Beyond symmetry-breaking: competition and negative feedback in GTPase regulation
Keywords: Cdc42; Rac; Rop; GEF; GAP
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Rapid parallel flow cytometry assays of active GTPases using effector beads
Keywords: Rho; Rac; Cdc42; Rab GTPases; Hantavirus; Integrins
miR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6
Keywords: miR-137; Lung cancer; Cdc42; Cdk6
Inactivation of Cdc42 in neural crest cells causes craniofacial and cardiovascular morphogenesis defects
Keywords: Cdc42; GTPase; Neural crest cell; Migration; Craniofacial malformation; Persistent truncus arteriosus
Inhibition of EphA4 signaling after ischemia-reperfusion reduces apoptosis of CA1 pyramidal neurons
Keywords: I/R; ischemia-reperfusion; RTKs; receptor tyrosine kinases; CNS; central nervous system; 4VO; four-vessel occlusion; Cdc42; cell division cycle 42; EphA4; EphA4-Fc; Hippocampal neuron; Ischemia-reperfusion; Apoptosis;
Endothelin-1 stimulates human trophoblast cell migration through Cdc42 activation
Keywords: ET-1; Cdc42; Trophoblast; HTR-8/SVneo cell;
The small GTPase Cdc42 modulates the number of exocytosis-competent dense-core vesicles in PC12 cells
Keywords: Cdc42; Dense-core vesicle; GTPase; Exocytosis; Live cell imaging; Neuroendocrine cells;
CDC42-positive macrophages may prevent malignant transformation of ovarian endometriosis
Keywords: Ovarian endometriosis; Macrophages; CDC42
Altered melusin pathways involved in cardiac remodeling following acute myocardial infarction
Keywords: Melusin; CDC42; Cardiac remodeling; Myocardial infarction; Heart failure
Research ArticleCdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes
Keywords: Palmitate; Small GTPases; MAP3K; JNK; NAFLD; SFA; saturated free fatty acids; JNK; c-Jun NH2-terminal kinase; Cdc42; cell division cycle protein 42; Rac1; ras-related C3 botulinum toxin substrate 1; NAFLD; non-alcoholic fatty liver disease; IRE1; inositol
Urinary Diversion Results in Marked Decreases in Proliferation and Apoptosis in Fetal Bladder
Keywords: fetal development; organogenesis; urinary bladder; urinary diversion; Bcl2; B-cell CLL/lymphoma 2; Cdc42; cell division control protein 42; Ki-67; Kiel-67 antigen; OCT; optimal cutting temperature; PCR; polymerase chain reaction;
ReviewGap junctions and non-neoplastic liver disease
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; cdc42; cell division cycle 42; Cx; connexin; GJIC; gap junctional intercellular communication; IFNγ; interferon gamma; IL-1(β)/2/6; interleukin 1 (beta)/2/6; LPS; lipopolysaccharide; NF-κÎ
Regulation of adherens junctions by Rho GTPases and p120-catenin
Keywords: Cell–cell adhesion; Metastasis; RhoA; Rac1; Cdc42; E-cadherin
Calcium Regulates Podocyte Actin Dynamics
Keywords: Cdc42; fibroblasts; synaptopodin; TRPC channels; TRPC5; TRPC6; Rac1; RhoA; tropomyosin;
Microtubule-associated protein light chain 3 regulates Cdc42-dependent actin ring formation in osteoclast
Keywords: LC3; Osteoclast; Actin ring; Bone-resorbing activity; Cdc42
Towards the elucidation of the regulatory network guiding the insulin producing cells' differentiation
Keywords: NGN3 (NEUROG3); neurogenin3; ESCs; Embryonic Stem Cells; TFBS; Transcription Factor Binding Sites; TFs; Transcription Factors; AP4 (TFAP4); Activating enhancer-binding Protein 4 (Transcription Factor AP-4); WISP1; WNT-Induced Secreted Protein 1; CTGF; Con
TGFβ and BMP-2 regulate epicardial cell invasion via TGFβR3 activation of the Par6/Smurf1/RhoA pathway
Keywords: ALK; Activin Receptor-Like Kinases; AVC; Atrioventricular Endocardial Cushion; BMP; Bone Morphogenetic Protein; Cdc42; Cell division control protein 42 homolog; EMT; Epithelial-Mesenchymal Transformation; GFP; Green Fluorescent Protein; GIPC; GAIP-interac
BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFβ receptor to promote invasion
Keywords: ALK; Activin Receptor-Like Kinases; BMP; Bone Morphogenetic Protein; Cdc42; Cell division control protein 42 homolog; EMT; Epithelial-Mesenchymal Transformation; GFP; Green Fluorescent Protein; GIPC; GAIP-interacting protein, C terminus; Par6; Par-6 parti
Spatiotemporal regulation of Src and its substrates at invadosomes
Keywords: Src; Invasion; Invadosome; Invadopodia; Podosome; Rosette; Rho; Cdc42; FAK; Cortactin; Mabp1; ROS; MT1-MMP
Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development
Keywords: Cdc42; Conditional knockout mice; Limb development; Programmed cell death; Chondrogenesis;
Ovarian steroids increase spinogenetic proteins in the macaque dorsal raphe
Keywords: estradiol; immunocytochemistry; PSD-95; progesterone; RhoGTPase; serotonin; ANOVA; analysis of variance; Cdc42; cell division control protein 42 homolog; DAB; diaminobenzidine; DPX; dibutyl phthalate and xylene; E; estradiol; E+P; estradiol+progesterone;
Rudhira/BCAS3 is a cytoskeletal protein that controls Cdc42 activation and directional cell migration during angiogenesis
Keywords: MTOC; Microtubule Organizing Centre; BCAS3; Breast Cancer Amplified Sequence 3; IF; Intermediate filament; Rudhira; Cell migration; Cytoskeleton; Cdc42; Polarity;
Specificity of peripheral nerve regeneration: Interactions at the axon level
Keywords: AKT/PKB; protein kinase B; BDNF; brain derived neurotrophic factor; cAMP; cyclic adenosine monophosphate; CAMs; cell adhesion molecules; Cdc42; cell division control protein 42 homolog; cGMP; cyclic guanosine monophosphate; ChAT; choline acetyltransferase
Alteration of gene expression of IQGAP1 and Rho-family GTPases in the cadmium-induced ventral body wall defects in the chick model
Keywords: Ventral body wall defects; IQGAP1; Rac1; Cdc42; Chick embryo
Rho GTPases and exocytosis: What are the molecular links?
Keywords: Arp; actin related protein; GAP; GTPase activating protein; GDI; guanosine nucleotide dissociation inhibitor; GEF; guanosine nucleotide exchange factor; GTPase; guanosine triphosphatase; MMPs; metalloproteinases; PA; phosphatidic acid; PI4K; phosphatidyl
Intersectin 2 nucleotide exchange factor regulates Cdc42 activity during Xenopus early development
Keywords: Intersectin 2; Actin cytoskeleton; Cdc42; Embryonic development;
Proper regulation of Cdc42 activity is required for tight actin concentration at the equator during cytokinesis in adherent mammalian Cells
Keywords: Cytokinesis; Actin; Cdc42; Adherent mammalian cells
Estrogen induces neurite outgrowth via Rho family GTPases in neuroblastoma cells
Keywords: Estrogen; Medroxyprogesterone acetate; Neurite outgrowth; Rac1; Cdc42;
Promyogenic function of Integrin/FAK signaling is mediated by Cdo, Cdc42 and MyoD
Keywords: Cell adhesion; FAK; Integrin; Cdo; Cdc42; MyoD;
Rho GTPases as regulators of morphological neuroplasticity
Keywords: C3; Clostridium botulinum ribosyltransferase; cAMP; cyclic adenosine monophosphate; Cdc42; cell division control protein 42 homolog; CRIB; Cdc42/Rac interactive binding; DRG; dorsal root ganglia; ERK; extracellular signal-regulated kinase; FAK; focal adhe
Schwannomin/merlin promotes Schwann cell elongation and influences myelin segment length
Keywords: SC, Schwann cell; NF2, Neurofibromatosis Type 2; PAK, p21-activated kinase; PKA, protein kinase A; DRG, dorsal root ganglion, NGF, nerve growth factor; NRG, neuregulin beta-1Schwannomin; Myelin; Cdc42; Rac; NF2; Neurofibromatosis
Hepatocellular carcinoma with progenitor cell features distinguishable by the hepatic stem/progenitor cell marker NCAM
Keywords: HCC; hepatocellular carcinoma; NCAM; neural cell adhesion molecule; CK19; cytokeratin 19; IM; intrahepatic metastasis; CC; cholangiocellular carcinoma; FGFR; fibroblast growth factor receptor; NK; natural killer; GPI; glycosyl-phosphatidylinositol; DAPI;
Molecular biology of the dimorphic fungi Paracoccidioides spp
Keywords: CDC42; GP43; Molecular tools; Paracoccidioides spp; Pathogenic fungi; Transcriptional profiling
Cdc42 in oncogenic transformation, invasion, and tumorigenesis
Keywords: Rho GTPases; Cdc42; Transformation; Tumorigenesis; Cell migration; Invasion; Polarity
Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers
Keywords: Cdc42; cell division cycle 42; GEF; Guanine nucleotide exchange factor; GPCR; G-protein coupled receptor; LFA-1; Leukocyte function-associated antigen-1; LTB4; leukotriene B4; PAF; platelet activating factor; PI3K; Phosphatidylinositol 3-kinase; PIP2; pho
Dynamic control of neuroexocytosis by phosphoinositides in health and disease
Keywords: Phosphoinositides; Phosphoinositides signalling; Exocytosis; Actin; Neurodegenerative diseases; Akt; protein kinase B; Arp2/3; actin related protein 2/3; CAPS; Ca2+-dependent activator protein for secretion; Cdc42; cell division control protein 42 homolog
Cdc42-mediated inhibition of GSK-3β improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis
Keywords: Vascular endothelial growth factor (VEGF); Pathological angiogenesis; Lumens; Endothelial cells; Cytoskeleton; Cdc42; Glycogen synthase kinase-3β (GSK-3β); Capillary morphogenesis
The FGD homologue EXC-5 regulates apical trafficking in C. elegans tubules
Keywords: Charcot–Marie–Tooth Syndrome; FGD; EEA1; RME-1; Rab; CDC42; Endosome recycling
LKB1 Regulated Pathways in Lung Cancer Invasion and Metastasis
Keywords: LKB1; Metastasis; Lung cancer; NSCLC; Adhesion; Polarity; Motility; Invasion; Anoikis; FAK; PAK1; STK11; cdc42; Energy; AMPK
The role of β1Pix/caveolin-1 interaction in endothelin signaling through Gα subunits
Keywords: Caveolin-1; β1Pix; Gαq; Gα12; Endothelin; Cdc42; Caveolae
Rab35 – A vesicular traffic-regulating small GTPase with actin modulating roles
Keywords: Actin; Cdc42; Cytokinesis; Fascin; Rab35
I-BAR domains, IRSp53 and filopodium formation
Keywords: I-BAR; IRSp53; Cdc42; F-actin; Membrane protrusion; Filopodia
Altered Cortical CDC42 Signaling Pathways in Schizophrenia: Implications for Dendritic Spine Deficits
Keywords: CDC42; dendritic spine; mRNA; prefrontal cortex; schizophrenia; septin;
Inflammatory biomarker, neopterin, predominantly enhances myelopoiesis, which suppresses erythropoiesis via activated stromal cells
Keywords: Neopterin; Erythropoiesis; Cdc42; SDF-1; Stromal cells
Pathway-based genome-wide association analysis identified the importance of EphrinA-EphR pathway for femoral neck bone geometry
Keywords: PAK1; p21-activated kinase 1; FAK1; PTK2 protein tyrosine kinase 2; EphA7; Eph receptor A7; PIK3CG; phosphoinositide-3-kinase, catalytic, gamma; PAK7; p21-activated kinase 7; RASA1; RAS p21 protein activator 1; FYN; FYN oncogene related to SRC, FGR, YES;
Src-family kinase signaling, actin-mediated membrane trafficking and organellar dynamics in the control of cell fate: Lessons to be learned from the adenovirus E4orf4 death factor
Keywords: Cell death; Mitosis; Src-family kinases; Recycling endosomes; Rab11a; Cdc42; Actin; Golgi; Mitochondria; Adenovirus E4orf4; Syntaxin 6
Rab35 regulates neurite outgrowth and cell shape
Keywords: Rab35; Neurite growth; Cell shape; Actin; Small GTPase; Rac1; RhoA; Cdc42
Molecular basis for the substrate specificity of plant guanine nucleotide exchange factors for ROP
Keywords: At; Arabidopsis thaliana; Cdc42; cell division cycle 42; cDNA; complementary DNA; Dbl; diffuse B-cell lymphoma; DH; Dbl homology; G protein; guanine nucleotide binding protein; GDI; guanine nucleotide dissociation inhibitor; GEF; guanine nucleotide exchan
Lipopolysaccharides increase the amount of CXCR4, and modulate the morphology and invasive activity of oral cancer cells in a CXCL12-dependent manner
Keywords: Oral cancer; Invasion; LPS; CXCR4; CXCL12; Filopodia; Cdc42
An expression screen for RhoGEF genes involved in C. elegans gonadogenesis
Keywords: C. elegans; Gonadogenesis; RhoGEF; Morphogenesis; Organogenesis; Anchor cell invasion; Gonad development; Rho GTPase; Rho; Rac; cdc42; Mig-2; Ced-10; cdc-42; Rho-1