidonoylethanolamine (AEA); 2-Arachidonoylglycerol (2-AG); Analgesia; Anorexia Nervosa (AN);
Synthetic cannabinoid BB-22 (QUCHIC): Human hepatocytes metabolism with liquid chromatography-high resolution mass spectrometry detection
Keywords: SC; synthetic cannabinoid; CB1; central cannabinoid receptors; CB2; peripheral cannabinoid receptors; HRMS; high resolution mass spectrometry; FullMS; full-scan mass spectrometry; ddMS2; data-dependent tandem mass spectrometry; AGC; automatic gain control
Cannabinoids induce apathetic and impulsive patterns of choice through CB1 receptors and TRPV1 channels
Keywords: Decision making; Vanilloid; Cannabinoid; CB1; TRPV1; Anterior cingulate cortex; Orbitofrontal cortex;
Scp-2/Scp-x ablation in Fabp1 null mice differentially impacts hepatic endocannabinoid level depending on dietary fat
Keywords: Mouse; Liver; FABP1; Gene ablation; Endocannabinoid; High fat diet; AEA; n-6 arachidonoylethanolamide (anandamide); 2-AG; 2-arachidonoyl glycerol; ARA; arachidonic acid; CB1; cannabinoid receptor-1; DAGLα; diacylglycerol lipase A; DHA; n-3 docosahexaenoi
FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats
Keywords: AEA; anandamide; ADT; acetone drop test; CB1; cannabinoid receptor 1; CB2; cannabinoid receptor 2; CD11b; cluster of differentiation molecule; 11b; CD68, cluster of differentiation 68; CNS; central nervous system; COX-2; cyclooxygenase 2; EPM; elevated pl
Redox system and phospholipid metabolism in the kidney of hypertensive rats after FAAH inhibitor URB597 administration
Keywords: 2-AG; 2-arachidonoylglycerol; 4-HNE; 4-hydroxynonenal; 8-isoPGF2α; F2 -isoprostanes; 8-OHdG; 8-hydroxy-2'-deoxyguanosine; AA; arachidonic acid; AEA; N-arachidonoylethanolamine, anandamide; AM3506; 5-(4-hydroxyphenyl) pentanesulfonyl fluoride; Bach1; ba
Sex-specific effects of CB1 receptor antagonism and stress in adolescence on anxiety, corticosterone concentrations, and contextual fear in adulthood in rats
Keywords: CB1; cannabinoid receptor type-1; PFC; prefrontal cortex; DH; dorsal hippocampus; PND; postnatal day; AM251; 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide; CORT; corticosterone; GAD67; glutamic acid decarboxyla
Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists
Keywords: BBB; Blood-Brain Barrier; CB1; Cannabinoid Receptor 1; CB2; Cannabinoid Receptor 2; CHO-K1; Chinese Hamster Ovary Cells; CNS; Central Nervous System; EtOH; ethanol; EtOAc; ethyl acetate; Ke; apparent affinity constant, MDCK-mdr1, Madin-Darby canine kidney
Assessing the real-time activation of the cannabinoid CB1 receptor and the associated structural changes using a FRET biosensor
Keywords: CB1; cannabinoid type 1 receptor; FRET; fluorescence resonance energy transfer; GPCRs; G protein-coupled receptors; HD; Huntington's disease; TM; transmembrane; G-proteins; GTP binding-proteins; cAMP; cyclic adenosine monophosphate; ERK1/2; extracellula
Antinociceptive effects of the endogenous cannabinoid peptide agonist VD-hemopressin(β) in mice
Keywords: ANOVA; analysis of variance; AM251; N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3- carboxamide; AM630; 6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3- yl(4-methoxyphenyl)-methanone; AUC; area under the curve; CB1
Pharmacological inhibition of 2-arachidonoilglycerol hydrolysis enhances memory consolidation in rats through CB2 receptor activation and mTOR signaling modulation
Keywords: JZL184; Rat; Monoacylglycerol lipase (MAGL); Inhibitory avoidance; Fear memory; Behavior; JZL184 [4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester]; MAGL inhibitor; SR141716 [5-(4-chlorophenyl)-1-(2,4-dichlorophen
CB1 cannabinoid receptor agonist mouse VD-hemopressin(α) produced supraspinal analgesic activity in the preclinical models of pain
Keywords: AM251; N-(piperidin-1-yl-5-(4-iodophenyl-1-(2,4-dichlorophenyl-4-methyl-1H-pyrazole-3-carboxamide; AM4113; 5-(4-alkylphenyl-1-(2,4-dichlorophenyl-4-methyl-N-(piperidin-1-yl-1H-pyrazole-3-carboxamide; AM630; 6-iodo-2-methyl-1-[2-(4-morpholinylethyl]-1H-ind
Experimental ischemia/reperfusion model impairs endocannabinoid signaling and Na+/K+ ATPase expression and activity in kidney proximal tubule cells
Keywords: 2-AG; 2-arachidonoylglycerol; AEA; anandamide; AM251; N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide; CB1; cannabinoid type-1 receptor; CB2; cannabinoid type-2 receptor; DGL; diacylglycerol lipase; ECS; endoc
Age-related regulation of bone formation by the sympathetic cannabinoid CB1 receptor
Keywords: eCBs; endocannabinoids; AEA; arachidonoyl ethanolamide; 2-AG; 2-arachidonoylglycerol; CB1; cannabinoid-1; CB2; cannabinoid-2; β2AR; β2 adrenergic receptors; NE; norepinephrine; CNS; central nervous system; DBH; dopamine-β-hydroxylase; BV/TV; bone volum
Periaqueductal gray glutamatergic, cannabinoid and vanilloid receptor interplay in defensive behavior and aversive memory formation
Keywords: Olfactory fear conditioning; Aversive memory formation; NMDA receptors; CB1 receptors; TRPV1 receptors; AMPA receptors; ANOVA; analysis of variance; CB1; cannabinoid receptor 1; PAG; periaqueductal gray matter; PMd; hypothalamic premammillar nucleus, dors
Novel behavioral assays of spontaneous and precipitated THC withdrawal in mice
Keywords: 2-AG; 2-arachidonoylglycerol; CB1; Cannabinoid receptor subtype 1; CB2; Cannabinoid receptor subtype 2; FAAH; Fatty acid amide hydrolase; JZL184; 4-nitrophenyl-4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate; JWH-018; Naphthalen-1-yl-
Targeted proteomics of cannabinoid receptor CB1 and the CB1b isoform
Keywords: CB1; CB1b; Cannabinoid receptor isoforms; SRM assay;
Cannabinoid system of dorsomedial telencephalon modulates behavioral responses to noxious stimulation in the fish Leporinus macrocephalus
Keywords: Amygdala; Cannabidiol; CB1; Nociception;
Immunohistochemical localization of cannabinoid receptor 1 (CB1) in the submandibular gland of mice under normal conditions and when stimulated by isoproterenol or carbachol
Keywords: CB1; Isoproterenol; Acinar cell; Granular convoluted duct cell; Mouse submandibular gland;
Pharmacological characterization of rat VD-hemopressin(α), an α-hemoglobin-derived peptide exhibiting cannabinoid agonist-like effects in mice
Keywords: ANOVA; analysis of variance; AUC; area under the curve; CB1; cannabinoid receptor type 1; CB2; cannabinoid receptor type 2; CP55,940; (2)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol; dNPA; D.NP(N-Me)AFLFQPQRFamide;
A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia
Keywords: ECS; endocannabinoid system; MAM; methylazoxymethanol acetate; CNR1; gene coding for the type-1 cannabinoid receptor; PBMCs; human peripheral blood mononuclear cells; MDD; major depressive disorder; BD; bipolar disorder; SZ; schizophrenia; THC; tetrahydro
Chronic CB1 cannabinoid receptor antagonism persistently increases dendritic spine densities in brain regions important to zebra finch vocal learning and production in an antidepressant-sensitive manner
Keywords: CB1; cannabinoid receptor 1; CB2; cannabinoid receptor 2; SR; SR141716A; MAOI; monoamine oxidase inhibitor; HVC; used as a proper name; Area X; Area X of striatum; DLM; nucleus dorsolateralis anterior, pars medialis; IMAN; lateral magnocellular nucleus of
Synthesis and preclinical evaluation of [11C]MA-PB-1 for in vivo imaging of brain monoacylglycerol lipase (MAGL)
Keywords: MAGL; [11C]MA-PB-1; MJN110; Biodistribution; PET imaging; AA; arachidonic acid; AEA; N-arachidonoyl ethanolamine; 2-AG; 2-arachidonoyl glycerol; BBB; blood brain barrier; Bmax; enzyme expression; BBr3; boron tribromide; CB1; cannabinoid 1 receptors; CDCl3
Research paperCannabidiol (CBD) induces functional Tregs in response to low-level T cell activation
Keywords: BCS; bovine calf serum; BFA; Brefeldin A; CBD; cannabidiol; CB1; cannabinoid receptor 1; CB2; cannabinoid receptor 2; cpm; counts per minute; DW; deionized water; ELISA; enzyme linked immunosorbent assay; FOXP3; forkhead box P3; FVD; fixable viability dye
Evaluation of monoacylglycerol lipase as a therapeutic target in a transgenic mouse model of ALS
Keywords: Amyotrophic lateral sclerosis; Endocannabinoid system; KML29; 2-Arachidonoylglycerol; Cannabinoid receptor 1; Monoacylglycerol lipase; Brain-derived neurotrophic factor; 2-AG; 2-arachidonoylglycerol; AA; arachidonic acid; CB1; cannabinoid receptor type 1;
Bidirectional allosteric interactions between cannabinoid receptor 1 (CB1) and dopamine receptor 2 long (D2L) heterotetramers
Keywords: ACEA (PubChem CID: 5311006); Quinpirole (PubChem CID: 54562); CB1; D2L; BRET2; SRET2; G protein coupling; Receptor heteromerization;
Emotional disorders induced by Hemopressin and RVD-hemopressin(α) administration in rats
Keywords: CB1; cannabinoid 1; COMT; catechol O-methyltransferase; DA; dopamine; eCB; encocannabinoid; Hp; hemopressin; 5-HT; serotonin; MAO-B; monoamine oxidase-B; NE; norepinephrine; RVD-hp(α); RVD-hemopressin(α); TRPV1; Transient Receptor Potential Vanilloid Ty
Palmitoylation of cysteine 415 of CB1 receptor affects ligand-stimulated internalization and selective interaction with membrane cholesterol and caveolin 1
Keywords: β2-AR; β2-adrenergic receptor; CB1; type 1 cannabinoid receptor; CCM; cholesterol consensus motif; CRAC; cholesterol interaction/recognition amino acid sequence consensus; CT-B; cholera toxin subunit B; GPCR; G-protein-coupled receptor; H8; helix 8; MD;
Enhanced anandamide signaling reduces flight behavior elicited by an approaching robo-beetle
Keywords: Panic; Anandamide; URB597; 2-AG; JZL184; Active-fear; Robo-beetle; Inbred mice; 2-AG; 2-arachidonoylglycerol; AEA; anandamide; BMT; beetle mania task; CB1; cannabinoid receptor 1; FAAH; fatty acid amide hydrolase; HAB; high-anxiety behavior; MAGL; monoacy
Optimization of cAMP fluorescence dataset from ACTOne cannabinoid receptor 1 cell line
Keywords: ACTOne; Cannabinoids; CB1; Pharmacology; cAMP
Cannabinoid CB1 receptor inhibition blunts adolescent-typical increased binge alcohol and sucrose consumption in male C57BL/6J mice
Keywords: Adolescent; Alcohol drinking; Binge; Cannabinoid; CB1; AM-251
Research paperEnkephalin levels and the number of neuropeptide Y-containing interneurons in the hippocampus are decreased in female cannabinoid-receptor 1 knock-out mice
Keywords: BSA; bovine serum albumin; CA; cornu ammonis; CB1; cannabinoid 1 receptors; CCK; cholecystokinin; DG; dentate gyrus; DOR; delta-opioid receptor; DYN; dynorphin; GABA; gamma amino butyric acid; GCL; granule cell layer; IML; inner molecular layer; KOR; kapp
Research reportPeripheral interactions between cannabinoid and opioid receptor agonists in a model of inflammatory mechanical hyperalgesia
Keywords: DAMGO; ACPA; μ Opioid receptor; CB1; Dorsal root ganglia; Isobologram; Complete freund's adjuvant;
Dorsal hippocampal NMDA receptors mediate the interactive effects of arachidonylcyclopropylamide and MDMA/ecstasy on memory retrieval in rats
Keywords: ACPA; Arachidonylcyclopropylamide; ANOVA; Analysis of variance; CA1; cornus ammonis; CB1; Cannabinoid receptor type 1; CB2; Cannabinoid receptor type 2; CP-55,940; (â)-cis-3-[2-Hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol;
Bisphenol A induces hypothalamic down-regulation of the the cannabinoid receptor 1 and anorexigenic effects in male mice
Keywords: 2-AG; 2-arachidonoylglycerol; AT; adipose tissue; AgRP; agouti-related protein; AEA; anandamide; ARC; arcuate nucleus; ArKO; aromatase knock-out; BPA; bisphenol A; BAT; brown adipose tissues; CB1; cannabinoid receptor 1; CART; cocaine and amphetamine-regu
CXCR4 activation promotes differentiation of human embryonic stem cells to neural stem cells
Keywords: AP; alkaline phosphatase; BDNF; brain-derived neurotrophic factor; cAMP; cyclic adenosine monophosphate; CB1; cannabinoid receptor type 1; CB2; cannabinoid receptor type 2; CNS; central nervous system; CXCR4; CXC chemokine receptor type 4; CXCR7; CXC chem
Pure Î9-tetrahydrocannabivarin and a Cannabis sativa extract with high content in Î9-tetrahydrocannabivarin inhibit nitrite production in murine peritoneal macrophages
Keywords: BSA; albumin bovine serum; CB1; cannabinoid receptor type 1; CB2; cannabinoid receptor type 2; CBC; cannabichromene; CBD; cannabidiol; CBG; cannabigerol; COX-2; cyclooxygenase-2; DAN; 2,3-diaminonaphthalene; DMSO; dimethyl sulfoxide (DMSO); DTT; 1,4-dithi
Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice
Keywords: Adenylyl cyclase; cAMP; CB1; GLP-1; Incretin; Insulin secretionAC, Adenylyl cyclase; ACEA, arachidonoyl 2′-chloroethylamide; AEA, anandamide; 2-AG, 2-arachidonoylglycerol; EC, endocannabinoid; GIP, glucose-dependent insulinotropic peptide; GLP-1, glucagon
Acute and chronic ethanol exposure differentially regulate CB1 receptor function at glutamatergic synapses in the rat basolateral amygdala
Keywords: Endogenous cannabinoid; CB1; Ethanol; Dependence; Anandamide; Basolateral amygdala;
Effects of the cannabinoid 1 receptor peptide ligands hemopressin, (m)RVD-hemopressin(α) and (m)VD-hemopressin(α) on memory in novel object and object location recognition tasks in normal young and Aβ1-42-treated mice
Keywords: AD; Alzheimer's disease; CB1; cannabinoid 1; CB2; cannabinoid 2; BLA; basolateral complex of the amygdala; CNS; central nervous system; Hp; hemopressin; RVD; (m)RVD-hemopressin(α); VD; (m)VD-hemopressin(α); NOR; novel object recognition; OLR; object l