کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2780223 | 1153294 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pathway-based genome-wide association analysis identified the importance of EphrinA-EphR pathway for femoral neck bone geometry
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کلمات کلیدی
CFL1Limk1Limk2ACTG2ACTG1PTPN11ACTA2EphA3PAK4ACAD8PAK2PAK6RASA1ADH1CEphA7EFNB2ESCO2EFNA3ADH4LIM domain kinase 1Epha1Rho-associated, coiled-coil containing protein kinase 1EphA4Epha5PAK1CDC42p21-Activated kinase 4EphA2PNPLA3ADAM10ACTA1CFL2ROCK1ROCK2Rac1Ephrinb2p21-activated kinase 1 - p21-فعال کیناز 1Bone strength - استحکام استخوانbeta actin - بتا آکتینRas-related C3 botulinum toxin substrate 1 - زیر بغل سم بوتولینوم C3 مرتبط با ریز 1cell division cycle 42 - سلول تقسیم سلولی 42Genetic factor - عامل ژنتیکیActb - عملFyn - فیونpatatin-like phospholipase domain containing 3 - پاتین مانند فسفولیپاز حاوی 3
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Femoral neck (FN) bone geometry is an important predictor of bone strength with high heritability. Previous studies have revealed certain candidate genes for FN bone geometry. However, the majority of the underlying genetic factors remain to be discovered. In this study, pathway-based genome-wide association analysis was performed to explore the joint effects of genes within biological pathways on FN bone geometry variations in a cohort of 1000 unrelated US whites. Nominal significant associations (nominal p value < 0.05) were observed between 76 pathways and a key FN bone geometry variable-section modulus (Z), biomechanically indicative of bone strength subject to bending. Among them, EphrinA-EphR pathway was most significantly associated with FN Z even after multiple testing adjustments (pFWER value = 0.035). The association of EphrinA-EphR pathway with FN Z was also observed in an independent sample from Framingham Osteoporosis Study. Overall, these results suggest the significant genetic contribution of EphrinA-EphR pathway to femoral neck bone geometry.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 46, Issue 1, January 2010, Pages 129-136
Journal: Bone - Volume 46, Issue 1, January 2010, Pages 129-136
نویسندگان
Yuan Chen, Dong-Hai Xiong, Yan-Fang Guo, Feng Pan, Qi Zhou, Feng Zhang, Hong-Wen Deng,