کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5548721 | 1556591 | 2017 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enhanced anandamide signaling reduces flight behavior elicited by an approaching robo-beetle
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کلمات کلیدی
2-arachidonoylglycerolDMSO (PubChem CID: 679)JZL184NaBURB597BMTFAAHTRPV1CB1magl2-AGHABAEAanandamide - آناندامیدFatty acid amide hydrolase - اسید آمینه هیدرولاز اسید چربmonoacylglycerol lipase - لیپاز monoacylglycerol لیپازInbred mice - موش های InbredPanic - پانیکtransient receptor potential vanilloid type 1 - پتانسیل ترانزیتی وینیلوئید نوع 1Cannabinoid receptor 1 - گیرنده کانابینوئید 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Enhanced anandamide signaling reduces flight behavior elicited by an approaching robo-beetle Enhanced anandamide signaling reduces flight behavior elicited by an approaching robo-beetle](/preview/png/5548721.png)
چکیده انگلیسی
Our current knowledge of the implications of endocannabinoids in fear and anxiety is largely based on fear conditioning paradigms and approach-avoidance conflicts. Here we establish the ethobehavioral beetle mania task (BMT), which confronts mice with an erratically moving robo-beetle. With the help of this task we demonstrate decreased tolerance yet increased avoidance responses to an approaching beetle in high-anxiety behavior (HAB) and BALBc mice compared to C57BL/6N, CD1 and normal-anxiety behavior (NAB) mice. Also DBA/2N mice showed decreased passive and increased active behavior, but followed the robo-beetle more often than HAB and BALBc mice. Treatment with diazepam (1Â mg/kg) increased tolerance without affecting avoidance behavior in HAB mice. Treatment with the MAGL inhibitor JZL184 (8Â mg/kg) increased flight behavior, but did not affect tolerance. The FAAH inhibitor URB597 (0.3Â mg/kg), however, reduced flight behavior and enhanced tolerance to the robo-beetle. The latter effects were blocked by co-treatment with the CB1 receptor antagonist SR141716A (3Â mg/kg), which failed to affect the behavior by itself. Taken together, we validate the BMT as a novel test for studying endocannabinoids beyond traditional paradigms and for assessing active fear responses in mice. Furthermore, we demonstrate panicolytic consequences of pharmacological enhancement of anandamide, but not 2-AG signaling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 126, November 2017, Pages 233-241
Journal: Neuropharmacology - Volume 126, November 2017, Pages 233-241
نویسندگان
Daniel E. Heinz, Andreas Genewsky, Carsten T. Wotjak,