High fat-diet and saturated fatty acid palmitate inhibits IGF-1 function in chondrocytes
Keywords: تکه کردن; Cartilage; IGF-1; CHOP; ER stress; Chondrocytes; High-fat diet;
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Research reportInhibition of the mitochondrial calcium uniporter inhibits Aβ-induced apoptosis by reducing reactive oxygen species-mediated endoplasmic reticulum stress in cultured microglia
Keywords: تکه کردن; Aβ; amyloid-beta; Ca2+; calcium; MCU; mitochondrial calcium uniporter; ROS; reactive oxygen species; ER; endoplasmic reticulum; GRP78; glucose-regulated protein 78; CHOP; C/-EBP homologous protein; AD; Alzheimer's disease; TNF-α; tumor necrosis factor
Identification of residues within the African swine fever virus DP71L protein required for dephosphorylation of translation initiation factor eIF2α and inhibiting activation of pro-apoptotic CHOP
Keywords: تکه کردن; EIF2α; Protein translation; CHOP; Unfolded protein response; African swine fever virus;
The Prevalence of Eosinophilic Esophagitis in Pediatric Patients with IgE-Mediated Food Allergy
Keywords: تکه کردن; IgE; Food allergy; Eosinophilic esophagitis; Oral immunotherapy; Prevalence; CHOP; Children's Hospital of Philadelphia; CPED; Center for Pediatric Eosinophilic Diseases; EMR; Electronic medical record; EoE; Eosinophilic esophagitis; ICD; International Cla
Prolyl-tRNA synthetase inhibition promotes cell death in SK-MEL-2Â cells through GCN2-ATF4 pathway activation
Keywords: تکه کردن; Prolyl tRNA synthetase; GCN2-ATF4; CHOP; Translation; tRNA synthetase;
N-methyl-d-aspartate receptor-mediated calcium overload and endoplasmic reticulum stress are involved in interleukin-1beta-induced neuronal apoptosis in rat hippocampus
Keywords: تکه کردن; AD; Alzheimer's disease; CHOP; C/EBP homologous protein-10; ER; endoplasmic reticulum; GRP-78; glucose-regulated protein 78; HPLC; high performance liquid chromatography; IL-1β; interleukin-1β; NMDAR; N-methyl-d-aspartate receptor; PBS; phosphate-buffer
Nicotine suppresses the neurotoxicity by MPP+/MPTP through activating α7nAChR/PI3K/Trx-1 and suppressing ER stress
Keywords: تکه کردن; PD; Parkinson's disease; MPP+1; methyl-4-phenylpyridinium ion; Trx-1; thioredoxin-1; ER; endoplasmic reticulum; GRP78/Bip; glucose-regulated protein 78; CHOP; C/EBP homologous protein; TH; tyrosine hydroxylase; PI3K; phosphatidylinositol 3-kinase; DA; d
Prophylactic topical paeoniflorin prevents mechanical allodynia caused by paclitaxel in mice through adenosine A1 receptors
Keywords: تکه کردن; Paeoniflorin; Paclitaxel; Allodynia; Adenosine A1 receptor; PTX; paclitaxel; PF; paeoniflorin; CHOP; C/EBP homologous protein; ER; endoplasmic reticulum; A1R; adenosine A1 receptor; DPCPX; 8-cyclopentyl-1,3-diprooylxanrhine; GAPDH; glyceraldehyde 3-phosph
Sesame oil lignans inhibit hepatic endoplasmic reticulum stress and apoptosis in high-fat diet-fed mice
Keywords: تکه کردن; CHOP; C/EBP homologous protein; CPT-1; carnitine palmitoyl transferase 1; ER; endoplasmic reticulum; FAS; fatty acid synthase; GC; gas chromatography; GRP78; 78-kDa glucose-regulated protein; HFD; high-fat diet; HMGCR; 3-hydroxy-3-methylglutaryl-CoA reduc
Research articleBone marrow mesenchymal stem cells decrease CHOP expression and neuronal apoptosis after spinal cord injury
Keywords: تکه کردن; BMSCs; bone marrow mesenchymal stem cells; BMSCs-CM; conditioned medium of BMSCs; CHOP; C/EBP homology protein; ER; endoplasmic reticulum; H&E; hematoxylin and eosin; OGD; oxygen-glucose deprivation; SCI; spinal cord injury; Spinal cord injury; Bone mar
Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation
Keywords: تکه کردن; AMPK; AMP-activated protein kinase; ATF4; Activating Transcription Factor 4; ATF6; Activating Transcription Factor 6; BAF; Bafilomycin A1; BiP (GRP78); Binding immunoglobulin Protein (78Â kDa glucose regulated protein); BZ; bortezomib; CHOP; C/EBP-Homolog
MicroRNAs 106b and 222 Improve Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes via Pancreatic β-Cell Proliferation
Keywords: تکه کردن; BM; bone marrow; BMT; bone marrow transplantation; CHOP; C/EBP homologous protein; Cip/Kip; CDK interacting protein/kinase inhibitory protein; DAPI; 4â²,6-Diamidino-2-phenylindole; GFP; green fluorescent protein; GNZ; a nuclear-localized GFP/LacZ fusion
Downregulation of TRB3 protects neurons against apoptosis induced by global cerebral ischemia and reperfusion injury in rats
Keywords: تکه کردن; ANOVA; analysis of variance; ATF4; transcription factor 4; Bad; Bcl-2-associated death protein; BCA; bicinchoninic acid assay; CA; cornu ammonis; CHOP; CCAAT/enhancer-binding protein (C/EBP) homologous protein; DAB; diaminobenzidine; DAPI; 4,6,diamidino-2
Cleistocalyx nervosum var. paniala berry fruit protects neurotoxicity against endoplasmic reticulum stress-induced apoptosis
Keywords: تکه کردن; Cleistocalyx nervosum var. paniala; Anthocyanin; ROS; glutamate; ER stress; Neuroprotective effect; AD; Alzheimer's disease; APPH; ((2,2'-azobis(2-methylpropionamidine) dihydrochloride)); CAT; catalase; CHOP; C/EBP homologous proteins; CNP; Cleistocalyx n
Methylseleninic acid and sodium selenite induce severe ER stress and subsequent apoptosis through UPR activation in PEL cells
Keywords: تکه کردن; ER stress; KSHV; Puma; CHOP; Primary effusion lymphoma; Unfolded protein response; ASK1; apoptosis signal-regulated kinase 1; ATF6; activating transcription factor-6; Bim; Bcl-2 interacting mediator of cell death; CHOP; CCAAT/enhancer-binding protein-homo
Original ArticleSensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis
Keywords: تکه کردن; Sodium trans-[tetrachlorobis(1H-indazole)ruthenate(III)]; Ruthenium; Extrinsic pathway of programmed cell death; GRP78; Caspase 8; 4-PBA; 4-phenylbutyric acid; CHOP; C/EBP-homologous protein; CI; combination index; CFTR; cystic fibrosis transmembrane cond
Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway
Keywords: تکه کردن; AMPK; 5'-AMP-activated protein kinase; ATF4; activating transcription factor-4; Atg7; autophagy-related protein-7; CHOP; C/EBP homologous protein; CO; carbon monoxide; CORM; CO-releasing molecule; eIF2α; eukaryotic initiation factor-2 alpha; ER; Endoplas
3â²,5-dihydroxy-3,4â²,7-trimethoxyflavone-induces ER-stress-associated HCT-116 programmed cell death via redox signaling
Keywords: تکه کردن; CHOP; CCAAT/enhancer-binding protein (C/EBP) homologous protein; Cleaved PARP-1; cleaved poly (ADP-ribose) polymerase-1; Cyt c; cytochrome c; DTMF; 3â²,5-dihydroxy-3,4â²,7-trimethoxyflavone; ER; endoplasmic reticulum; eIF2-α; eukaryotic initiation fact
Activation of phospholipase C-γ1 and translocation of phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase contribute to GL-V9-induced apoptosis in human gastric cancer cells
Keywords: تکه کردن; PLCγ1; phospholipase C-γ1; PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase; CHOP; CCAAT/enhancer-binding protein-homologous protein; ER; endoplasmic reticulum; ROS; reactive oxygen species; IP3; inositol1,4,5-trisphosphate; IP3R; inositol1,
Molecular cloning and characterization of unfolded protein response genes from large yellow croaker (Larimichthys crocea) and their expression in response to dietary fatty acids
Keywords: تکه کردن; ATF6; activating transcription factor-6; ATF4; activating transcription factor 4; BiP/GRP78; immunoglobulin heavy chain binding protein/glucose-regulated protein 78; CHOP; C/EBP homologous protein; ER; endoplasmic reticulum; ERAD; ER-associated protein de
Inhibition of endoplasmic reticulum stress by neuregulin-1 protects against myocardial ischemia/reperfusion injury
Keywords: تکه کردن; ER; endoplasmic reticulum; Tm; tunicamycin; DTT; dithiothreitol; CHOP; CCAAT/enhancer binding protein homologous protein; I/R; ischemia/reperfusion; NRG-1; Neuregulin-1; CM; cardiomyocyte; ERK; extracellular signal-regulated kinase; SD; Sprague-Dawley; P1
HPW-RX40 prevents human platelet activation by attenuating cell surface protein disulfide isomerases
Keywords: تکه کردن; CHOP; CCAAT-enhancer-binding protein homologous protein; Di-E-GSSG; dieosin glutathione disulfide; DiOC6(3); 3,3â²-dihexyloxacarbocyanine iodide; DTT; dithiothreitol; GSSG; oxidized glutathione; ER; endoplasmic reticulum; EGSH; eosin-coupled glutathione;
Original ArticleGRP78 inhibition enhances ATF4-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma
Keywords: تکه کردن; Osteosarcoma; ATF4; GRP78; CHOP; Ubiquitination; ATF4; activating transcription factor 4; BTZ; bortezomib; CFDA SE; carboxyfluorescein diacetate succinimidyl ester; CHOP; CCAAT/enhancer-binding protein (C/EBP) homologous protein; CHX; cycloheximide; DDIT3
Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa
Keywords: تکه کردن; ad; autosomal dominant; BP; biological process; CHOP; C/EBP homologous protein; CRE; the cAMP-responsive element; CREB; the cAMP-responsive element-binding protein; CREM; the cAMP-responsive element modulator; ATF-1; activating transcription factor-1; DAV
ReviewThe dynamic plasticity of insulin production in β-cells
Keywords: تکه کردن; T2DM; Insulin production; β-cell rest; ATF6; Activating Transcription Factor 6; CHOP; CCAAT/Enhancer-Binding Homologous Protein; EPAC; Exchange Factor Directly Activated by cAMP; EROβ1; ER-resident oxidoreductase β1; GIP; Gastric Inhibitory Polypeptide
Angioimmunoblastic T-Cell Lymphoma
Keywords: تکه کردن; Angioimmunoblastic T-cell lymphoma; Autologous stem cell transplantation; Brentuximab vedotin; CHOP; DNMT3A; Follicular T-helper; IDH2; Lenalidomide;
ReviewEndoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells
Keywords: تکه کردن; Diabetes; Endoplasmic reticulum stress; eIF2α; Pancreatic β cell; Insulin; Islet; ATF; activating transcription factor; CHOP; C/EBP homologous protein; CReP; constitutive repressor of eIF2α phosphorylation; CRISPR; clustered regularly interspaced short
BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells
Keywords: تکه کردن; Annexin V; FITC-conjugated annexinV; BCA; bicinchoninic acid; BNIP3; Bcl2/adenovirus E1B 19Â kDa protein-interacting protein 3; CBP; CREB-binding protein; CCCP; carbonyl cyanide m-chlorophenyl hydrazine; CHIP; chromatin immunoprecipitation; CHOP; CCAAT-en
Peripheral T-Cell Lymphoma, Not Otherwise Specified
Keywords: تکه کردن; Peripheral T-cell lymphoma, not otherwise specified; PTCL-NOS; CHOP;
Cyperus amuricus induces G1 arrest and apoptosis through endoplasmic reticulum stress and mitochondrial signaling in human hepatocellular carcinoma Hep3B cells
Keywords: تکه کردن; ATF6; activating transcription factor 6; C. amuricus:; Cyperus amuricus; CDKIs; cyclin-dependent kinases inhibitors; CDKs; cyclin-dependent kinases; CHOP; C/EBP-homologous protein; DAPI; 4â²,6-diamidino-2-phenylindole; eIF2α; eukaryotic initiation facto
Both nitric oxide and nitrite prevent homocysteine-induced endoplasmic reticulum stress and subsequent apoptosis via cGMP-dependent pathway in neuronal cells
Keywords: تکه کردن; Nitric oxide; Nitrite; Endoplasmic reticulum stress; Apoptosis; cGMP; Neuronal cells; 7-AAD; 7-aminoactinomycin D; AD; Alzheimer's disease; ATF6; activating transcription factor 6; Br-cGMP; 8-bromo-cyclic cyclic guanosine 3â²,5â²-monophosphate; cGMP; cy
Glutamine deprivation sensitizes human breast cancer MDA-MB-231 cells to TRIAL-mediated apoptosis
Keywords: تکه کردن; Glutamine; TRAIL; Apoptosis; ER stress; CHOP; DR5;
Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages
Keywords: تکه کردن; TFPI; Cholesterol crystals; ER stress; Macrophages; Carotid endarterectomies; Inflammation; CC; cholesterol crystals; CHOP; CCAAT/enhancer-binding protein homologous protein; ER; endoplasmic reticulum; MDMs; monocyte-derived macrophages; PBA; 4-phenylbuty
Mesencephalic astrocyte-derived neurotrophic factor (MANF), a new player in endoplasmic reticulum diseases: structure, biology, and therapeutic roles
Keywords: تکه کردن; AAV; adeno-associated virus; AKI; acute kidney injury; ARMET; arginine-rich mutated in early tumors; ATF6; activating transcription factor 6; BiP; Ig-binding protein; CDNF; conserved dopamine neurotrophic factor; CHOP; C/EBP homologous protein; DM; diabet
Chimeric antigen receptor T-cells for B-cell malignancies
Keywords: تکه کردن; ALL; acute lymphoblastic leukemia; B-ALL; B-cell acute lymphoblastic leukemia; CAR-T; chimeric antigen receptor T-cell; CAR; chimeric antigen receptor; CD; cluster of differentiation; CHOP; Children's Hospital of Philadelphia; CLL; chronic lymphocytic leu
HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum
Keywords: تکه کردن; aa; amino acid; ATF6; activating transcription factor 6; BIK; BCL2-interacting killer; BiP; binding immunoglobulin protein; CD86; cluster of differentiation 86; CHOP; CCAAT-enhancer-binding protein homologous protein; Derlin-1; degradation in ER protein 1
Astrocyte elevated gene-1 (AEG-1) and the A(E)Ging HIV/AIDS-HAND
Keywords: تکه کردن; Astrocytes; Aging; HIV-associated neurocognitive disorders; Neuroinflammation; ER/Nucleolar/Oxidative stress; Excitotoxicity; Aβ; amyloid beta; AEG-1; astrocyte elevated gene-1; AD; Alzheimer's disease; AIDS; acquired immune deficiency syndrome; ARE; a
Intraventricular administration of Tenebrio molitor larvae extract regulates food intake and body weight in mice with high-fat diet-induced obesity
Keywords: تکه کردن; Appetite; Diet-induced obesity; Hypothalamus; Neuropeptide; Tenebrio molitor larvae; AgRP; agouti-related peptide; ATF4; activating transcription factor 4; CHOP; c/EBP-homologous protein; eIF2α; α subunit of eukaryotic translation initiation factor 2; E
Tunicamycin impairs olfactory learning and synaptic plasticity in the olfactory bulb
Keywords: تکه کردن; ACSF; artificial cerebrospinal fluid; CHOP; C/EBP-homologous protein; ER; endoplasmic reticulum; fEPSP; field excitatory postsynaptic potential; GADD153; growth arrest- and DNA damage-inducible gene 153; GCL; granule cell layer; IPIs; inter-pulse interval
Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and enhancing the Nrf2-mediated adaptive response
Keywords: تکه کردن; RFP; rifampicin; TUDCA; tauroursodeoxycholic acid; Nrf2; nuclear factor erythroid 2-related factor; DILI; drug-induced liver injury; ALF; acute liver failure; TB; tuberculosis; INH; isoniazid; GSH; glutathione; BAs; bile acids; ER; endoplasmic reticulum;
Human Keratinocyte Differentiation Requires Translational Control by the eIF2α Kinase GCN2
Keywords: تکه کردن; ATF4; activating transcription factor 4; CHOP; C/EBP homologous protein; eIF2α; eukaryotic initiation factor 2 alpha; eIF2α-P; phosphorylated eukaryotic initiation factor 2; ER; endoplasmic reticulum; GADD34; growth arrest and DNA damage protein 34; GCN
CHOP negatively regulates Polo-like kinase 2 expression via recruiting C/EBPα to the upstream-promoter in human osteosarcoma cell line during ER stress
Keywords: تکه کردن; ER stress; Plk2; Expression regulation; CHOP; C/EBPα;
Reduced FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and death in endothelial cells
Keywords: تکه کردن; APB; 2-aminoethoxydiphenylborane; ANOVA; One way analysis of variance; ATPase; Adenosine triphosphate synthase; bEnd5; Mouse brain endothelioma cell line; bpV; bisperoxovanadium; BSA; Bovine serum albumin; Cas9; CRISPR-associated protein 9; CHOP; CCAAT-en
Ethanol-induced PGE2 up-regulates Aβ production through PKA/CREB signaling pathway
Keywords: تکه کردن; Aβ; amyloid beta; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; beta-site APP-cleaving enzyme 1; ROS; reactive oxygen species; ER; endoplasmic reticulum; eIF2α; eukaryotic initiation factor alpha; CHOP; C/EBP-homologous protein; PGE2;
Metformin attenuates ER stress-induced mitochondrial dysfunction
Keywords: تکه کردن; AIF; apoptosis inducing factor; AMPK; AMP-activated protein kinase; ASPP2; apoptosis-stimulating protein of p53-2; ADP; adenosine diphosphate; ATP; adenosine triphosphate; CHOP; C/EBP homologous protein; BSA; bovine serum albumin; CRC; calcium retention c
BH3-only protein BIM: An emerging target in chemotherapy
Keywords: تکه کردن; A1; Bcl-2-related protein A1; Apaf-1; Apoptotic protease-activating factor 1; ASK1; Apoptosis Signal Regulated Kinase 1; Bad; Bcl-2 associated agonist of cell death; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2-associated X protein; Bcl-2; B-cell l
Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury
Keywords: تکه کردن; Ad; adenovirus; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ATF6; activating transcription factor 6; ChIP; chromatin immunoprecipitation; CHOP; C/EBP homologous protein; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxid
Ageing sensitized by iPLA2β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids
Keywords: تکه کردن; ACC; acetyl-CoA carboxylase; ATF6; activating transcription factor6; AB-PAS; alcian blue-periodic acidschiff; ACC; acetyl-CoA carboxylase; ACSL; long-chain acyl-CoA synthetase; Bad; Bcl-2-associated death promoter; Bax; Bcl-2-like protein 4; Bcl-2; B-cell
The regulation of cellular apoptosis by the ROS-triggered PERK/EIF2α/chop pathway plays a vital role in bisphenol A-induced male reproductive toxicity
Keywords: تکه کردن; AIF; apoptosis-inducing factor; ATF6; activating transcription factor 6; BPA; bisphenol A; CHOP; CCAAT/enhancer-binding protein-homologous protein; Cyt-c; cytochrome complex; EdU; 5-ethynyl-2â²-deoxyuridine; EIF2α; eukaryotic initiation factor 2 α; ER;
Chemistry and biology of reactive species with special reference to the antioxidative defence status in pancreatic β-cells
Keywords: تکه کردن; ACOXs; acyl-CoA oxidases; BiP; binding protein; CHOP; CCAAT-enhancer-binding protein homologous protein; Cu/ZnSOD; Cu/Zn superoxide dismutase; Dmt1; divalent metal transporter 1; EDTA; ethylenediaminetetraacetic acid; eNOS; endothelial nitric oxide syntha