Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities
Keywords: Blaps japanensis; Insects; N-Acetyldopamine dimers; COX-1; COX-2;
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Structure Based Library Design (SBLD) for new 1,4-dihydropyrimidine scaffold as simultaneous COX-1/COX-2 and 5-LOX inhibitors
Keywords: COX-2; COX-1; 5-LOX; Structure Based Library Design (SBLD); Virtual Combinatorial Library Design; Virtual screening; Docking study; 1,4-Dihydropyrimidine;
Prostaglandin receptor EP1-mediated differential degradation of cyclooxygenases involves a specific lysine residue
Keywords: Cyclooxygenase; COX-2; COX-1; EP1; Ubiquitination; Degradation;
Impacts of COX-1 gene polymorphisms on vascular outcomes in patients with ischemic stroke and treated with aspirin
Keywords: COX-1; cyclooxygenase-1; TXA2; thromboxane A2; SNP; single nucleotide polymorphism; MAF; minor allele frequency; iMLDR; improved multiplex ligase detection reaction; LD; linkage disequilibrium; TIA; transient ischemic attack; Aspirin nonresponsiveness; Pr
A computational prospect to aspirin side effects: Aspirin and COX-1 interaction analysis based on non-synonymous SNPs
Keywords: Aspirin; COX-1; nsSNP; Amber score
Bases chimiques et pharmacologiques des AINS
Keywords: AINS; COX-1; COX-2; Sélectivité; ClassificationNSAIDs; COX-1; COX-2; Coxibs; Selectivity; Classification
Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries
Keywords: 2-AG; 2-arachidonoylglcerol; AEA; anandamide; ANOVA; analysis of variance; CB1; cannabinoid receptor one; CB2; cannabinoid receptor two; COX-1; cyclooxygenase one; COX-2; cyclooxygenase two; ECS; endocannabinoid system; FAAH; fatty acid amide hydrolase; K
PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1
Keywords: PD; Parkinson's disease; PPARγ; peroxisome proliferator-activated receptor gamma; TZDs; thiazolidinediones; RGS; Rosiglitazone; ÎΨm; Mitochondrial membrane potential; ROS; reactive oxygen species; PI; propidium Iodide; TMRM; Tetramethylrhodamine methyl
The pore-lining regions in cytochrome c oxidases: A computational analysis of caveolin, cholesterol and transmembrane helix contributions to proton movement
Keywords: Cytochrome c oxidase; COX-1; Cholesterol; Caveolin; Protein topology; Channels;
Nonsteroidal Antiinflammatory Drugs, Cyclooxygenase-2, and the Kidneys
Keywords: NSAIDS; COX-1; COX-2; Kidneys; Hypertension; Acute kidney injury; Electrolytes; Glomerular filtration rate;
Phenolic profile, antioxidant, anti-inflammatory and cytotoxic activities of black (Tuber aestivum Vittad.) and white (Tuber magnatum Pico) truffles
Keywords: 12-HETE; 12(S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid; 12-HHT; 12(S)-hydroxy-(5Z,8E,10E)-heptadecatrienoic acid; 12-LOX; 12-lipoxygenase; AAE; ascorbic acid equivalents; BHT; butylated hydroxytoluene; COX-1; cyclooxygenase-1; DMEM; Dulbecco's mod
Involvement of bradykinin and prostaglandins in the diuretic effects of Achillea millefolium L. (Asteraceae)
Keywords: ACE; Angiotensin-converting enzyme; AEAM; Aqueous extracts of Achillea millefolium L.; ANOVA; Analysis of variance; B2; Bradykinin B2 receptor; CNPq; Conselho Nacional de Desenvolvimento CientÃï¬co e Tecnológico; COX; Cyclooxygenase; COX-1; Cyclooxygen
Differential role of cyclooxygenase-1 and -2 on renal vasoconstriction to α1-adrenoceptor stimulation in normotensive and hypertensive rats
Keywords: SHR; COX-1; COX-2; α1-Adrenoceptors; Renal vascular bed;
Establishing novel prostacyclin-synthesizing cells with therapeutic potential against heart diseases
Keywords: AA; arachidonic acid; COX; Cylclooxygenase; COX-1; Cylclooxygenase isomer-1; COX-2; Cylclooxygenase isomer-2; cPGES; cytosolic PGE2 synthase; DP; Prostaglandin D2 receptor; EP; Prostaglandin E2 receptor; FP; Prostaglandin F2 receptor; HPLC; high-performan
A prospective, randomized, double-blind, multicenter comparative study on the safety and efficacy of Celecoxib and GCSB-5, dried extracts of six herbs, for the treatment of osteoarthritis of knee joint
Keywords: ADR; adverse drug reaction; AE; adverse events; COX-1; cyclooxygenase-1; COX-2 inhibitor; cyclooxygenase-2 inhibitor; FDA; Food and Drug Administration; GEE; generalized estimating equation; ITT; intention to Treat; IL-1beta; inteleukin-1β; K/L; Kellgren
PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins
Keywords: PSAP; presenilin-associated protein; PARP; poly(ADP-ribose) polymerase; Bcl-2; B-cell lymphoma 2; LacZ; β-galactosidase; Z-VAD-fmk; benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone; FADD; Fas-associated death domain; DISC; death-inducing signaling comple
Synthesis and SAR study of imidazoquinolines as a novel structural class of microsomal prostaglandin E2 synthase-1 inhibitors
Keywords: mPGES-1; PGE2; Imidazoquinoline; COX-1; COX-2;
Helicobacter pylori Infection and Nonsteroidal Anti-inflammatory Drug Use: Eradication, Acid-Reducing Therapy, or Both?
Keywords: ASA; acetylsalicylic acid; CI; confidence interval; COX-1; cyclooxygenase 1; CV; cardiovascular; GI; gastrointestinal; NSAID; nonsteroidal anti-inflammatory drug; OR; odds ratio; PPI; proton pump inhibitor;
myo-Inositol esters of indomethacin as COX-2 inhibitors
Keywords: Cyclooxygenase; COX-1; COX-2; Indomethacin; myo-Inositol
A comparative study of chronic kidney disease in dogs and cats: Induction of cyclooxygenases
Keywords: Cats; Chronic kidney disease; COX-1; COX-2; Dogs;
Phenolic profile, antioxidant, anti-inflammatory and cytotoxic activities of endemic Plantago reniformis G. Beck
Keywords: 12-HETE; 12(S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid; 12-HHT; 12(S)-hydroxy-(5Z,8E,10E)-heptadecatrienoic acid; 12-LOX; 12-lipoxygenase; AAE; ascorbic acid equivalents; BHA; butylated hydroxyanisole; COX-1; cyclooxygenase-1; DMEM; Dulbecco's modif
Comparative analysis of phenolic profile, antioxidant, anti-inflammatory and cytotoxic activity of two closely-related Plantain species: Plantago altissima L. and Plantago lanceolata L.
Keywords: Plantago; Phenolics; LC-MS/MS; Antioxidant; Anti-inflammatory; Cytotoxic; COX-1; cyclooxygenase-1; 12-LOX; 12-lipoxygenase; 12-HHT; 12(S)-hydroxy-(5Z,8E,10E)-heptadecatrienoic acid; 12-HETE; 12(S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid; SRB; sulf
Evaluation of Cissus quadrangularis extracts as an inhibitor of COX, 5-LOX, and proinflammatory mediators
Keywords: Cissus quadrangularis; Cycloxygenase; Inflammation; COX-1; COX-2; 5-LOX; COX-LOX inhibition; AA; Proinflammatory mediator; Nrf-2; HO-1;
Cardiovascular effects and molecular targets of resveratrol
Keywords: 4-HNE; 4-hydroxy-2-nonenal; ADMA; asymmetric dimethylarginine; AMPK; AMP-activated protein kinase; ApoE; apolipoprotein E; ARE; antioxidant response element; BH4; tetrahydrobiopterin; Cav-1; caveolin-1; COX-1; cyclooxygenase 1; CREB; cAMP response element
Caffeic acid phenethyl ester reduces the activation of the nuclear factor κB pathway by high-fat diet-induced obesity in mice
Keywords: CAPE; caffeic acid phenethyl ester; HFD; high-fat diet; AUGC; area under glucose curve; OGTT; Oral glucose tolerance test; IRS; insulin receptor substrate; JNK; c-jun N-terminal kinase; IKKβ; inhibitor of nuclear factor kappa B kinase beta subunit; IκB;
Evaluation of the antinociceptive, anti-inflammatory and gastric antiulcer activities of the essential oil from Piper aleyreanum C.DC in rodents
Keywords: List: EOPa; Essential oils from the aerial parts of Piper aleyreanum; GSH; glutathione; GC/MS; gas chromatography and mass spectrometry; ASA; acetylsalicylic acid; DEX; dexamethasone; IND; indomethacin; SEM; standard error of mean; ANOVA; analysis of vari
Abnormal Plasma Microparticles Impair Vasoconstrictor Responses in Patients With Cirrhosis
Keywords: Microvesicle; COX-1; Hypocontractility; Hepatitis; CFSE; carboxyfluorescein succinimidyl ester; COX; cyclooxygenase; DMEM; Dulbecco's modified Eagle medium; HUVEC; human umbilical vein endothelial cell; MELD; Model of End-Stage Liver Disease; MP; micropar
Semisynthesis and pharmacological investigation of lipo-alkaloids prepared from aconitine
Keywords: COX-1, cyclooxygenase-1; COX-2, cyclooxygenase-2; LTB4, leukotriene B4Processed aconite roots; Lipo-alkaloids; COX-1; COX-2; LTB4
Anorectal Motility Abnormalities in Children with Encopresis and Chronic Constipation
Keywords: COX-1; Cyclooxygenase-1; IAS; Internal anal sphincter; RAIR; Rectoanal inhibitory reflex;
Measurement of cyclooxygenase inhibition using liquid chromatography–tandem mass spectrometry
Keywords: LC–MS–MS; COX-1; COX-2; Cyclooxygenase; Prostaglandin E2
Mitragynine inhibits the COX-2 mRNA expression and prostaglandin E2 production induced by lipopolysaccharide in RAW264.7 macrophage cells
Keywords: Mitragyna speciosa; Mitragynine; COX-1; COX-2; Anti-inflammatory
Analogue-based design, synthesis and molecular docking analysis of 2,3-diaryl quinazolinones as non-ulcerogenic anti-inflammatory agents
Keywords: Analogue-based design; 2,3-Diaryl quinazolinones; COX-1; COX-2; Anti-inflammatory activity; Ulcerogenic activity; Molecular docking
Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities
Keywords: LOX; COX-1; Antioxidant agents; Anti-inflammatory agents; Lipoxygenase inhibitors; Cyclooxygenase inhibitors; Substituted acrylic acids;
A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract
Keywords: A; adrenaline; ACE; angiotensin converting enzyme; AD; Alzheimer's disease; ADHD; attention deficit hyperactivity disorder; ADRP; adipose differentiation-related protein; AIDS; acquired immunodeficiency syndrome; ALP; alkaline phosphatase; ALT; alanine am
Platelet reactivity on aspirin, clopidogrel and abciximab in patients with acute coronary syndromes and reduced estimated glomerular filtration rate
Keywords: ACS; acute coronary syndrome; ADPtest; platelet reactivity test with adenosine diphosphate; ASPItest; platelet reactivity test with arachidonic acid; AU; aggregation unit; BMI; body mass index; CABG; coronary artery bypass grafting; CI; confidence interva
The role of Cox-2 expression in the prognosis of dogs with malignant mammary tumours
Keywords: Canine; Cox-1; Cox-2; Dog; Immunohistochemistry; Mammary tumours; Prognosis
Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata
Keywords: Neocheiropteris palmatopedata; Polypodiaceae; Flavone; Kaempferol glycosides; Palmatosides; Cancer chemoprevention; NF-κB; NO; QR2; Aromatase; COX-1; COX-2;
The N-terminus of COX-1 and its effect on cyclooxygenase-1 catalytic activity
Keywords: COX-1; COX-2; dimerization; glycosylation; aspirin; KM; Vmax
COX-1 and COX-2 Expression in Canine Cutaneous, Oral and Ocular Melanocytic Tumours
Keywords: COX-1; COX-2; dog; malignant melanoma
In vitro and ex vivo inhibition of canine cyclooxygenase isoforms by robenacoxib: A comparative study
Keywords: Robenacoxib; NSAIDs; Cyclooxygenase; COX-1; COX-2; Dog; Pharmacokinetics; Pharmacodynamics
The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1
Keywords: Cytokines; Behaviour; Systemic inflammation; Indomethacin; COX-1; COX-2;
Synthesis and antiinflammatory activity of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide
Keywords: 2-Pyrazolines; Celecoxib; Anti-inflammatory activity; COX-1; COX-2
In vitro pharmacological evaluation of three Barleria species
Keywords: Antibacterial; Anti-inflammatory; Barleria species; COX-1; COX-2
Qualitative and quantitative analysis of aconitine-type and lipo-alkaloids of Aconitum carmichaelii roots
Keywords: Aconitum carmichaelii; Diterpene alkaloids; Lipo-alkaloids; 14-Benzoylaconine-8-palmitate; 14-Benzoylaconine-8-linoleate; COX-1; COX-2; LTB4 formation; LD50; LC-APCI-MSn
Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors
Keywords: 4,5-Diphenyloxazolone; Cyclooxygenase inhibition; COX-1; COX-2; Docking
Role of the cyclooxygenase 2–thromboxane pathway in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced decrease in mesencephalic vein blood flow in the zebrafish embryo
Keywords: Blood flow; Cardiovascular toxicity; COX-1; COX-2; CYP5A; Danio rerio; Halogenated aromatic hydrocarbon; Prostaglandin; TCDD; Thromboxane; Zebrafish embryo
Stage- and region-specific cyclooxygenase expression and effects of a selective COX-1 inhibitor in the mouse amygdala kindling model
Keywords: Epilepsy; Kindling; COX-1; Microglia; Epileptogenesis
Altered apoptosis of inflammatory neutrophils in MMP-9-deficient mice is due to lower expression and activity of caspase-3
Keywords: Gelatinase B; Matrix metalloproteinase-9; Peritoneal inflammation; Peritonitis; COX-1; Leukocytes; Caspase-3
Peroxide-induced radical formation at TYR385 and TYR504 in human PGHS-1
Keywords: Prostaglandin; COX-1; Tyrosyl radical; EPR;
Expression of cyclooxygenase-1/-2, microsomal prostaglandin-E synthase-1 and E-prostanoid receptor 2 and regulation of inflammatory mediators by PGE2 in the amoeboid microglia in hypoxic postnatal rats and murine BV-2 cells
Keywords: microglia; hypoxia; COX-1/-2; mPGES-1; EP2 receptor antagonist; PGE2; AA; arachidonic acid; AMC; amoeboid microglial cells; cAMP; cyclic adenosine monophosphate; CNS; central nervous system; COX-1; cyclooxygenase-1; COX-2; cyclooxygenase-2; cPGES; cytosol