Role of the p21-activated kinases (PAKs) in influenza A virus replication

► PAK1 activation during influenza A virus (IAV) infection was examined. ► IAV propagation corresponded to stimulated PAK1 phosphorylation. ► Alteration of PAK1 expression substantially affected virus production in vitro. ► PAK1 inhibition consequently suppressed ERK 1/2 phosphorylation and virus production. ► PAK1 activation maybe associated with ERK-dependent regulation of IAV replication.