کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2538847 | 1122157 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Semisynthesis and pharmacological investigation of lipo-alkaloids prepared from aconitine Semisynthesis and pharmacological investigation of lipo-alkaloids prepared from aconitine](/preview/png/2538847.png)
Processed aconite drugs are widely used in Eastern medicine as painkillers and antirheumatic agents. It is known that the traditional processing of aconite drugs increases the amount of lipo-alkaloids. In order to obtain information about the pharmacological potential of these compounds, semisynthesis of 9 aconitine-derived lipo-alkaloids was carried out and their COX-1, COX-2 and LTB4 formation inhibitory activities were investigated. It was found that compounds esterified with unsaturated fatty acids demonstrated significant COX-2 inhibitory effects, while in the COX-1 assay only 14-benzoylaconine-8-O-eicosapentaenoate exerted remarkable activity. The inhibition of LTB4 formation was pronounced in cases of long chain fatty acid derivatives.
Graphical AbstractNine aconitine-derived lipo-alkaloids were prepared by semisynthesis and their COX-1, COX-2 and LTB4 formation inhibitory activities were investigated for the first time.Figure optionsDownload as PowerPoint slide
Journal: Fitoterapia - Volume 82, Issue 3, April 2011, Pages 365–368