Targeted therapy of chronic myeloid leukemia
Keywords: BCR-ABL; Kinase inhibitor; Leukemia stem cells; CML; Targeted therapy;
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Nɛ-(carboxymethyl)lysine linkage to α-synuclein and involvement of advanced glycation end products in α-synuclein deposits in an MPTP-intoxicated mouse model
Keywords: Parkinson’s disease; CML; CEL; Pentosidine; Pyrralineadvanced glycation end products, AGEs; AGEs-modified BSA, AGE-BSA; Alzheimer’s disease, AD; bovine serum albumin, BSA; Nɛ-(carboxyethyl)lysine, CEL; Nɛ-(carboxymethyl)lysine, CML; diffuse Lewy body dise
Diabetes-associated changes and role of NÉ-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction
Keywords: Big ET-1; CML; Coronary artery; Diabetes; Endothelin; Perfused heart;
Meta-analysis of microarray data: The case of imatinib resistance in chronic myelogenous leukemia
Keywords: Meta-analysis; Microarrays; Imatinib resistance; CML; Gene expression
Imatinib does not induce cardiotoxicity at clinically relevant concentrations in preclinical studies
Keywords: ADP; adenosine diphosphate; ATP; adenosine triphosphate; AUC; area under the concentration-time curve; Cmax; maximal concentration; c-Abl; C-terminus of Abl gene; CML; chronic myeloid leukemia; ED; end-diastole; ER; endoplasmic reticulum; ES; end-systol
Structural resemblances and comparisons of the relative pharmacological properties of imatinib and nilotinib
Keywords: Imatinib; Nilotinib; BCR-ABL1; CSF-1R; CML; Similarity; Adverse events; TanimotoBCR-ABL1, breakpoint cluster region-Abelson fusion protein; CML, chronic myeloid leukaemia; DDR, discoidin domain receptor; PDGFR, platelet-derived growth factor receptor; KIT
Design, synthesis, and biological evaluation of novel water-soluble triptolide derivatives: Antineoplastic activity against imatinib-resistant CML cells bearing T315I mutant Bcr-Abl
Keywords: Triptolide; Derivatives; Synthesis; RNA polymerase; Inhibitor; Modeling; Tyrosine kinase inhibitors; Imatinib-resistance; CML
Celastrol, a novel HSP90 inhibitor, depletes Bcr–Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation
Keywords: CML; Bcr–Abl; T315I mutation; Imatinib; Celastrol; Apoptosis
PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60
Keywords: ZNF300; zinc finger 300; APL; acute promyelocytic leukemia; CML; chronic myelogenous leukemia; DMSO; dimethyl sulfoxide; PU.1; purine-rich box 1; ChIP; chromatin immunoprecipitation; EMSA; electrophoretic mobility shift assays; PU.1; ZNF300; Transcription
Chronic myeloid leukemia in the Asia-Pacific region: Current practice, challenges and opportunities in the targeted therapy era
Keywords: Asia; Clinical practice; CML; Imatinib; Management; Survey; TKI
BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: A review
Keywords: CML; Philadelphia chromosome; TKI; BCR-ABL;
Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: Role of macrophage scavenger receptor class A type I and II
Keywords: Food allergy; food allergen; Maillard reaction; T-cell immunogenicity; dendritic cells; macrophage scavenger receptor; AGE; Advanced glycation end product; APC; Antigen-presenting cell; CEL; Nε-carboxyethyl-lysine; CFSE; Carboxyfluorescein succinimidyl e
Aleukemic bcr-abl positive granulocytic sarcoma
Keywords: Granulocytic sarcoma; Bcr-abl; CML;
Late Mortality and Relapse following BuCy2 and HLA-Identical Sibling Marrow Transplantation for Chronic Myelogenous Leukemia
Keywords: CML; Long-term follow-up; Relapse
Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: Toward selective Abl inhibitors
Keywords: Pyridopyrimidines; CML; Abl kinase; Inhibitor;
Controlling subcellular localization to alter function: Sending oncogenic Bcr–Abl to the nucleus causes apoptosis
Keywords: Bcr–Abl; Apoptosis; Nuclear localization; Protein switch; CML
Quantitative monitoring of the T315I mutation in patients with chronic myeloid leukemia (CML)
Keywords: CML; BCR-ABL; T315I mutation; Monitoring;
Association between polymorphisms of folate-metabolizing enzymes and hematological malignancies
Keywords: AML; CML; MDS; ALL; Polymorphism; Folate-metabolizing enzymes; Association
C3G silencing enhances STI-571-induced apoptosis in CML cells through p38 MAPK activation, but it antagonizes STI-571 inhibitory effect on survival
Keywords: C3G; p38 MAPK; Apoptosis; STI-571; CML;
Discrimination of HLA null and low expression alleles by cytokine-induced secretion of recombinant soluble HLA
Keywords: aa; amino acid; β2-m; β2-microglobulin; B-LCL; B-lymphoblastoid cell line; Bp; base pair; CML; chronic myeloid leukemia; EBV; Epstein-Barr virus; FACS; fluorescence-activated cell sorter; FITC; fluorescein isothiocyanate; GvHD; graft-versus-host disease
The amelioration of streptozotocin diabetes-induced renal damage by Wu-Ling-San (Hoelen Five Herb Formula), a traditional Chinese prescription
Keywords: ACEIs; angiotensin-converting enzyme inhibitors; ARBs; angiotensin receptor blockers; AGEs; advanced glycation end products; BSA; bovine serum albumin; BUN; blood urea nitrogen; CML; NÉ-(carboxymethyl)lysine; Cr; creatinine; Ccr; creatinine clearance; DA
Exploring the Human Genome in Cancer with Genomic Approaches
Keywords: ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; CML; chronic myeloid leukemia; ER; estrogen receptor;
Suboptimal Response to or Failure of Imatinib Treatment for Chronic Myeloid Leukemia: What Is the Optimal Strategy?
Keywords: CCyR; complete cytogenetic response; CHR; complete hematologic response; CML; chronic myeloid leukemia; CP; chronic phase; ELN; European LeukemiaNet; IRIS; International Randomized Study of Interferon vs STI571; MCyR; major cytogenetic response; MMR; majo
Intrinsic innervation of the horse ileum
Keywords: CGRP; calcitonin gene-related peptide; ChAT; choline acetyl transferase; CML; circular muscle layer; DRG; dorsal root ganglion; EGS; equine grass sickness; ENS; enteric nervous systems; GIT; gastrointestinal tract; ICJ; ileocaecal junction; IPANs; intrins
Treatment strategies for CML
Keywords: CML; imatinib; BCR-ABL1; dasatinib; nilotinib; adherence
Cause and management of therapy resistance
Keywords: CML; tyrosine kinase inhibitors; resistance; imatinib; nilotinib; dasatinib; mutations; BCR-ABL
Epigenetic down-regulation of BIM expression is associated with reduced optimal responses to imatinib treatment in chronic myeloid leukaemia
Keywords: BIM; CML; Imatinib; Methylation;
LipoproteÃnas, plaquetas y aterotrombosis
Keywords: LipoproteÃnas de baja densidad; Aterosclerosis; Plaquetas; Células vasculares residentes; Low-density lipoprotein; Atherosclerosis; Platelets; Resident vascular cells; ADP; adenosindifosfato; AMP; adenosinmonofosfato; CE; célula endothelial; CML; célu
Management of Drug Toxicities in Chronic Myeloid Leukaemia
Keywords: CML; toxicity; kinase inhibitors
Tailoring tyrosine kinase inhibitor therapy to tackle specific BCR-ABL1 mutant clones
Keywords: CML; Imatinib; Nilotinib; Bosutinib; BCR-ABL1; Clones
Repetitive DNA hypomethylation in the advanced phase of chronic myeloid leukemia
Keywords: LINE1; Alu; Satellite-alpha; Satellite-2; Hypomethylation; CML
Cryptanalysis of a spatiotemporal chaotic image/video cryptosystem
Keywords: Cryptanalysis; Chaotic encryption; Keystream; CML; CBC; PCBC
Increased serum endogenous secretory receptor for advanced glycation end-product (esRAGE) levels in type 2 diabetic patients with decreased renal function
Keywords: esRAGE; AGEs; CML; Diabetic nephropathy; Hemodialysis
La réaction de Maillard dans les aliments : quels enjeux pour la santé humaine ?
Keywords: Réaction de Maillard; Contaminants néoformés; Traitements thermiques; Aliments; Santé; Maillard reaction; Neoformed contaminants; Heat treatment; Food; Health; AGEs; Produits avancés de Maillard endogènes (Advanced Glycation End Products); CML; carb
High-resolution melt curve analysis: Initial screening for mutations in BCR-ABL kinase domain
Keywords: CML; BCR-ABL; HRM; Kinase domain; Mutation; Resistance
Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease
Keywords: AASA; aminoadipic semialdehyde; BSE; bovine spongiform encephalopathy; CEL; N-É-carboxyethyllysine; CJD; Creutzfeldt-Jakob disease; CML; N-É-carboxymethyllysine; DBI; double bond index; GSA; glutamic semialdehyde, 4-HNE, 4-hydroxynonenal; MCO; metal-cat
An immunological method for the detection of BCR-ABL fusion protein and monitoring its activation
Keywords: BCR-ABL; Fusion protein; CML; Beads; Phosphorylation; MDR; Imatinib;
Spatial autocorrelation in masting phenomena of Quercus serrata detected by multi-spectral imaging
Keywords: Masting; Remote sensing; Quercus serrata; CML; Correlogram; Spatio-temporal dynamics; eCognition; Multi-spectral imaging;
STI571 and morpholine derivative of doxorubicin collaborate in inhibition of K562 cell proliferation by inducing differentiation and mitochondrial pathway of apoptosis
Keywords: Differentiation; CML; STI571; Anthracycline derivatives
Computer aided aroma design I–Molecular knowledge framework
Keywords: Computer aided aroma design; Molecular framework; Molecular graph; CML; ThermoML; Odour quality; Subjective property
HOXA10 expression induced by Abl kinase inhibitors enhanced apoptosis through PI3K pathway in CML cells
Keywords: Bcr-Abl; HOXA10; Stem cells; Apoptosis; CML
Detection of BCR-ABL gene mutations in Philadelphia chromosome positive leukemia patients resistant to STI-571 cancer therapy
Keywords: ALL; CML; MRD; dHPLC; STI571; Imatinib; Gene mutation
STI571/doxorubicin concentration-dependent switch for diverse caspase actions in CML cell line K562
Keywords: Ara-C; cytarabine, cytosine arabinoside; Bcl-XL(B-cell leukemia/lymphoma extra long); anti-apoptotic protein; CML; chronic myelogenous leukemia; DAPI; 4,6-diamidino-2-phenylidole; ÎΨm; mitochondrial transmembrane potential; DMSO; dimethyl sulfoxide; DOX
FoxO tumor suppressors and BCR–ABL-induced leukemia: A matter of evasion of apoptosis
Keywords: Apoptosis; BCR–ABL; CML; FoxO; Imatinib resistance; Proteasomal degradation
Electrochemical DNA biosensor for the detection of short DNA species of Chronic Myelogenous Leukemia by using methylene blue
Keywords: Biosensors; DNA; Hybridization; CML; Methylene blue; Sequence-specific electrochemical detection
mRNA expression of MAGE-A3 gene in leukemia cells
Keywords: MAGE-A; Leukemia; AML; ALL; CML
Increased frequencies of glutathione-S-transferase (GSTM1 and GSTT1) null genotypes in Indian patients with chronic myeloid leukemia
Keywords: Polymorphism; Glutathione-S-transferase; CML
MTHFR 677CC/1298CC genotypes are highly associated with chronic myelogenous leukemia: A case-control study in Korea
Keywords: MTHFR; Polymorphism; CML; AML; MM
Optimization of novel combi-molecules: Identification of balanced and mixed bcr-abl/DNA targeting properties
Keywords: bcr-abl; CML; Triazene; Inhibitors; Chronic myelogenous leukemia; Pyridopyrimidine; Gleevec; Combi-molecule
The design and preliminary structure–activity relationship studies of benzotriazines as potent inhibitors of Abl and Abl-T315I enzymes
Keywords: Abl inhibitor; Abl-T315I; Bcr-Abl; Cancer; Kinase inhibitor; Benzotriazines; CML; Chronic myeloid leukemia