دانلود مقالات ISI درباره Pak1 + ترجمه فارسی

تجزیه و تحلیل نقش هدف سیگنالینگ رپامایسین در متابولیسم اسپینگولایپید

Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism

Keywords: AbA; Aureobasidin A; ABC; ATP-binding cassette; AMPK; AMP-activated protein kinase; ATG; Autophagy-related; ATP; Adenosine triphosphate; C1P; Ceramide-1-phosphate; CERS; Ceramide synthase; CK2; Casein kinase II; CLS; Chronological lifespan; CMA; Chaperone

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2016 سفارش ترجمه

مدل سازی ارتباط سیگنال سلولی که متاثر از تعامل وابسته به فسفوریلاسیون با پروتئین های 14-3-3 است

Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins

Keywords: AANAT; aralkylamine N-acetyltransferase; Bad; Bcl-2 antagonist of cell death; Cdc25B; cell division cycle 25B; Foxo4; forkhead box protein O4; MAPKAP-K1; mitogen activated protein kinase activated protein kinase 1; p27Kip1; cyclin-dependent kinase inhibit

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

اختلال و بهبودی مانع اندوتلیال با سفتی سوبسترا کنترل می شود

Endothelial barrier disruption and recovery is controlled by substrate stiffness

Keywords: EC; endothelial cells; HPAEC; human pulmonary artery endothelial cells; HLMVEC; human lung microvascular endothelial cells; MLC; myosin light chain; MYPT; myosin-associated phosphatase; PAK1; p21-activated kinase;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

جذب محصولات پیشرفته گلیساسیون توسط سلول های اپیتلیال مجاری پروگزیمال از طریق ماکروپینوسیتوز

Uptake of advanced glycation end products by proximal tubule epithelial cells via macropinocytosis

Keywords: AGEs; advanced glycation end products; BSA; bovine serum albumin; LLC-PK1; porcine kidney proximal tubule epithelial cells; HK2; human kidney proximal tubule epithelial cells; SFM; serum-free medium; GM; growth medium; PIP5Kγ; phosphatidylinositol 4-phos

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

PAK1 در واکنش به پرولاکتین به هسته تبدیل می شود، اما نه به استروژن

PAK1 translocates into nucleus in response to prolactin but not to estrogen

Keywords: PAK1; Tyrosyl phosphorylation; Prolactin; EstrogenE2, 17β-estradiol; EGF, epidermal growth factor; JAK2, Janus kinase 2; NLS, nuclear localization signal; PAK, p21-activated serine–threonine kinase; PRL, prolactin; pTyr, phosphorylated on tyrosines; Tyr,

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

DOCK9 induces membrane ruffles and Rac1 activity in cancer HeLa epithelial cells

Keywords: DOCK; dedicator-of-cytokinesis; dox; doxycycline; GEF; guanine-nucleotide exchange factor; GST; glutathione S-transferase; HA; hemagglutinin; PAK1; p21-activated kinase 1; PBD; p21-binding domain; tTA; tetracycline transactivator; wt; wild type; DOCK9; DO

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2018 سفارش ترجمه

PAK1 overexpression promotes cell proliferation in cutaneous T cell lymphoma via suppression of PUMA and p21

Keywords: CTCL; cutaneous T cell lymphoma; MF; mycosis fungoides; SS; Sézary syndrome; BID; benign inflammatory dermatoses; PBMC; peripheral blood mononuclear cell; IPA3; p21-activated kinase inhibitor III; IHC; immunohistochemistry; PBS; phosphate buffer saline;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages

Keywords: Macrophage; Podosome; Actin; PAK1; mTOR; mTORC2; RhoA; Rac-1; FTY720; Matrix degradation;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

Manganese exposure: Linking down-regulation of miRNA-7 and miRNA-433 with α-synuclein overexpression and risk of idiopathic Parkinson's disease

Keywords: BCL2; B-cell CLL/lymphoma 2; CCND1; cyclin D1; CCNE1; cyclin E1; CRKL; V-Crk avian sarcoma virus CT10 oncogene homolog-like; FGF20; fibroblast growth factor 20; FGF7; fibroblast growth factor 7; FOXO1; forkhead box protein O1A; GRB2; growth factor recepto

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

The origins of rimmed vacuoles and granulovacuolar degeneration bodies are associated with the Wnt signaling pathway

Keywords: AD; Alzheimer's disease; APC; adenomatous polyposis coli; Arf6; ADP-ribosylation factor 6; CK1δ; casein kinase 1δ; Dvl; dishevelled; GSK-3β; glycogen-synthase kinase 3β; GVD; granulovacuolar degeneration; Hsp70; heat shock protein 70; Lrp4; low dens

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Role of Rho-specific guanine nucleotide dissociation inhibitor α regulation in cell migration

Keywords: Rho GEFs; Rho guanine nucleotide exchange factors; Rho GAPs; Rho GTPases activating protein; RhoGDIs; Rho-specific guanine nucleotide dissociation inhibitors; ROCK; Rho kinase; ER; estrogen receptor; HCC; hepatocellular carcinoma; ERM; Ezrin-radixin-moesi

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

1,2,3-Triazolyl ester of Ketorolac: A “Click Chemistry”-based highly potent PAK1-blocking cancer-killer

Keywords: PAK1; COX-2; Ketorolac; Click chemistry; Triazole ring; Cancer;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Nicotine mediated activation of Pak1/NFkB cascade in pancreatic cancer cells - A pilot study

Keywords: Smoking; Nicotine; Pancreatic cancer; Pak1; Inhibitor; IPA-3;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy

Keywords: PAK1; Propolis; Cancer; Longevity; C. elegans; Click Chemistry;

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors

Keywords: PAK1; Kinase; 4-Azaindole; Aminopyrazole; Diaminopyrimidine

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

miR-181b-3p promotes epithelial-mesenchymal transition in breast cancer cells through Snail stabilization by directly targeting YWHAG

Keywords: AP; alkaline phosphatase; DIG; digoxigenin; CHX; cycloheximide; EGF; epidermal growth factor; EMT; epithelial-mesenchymal transition; FBS; fetal bovine serum; FGF; fibroblast growth factor; GSK3β; glycogen synthase kinase 3β; IHC; immunohistochemistry

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Macrocyclic Lactones Block Melanoma Growth, Metastases Development and Potentiate Activity of Anti-BRAF V600 Inhibitors

Keywords: Dabrafenib; Ivermectin; MAPK; PAK1; Vemurafenib;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

GIT1/βPIX signaling proteins and PAK1 kinase regulate microtubule nucleation

Keywords: Ab; Antibody; EB1; end-binding protein 1; GIT1; G protein-coupled receptor kinase-interacting protein 1; PAK1; p21 protein (Cdc42/Rac)-activated kinase 1; βPIX; p21-activated kinase interacting exchange factor; ROI; region of interest; γTuRC; γ-tubulin

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2016 سفارش ترجمه

The investigation of miR-221-3p and PAK1 gene expressions in breast cancer cell lines

Keywords: qRT-PCR; Real-time PCR; ER/PR; estrogen and progesterone receptor; HER2; human epidermal growth factor receptor 2; SERM; selective ER modulators; SRC-1; steroid receptor coactivator-1; miRNA; microRNAs; DMEM; Dulbecco's modified Eagle's minimum essential

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Improvement of insulin signaling in myoblast cells by an addition of SKIP-binding peptide within Pak1 kinase domain

Keywords: SKIP; Pak1; Insulin signaling; Skeletal muscle;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Krüppel-like factor 5 incorporates into the β-catenin/TCF complex in response to LPA in colon cancer cells

Keywords: LPA; lysophosphatidic acid; KLF5; Krüppel-like factor 5; TCF; T-cell factor; LEF; lymphoid enhancer-binding factor; APC; adenomatous polyposis loci; GSK; glycogen synthase kinase; PI3K; phosphatidylinositol 3-kinase; IP; immunoprecipitation; ChIP; chroma

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1α and β-catenin via a p-21 activated kinase 1-dependent pathway

Keywords: PAK1, p-21 activated kinase 1; CRC, colorectal cancer; Glau, glaucarubinone; HIF-1α, hypoxia-inducible factor 1α; Apc, adenomatous polyposis coliGlaucarubinone; PAK1; HIF-1α; β-Catenin; CRC

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

MicroRNA-7: A miRNA with expanding roles in development and disease

Keywords: ACK1; activated CDC42 kinase 1; BASP1; brain abundant, membrane attached signal protein 1; c-Myc; v-Myc avian myelocytomatosis viral oncogene homolog; CD57; cluster of differentiation 57; CD44; cluster of differentiation 44; ciRS-7; circular RNA sponge fo

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

P21 activated kinase-1 mediates transforming growth factor β1-induced prostate cancer cell epithelial to mesenchymal transition

Keywords: TGFβ; Pak1; Prostate cancer; EMT; Snail

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation

Keywords: PAK1; p-21 activated kinase 1; PPARγ; peroxisome proliferator associated receptor gamma; IBD; inflammatory bowel disease; NF-κB; nuclear factor-kappa B; CRC; colorectal cancer; UC; ulcerative colitis; CD; Crohn's disease; CAC; colitis-associated cancer;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

PAK1 is involved in sensing the orientation of collagen stiffness gradients in mouse fibroblasts

Keywords: ECM; extracellular matrix; PAK1; p21-activated kinase; PAK1 K299R; p21-activated kinase dominant negative-kinase dead; PAK1 KD; p21-activated kinase knockdown; PAK1 T423E; p21-activated kinase constitutively active; PAK1 OE; p21-activated kinase over-expr

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

microRNA-7: A tumor suppressor miRNA with therapeutic potential

Keywords: ACK1; activated CDC42 kinase 1; Akt; V-Akt murine thymoma viral oncogene homolog; BCL-2; B-cell CLL/lymphoma 2; CCNE1; cyclin E1; ciRS-7; circular RNA sponge 7; c-Myc; V-Myc avian myelocytomatosis viral oncogene homolog; EGFR; epidermal growth factor rece

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Vav1 increases Bcl-2 expression by selective activation of Rac2-Akt in leukemia T cells

Keywords: GEF; guanine nucleotide exchange factor; T-CVID; T cell type common variable immunodeficiency; B-CLL; B-cell chronic lymphocytic leukemia; shRNA; short-hairpin RNA; SDS-PAGE; SDS-polyacrylamide gel electrophoresis; GST; Glutathione S-transferase; PAK1; p2

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

miR-145 inhibits invasion of bladder cancer cells by targeting PAK11

Keywords: PAK1; miR-145; Bladder cancer; Invasion; MMP-9;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells

Keywords: F-actin remodeling; Diabetes; PAK1; L6-GLUT4myc muscle cells; Skeletal muscle; GLUT4 vesicle exocytosis; Small Rho family GTPase; Rac1

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance

Keywords: AS160; Akt substrate 160; EDL; extensor digitorum longus; FWHM; Full Width at the Half Maximum; GAP; GTPase activating protein; KO; knockout; PAK1; p21 protein-activated kinase 1; PI3K; phosphatidylinositol 3-kinase; Rac1; Ras-related C3 botulinum toxin s

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Modulation of N-glycosylation by mesalamine facilitates membranous E-cadherin expression in colon epithelial cells

Keywords: CRC; colorectal cancer; IBD; inflammatory bowel diseases; UC; ulcerative colitis; GnT-III; N-acetylglucosaminyltransferase-III; AJ; adherens junction; PAK1; p21 activated kinase 1; E-cadherin; GnT-III; 5-ASA; Glycosylation; Ulcerative colitis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

P21-activated kinase in inflammatory and cardiovascular disease

Keywords: AID; Auto-inhibitory domain; ATP; Adenosine-triphosphate; B-cell; B lymphocytes; BLNK; B cell linker protein; CaM; Calmodulin; Cdc; Cell division control protein; cyt b558; Flavocytochrome b558; DUOX1/2; Dual oxidase 1/2; EF hand motif; Helix-loop-helix s

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Research ReportInhibition of p21-activated kinase 1 by IPA-3 attenuates secondary injury after traumatic brain injury in mice

Keywords: PAK1; p21-activated kinase 1; TBI; traumatic brain injury; BBB; blood-brain barrier; CNS; central nervous system; TUNEL; terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling; IF; immunofluorescence; PCR; polymerase chain reaction; SAH; s

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

The links between AKT and two intracellular proteolytic cascades: Ubiquitination and autophagy

Keywords: BRCA1; breast cancer susceptibility gene 1; BRCT; Brca1 C-terminal; CHIP; chaperone-associated ubiquitin ligase; CYLD; cylindromatosis; DAPK; death-associated protein kinase; DUB; deubiquitinating enzyme); EGF; epidermal growth factor; FADD; fas-associate

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Interleukin-1-induced activation of the small GTPase Rac1 depends on receptor internalization and regulates gene expression

Keywords: MiTMAB; myristyl trimethyl ammonium bromide; PBD; p21-binding domain; PAK1; p21-activated protein kinase 1; IL-1; Rac1; Endocytosis; Dynamin; Dynasore; NF-κB;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2014 سفارش ترجمه

miRNA-7-5p inhibits melanoma cell migration and invasion

Keywords: miRNA; microRNA; IRS-2; insulin receptor substrate-2; IRS-1; insulin receptor substrate-1; PI3K; phosphatidylinositol 3-kinase; Akt; protein kinase B; RT-qPCR; reverse transcription and quantitative polymerase chain reaction; BRAF; v-Raf murine sarcoma vi

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells

Keywords: DEX; Dexamethasone; FAK; Focal Adhesion Kinase; HSA; human serum albumin; iAR; intracellular androgen receptor; mTOR; mammalian target of rapamycin; mAR; membrane androgen receptor; PAK1; p21-activated kinase 1; p70S6K; S6 kinase; PFA; paraformaldehyde; P

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Tiam-1, a GEF for Rac1, plays a critical role in metformin-mediated glucose uptake in C2C12 cells

Keywords: ACC; acetyl-CoA carboxylase; AICAR; 5-aminoimidazole-4-carboxyamide-1-d-robofuranoside; AMPK; AMP-activated protein kinase; GEF; guanine nucleotide exchange factor; Tiam-1; T-lymphoma invasion and metastasis-inducing protein-1; AMPK; GEF; Glucose uptake;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1α

Keywords: PAK1; HIF-1α; β-Catenin; CRC;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells

Keywords: Insulin granule; Exocytosis; Cdc42; F-actin remodeling; Islet β cell; PAK1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Rac1/PAK1 signaling promotes epithelial-mesenchymal transition of podocytes in vitro via triggering β-catenin transcriptional activity under high glucose conditions

Keywords: EMT; Rac1; PAK1; β-Catenin; Snail; Podocyte;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1

Keywords: CRC; colorectal cancer; IBD; inflammatory bowel diseases; UC; ulcerative colitis; AJ; adherens junction; PAK1; p21 activated kinase 1; PAK1; Mesalamine; Beta-catenin; E-cadherin; Cell adhesion;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

PAK1 limits the expression of the pro-apoptotic protein Bad in pancreatic islet β-cells

Keywords: PAK1; Bad; Pancreatic β-cell; Mouse islet; Human islet; Apoptosis

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth

Keywords: PAK1; β-Catenin; CRC

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

c-Jun N-terminal kinase controls a negative loop in the regulation of glial fibrillary acidic protein expression by retinoic acid

Keywords: GFAP; c-Jun N-terminal kinase; retinoic acid; neural precursor cells; BMP-2; bone morphogenetic protein-2; DNA-PKcs; DNA-protein kinase catalytic subunit; ERK; extracelular-regulated kinase; GFAP; glial fibrillary acidic protein; GSK-β; glycogen synthase

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Trypanosoma cruzi uses macropinocytosis as an additional entry pathway into mammalian host cell

Keywords: Phagocytic cells; Non professional phagocytic cells; Trypanosoma cruzi; Macropinocytosis; PAK1;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Role of group A p21-activated kinases in the anti-apoptotic activity of the pseudorabies virus US3 protein kinase

Keywords: Pseudorabies virus; Herpes; US3; Apoptosis; p21-Activated kinases; PAK1

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Role of the p21-activated kinases (PAKs) in influenza A virus replication

Keywords: Influenza virus; PAK1; ERK; Protein activation; Virus replication;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

The frequent co-expression of the oncogenes PIK3CA and PAK1 in oral carcinomas

Keywords: Amplification; Carcinoma; Oral cavity; PAK1; PIK3CA;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه