کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8461986 1549020 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rho GTPases as regulators of morphological neuroplasticity
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Rho GTPases as regulators of morphological neuroplasticity
چکیده انگلیسی
GTPases function as intracellular, bimolecular switches by adopting different conformational states in response to binding GDP or GTP. Their activation is mediated through cell-surface receptors. Rho GTPases act on several downstream effectors involved in cellular morphogenesis, cell polarity, migration and cell division. In neurons, Rho GTPases regulate various features of dendritic and axonal outgrowth during development and regeneration mainly through their effects on the cytoskeleton. This review summarizes the main functions of Rho, Rac and Cdc42 GTPases as key regulators of morphological neuroplasticity under normal and pathological conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Anatomy - Anatomischer Anzeiger - Volume 193, Issue 4, July 2011, Pages 259-266
نویسندگان
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