Keywords: نورونهای گرانشی مخچه; Cerebellar granule neurons; Migration; Leading process; Axon; Microtubules; Glycogen synthase kinase-3; CGN; cerebellar granule neuron; EGL; external granule layer; IGL; internal granule layer; ML; molecular layer; CNS; central nervous system; DIV; days i
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Keywords: نورونهای گرانشی مخچه; CGN; cerebellar granule neurons; GSK-3; glycogen synthase kinase-3; div; days in vitro; CS; calf serum; BIO; 6-bromoindirubin-3â²-oxime; LiCl; lithium chloride; DMSO; dimethyl sulfoxide; BME; basal medium Eagle; GFP; green fluorescent protein; PBS; phosp
Keywords: نورونهای گرانشی مخچه; Metformin; Cerebellar granule neurons; Glutamate; Excitotoxicity; MAPK; Neuroprotection
Roles of Cdc42 and Rac in Bergmann glia during cerebellar corticogenesis
Keywords: نورونهای گرانشی مخچه; Astrocytes; Cerebellar development; Cerebellar granule neurons; Gliophilic migration; Neuregulin 1; Notch3; Radial migration; Rho-family small GTPases;
The histone demethylase Kdm6b regulates a mature gene expression program in differentiating cerebellar granule neurons
Keywords: نورونهای گرانشی مخچه; CGNs; cerebellar granule neurons; GNPs; granule neuron precursors; EGL; external granule layer; IGL; internal granule layer; H3K4me1 or H3K4me3; histone H3 lysine 4 monomethylation or trimethylation; H3K27me3; histone H3 lysine 27 trimethylation; JmjC; ju
Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures
Keywords: نورونهای گرانشی مخچه; HTT; Huntingtin; HD; Huntington's Disease; MID1; Midline 1; PP2A; Protein Phosphatase 2A; mHTT; Mutant Huntingtin; wtHTT; Wild type Huntingtin; S6K; 40S ribosomal S6 kinase; mTOR; Mammalian target of rapamycin; CGN; Cerebellar granule neurons; MAP2; Mic
N-acetyl-l-cysteine and Mn2+ attenuate Cd2+-induced disturbance of the intracellular free calcium homeostasis in cultured cerebellar granule neurons
Keywords: نورونهای گرانشی مخچه; CGNs; cerebellar granule neurons; NAC; N-acetyl-l-cysteine; Cadmium; Cultured neurons; Mitochondria; Calcium;
PFOS-induced excitotoxicity is dependent on Ca2+ influx via NMDA receptors in rat cerebellar granule neurons
Keywords: نورونهای گرانشی مخچه; Cerebellar granule neurons; Cytosolic Ca2+; Excitotoxicity; Fura-2; N-methyl-d-aspartate receptor; Perfluorooctanesulfonic acid;
Release of soluble and vesicular purine nucleoside phosphorylase from rat astrocytes and microglia induced by pro-inflammatory stimulation with extracellular ATP via P2X7 receptors
Keywords: نورونهای گرانشی مخچه; Brain cell cultures; Extracellular purine nucleoside phosphorylase (PNP); P2X7 receptor; Mechanism of release; Lysosomal vesicles; A-CM; astrocyte derived-conditioned medium; BME; Basal Medium Eagle; Bz-ATP; 3â²-O-benzoyl-benzoyl-ATP; CGNs; cerebellar gr
Neuregulin-1 protects mouse cerebellum against oxidative stress and neuroinflammation
Keywords: نورونهای گرانشی مخچه; Nrg1; neuregulin-1; rNrg1β; recombinant Nrg1β; ErbB; epidermal growth factor receptor; LPS; lipopolysaccharides; CGNs; cerebellar granule neurons; AD; Alzheimer's disease; PD; Parkinson's disease; HD; Huntington's disease; ALS; amyotrophic lateral
Regulation of PCSK9 by nutraceuticals
Keywords: نورونهای گرانشی مخچه; ALA; alpha-linolenic acid; ApoB; apolipoprotein B; ApoER2; apolipoprotein E receptor2; APMF; aqueous extract of PM fruit;; ASCVD; atherosclerotic cardiovascular disease; COMIT; canola oil multicenter intervention trial; CGN; cerebellar granule neurons; DH
Neurobasal media facilitates increased specificity of siRNA-mediated knockdown in primary cerebellar cultures
Keywords: نورونهای گرانشی مخچه; CGNs; cerebellar granule neurons; Ara-C; cytosine β-d-arabinofuranoside hydrochloride; NBM; Neurobasal⢠media; Neuron; Transfection; siRNA; Neurobasal media;
Interleukin-6 reduces NMDAR-mediated cytosolic Ca2+ overload and neuronal death via JAK/CaN signaling
Keywords: نورونهای گرانشی مخچه; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF; brain-derived neurotrophic factor; bFGF; basic fibroblast growth factor; CaN; calcineurin; CGNs; cerebellar granule neurons; CNS; central nervous system; Ifen; ifenprodil; IL-6; interleuki
Tunicamycin-induced unfolded protein response in the developing mouse brain
Keywords: نورونهای گرانشی مخچه; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; CGNs; cerebellar granule neurons; DAB; 3,3â²-diaminobenzidine; DAPI; 4,6-diamidino-phenylindole; DCN; deep cerebellar nucleus; DG; dentate gyrus; DIV; days in vitro; EGL; external germinal laye
Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases
Keywords: نورونهای گرانشی مخچه; Aβ; amyloid β protein; AMPK; adenosine monophosphate activated protein kinase; CGNs; cerebellar granule neurons; ETC; electron transport chain; H2O2; hydrogen peroxide; HO-1; heme oxygenase-1; LXR; liver X receptor; MAPK; mitogen-activated protein kinas
CYP2E1 induction leads to oxidative stress and cytotoxicity in glutathione-depleted cerebellar granule neurons
Keywords: نورونهای گرانشی مخچه; CGNs; cerebellar granule neurons; CYP2E1; cytochrome P450 2E1; ROS; reactive oxygen species; GSH; glutathione; DIV; days in vitro; INH; isoniazid; BSO; l-buthionine sulfoximine; DAS; diallyl sulfide; EUKA; Eukarion-134; 8-oxodG; 8-oxo-7,8-dihydro-2-deoxyg
Endogenous XIAP, but not other members of the inhibitory apoptosis protein family modulates cerebellar granule neurons survival
Keywords: نورونهای گرانشی مخچه; Apoptotic-like death; IAPs; Caspases; Cerebellum development; Cerebellar granule neurons; Potassium deprivation;
Subcellular distribution and early signalling events of P2X7 receptors from mouse cerebellar granule neurons
Keywords: نورونهای گرانشی مخچه; ATP; adenosine 5â²-triphosphate; A-438079; 3-(5-(2,3-dichlorophenyl)-1 H-tetrazol-1-yl)methyl pyridine hydrochloride hydrate; BSA; bovine serum albumin; BBG; Brilliant Blue G; BzATP; 2â²-3â²-o-(4-benzoylbenzoyl)-adenosine 5â²-triphosphate; CNS; centra
Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain
Keywords: نورونهای گرانشی مخچه; BafA1; bafilomycin A1; BoNT/X; botulinum neurotoxin/serotype X; CGNs; cerebellar granule neurons; FBS; foetal bovine serum; HC; heavy chain; HC; C-terminal half of HC; HCC; C-terminal domain of the HC-fragment; HCN; N-terminal domain of the HC-fragment; H
Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade
Keywords: نورونهای گرانشی مخچه; AChE; acetylcholinesterase; AD; Alzheimer's disease; B12H; bis(12)-hupyridone; CGNs; cerebellar granule neurons; DHβE; dihydro-β-erythroidine; GSK3β; glycogen synthase kinase 3β; mAChR; muscarinic acetylcholine receptor; MLA; methyllycaconitine; NMD
C-terminal binding proteins are essential pro-survival factors that undergo caspase-dependent downregulation during neuronal apoptosis
Keywords: نورونهای گرانشی مخچه; 6-OHDA; 6-hydroxydopamine; AD; actinomycin D; Anti; morpholino-antisense oligonucleotides; Bcl-3; B-cell lymphoma-3; BKLF; basic Krüppel-like factor; CCD; charge-coupled device; CGNs; cerebellar granule neurons; Con; control; CtBP; C-terminal binding pro
Mechanisms of penitrem-induced cerebellar granule neuron death in vitro: Possible involvement of GABAA receptors and oxidative processes
Keywords: نورونهای گرانشی مخچه; Penitrem A; Neurological disorders; Cerebellar granule neurons; Oxidative stress; GABAA receptors
Research reportGlucose starvation stimulates Zn2+ toxicity in cultures of cerebellar granule neurons
Keywords: نورونهای گرانشی مخچه; Zinc; Cerebellar granule neurons; Glucose starvation;
L-type voltage-operated calcium channels, N-methyl-d-aspartate receptors and neuronal nitric-oxide synthase form a calcium/redox nano-transducer within lipid rafts
Keywords: نورونهای گرانشی مخچه; CGN; cerebellar granule neurons; CTB; cholera toxin subunit B; FRET; fluorescence or Förster resonance energy transfer; IgG; immunoglobulin G; L-VOCC; L-type voltage-operated calcium channels; NMDAr; N-methyl d-aspartate receptor; nNOS; neuronal nitric-o
A new in vitro injury model of mouse neurons induced by mechanical scratching
Keywords: نورونهای گرانشی مخچه; Mechanical injury; Cerebellar granule neurons; Scratching insult; Tissue culture; Neurotrophin-3; Neuroprotection;
Electro-acupuncture upregulates CGRP expression after rat spinal cord transection
Keywords: نورونهای گرانشی مخچه; Electro-acupuncture; Calcitonin gene-related peptide; Neuroprotection; Spinal cord injury; Cerebellar granule neurons;
Neuroprotective and memory enhancing properties of a dual agonist of the FGF receptor and NCAM
Keywords: نورونهای گرانشی مخچه; BBB; blood brain barrier; CGN; cerebellar granule neurons; EAE; experimental autoimmune encephalomyelitis; FGFR; fibroblast growth factor receptor; HRP; horseradish peroxidase; Ig; immunoglobulin; iNOS; inducible nitric oxide synthase; LPS; lipopolysaccha
Akt/mammalian target of rapamycin signaling pathway regulates neurite outgrowth in cerebellar granule neurons stimulated by methylcobalamin
Keywords: نورونهای گرانشی مخچه; ANOVA; one way analysis of variance; CGNs; cerebellar granule neurons; DMEM; Dulbecco's modified Eagle's medium; Icmt; isoprenylcysteine carboxyl methyltransferase; MeCbl; methylcobalamin; mTOR; mammalian target of rapamycin; p70S6K; p70 ribosomal S6 prot
Tropisetron upregulates cannabinoid CB1 receptors in cerebellar granule cells: Possible involvement of calcineurin
Keywords: نورونهای گرانشی مخچه; CB1, cannabinoid type one; CGNs, cerebellar granule neuronsTropisetron; Cannabinoid receptor; Cerebellar granule neurons; Calcineurin
Study of the pathways involved in apoptosis induced by PI3K inhibition in cerebellar granule neurons
Keywords: نورونهای گرانشی مخچه; CGNs; cerebellar granule neurons; S/K; serum potassium deprivation; CDK; cyclin-dependent kinase; JNK; c-Jun N-terminal kinase; GSK3β; glycogen synthase kinase 3β; PI3K; phosphatidylinositol-3 kinase; IGF-1; insulin-like growth factor-I; CDK5/p25; LY294
NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1α
Keywords: نورونهای گرانشی مخچه; NGF/TrkA; BDNF/TrkB; VEGF; HIF-1α; Dorsal root ganglion neurons; Cerebellar granule neurons; Neuroblastoma;
Role for apoptosis-inducing factor in the physiological death of cerebellar neurons
Keywords: نورونهای گرانشی مخچه; Apoptotic-like death; AIF; Caspases; Cerebellum development; Cerebellar granule neurons; Potassium deprivation
Research ReportNeuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets
Keywords: نورونهای گرانشی مخچه; AChE; acetylcholinesterase; AD; Alzheimer's disease; B12H; bis(12)-hupyridone; CGNs; cerebellar granule neurons; FDA; fluorescein diacetate; GSK3β; glycogen synthase kinase 3β; MCAO; middle cerebral artery occlusion; NMDA; N-methyl-d-aspartate; rCBF; re
Reactive oxygen species participate in the p38-mediated apoptosis induced by potassium deprivation and staurosporine in cerebellar granule neurons
Keywords: نورونهای گرانشی مخچه; K25; high potassium; K5; potassium deprivation; CGN; cerebellar granule neurons; Kmp; kaempferol; CAT; catalase; SOD; superoxide dismutase; SB; SB203580; DHEt; dihydroethidium; FDA; flourescein diacetate; PI; propidium iodide; DIV; days in vitro; MAPKs; m
Research ReportPreventing H2O2-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone
Keywords: نورونهای گرانشی مخچه; AChE; acetylcholinesterase; AD; Alzheimer's disease; BDNF; brain-derived neurotrophic factor; B12H; bis(12)-hupyridone; CGNs; cerebellar granule neurons; DIV; days in vitro; ERK; extracellular signal-regulated kinase; GSK; glycogen synthase kinase; IGF-1;
The role of CD4-dependent signaling in interleukin-16 induced c-Fos expression and facilitation of neurite outgrowth in cerebellar granule neurons
Keywords: نورونهای گرانشی مخچه; Interleukin-16; CD4; Cerebellar granule neurons; Neuronal interleukin-16; Neurite outgrowth
Evaluation of transcriptional activity of caspase-3 gene as a marker of acute neurotoxicity in rat cerebellar granular cells
Keywords: نورونهای گرانشی مخچه; Apoptosis; Cell-cycle; Caspase-3; Oxidative stress; Cerebellar granule neurons; Acute toxicity
L-type calcium channels and cytochrome b5 reductase are components of protein complexes tightly associated with lipid rafts microdomains of the neuronal plasma membrane
Keywords: نورونهای گرانشی مخچه; Cb5R; cytochrome b5 reductase; CGN; cerebellar granule neurons; FRET; Förster resonance energy transfer; L-VOCC; L-type voltage-operated calcium channels; PBS; phosphate-buffered saline; ROS; reactive oxygen species; Triton X-100; (1,1,3,3-tetramethylbut
An imaging assay to analyze primary neurons for cellular neurotoxicity
Keywords: نورونهای گرانشی مخچه; High-content analysis; Neurite outgrowth; Neurotoxicity; Cerebellar granule neurons
Methylmercury disrupts the balance between phosphorylated and non-phosphorylated cofilin in primary cultures of mice cerebellar granule cells A proteomic study
Keywords: نورونهای گرانشی مخچه; Neuroproteome; Cerebellar granule neurons; Methylmercury; Neurotoxicity; Cofilin; In vitro
Neuroprotection of interleukin-6 against NMDA attack and its signal transduction by JAK and MAPK
Keywords: نورونهای گرانشی مخچه; Interleukin-6; Neuroprotection; Cerebellar granule neurons; NMDA; JAK; MAPK
p38 and ERK, but not JNK, are involved in copper-induced apoptosis in cultured cerebellar granule neurons
Keywords: نورونهای گرانشی مخچه; Copper; Cerebellar granule neurons; Mitogen-activated protein kinases; Nimodipine; Reactive oxygen species
Evaluation of pathways involved in pentachlorophenol-induced apoptosis in rat neurons
Keywords: نورونهای گرانشی مخچه; Pentachlorophenol; Apoptosis; Cell cycle; Caspase; Oxidative stress; Cerebellar granule neurons; Acute toxicity
Xanthine oxidase-induced neuronal death via the oxidation of NADH: Prevention by micromolar EDTA
Keywords: نورونهای گرانشی مخچه; Xanthine oxidase; NADH; Nicotinamide adenine dinucleotide; Peroxide; Cerebellar granule neurons; Superoxide dismutase
ROS scavenging capacity and neuroprotective effect of α-mangostin against 3-nitropropionic acid in cerebellar granule neurons
Keywords: نورونهای گرانشی مخچه; Cerebellar granule neurons; Neuroprotection; Reactive oxygen species; Garcinia mangostana; α-mangostin; Singlet oxygen; Superoxide anion; Peroxynitrite; 3-nitropropionic acid; Scavenging capacity
Heme oxygenase-1 induction prevents neuronal damage triggered during mitochondrial inhibition: Role of CO and bilirubin
Keywords: نورونهای گرانشی مخچه; Cerebellar granule neurons; Neuroprotection; Reactive oxygen species; Heme oxygenase
Preconditioning with NMDA protects against toxicity of 3-nitropropionic acid or glutamate in cultured cerebellar granule neurons
Keywords: نورونهای گرانشی مخچه; Preconditioning; Cerebellar granule neurons; NMDA receptors; Glutamate; 3-nitropropionic acid
DNA low-density array analysis of colchicine neurotoxicity in rat cerebellar granular neurons
Keywords: نورونهای گرانشی مخچه; Colchicine; Apoptosis; Cell cycle; Caspase; Oxidative stress; Cerebellar granule neurons; Acute toxicity
Insulin-like growth factor-I activation of Akt survival cascade in neuronal cells requires the presence of its cognate receptor in caveolae
Keywords: نورونهای گرانشی مخچه; Insulin-like growth factor-I; Insulin-like growth factor-I receptor; Neuron; Caveolae; Cholesterol; Akt; Apoptosis; Cerebellar granule neurons
The effect of gallium nitride on long-term culture induced aging of neuritic function in cerebellar granule cells
Keywords: نورونهای گرانشی مخچه; Gallium nitride (GaN); Cerebellar granule neurons; Long-term culture