In vivo effect of borneol on rat hepatic CYP2B expression and activity
Keywords: گیرنده آندروستان پایدار; Borneol; CYP2B; Rat liver; Constitutive androstane receptor;
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Effect of carbamazepine on expression of UDP-glucuronosyltransferase 1A6 and 1A7 in rat brain
Keywords: گیرنده آندروستان پایدار; Uridine 5â²-diphosphate-glucuronosyltransferases; Carbamazepine; Brain; Induction; Constitutive androstane receptor;
Intracellular localization of pregnane X receptor in HepG2 cells cultured by the hanging drop method
Keywords: گیرنده آندروستان پایدار; Pregnane X receptor; Three-dimensional culture; Hanging drop method; Cytoplasmic retention; Nuclear translocation; Human hepatocarcinoma cell; 2D; two-dimensionally; 3D; three-dimensionally; CAR; constitutive androstane receptor; CCRP; cytoplasmic CAR ret
Pregnane X receptor (PXR) deficiency improves high fat diet-induced obesity via induction of fibroblast growth factor 15 (FGF15) expression
Keywords: گیرنده آندروستان پایدار; FGF; fibroblast growth factor; PXR; pregnane X receptor; NR; nuclear receptor; CAR; constitutive androstane receptor; CYP; cytochrome P450; CYP7A1; cholesterol 7α-hydroxylase; CYP8B1; sterol 12α-hydroxylase; HFD; high fat diet; KO; knockout; ob; obesity
Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[α]-pyrene-induced DNA damage
Keywords: گیرنده آندروستان پایدار; PXR; pregnane X receptor; AhR; aryl hydrocarbon receptor; DRE; dioxin response element; BaP; benzo[a]pyrene; RIF; rifampicin; H2Ax; histone 2Ax; CAR; constitutive androstane receptor; FXR; farnesoid X receptor; CYP450; cytochrome P450; EROD; 7-ethoxyresor
RNA sequencing indicates that atrazine induces multiple detoxification genes in Daphnia magna and this is a potential source of its mixture interactions with other chemicals
Keywords: گیرنده آندروستان پایدار; Gene expression; Mixture model; Nuclear receptor; Aquatic toxicology; Induction; Concentration-dependent; ADH; Alcohol dehydrogenase; AUC; Area under the curve; ABC transporter; ATP-binding cassette transporter; BPA; Bisphenol A; CATAM; Computational Appr
Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation
Keywords: گیرنده آندروستان پایدار; Food-drug interactions; Drug metabolism; Nuclear receptors; Steviol; Stevioside; ADI; accepted daily intake; AHR; arylhydrocarbon receptor; CAR; constitutive androstane receptor; CYP; cytochrome P450; DDIs; drug-drug interactions; FDIs; food-drug interact
Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity
Keywords: گیرنده آندروستان پایدار; Ursolic acid; Pregnane x receptor; Constitutive androstane receptor; Cytochrome P450; Rifampin; Isoniazid; CAR; constitutive androstane receptor; CITCO; 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde o-(3,4-dichlorobenzyl)-oxime; CYP450; cyt
Comparison of xenobiotic-metabolising human, porcine, rodent, and piscine cytochrome P450
Keywords: گیرنده آندروستان پایدار; Comparison; Detoxification; Drug; Model organism; Pollution; BaP; benzo[a]pyrene; BFCOD; benzyloxy-4-trifluoromethylcoumarin O-debenzylase; CAR; constitutive androstane receptor; CYP; cytochrome P450; EROD-7; ethoxyresorufin dealkylation; GR; glucocortico
Cellular adaptation to xenobiotics: Interplay between xenosensors, reactive oxygen species and FOXO transcription factors
Keywords: گیرنده آندروستان پایدار; AhR; arylhydrocarbon receptor; AIP; AhR interacting protein; ARE; antioxidant response element; ARNT; AhR nuclear translocator; bHLH; basic helix-loop-helix (DNA binding and dimerisation domain); CAR; constitutive androstane receptor; CBP; CREB-binding pr
Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of α-endosulfan and dioxin in HepaRG human cells
Keywords: گیرنده آندروستان پایدار; ADH; Alcohol dehydrogenase; AHR; Aryl hydrocarbon receptor; ALD; Alcohol liver disease; ARNT; AHR nuclear translocator; CAR; Constitutive androstane receptor; CYP; Cytochrome P450; ER; Estrogen receptor; OCP; Organochlorine pesticide; POP; Persistent orga
RNAi suppression of nuclear receptor genes results in increased susceptibility to sulfoxaflor in brown planthopper, Nilaparvata lugens
Keywords: گیرنده آندروستان پایدار; AHR; aryl hydrocarbon receptor; BLAST; basic local alignment search tool; CAR; constitutive androstane receptor; CYP; cytochrome P450; DBD; DNA-binding domain; ERR; estrogen-related receptor; EST; expressed sequence tag; GR; glucocorticoid receptor; HNF4;
Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal
Keywords: گیرنده آندروستان پایدار; CAR; constitutive androstane receptor; CDK2; cyclin-dependent kinase 2; ChIP assay; chromatin immunoprecipitation assay; CYP; cytochrome P450; FOXO1; forkhead box protein O1; PCK1; phosphoenolpyruvate carboxykinase 1; PPARα; peroxisome proliferator-activ
Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction
Keywords: گیرنده آندروستان پایدار; Human induced pluripotent stem cells; Hepatocyte; Drug metabolism; ATF5; c/EBPα; PROX1; Human iPS-HLCs; Human induced pluripotent stem cells-derived hepatocyte-like cells; HLCs; Hepatocyte-like cells; ATF5; Activating transcription factor 5; c/EBPα; CCA
Research ArticleThe metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival
Keywords: گیرنده آندروستان پایدار; 2-AAF; 2-acetylaminofluorene; CAR; constitutive androstane receptor; CMD; choline devoid-methionine deficient diet; DENA; diethylnitrosamine; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GSTP; placental glutathione S-transferase; HAO2; 2-hydroxy acid
MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes
Keywords: گیرنده آندروستان پایدار; CYP; cytochrome P450; miRNA; microRNA; DMETs; drug metabolizing enzymes and transporters; CAR; constitutive androstane receptor; PXR; pregnane X receptor; RE; response element; 3â²-UTR; 3â²-untranslated region; SULT; sulfotransferase; Ago; argonaute RIS
Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis
Keywords: گیرنده آندروستان پایدار; apoE; apolipoprotein E; BA; bile acids; CAR; constitutive androstane receptor; CD36; cluster of differentiation 36 or fatty acid translocase (FAT); CEBPα; transcription factor CCAAT/enhancer binding protein α; DGAT2; diacylglycerol O-acyltransferase 2;
RXRα, PXR and CAR xenobiotic receptors mediate the apoptotic and neurotoxic actions of nonylphenol in mouse hippocampal cells
Keywords: گیرنده آندروستان پایدار; bbb; blood-brain barrier; CAR; constitutive androstane receptor; DIV; day in vitro; DMSO; dimethyl sulfoxide; EDC; endocrine-disrupting chemical; ER; estrogen receptor; LDH; lactate dehydrogenase; NP; nonylphenol; PBS; phosphate-buffered saline; PXR; pr
Bioinformatic analysis of microRNA networks following the activation of the constitutive androstane receptor (CAR) in mouse liver
Keywords: گیرنده آندروستان پایدار; microRNA; Liver cancer; Constitutive androstane receptor; TCPOBOP; Mouse
Inhibition of β-catenin signaling by phenobarbital in hepatoma cells in vitro
Keywords: گیرنده آندروستان پایدار; 5-ethyl-5-phenylbarbituric acid; Wnt signaling; Liver tumor; Constitutive androstane receptor; Tumor promotion; Hepatocyte;
Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor
Keywords: گیرنده آندروستان پایدار; Gluconeogenesis; Lipogenesis; Rutaecarpine; Evodiamine; Constitutive androstane receptor
The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4
Keywords: گیرنده آندروستان پایدار; FLU; flutamide; AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; CYP; cytochrome P450; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; 3-MC; 3-methylcholanthrene; ABCC4; ATP-binding cassette sub-family C member 4; MRP4; mul
Insights into CYP2B6-mediated drug-drug interactions
Keywords: گیرنده آندروستان پایدار; CAR; constitutive androstane receptor; C/EBP; CCAAT/enhancer-binding protein; CHOP; cyclophosphamide-doxorubicin-vincristine-prednisone; CITCO; (6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime); COUP-TF; chic
Characterizing drug-metabolizing enzymes and transporters that are bona fide CAR-target genes in mouse intestine
Keywords: گیرنده آندروستان پایدار; Aldh; aldehyde dehydrogenase; Asbt; solute carrier family 10, member 2 (apical sodium/bile acid cotransporter); CAR; constitutive androstane receptor; cDNA; complementary DNA; CITCO; 6-(4-chlorophenyl)imidazo [2,1-b](1,3)thiazole-5-carbaldehyde O-(3,4-dic
Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor
Keywords: گیرنده آندروستان پایدار; Constitutive androstane receptor; CINPA1; Inverse agonist; TR-FRETCAR, constitutive androstane receptor; PXR, pregnane X receptor; NR, nuclear receptor; CYP2Bs, cytochrome P450, family 2, subfamily B proteins; CYP2Cs, cytochrome P450, family 2, subfamily
Phenobarbital reduces blood glucose and gluconeogenesis through down-regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression in rats
Keywords: گیرنده آندروستان پایدار; PEPCK; Phenobarbital; Blood glucose; Pyruvate challenge; Diabetes; Hepatocyte; apo; apolipoprotein; AUC; area under the curve; CAR; constitutive androstane receptor; CAT; chloramphenicol acetyltransferase; CREB; cAMP response element binding protein; CYP;
In vivo induction of CYP in mice by carbamazepine is independent on PXR
Keywords: گیرنده آندروستان پایدار; CBZ; carbamazepine; CYP; cytochrome P450; PXR; pregnane X receptor; CBZ-E; CBZ 10,11-epoxide; CAR; constitutive androstane receptor; Wt; wild-type; ALT; alanine aminotransferase; AST; aspartate aminotransferase; q-PCR; quantitative real-time PCR; Inductio
Investigation of the dominant positive effect of porcine farnesoid X receptor (FXR) splice variant 1
Keywords: گیرنده آندروستان پایدار; CAR; constitutive androstane receptor; PXR; pregnane X receptor; FXR; farnesoid X receptor; CYP3A4; cytochrome P450 3A4; SULT2A1; hydroxysteroid sulfotransferase; UGT2B4; UDP-glucuronosyltransferase 2B4; GRβ; glucocorticoid receptor β; ERE; estrogen res
CommentaryRoles of human UDP-glucuronosyltransferases in clearance and homeostasis of endogenous substrates, and functional implications
Keywords: گیرنده آندروستان پایدار; UDP-glucuronosyltransferase; Bilirubin; Serotonin; 20-HETE; Vitamins A and D; AhR; aryl hydrocarbon receptor; CAR; constitutive androstane receptor; HETE; hydroxyeicosatetraenoic acid; LTB4; leucotriene B4; PPAR; peroxisome proliferator-activated receptor
Xenosensor CAR mediates down-regulation of miR-122 and up-regulation of miR-122 targets in the liver
Keywords: گیرنده آندروستان پایدار; Constitutive androstane receptor; HNF4α; MiR-122; cMyc; TCPOBOP; Liver
Research paperHigh resolution melting analysis of the NR1I3 genetic variants: Is there an association with neonatal hyperbilirubinemia?
Keywords: گیرنده آندروستان پایدار; CAR; constitutive androstane receptor; NR1I3; nuclear receptor subfamily 1, group I, member 3; HRM; high resolution melting; UGT1A1; uridine diphosphate glucuronosyltransferase 1A1; gtPBREM; glucuronosyltransferase phenobarbital-responsive enhancer module
Research ArticleMetformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice
Keywords: گیرنده آندروستان پایدار; APAP; acetaminophen; ALT; alanine aminotransferase; AST; aspartate aminotransferase; CAR; constitutive androstane receptor; CYP450; cytochrome P450; GSH; glutathione; Gadd45β; growth arrest and DNA damage-inducible 45 beta; JNK; c-Jun-N-terminal kinase;
Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene-induced lipid accumulation in hepatocytes
Keywords: گیرنده آندروستان پایدار; AhR; arylhydrocarbon receptor; BaP; benzo[a]pyrene; NAFLD; non-alcoholic fatty liver disease; TCDD; 2,3,7,8-tetrachlorodibenzodioxin; SDS; sodiumdodecyl-sulfate; CAR; constitutive androstane receptor; PXR; pregnane X receptor; ARNT; aryl hydrocarbon recep
Detection and measurement of the agonistic activities of PCBs and mono-hydroxylated PCBs to the constitutive androstane receptor using a recombinant yeast assay
Keywords: گیرنده آندروستان پایدار; Constitutive androstane receptor; Polychlorinated biphenyls; Hydroxylated PCB; Recombinant yeast; 2â²,4â²,6â²-Trichlorobiphenyl-4-ol (4â²-OH-CB30); 2,2â²,4â²,6â²-Tetrachlorobiphenyl-4-ol (4â²-OH-CB50);
Tunicate pregnane X receptor (PXR) orthologs: Transcript characterization and natural variation
Keywords: گیرنده آندروستان پایدار; AF-1; transcription activation function 1; AR; androgen receptor; BsVDR/PXRα; Botryllus schlosseri VDR/PXR ortholog α; BSA; bovine serum albumin; bp; base pair; CAR; constitutive androstane receptor; CiVDR/PXRα; Ciona intestinalis VDR/PXR ortholog α;
Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR)
Keywords: گیرنده آندروستان پایدار; CAR; constitutive androstane receptor; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor (ErbB-1, ERBB, HER1); ELK1; transcription factor, a member of ETS oncogene family; ERK; mitogen-activated protein kinases 1 and 3 (MAPK1 and 3); LB
Tanshinone IIA exerts protective effects in a LCA-induced cholestatic liver model associated with participation of pregnane X receptor
Keywords: گیرنده آندروستان پایدار; BAs; Bile acids; LCA; lithocholic acid; Tan IIA; Tanshinone IIA; siRNA; Small interfering RNA; RIF; Rifampicin; PCN; pregnenolone 16a-carbonitrile; PXR; pregnane X receptor; CAR; constitutive androstane receptor; VDR; vitamin D receptor; Tanshinone IIA (P
Impact of gender on efficacy and acute toxicity of alkylating agent -based chemotherapy in Ewing sarcoma: Secondary analysis of the Euro-Ewing99-R1 trial
Keywords: گیرنده آندروستان پایدار; Ewing sarcomas; Alkylating agent; Gender; Efficacy; Toxicity; Interaction; Metabolism; Constitutive androstane receptor; CYP3A4; CYP2B6;
Efectos de los inductores antiepilépticos en la neuropsicofarmacología: una cuestión ignorada. Parte II: cuestiones farmacológicas y comprensión adicional
Keywords: گیرنده آندروستان پایدار; Anticonvulsivos; Receptor de aril hidrocarburos; Receptor constitutivo de androstano; Receptores de los estrógenos; Receptor de los glucocorticoides; Receptor de pregnano XAnticonvulsants; Aryl hydrocarbon receptor; Constitutive androstane receptor; Estro
Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor
Keywords: گیرنده آندروستان پایدار; AhR; arylhydrocarbon receptor; CAR; constitutive androstane receptor; CYP; cytochrome P450; DMSO; dimethylsulphoxide; DBD; DNA binding domain; LBD; ligand binding domain; NBH; New Bedford Harbor; PCR; polymerase chain reaction; PXR; pregnane-X-receptor; P
Assessment of estrogenic and anti-androgenic activities of the mycotoxin zearalenone and its metabolites using in vitro receptor-specific bioassays
Keywords: گیرنده آندروستان پایدار; E2; 17β-estradiol; MTT; 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-tetrazolium bromide; AhR; aryl hydrocarbon receptor; CPP; central precocious puberty; CAR; constitutive androstane receptor; DCC; dextran-coated charcoal; DMSO; dimethyl sulfoxide; ERs; es
CAR-mediated repression of Foxo1 transcriptional activity regulates the cell cycle inhibitor p21 in mouse livers
Keywords: گیرنده آندروستان پایدار; Constitutive androstane receptor; FOXO1; Cell cycle; Mitogen; TCPOBOP; Liver
Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action
Keywords: گیرنده آندروستان پایدار; Conazoles; Phenobarbital; Propiconazole; Toxicogenomics; Constitutive androstane receptor
Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes
Keywords: گیرنده آندروستان پایدار; Constitutive androstane receptor; Energy metabolism; Human primary hepatocytes; Species difference
Comparative study of bisphenol A and its analogue bisphenol S on human hepatic cells: A focus on their potential involvement in nonalcoholic fatty liver disease
Keywords: گیرنده آندروستان پایدار; Ab; antibody; BPA; bisphenol A; BPS; bisphenol S; BSA; bovine serum albumin; CAR; constitutive androstane receptor; CsA; cyclosporine A; DES; diethylstilbestrol; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; HCS; high content screening; NAFLD; nonalc
Short-term calorie restriction feminizes the mRNA profiles of drug metabolizing enzymes and transporters in livers of mice
Keywords: گیرنده آندروستان پایدار; Abc; ATP-binding cassette; Adh; alcohol dehydrogenase; AhR; aryl hydrocarbon receptor; Aldh; aldehyde dehydrogenase; AL; ad libitum; Bcrp; breast cancer resistant protein; CAR; constitutive androstane receptor; Ces; carboxylesterase; Comt; catechol-O-meth
Menthol reduces the anticoagulant effect of warfarin by inducing cytochrome P450 2C expression
Keywords: گیرنده آندروستان پایدار; Cytochrome P450; Menthol; Warfarin; Liver; Constitutive androstane receptor; Pregnane X receptor
Cooperation of structurally different aryl hydrocarbon receptor agonists and β-catenin in the regulation of CYP1A expression
Keywords: گیرنده آندروستان پایدار; AhR; aryl hydrocarbon receptor; BHA; butylated hydroxyanisole; BNF; β-naphthoflavone; CAR; constitutive androstane receptor; CYP; cytochrome P450; DRE; dioxin response element; GS; glutamine synthetase; GST; glutathione S-transferase; 3MC; 3-methylcholan
Integrated systems toxicology approaches identified the possible involvement of ABC transporters pathway in erythromycin estolate-induced liver injury in rat
Keywords: گیرنده آندروستان پایدار; AA; arachidonic acid; ABC; ATP-binding cassette; AhR; aryl hydrocarbon receptor; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ALP; alkaline phosphatase; CAR; constitutive androstane receptor; Cyp1a1; P450 family 1 subfamily a, polypepti
Human cytochrome P450 epoxygenases: Variability in expression and role in inflammation-related disorders
Keywords: گیرنده آندروستان پایدار; Inflammation; Cytochrome P450; Epoxygenase; Epoxyeicosatrienoic acids; Variability; AA; arachidonic acid; AhR; aryl hydrocarbon receptor; AP-1; activator protein-1; bZIP; basic leucine zipper; CAR; constitutive androstane receptor; CCRP; cytoplasmic CAR r