Rudhira/BCAS3 is a cytoskeletal protein that controls Cdc42 activation and directional cell migration during angiogenesis

► rudhira-depleted endothelial cells show reduced tube formation due to slow and random cell migration. ► Rudhira re-localizes towards the leading edge and promotes cell migration in endothelial and other cell types. ► During cell migration Rudhira regulates Cdc42 activation and recruitment, controls actin reorganization and cell polarity. ► Rudhira is a novel cytoskeletal protein that interacts with microtubules and intermediate filaments.