L-type voltage-operated calcium channels, N-methyl-d-aspartate receptors and neuronal nitric-oxide synthase form a calcium/redox nano-transducer within lipid rafts

► L-VOCC, NMDAr and nNOS are present in isolated neuronal lipid rafts. ► L-VOCC and NMDAr are close proteins within lipid rafts-associated sub-microdomains. ► nNOS is separated less than 80 nm from NMDAr and L-VOCC. ► This compartmentation is a major gain for rapid and focalized stimulation of nNOS.